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Emerging Role of Cellular Prion Protein in the Maintenance and Expansion of Glioma Stem Cells.

Thellung S, Corsaro A, Bosio AG, Zambito M, Barbieri F, Mazzanti M, Florio T.

Cells. 2019 Nov 18;8(11). pii: E1458. doi: 10.3390/cells8111458. Review.


An Italian pilot study of a psycho-social intervention to support family caregivers' engagement in taking care of patients with complex care needs: the Engage-in-Caring project.

Guida E, Barello S, Corsaro A, Galizi MC, Giuffrida F, Graffigna G, Damiani G.

BMC Health Serv Res. 2019 Aug 2;19(1):541. doi: 10.1186/s12913-019-4365-x.


Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity.

Thellung S, Corsaro A, Nizzari M, Barbieri F, Florio T.

Int J Mol Sci. 2019 Feb 19;20(4). pii: E901. doi: 10.3390/ijms20040901. Review.


Effects of Prion Protein on Aβ42 and Pyroglutamate-Modified AβpΕ3-42 Oligomerization and Toxicity.

Pagano K, Galante D, D'Arrigo C, Corsaro A, Nizzari M, Florio T, Molinari H, Tomaselli S, Ragona L.

Mol Neurobiol. 2019 Mar;56(3):1957-1971. doi: 10.1007/s12035-018-1202-x. Epub 2018 Jul 6.


Troglostrongylus brevior: a feline lungworm of paediatric concern.

Cavalera MA, Iatta R, Colella V, Dantas-Torres F, Corsaro A, Brianti E, Otranto D.

Vet Parasitol. 2018 Apr 15;253:8-11. doi: 10.1016/j.vetpar.2018.02.017. Epub 2018 Feb 12.


[A health promotion campaign to improve flu vaccination adherence among medical residents in an Italian Teaching Hospital].

Barbara A, Poscia A, De Meo C, De Waure C, Anzelmo V, Santoro PE, Maruccia A, Giubbini G, Corsaro A, Berloco F, Damiani G, Ricciardi W, Laurenti P.

Ig Sanita Pubbl. 2017 Sep-Oct;73(5):545-555. Italian.


Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death.

Thellung S, Scoti B, Corsaro A, Villa V, Nizzari M, Gagliani MC, Porcile C, Russo C, Pagano A, Tacchetti C, Cortese K, Florio T.

Cell Death Dis. 2018 Feb 7;9(2):166. doi: 10.1038/s41419-017-0252-8.


In vitro and in vivo characterization of stem-like cells from canine osteosarcoma and assessment of drug sensitivity.

Gatti M, Solari A, Pattarozzi A, Campanella C, Thellung S, Maniscalco L, De Maria R, Würth R, Corsaro A, Bajetto A, Ratto A, Ferrari A, Daga A, Barbieri F, Florio T.

Exp Cell Res. 2018 Feb 1;363(1):48-64. doi: 10.1016/j.yexcr.2018.01.002. Epub 2018 Jan 4.


Different Effects of Human Umbilical Cord Mesenchymal Stem Cells on Glioblastoma Stem Cells by Direct Cell Interaction or Via Released Soluble Factors.

Bajetto A, Pattarozzi A, Corsaro A, Barbieri F, Daga A, Bosio A, Gatti M, Pisaturo V, Sirito R, Florio T.

Front Cell Neurosci. 2017 Oct 13;11:312. doi: 10.3389/fncel.2017.00312. eCollection 2017.


Fostering Flu Vaccination in Healthcare Workers: Forum Theatre in a University Hospital.

Corsaro A, Poscia A, de Waure C, De Meo C, Berloco F, Ricciardi W, Damiani G, Laurenti P, Group C.

Med Sci Monit. 2017 Sep 24;23:4574-4578.


Urology Residency Training in Italy: Results of the First National Survey.

Cocci A, Patruno G, Gandaglia G, Rizzo M, Esperto F, Parnanzini D, Pietropaolo A, Principi E, Talso M, Baldesi R, Battaglia A, Shehu E, Carrobbio F, Corsaro A, La Rocca R, Marchioni M, Bianchi L, Miglioranza E, Mantica G, Martorana E, Misuraca L, Fontana D, Forte S, Napoli G, Russo GI; Senato degli Specializzandi Study Group.

Eur Urol Focus. 2018 Mar;4(2):280-287. doi: 10.1016/j.euf.2016.06.006. Epub 2016 Jun 21.


Different Molecular Mechanisms Mediate Direct or Glia-Dependent Prion Protein Fragment 90-231 Neurotoxic Effects in Cerebellar Granule Neurons.

