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Enantioselective Synthesis of Homoisoflavanones by Asymmetric Transfer Hydrogenation and Their Biological Evaluation for Antiangiogenic Activity.

Heo M, Lee B, Sishtla K, Fei X, Lee S, Park S, Yuan Y, Lee S, Kwon S, Lee J, Kim S, Corson TW, Seo SY.

J Org Chem. 2019 Aug 16;84(16):9995-10011. doi: 10.1021/acs.joc.9b01134. Epub 2019 Aug 5.


Small molecule target identification using photo-affinity chromatography.

Seo SY, Corson TW.

Methods Enzymol. 2019;622:347-374. doi: 10.1016/bs.mie.2019.02.028. Epub 2019 Mar 15.


The Antiangiogenic Activity of Naturally Occurring and Synthetic Homoisoflavonoids from the Hyacinthaceae ( sensu APGII).

Schwikkard S, Whitmore H, Sishtla K, Sulaiman RS, Shetty T, Basavarajappa HD, Waller C, Alqahtani A, Frankemoelle L, Chapman A, Crouch N, Wetschnig W, Knirsch W, Andriantiana J, Mas-Claret E, Langat MK, Mulholland D, Corson TW.

J Nat Prod. 2019 May 24;82(5):1227-1239. doi: 10.1021/acs.jnatprod.8b00989. Epub 2019 Apr 5.


Soluble Epoxide Hydrolase Inhibition for Ocular Diseases: Vision for the Future.

Park B, Corson TW.

Front Pharmacol. 2019 Feb 7;10:95. doi: 10.3389/fphar.2019.00095. eCollection 2019.


Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD⋅Yap Protein-Protein Interaction.

Bum-Erdene K, Zhou D, Gonzalez-Gutierrez G, Ghozayel MK, Si Y, Xu D, Shannon HE, Bailey BJ, Corson TW, Pollok KE, Wells CD, Meroueh SO.

Cell Chem Biol. 2019 Mar 21;26(3):378-389.e13. doi: 10.1016/j.chembiol.2018.11.010. Epub 2018 Dec 20.


Small molecules inhibit ex vivo tumor growth in bone.

Zhou D, Bum-Erdene K, Xu D, Liu D, Tompkins D, Sulaiman RS, Corson TW, Chirgwin JM, Meroueh SO.

Bioorg Med Chem. 2018 Dec 15;26(23-24):6128-6134. doi: 10.1016/j.bmc.2018.11.025. Epub 2018 Nov 16.


Observations on spontaneous tumor formation in mice overexpressing mitotic kinesin Kif14.

Sishtla K, Pitt N, Shadmand M, O'Hare MN, Sulaiman RS, Sinn AL, Condon K, Pollok KE, Sandusky GE, Corson TW.

Sci Rep. 2018 Nov 1;8(1):16152. doi: 10.1038/s41598-018-34603-4.


Ref-1/APE1 Inhibition with Novel Small Molecules Blocks Ocular Neovascularization.

Sardar Pasha SPB, Sishtla K, Sulaiman RS, Park B, Shetty T, Shah F, Fishel ML, Wikel JH, Kelley MR, Corson TW.

J Pharmacol Exp Ther. 2018 Oct;367(1):108-118. doi: 10.1124/jpet.118.248088. Epub 2018 Aug 3.


Antiangiogenic Activity and Cytotoxicity of Triterpenoids and Homoisoflavonoids from Massonia pustulata and Massonia bifolia.

Schwikkard SL, Whitmore H, Corson TW, Sishtla K, Langat MK, Carew M, Mulholland DA.

Planta Med. 2018 Jul;84(9-10):638-644. doi: 10.1055/a-0577-5322. Epub 2018 Feb 28.


Retinoblastoma, the visible CNS tumor: A review.

Dimaras H, Corson TW.

J Neurosci Res. 2019 Jan;97(1):29-44. doi: 10.1002/jnr.24213. Epub 2018 Jan 3.


Chemical Proteomics Reveals Soluble Epoxide Hydrolase as a Therapeutic Target for Ocular Neovascularization.

Sulaiman RS, Park B, Sheik Pran Babu SP, Si Y, Kharwadkar R, Mitter SK, Lee B, Sun W, Qi X, Boulton ME, Meroueh SO, Fei X, Seo SY, Corson TW.

