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Control and Regulation of Substrate Selection in Cytoplasmic and Mitochondrial Catabolic Networks. A Systems Biology Analysis.

Cortassa S, Aon MA, Sollott SJ.

Front Physiol. 2019 Mar 8;10:201. doi: 10.3389/fphys.2019.00201. eCollection 2019.


Temporal metabolic partitioning of the yeast and protist cellular networks: the cell is a global scale-invariant (fractal or self-similar) multioscillator.

Lloyd D, Murray DB, Aon MA, Cortassa S, Roussel MR, Beckmann M, Poole RK.

J Biomed Opt. 2018 Dec;24(5):1-17. doi: 10.1117/1.JBO.24.5.051404.


Metabolic remodelling of glucose, fatty acid and redox pathways in the heart of type 2 diabetic mice.

Cortassa S, Caceres V, Tocchetti CG, Bernier M, de Cabo R, Paolocci N, Sollott SJ, Aon MA.

J Physiol. 2018 Nov 21. doi: 10.1113/JP276824. [Epub ahead of print]


Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stability.

Kembro JM, Cortassa S, Lloyd D, Sollott SJ, Aon MA.

Sci Rep. 2018 Oct 18;8(1):15422. doi: 10.1038/s41598-018-33582-w.


Computational Modeling of Mitochondrial Function from a Systems Biology Perspective.

Cortassa S, Sollott SJ, Aon MA.

Methods Mol Biol. 2018;1782:249-265. doi: 10.1007/978-1-4939-7831-1_14.


Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice.

Mitchell SJ, Bernier M, Aon MA, Cortassa S, Kim EY, Fang EF, Palacios HH, Ali A, Navas-Enamorado I, Di Francesco A, Kaiser TA, Waltz TB, Zhang N, Ellis JL, Elliott PJ, Frederick DW, Bohr VA, Schmidt MS, Brenner C, Sinclair DA, Sauve AA, Baur JA, de Cabo R.

Cell Metab. 2018 Mar 6;27(3):667-676.e4. doi: 10.1016/j.cmet.2018.02.001.


Metabolic and molecular framework for the enhancement of endurance by intermittent food deprivation.

Marosi K, Moehl K, Navas-Enamorado I, Mitchell SJ, Zhang Y, Lehrmann E, Aon MA, Cortassa S, Becker KG, Mattson MP.

FASEB J. 2018 Jul;32(7):3844-3858. doi: 10.1096/fj.201701378RR. Epub 2018 Feb 27.


Mitochondrial respiration and ROS emission during β-oxidation in the heart: An experimental-computational study.

Cortassa S, Sollott SJ, Aon MA.

PLoS Comput Biol. 2017 Jun 9;13(6):e1005588. doi: 10.1371/journal.pcbi.1005588. eCollection 2017 Jun.


Network dynamics: quantitative analysis of complex behavior in metabolism, organelles, and cells, from experiments to models and back.

Kurz FT, Kembro JM, Flesia AG, Armoundas AA, Cortassa S, Aon MA, Lloyd D.

Wiley Interdiscip Rev Syst Biol Med. 2017 Jan;9(1). doi: 10.1002/wsbm.1352. Epub 2016 Sep 7. Review.


Mitochondrial health, the epigenome and healthspan.

Aon MA, Cortassa S, Juhaszova M, Sollott SJ.

Clin Sci (Lond). 2016 Aug 1;130(15):1285-305. doi: 10.1042/CS20160002. Review.


Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.

Mitchell SJ, Madrigal-Matute J, Scheibye-Knudsen M, Fang E, Aon M, González-Reyes JA, Cortassa S, Kaushik S, Gonzalez-Freire M, Patel B, Wahl D, Ali A, Calvo-Rubio M, Burón MI, Guiterrez V, Ward TM, Palacios HH, Cai H, Frederick DW, Hine C, Broeskamp F, Habering L, Dawson J, Beasley TM, Wan J, Ikeno Y, Hubbard G, Becker KG, Zhang Y, Bohr VA, Longo DL, Navas P, Ferrucci L, Sinclair DA, Cohen P, Egan JM, Mitchell JR, Baur JA, Allison DB, Anson RM, Villalba JM, Madeo F, Cuervo AM, Pearson KJ, Ingram DK, Bernier M, de Cabo R.