Thellung S, Gatta E, Pellistri F, Villa V, Corsaro A, Nizzari M, Robello M, Florio T.

Neurotox Res. 2017 Oct;32(3):381-397. doi: 10.1007/s12640-017-9749-2. Epub 2017 May 25.


Temporal and seasonal variations of black carbon in a highly polluted European city: Apportionment of potential sources and the effect of meteorological conditions.

Kucbel M, Corsaro A, Švédová B, Raclavská H, Raclavský K, Juchelková D.

J Environ Manage. 2017 Dec 1;203(Pt 3):1178-1189. doi: 10.1016/j.jenvman.2017.05.038. Epub 2017 May 18.


Enrichment and distribution of 24 elements within the sub-sieve particle size distribution ranges of fly ash from wastes incinerator plants.

Raclavská H, Corsaro A, Hartmann-Koval S, Juchelková D.

J Environ Manage. 2017 Dec 1;203(Pt 3):1169-1177. doi: 10.1016/j.jenvman.2017.03.073. Epub 2017 Apr 5.


Are community-based nurse-led self-management support interventions effective in chronic patients? Results of a systematic review and meta-analysis.

Massimi A, De Vito C, Brufola I, Corsaro A, Marzuillo C, Migliara G, Rega ML, Ricciardi W, Villari P, Damiani G.

PLoS One. 2017 Mar 10;12(3):e0173617. doi: 10.1371/journal.pone.0173617. eCollection 2017. Review.


Cellular prion protein controls stem cell-like properties of human glioblastoma tumor-initiating cells.

Corsaro A, Bajetto A, Thellung S, Begani G, Villa V, Nizzari M, Pattarozzi A, Solari A, Gatti M, Pagano A, Würth R, Daga A, Barbieri F, Florio T.

Oncotarget. 2016 Jun 21;7(25):38638-38657. doi: 10.18632/oncotarget.9575.


A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates.

Galante D, Ruggeri FS, Dietler G, Pellistri F, Gatta E, Corsaro A, Florio T, Perico A, D'Arrigo C.

Int J Biochem Cell Biol. 2016 Oct;79:261-270. doi: 10.1016/j.biocel.2016.08.037. Epub 2016 Aug 31.


Canine osteosarcoma cell lines contain stem-like cancer cells: biological and pharmacological characterization.

Gatti M, Wurth R, Vito G, Pattarozzi A, Campanella C, Thellung S, Maniscalco L, De Maria R, Villa V, Corsaro A, Nizzari M, Bajetto A, Ratto A, Ferrari A, Barbieri F, Florio T.

Jpn J Vet Res. 2016 May;64(2):101-12.


5'-Spiro-cyclopropanated lactose derivatives as suitable intermediates for the chain elongation: synthesis of a new 6-deoxy-6-methyl δ-eptulose.

Pistarà V, Rescifina A, Corsaro A.

Carbohydr Res. 2016 Mar 3;422:45-52. doi: 10.1016/j.carres.2016.01.008. Epub 2016 Jan 25.


Synthesis and physico-chemical characterization of a β-cyclodextrin conjugate for sustained release of Acyclovir.

Pedotti S, Pistarà V, Cannavà C, Carbone C, Cilurzo F, Corsaro A, Puglisi G, Ventura CA.

Carbohydr Polym. 2015 Oct 20;131:159-67. doi: 10.1016/j.carbpol.2015.05.071. Epub 2015 Jun 8.


The effect of moisture on the release and enrichment of heavy metals during pyrolysis of municipal solid waste.

Raclavská H, Corsaro A, Hlavsová A, Juchelková D, Zajonc O.

Waste Manag Res. 2015 Mar;33(3):267-74. doi: 10.1177/0734242X14568609. Epub 2015 Feb 4.


Syntheses of isoxazoline-carbocyclic nucleosides and their antiviral evaluation: a standard protocol.

Quadrelli P, Vazquez Martinez N, Scrocchi R, Corsaro A, Pistarà V.

ScientificWorldJournal. 2014;2014:492178. doi: 10.1155/2014/492178. Epub 2014 Oct 30.


Combined microwave thermal ablation and liver resection for single step treatment of otherwise unresectable colorectal liver metastases; a monoistitutional experiences.

Tropea A, Biondi A, Corsaro A, Donati M, Basile F, Gruttadauria S.

Eur Rev Med Pharmacol Sci. 2014 Dec;18(2 Suppl):6-10.


Emerging Targets in Pituitary Adenomas: Role of the CXCL12/CXCR4-R7 System.

Barbieri F, Thellung S, Würth R, Gatto F, Corsaro A, Villa V, Nizzari M, Albertelli M, Ferone D, Florio T.