ACS Chem Biol. 2018 Jan 19;13(1):45-52. doi: 10.1021/acschembio.7b00854. Epub 2017 Dec 1.


Ferrochelatase is a therapeutic target for ocular neovascularization.

Basavarajappa HD, Sulaiman RS, Qi X, Shetty T, Sheik Pran Babu S, Sishtla KL, Lee B, Quigley J, Alkhairy S, Briggs CM, Gupta K, Tang B, Shadmand M, Grant MB, Boulton ME, Seo SY, Corson TW.

EMBO Mol Med. 2017 Jun;9(6):786-801. doi: 10.15252/emmm.201606561.


Synthesis of Natural Homoisoflavonoids Having Either 5,7-Dihydroxy-6-methoxy or 7-Hydroxy-5,6-dimethoxy Groups.

Lee H, Yuan Y, Rhee I, Corson TW, Seo SY.

Molecules. 2016 Aug 13;21(8). pii: E1058. doi: 10.3390/molecules21081058.


Design, synthesis and biological evaluation of photoaffinity probes of antiangiogenic homoisoflavonoids.

Lee B, Sun W, Lee H, Basavarajappa H, Sulaiman RS, Sishtla K, Fei X, Corson TW, Seo SY.

Bioorg Med Chem Lett. 2016 Sep 1;26(17):4277-81. doi: 10.1016/j.bmcl.2016.07.043. Epub 2016 Jul 21.


Molecular analysis distinguishes metastatic disease from second cancers in patients with retinoblastoma.

Racher H, Soliman S, Argiropoulos B, Chan HS, Gallie BL, Perrier R, Matevski D, Rushlow D, Piovesan B, Shaikh F, MacDonald H, Corson TW.

Cancer Genet. 2016 Jul-Aug;209(7-8):359-63. doi: 10.1016/j.cancergen.2016.06.001. Epub 2016 Jun 3.


Kif14 overexpression accelerates murine retinoblastoma development.

O'Hare M, Shadmand M, Sulaiman RS, Sishtla K, Sakisaka T, Corson TW.

Int J Cancer. 2016 Oct 15;139(8):1752-8. doi: 10.1002/ijc.30221. Epub 2016 Jun 24.


A novel small molecule ameliorates ocular neovascularisation and synergises with anti-VEGF therapy.

Sulaiman RS, Merrigan S, Quigley J, Qi X, Lee B, Boulton ME, Kennedy B, Seo SY, Corson TW.

Sci Rep. 2016 May 5;6:25509. doi: 10.1038/srep25509.


A Simple Optical Coherence Tomography Quantification Method for Choroidal Neovascularization.

Sulaiman RS, Quigley J, Qi X, O'Hare MN, Grant MB, Boulton ME, Corson TW.

J Ocul Pharmacol Ther. 2015 Oct;31(8):447-54. doi: 10.1089/jop.2015.0049. Epub 2015 Jun 10.


Cancer genetics education in a low- to middle-income country: evaluation of an interactive workshop for clinicians in Kenya.

Hill JA, Lee SY, Njambi L, Corson TW, Dimaras H.

PLoS One. 2015 Jun 2;10(6):e0129852. doi: 10.1371/journal.pone.0129852. eCollection 2015.


Synthesis and Biological Evaluation of Novel Homoisoflavonoids for Retinal Neovascularization.

Basavarajappa HD, Lee B, Lee H, Sulaiman RS, An H, Magaña C, Shadmand M, Vayl A, Rajashekhar G, Kim EY, Suh YG, Lee K, Seo SY, Corson TW.

J Med Chem. 2015 Jun 25;58(12):5015-5027. doi: 10.1021/acs.jmedchem.5b00449. Epub 2015 Jun 16.


Optical coherence tomography enables imaging of tumor initiation in the TAg-RB mouse model of retinoblastoma.

Wenzel AA, O'Hare MN, Shadmand M, Corson TW.

Mol Vis. 2015 May 1;21:515-22. eCollection 2015.



Dimaras H, Corson TW, Cobrinik D, White A, Zhao J, Munier FL, Abramson DH, Shields CL, Chantada GL, Njuguna F, Gallie BL.