Cell Metab. 2016 Jun 14;23(6):1093-1112. doi: 10.1016/j.cmet.2016.05.027.


Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure.

Nickel AG, von Hardenberg A, Hohl M, Löffler JR, Kohlhaas M, Becker J, Reil JC, Kazakov A, Bonnekoh J, Stadelmaier M, Puhl SL, Wagner M, Bogeski I, Cortassa S, Kappl R, Pasieka B, Lafontaine M, Lancaster CR, Blacker TS, Hall AR, Duchen MR, Kästner L, Lipp P, Zeller T, Müller C, Knopp A, Laufs U, Böhm M, Hoth M, Maack C.

Cell Metab. 2015 Sep 1;22(3):472-84. doi: 10.1016/j.cmet.2015.07.008. Epub 2015 Aug 6.


Impaired mitochondrial energy supply coupled to increased H2O2 emission under energy/redox stress leads to myocardial dysfunction during Type I diabetes.

Tocchetti CG, Stanley BA, Sivakumaran V, Bedja D, O'Rourke B, Paolocci N, Cortassa S, Aon MA.

Clin Sci (Lond). 2015 Oct;129(7):561-74. doi: 10.1042/CS20150204. Epub 2015 Jun 11.


Protective mechanisms of mitochondria and heart function in diabetes.

Aon MA, Tocchetti CG, Bhatt N, Paolocci N, Cortassa S.

Antioxid Redox Signal. 2015 Jun 10;22(17):1563-86. doi: 10.1089/ars.2014.6123. Epub 2015 Mar 31. Review.


Function of metabolic and organelle networks in crowded and organized media.

Aon MA, Cortassa S.

Front Physiol. 2015 Jan 21;5:523. doi: 10.3389/fphys.2014.00523. eCollection 2014. Review.


From metabolomics to fluxomics: a computational procedure to translate metabolite profiles into metabolic fluxes.

Cortassa S, Caceres V, Bell LN, O'Rourke B, Paolocci N, Aon MA.

Biophys J. 2015 Jan 6;108(1):163-72. doi: 10.1016/j.bpj.2014.11.1857.


Restoring redox balance enhances contractility in heart trabeculae from type 2 diabetic rats exposed to high glucose.

Bhatt NM, Aon MA, Tocchetti CG, Shen X, Dey S, Ramirez-Correa G, O'Rourke B, Gao WD, Cortassa S.

Am J Physiol Heart Circ Physiol. 2015 Feb 15;308(4):H291-302. doi: 10.1152/ajpheart.00378.2014. Epub 2014 Dec 5.


Mitochondrial and cellular mechanisms for managing lipid excess.

Aon MA, Bhatt N, Cortassa SC.

Front Physiol. 2014 Jul 31;5:282. doi: 10.3389/fphys.2014.00282. eCollection 2014. Review.


Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function.

Kembro JM, Cortassa S, Aon MA.

Front Physiol. 2014 Jul 8;5:257. doi: 10.3389/fphys.2014.00257. eCollection 2014.


Effect of isoflurane on myocardial energetic and oxidative stress in cardiac muscle from Zucker diabetic fatty rat.

Shen X, Bhatt N, Xu J, Meng T, Aon MA, O'Rourke B, Berkowitz DE, Cortassa S, Gao WD.

J Pharmacol Exp Ther. 2014 Apr;349(1):21-8. doi: 10.1124/jpet.113.211144. Epub 2014 Jan 15.


Effects of regional mitochondrial depolarization on electrical propagation: implications for arrhythmogenesis.

Zhou L, Solhjoo S, Millare B, Plank G, Abraham MR, Cortassa S, Trayanova N, O'Rourke B.

Circ Arrhythm Electrophysiol. 2014 Feb;7(1):143-51. doi: 10.1161/CIRCEP.113.000600. Epub 2014 Jan 1.


Redox-optimized ROS balance and the relationship between mitochondrial respiration and ROS.

Cortassa S, O'Rourke B, Aon MA.