Int J Endocrinol. 2014;2014:753524. doi: 10.1155/2014/753524. Epub 2014 Nov 17. Review.


Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells.

Villa V, Thellung S, Corsaro A, Novelli F, Tasso B, Colucci-D'Amato L, Gatta E, Tonelli M, Florio T.

Mol Neurobiol. 2016 Jan;53(1):57-72. doi: 10.1007/s12035-014-8982-4. Epub 2014 Nov 18.


Syngas production from pyrolysis of nine composts obtained from nonhybrid and hybrid perennial grasses.

Hlavsová A, Corsaro A, Raclavská H, Juchelková D, Škrobánková H, Frydrych J.

ScientificWorldJournal. 2014;2014:723092. doi: 10.1155/2014/723092. Epub 2014 Jul 1.


Recent advances in small organic molecules as DNA intercalating agents: synthesis, activity, and modeling.

Rescifina A, Zagni C, Varrica MG, Pistarà V, Corsaro A.

Eur J Med Chem. 2014 Mar 3;74:95-115. doi: 10.1016/j.ejmech.2013.11.029. Epub 2014 Jan 3. Review.


Prevalence of oxetanose forms in the tautomeric equilibrium of β-hydroxy-1,5-dicarbonyl monosaccharides.

Pistarà V, Corsaro A, Rescifina A, Catelani G, D'Andrea F, Guazzelli L.

J Org Chem. 2013 Sep 20;78(18):9444-9. doi: 10.1021/jo400953s. Epub 2013 Sep 3.


Synthesis and biological evaluation of furopyrimidine N,O-nucleosides.

Romeo R, Giofrè SV, Garozzo A, Bisignano B, Corsaro A, Chiacchio MA.

Bioorg Med Chem. 2013 Sep 15;21(18):5688-93. doi: 10.1016/j.bmc.2013.07.031. Epub 2013 Jul 24.


Peptide receptor targeting in cancer: the somatostatin paradigm.

Barbieri F, Bajetto A, Pattarozzi A, Gatti M, Würth R, Thellung S, Corsaro A, Villa V, Nizzari M, Florio T.

Int J Pept. 2013;2013:926295. doi: 10.1155/2013/926295. Epub 2013 Feb 7.


Metformin selectively affects human glioblastoma tumor-initiating cell viability: A role for metformin-induced inhibition of Akt.

Würth R, Pattarozzi A, Gatti M, Bajetto A, Corsaro A, Parodi A, Sirito R, Massollo M, Marini C, Zona G, Fenoglio D, Sambuceti G, Filaci G, Daga A, Barbieri F, Florio T.

Cell Cycle. 2013 Jan 1;12(1):145-56. doi: 10.4161/cc.23050. Epub 2012 Dec 19.


Role of prion protein aggregation in neurotoxicity.

Corsaro A, Thellung S, Villa V, Nizzari M, Florio T.

Int J Mol Sci. 2012;13(7):8648-69. doi: 10.3390/ijms13078648. Epub 2012 Jul 11. Review.


Differential toxicity, conformation and morphology of typical initial aggregation states of Aβ1-42 and Aβpy3-42 beta-amyloids.

Galante D, Corsaro A, Florio T, Vella S, Pagano A, Sbrana F, Vassalli M, Perico A, D'Arrigo C.

Int J Biochem Cell Biol. 2012 Nov;44(11):2085-93. doi: 10.1016/j.biocel.2012.08.010. Epub 2012 Aug 10.


Excitotoxicity through NMDA receptors mediates cerebellar granule neuron apoptosis induced by prion protein 90-231 fragment.

Thellung S, Gatta E, Pellistri F, Corsaro A, Villa V, Vassalli M, Robello M, Florio T.

Neurotox Res. 2013 May;23(4):301-14. doi: 10.1007/s12640-012-9340-9. Epub 2012 Aug 2.


Calcium binding promotes prion protein fragment 90-231 conformational change toward a membrane destabilizing and cytotoxic structure.

Sorrentino S, Bucciarelli T, Corsaro A, Tosatto A, Thellung S, Villa V, Schininà ME, Maras B, Galeno R, Scotti L, Creati F, Marrone A, Re N, Aceto A, Florio T, Mazzanti M.

PLoS One. 2012;7(7):e38314. doi: 10.1371/journal.pone.0038314. Epub 2012 Jul 11.


Neurodegeneration in Alzheimer disease: role of amyloid precursor protein and presenilin 1 intracellular signaling.

Nizzari M, Thellung S, Corsaro A, Villa V, Pagano A, Porcile C, Russo C, Florio T.