Nat Rev Dis Primers. 2015 Aug 27;1:15021. doi: 10.1038/nrdp.2015.21. Review.


Natural product inhibitors of ocular angiogenesis.

Sulaiman RS, Basavarajappa HD, Corson TW.

Exp Eye Res. 2014 Dec;129:161-71. doi: 10.1016/j.exer.2014.10.002. Epub 2014 Oct 7. Review.


The first synthesis of the antiangiogenic homoisoflavanone, cremastranone.

Lee B, Basavarajappa HD, Sulaiman RS, Fei X, Seo SY, Corson TW.

Org Biomol Chem. 2014 Oct 21;12(39):7673-7. doi: 10.1039/c4ob01604a. Epub 2014 Aug 28.


Primary cilia signaling mediates intraocular pressure sensation.

Luo N, Conwell MD, Chen X, Kettenhofen CI, Westlake CJ, Cantor LB, Wells CD, Weinreb RN, Corson TW, Spandau DF, Joos KM, Iomini C, Obukhov AG, Sun Y.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12871-6. doi: 10.1073/pnas.1323292111. Epub 2014 Aug 20.


Multimodality imaging methods for assessing retinoblastoma orthotopic xenograft growth and development.

Corson TW, Samuels BC, Wenzel AA, Geary AJ, Riley AA, McCarthy BP, Hanenberg H, Bailey BJ, Rogers PI, Pollok KE, Rajashekhar G, Territo PR.

PLoS One. 2014 Jun 5;9(6):e99036. doi: 10.1371/journal.pone.0099036. eCollection 2014.


KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer.

Singel SM, Cornelius C, Zaganjor E, Batten K, Sarode VR, Buckley DL, Peng Y, John GB, Li HC, Sadeghi N, Wright WE, Lum L, Corson TW, Shay JW.

Neoplasia. 2014 Mar;16(3):247-56, 256.e2. doi: 10.1016/j.neo.2014.03.008.


Synthesis and mechanistic studies of a novel homoisoflavanone inhibitor of endothelial cell growth.

Basavarajappa HD, Lee B, Fei X, Lim D, Callaghan B, Mund JA, Case J, Rajashekhar G, Seo SY, Corson TW.

PLoS One. 2014 Apr 21;9(4):e95694. doi: 10.1371/journal.pone.0095694. eCollection 2014.


Transcriptional and epigenetic regulation of KIF14 overexpression in ovarian cancer.

Thériault BL, Basavarajappa HD, Lim H, Pajovic S, Gallie BL, Corson TW.

PLoS One. 2014 Mar 13;9(3):e91540. doi: 10.1371/journal.pone.0091540. eCollection 2014.


The genomic landscape of retinoblastoma: a review.

Thériault BL, Dimaras H, Gallie BL, Corson TW.

Clin Exp Ophthalmol. 2014 Jan-Feb;42(1):33-52. doi: 10.1111/ceo.12132. Epub 2013 May 22. Review.


Posttranslational protein knockdown coupled to receptor tyrosine kinase activation with phosphoPROTACs.

Hines J, Gough JD, Corson TW, Crews CM.

Proc Natl Acad Sci U S A. 2013 May 28;110(22):8942-7. doi: 10.1073/pnas.1217206110. Epub 2013 May 14.


Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies.

Rushlow DE, Mol BM, Kennett JY, Yee S, Pajovic S, Thériault BL, Prigoda-Lee NL, Spencer C, Dimaras H, Corson TW, Pang R, Massey C, Godbout R, Jiang Z, Zacksenhaus E, Paton K, Moll AC, Houdayer C, Raizis A, Halliday W, Lam WL, Boutros PC, Lohmann D, Dorsman JC, Gallie BL.

Lancet Oncol. 2013 Apr;14(4):327-34. doi: 10.1016/S1470-2045(13)70045-7. Epub 2013 Mar 13.


KIF14 as an oncogene in retinoblastoma: a target for novel therapeutics?

Basavarajappa HD, Corson TW.

Future Med Chem. 2012 Nov;4(17):2149-52. doi: 10.4155/fmc.12.158. No abstract available.


Retinoblastoma tumorigenesis: genetic and epigenetic changes walk hand in hand.

Temming P, Corson TW, Lohmann DR.

Future Oncol. 2012 May;8(5):525-8. doi: 10.2217/fon.12.41.