Biochim Biophys Acta. 2014 Feb;1837(2):287-95. doi: 10.1016/j.bbabio.2013.11.007. Epub 2013 Nov 20.


A computational model of reactive oxygen species and redox balance in cardiac mitochondria.

Gauthier LD, Greenstein JL, Cortassa S, O'Rourke B, Winslow RL.

Biophys J. 2013 Aug 20;105(4):1045-56. doi: 10.1016/j.bpj.2013.07.006.


Integrating mitochondrial energetics, redox and ROS metabolic networks: a two-compartment model.

Kembro JM, Aon MA, Winslow RL, O'Rourke B, Cortassa S.

Biophys J. 2013 Jan 22;104(2):332-43. doi: 10.1016/j.bpj.2012.11.3808.


Mitochondrial network energetics in the heart.

Aon MA, Cortassa S.

Wiley Interdiscip Rev Syst Biol Med. 2012 Nov-Dec;4(6):599-613. doi: 10.1002/wsbm.1188. Epub 2012 Aug 15. Review.


GSH or palmitate preserves mitochondrial energetic/redox balance, preventing mechanical dysfunction in metabolically challenged myocytes/hearts from type 2 diabetic mice.

Tocchetti CG, Caceres V, Stanley BA, Xie C, Shi S, Watson WH, O'Rourke B, Spadari-Bratfisch RC, Cortassa S, Akar FG, Paolocci N, Aon MA.

Diabetes. 2012 Dec;61(12):3094-105. doi: 10.2337/db12-0072. Epub 2012 Jul 17.


Glutathione/thioredoxin systems modulate mitochondrial H2O2 emission: an experimental-computational study.

Aon MA, Stanley BA, Sivakumaran V, Kembro JM, O'Rourke B, Paolocci N, Cortassa S.

J Gen Physiol. 2012 Jun;139(6):479-91. doi: 10.1085/jgp.201210772. Epub 2012 May 14.


Metabolic control analysis applied to mitochondrial networks.

Cortassa S, Aon MA, O'Rourke B, Winslow RL.

Conf Proc IEEE Eng Med Biol Soc. 2011;2011:4673-6. doi: 10.1109/IEMBS.2011.6091157.


What yeast and cardiomyocytes share: ultradian oscillatory redox mechanisms of cellular coherence and survival.

Lloyd D, Cortassa S, O'Rourke B, Aon MA.

Integr Biol (Camb). 2012 Jan;4(1):65-74. doi: 10.1039/c1ib00124h. Epub 2011 Dec 5. Review.


Computational modeling of mitochondrial function.

Cortassa S, Aon MA.

Methods Mol Biol. 2012;810:311-26. doi: 10.1007/978-1-61779-382-0_19.


Mitochondrial energetics, pH regulation, and ion dynamics: a computational-experimental approach.

Wei AC, Aon MA, O'Rourke B, Winslow RL, Cortassa S.

Biophys J. 2011 Jun 22;100(12):2894-903. doi: 10.1016/j.bpj.2011.05.027.


Mitochondrial Ca2+ influx and efflux rates in guinea pig cardiac mitochondria: low and high affinity effects of cyclosporine A.

Wei AC, Liu T, Cortassa S, Winslow RL, O'Rourke B.

Biochim Biophys Acta. 2011 Jul;1813(7):1373-81. doi: 10.1016/j.bbamcr.2011.02.012. Epub 2011 Feb 26.


Integrative modeling of the cardiac ventricular myocyte.

Winslow RL, Cortassa S, O'Rourke B, Hashambhoy YL, Rice JJ, Greenstein JL.

Wiley Interdiscip Rev Syst Biol Med. 2011 Jul-Aug;3(4):392-413. doi: 10.1002/wsbm.122. Epub 2010 Sep 23. Review.


Redox-optimized ROS balance: a unifying hypothesis.

Aon MA, Cortassa S, O'Rourke B.

Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):865-77. doi: 10.1016/j.bbabio.2010.02.016. Epub 2010 Feb 20.


A reaction-diffusion model of ROS-induced ROS release in a mitochondrial network.

Zhou L, Aon MA, Almas T, Cortassa S, Winslow RL, O'Rourke B.