J Toxicol. 2012;2012:187297. doi: 10.1155/2012/187297. Epub 2012 Feb 8.


Recombinant human prion protein fragment 90-231, a useful model to study prion neurotoxicity.

Corsaro A, Thellung S, Villa V, Nizzari M, Aceto A, Florio T.

OMICS. 2012 Jan-Feb;16(1-2):50-9. doi: 10.1089/omi.2011.0038.


Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction.

Thellung S, Corsaro A, Villa V, Simi A, Vella S, Pagano A, Florio T.

Cell Death Dis. 2011 Mar 31;2:e138. doi: 10.1038/cddis.2011.21.


Neurotoxic properties of the anabolic androgenic steroids nandrolone and methandrostenolone in primary neuronal cultures.

Caraci F, Pistarà V, Corsaro A, Tomasello F, Giuffrida ML, Sortino MA, Nicoletti F, Copani A.

J Neurosci Res. 2011 Apr;89(4):592-600. doi: 10.1002/jnr.22578. Epub 2011 Feb 2.


High hydrophobic amino acid exposure is responsible of the neurotoxic effects induced by E200K or D202N disease-related mutations of the human prion protein.

Corsaro A, Thellung S, Bucciarelli T, Scotti L, Chiovitti K, Villa V, D'Arrigo C, Aceto A, Florio T.

Int J Biochem Cell Biol. 2011 Mar;43(3):372-82. doi: 10.1016/j.biocel.2010.11.007. Epub 2010 Nov 19.


Isoxazolidinyl polycyclic aromatic hydrocarbons as DNA-intercalating antitumor agents.

Rescifina A, Chiacchio U, Corsaro A, Piperno A, Romeo R.

Eur J Med Chem. 2011 Jan;46(1):129-36. doi: 10.1016/j.ejmech.2010.10.023. Epub 2010 Oct 28.


Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity.

Villa V, Tonelli M, Thellung S, Corsaro A, Tasso B, Novelli F, Canu C, Pino A, Chiovitti K, Paludi D, Russo C, Sparatore A, Aceto A, Boido V, Sparatore F, Florio T.

Neurotox Res. 2011 May;19(4):556-74. doi: 10.1007/s12640-010-9189-8. Epub 2010 Apr 20.


Towards the synthesis of new dideoxy delta-dicarbonyl heptoses.

Pistarà V, Chiacchio MA, Corsaro A.

Carbohydr Res. 2010 Jul 2;345(10):1482-5. doi: 10.1016/j.carres.2010.03.013. Epub 2010 Mar 20.


The interaction of humic substances with the human prion protein fragment 90-231 affects its protease K resistance and cell internalization.

Corsaro A, Anselmi C, Polano M, Aceto A, Florio T, De Nobili M.

J Biol Regul Homeost Agents. 2010 Jan-Mar;24(1):27-39.


Chemical synthesis of heterocyclic-sugar nucleoside analogues.

Romeo G, Chiacchio U, Corsaro A, Merino P.

Chem Rev. 2010 Jun 9;110(6):3337-70. doi: 10.1021/cr800464r. Review. No abstract available.


Dual modulation of ERK1/2 and p38 MAP kinase activities induced by minocycline reverses the neurotoxic effects of the prion protein fragment 90-231.

Corsaro A, Thellung S, Chiovitti K, Villa V, Simi A, Raggi F, Paludi D, Russo C, Aceto A, Florio T.

Neurotox Res. 2009 Feb;15(2):138-54. doi: 10.1007/s12640-009-9015-3. Epub 2009 Feb 26.


[Perforated jejunal diverticulum. A case report].

Basile G, Buffone A, Boscarelli G, Maria S, Santagati G, Corsaro A, Cirino E.

Ann Ital Chir. 2008 Jan-Feb;79(1):53-6. Italian.


Intracellular accumulation of a mild-denatured monomer of the human PrP fragment 90-231, as possible mechanism of its neurotoxic effects.

Chiovitti K, Corsaro A, Thellung S, Villa V, Paludi D, D'Arrigo C, Russo C, Perico A, Ianieri A, Di Cola D, Vergara A, Aceto A, Florio T.

J Neurochem. 2007 Dec;103(6):2597-609. Epub 2007 Oct 18.


Different structural stability and toxicity of PrP(ARR) and PrP(ARQ) sheep prion protein variants.

Paludi D, Thellung S, Chiovitti K, Corsaro A, Villa V, Russo C, Ianieri A, Bertsch U, Kretzschmar HA, Aceto A, Florio T.

J Neurochem. 2007 Dec;103(6):2291-300. Epub 2007 Oct 4.

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