Author response: Does the time of inactivation of pRb determine the cell of origin of retinoblastoma?

Corson TW, Pajovic S, Dimaras H, Thériault BL, Gallie BL.

Invest Ophthalmol Vis Sci. 2012 Feb 13;53(2):676. doi: 10.1167/iovs.11-9371. No abstract available.


The TAg-RB murine retinoblastoma cell of origin has immunohistochemical features of differentiated Muller glia with progenitor properties.

Pajovic S, Corson TW, Spencer C, Dimaras H, Orlic-Milacic M, Marchong MN, To KH, Thériault B, Auspitz M, Gallie BL.

Invest Ophthalmol Vis Sci. 2011 Sep 29;52(10):7618-24. doi: 10.1167/iovs.11-7989.


Small-molecule hydrophobic tagging-induced degradation of HaloTag fusion proteins.

Neklesa TK, Tae HS, Schneekloth AR, Stulberg MJ, Corson TW, Sundberg TB, Raina K, Holley SA, Crews CM.

Nat Chem Biol. 2011 Jul 3;7(8):538-43. doi: 10.1038/nchembio.597.


Triptolide directly inhibits dCTP pyrophosphatase.

Corson TW, Cavga H, Aberle N, Crews CM.

Chembiochem. 2011 Jul 25;12(11):1767-73. doi: 10.1002/cbic.201100007. Epub 2011 Jun 10.


Bcl-2 SNP rs956572 associates with disrupted intracellular calcium homeostasis in bipolar I disorder.

Uemura T, Green M, Corson TW, Perova T, Li PP, Warsh JJ.

Bipolar Disord. 2011 Feb;13(1):41-51. doi: 10.1111/j.1399-5618.2011.00897.x.


HIV protease-mediated activation of sterically capped proteasome inhibitors and substrates.

Buckley DL, Corson TW, Aberle N, Crews CM.

J Am Chem Soc. 2011 Feb 2;133(4):698-700. doi: 10.1021/ja109377p.


Design and Applications of Bifunctional Small Molecules: Why Two Heads Are Better Than One.

Corson TW, Aberle N, Crews CM.

ACS Chem Biol. 2008 Nov 21;3(11):677-692. doi: 10.1021/cb8001792. Review.


Loss of RB1 induces non-proliferative retinoma: increasing genomic instability correlates with progression to retinoblastoma.

Dimaras H, Khetan V, Halliday W, Orlic M, Prigoda NL, Piovesan B, Marrano P, Corson TW, Eagle RC Jr, Squire JA, Gallie BL.

Hum Mol Genet. 2008 May 15;17(10):1363-72. doi: 10.1093/hmg/ddn024. Epub 2008 Jan 22.


Using expression profiling data to identify human microRNA targets.

Huang JC, Babak T, Corson TW, Chua G, Khan S, Gallie BL, Hughes TR, Blencowe BJ, Frey BJ, Morris QD.

Nat Methods. 2007 Dec;4(12):1045-9. Epub 2007 Nov 18.


High expression of KIF14 in retinoblastoma: association with older age at diagnosis.

Madhavan J, Coral K, Mallikarjuna K, Corson TW, Amit N, Khetan V, George R, Biswas J, Gallie BL, Kumaramanickavel G.

Invest Ophthalmol Vis Sci. 2007 Nov;48(11):4901-6.


KIF14 messenger RNA expression is independently prognostic for outcome in lung cancer.

Corson TW, Zhu CQ, Lau SK, Shepherd FA, Tsao MS, Gallie BL.

Clin Cancer Res. 2007 Jun 1;13(11):3229-34.


One hit, two hits, three hits, more? Genomic changes in the development of retinoblastoma.

Corson TW, Gallie BL.

Genes Chromosomes Cancer. 2007 Jul;46(7):617-34. Review.


Profiling genomic copy number changes in retinoblastoma beyond loss of RB1.

Bowles E, Corson TW, Bayani J, Squire JA, Wong N, Lai PB, Gallie BL.

Genes Chromosomes Cancer. 2007 Feb;46(2):118-29.


KIF14 mRNA expression is a predictor of grade and outcome in breast cancer.

Corson TW, Gallie BL.

Int J Cancer. 2006 Sep 1;119(5):1088-94.

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