PLoS Comput Biol. 2010 Jan 29;6(1):e1000657. doi: 10.1371/journal.pcbi.1000657.


Calcium sensitivity, force frequency relationship and cardiac troponin I: critical role of PKA and PKC phosphorylation sites.

Ramirez-Correa GA, Cortassa S, Stanley B, Gao WD, Murphy AM.

J Mol Cell Cardiol. 2010 May;48(5):943-53. doi: 10.1016/j.yjmcc.2010.01.004. Epub 2010 Jan 18.


Modeling cardiac action potential shortening driven by oxidative stress-induced mitochondrial oscillations in guinea pig cardiomyocytes.

Zhou L, Cortassa S, Wei AC, Aon MA, Winslow RL, O'Rourke B.

Biophys J. 2009 Oct 7;97(7):1843-52. doi: 10.1016/j.bpj.2009.07.029.


Energetic performance is improved by specific activation of K+ fluxes through K(Ca) channels in heart mitochondria.

Aon MA, Cortassa S, Wei AC, Grunnet M, O'Rourke B.

Biochim Biophys Acta. 2010 Jan;1797(1):71-80. doi: 10.1016/j.bbabio.2009.08.002. Epub 2009 Sep 8.


From mitochondrial dynamics to arrhythmias.

Aon MA, Cortassa S, Akar FG, Brown DA, Zhou L, O'Rourke B.

Int J Biochem Cell Biol. 2009 Oct;41(10):1940-8. doi: 10.1016/j.biocel.2009.02.016. Epub 2009 Mar 5. Review.


Control and regulation of integrated mitochondrial function in metabolic and transport networks.

Cortassa S, O'Rourke B, Winslow RL, Aon MA.

Int J Mol Sci. 2009 Apr 1;10(4):1500-13. Review.


Control and regulation of mitochondrial energetics in an integrated model of cardiomyocyte function.

Cortassa S, O'Rourke B, Winslow RL, Aon MA.

Biophys J. 2009 Mar 18;96(6):2466-78. doi: 10.1016/j.bpj.2008.12.3893.


The scale-free dynamics of eukaryotic cells.

Aon MA, Roussel MR, Cortassa S, O'Rourke B, Murray DB, Beckmann M, Lloyd D.

PLoS One. 2008;3(11):e3624. doi: 10.1371/journal.pone.0003624. Epub 2008 Nov 4.


Mitochondrial oscillations in physiology and pathophysiology.

Aon MA, Cortassa S, O'Rourke B.

Adv Exp Med Biol. 2008;641:98-117. Review.


From mitochondrial ion channels to arrhythmias in the heart: computational techniques to bridge the spatio-temporal scales.

Plank G, Zhou L, Greenstein JL, Cortassa S, Winslow RL, O'Rourke B, Trayanova NA.

Philos Trans A Math Phys Eng Sci. 2008 Sep 28;366(1879):3381-409. doi: 10.1098/rsta.2008.0112. Review.


Mitochondrial ion channels in cardiac function and dysfunction.

O'Rourke B, Cortassa S, Akar F, Aon M.

Novartis Found Symp. 2007;287:140-51; discussion 152-6. Review.


Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status.

Aon MA, Cortassa S, Maack C, O'Rourke B.

J Biol Chem. 2007 Jul 27;282(30):21889-900. Epub 2007 May 31.


Single and cell population respiratory oscillations in yeast: a 2-photon scanning laser microscopy study.

Aon MA, Cortassa S, Lemar KM, Hayes AJ, Lloyd D.

FEBS Lett. 2007 Jan 9;581(1):8-14. Epub 2006 Dec 4.


The fundamental organization of cardiac mitochondria as a network of coupled oscillators.

Aon MA, Cortassa S, O'Rourke B.

Biophys J. 2006 Dec 1;91(11):4317-27. Epub 2006 Sep 15.


Elevated cytosolic Na+ decreases mitochondrial Ca2+ uptake during excitation-contraction coupling and impairs energetic adaptation in cardiac myocytes.

Maack C, Cortassa S, Aon MA, Ganesan AN, Liu T, O'Rourke B.

Circ Res. 2006 Jul 21;99(2):172-82. Epub 2006 Jun 15.

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