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Items: 1 to 50 of 69

1.

Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation.

Hu H, Nemecz Á, Van Renterghem C, Fourati Z, Sauguet L, Corringer PJ, Delarue M.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E3959-E3968. doi: 10.1073/pnas.1717700115. Epub 2018 Apr 9.

PMID:
29632192
2.

The dual-gate model for pentameric ligand-gated ion channels activation and desensitization.

Gielen M, Corringer PJ.

J Physiol. 2018 May 15;596(10):1873-1902. doi: 10.1113/JP275100. Epub 2018 Apr 17.

PMID:
29484660
3.

Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel.

Nemecz Á, Hu H, Fourati Z, Van Renterghem C, Delarue M, Corringer PJ.

PLoS Biol. 2017 Dec 27;15(12):e2004470. doi: 10.1371/journal.pbio.2004470. eCollection 2017 Dec.

4.

Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors.

Durek T, Shelukhina IV, Tae HS, Thongyoo P, Spirova EN, Kudryavtsev DS, Kasheverov IE, Faure G, Corringer PJ, Craik DJ, Adams DJ, Tsetlin VI.

Sci Rep. 2017 Nov 30;7(1):16606. doi: 10.1038/s41598-017-16809-0.

5.

Identification of a pre-active conformation of a pentameric channel receptor.

Menny A, Lefebvre SN, Schmidpeter PA, Drège E, Fourati Z, Delarue M, Edelstein SJ, Nimigean CM, Joseph D, Corringer PJ.

Elife. 2017 Mar 15;6. pii: e23955. doi: 10.7554/eLife.23955.

6.

Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain.

Acuña MA, Yévenes GE, Ralvenius WT, Benke D, Di Lio A, Lara CO, Muñoz B, Burgos CF, Moraga-Cid G, Corringer PJ, Zeilhofer HU.

J Clin Invest. 2016 Jul 1;126(7):2547-60. doi: 10.1172/JCI83817. Epub 2016 Jun 6.

7.

Rattlesnake Phospholipase A2 Increases CFTR-Chloride Channel Current and Corrects ∆F508CFTR Dysfunction: Impact in Cystic Fibrosis.

Faure G, Bakouh N, Lourdel S, Odolczyk N, Premchandar A, Servel N, Hatton A, Ostrowski MK, Xu H, Saul FA, Moquereau C, Bitam S, Pranke I, Planelles G, Teulon J, Herrmann H, Roldan A, Zielenkiewicz P, Dadlez M, Lukacs GL, Sermet-Gaudelus I, Ollero M, Corringer PJ, Edelman A.

J Mol Biol. 2016 Jul 17;428(14):2898-915. doi: 10.1016/j.jmb.2016.05.016. Epub 2016 May 27.

PMID:
27241308
8.

Emerging Molecular Mechanisms of Signal Transduction in Pentameric Ligand-Gated Ion Channels.

Nemecz Á, Prevost MS, Menny A, Corringer PJ.

Neuron. 2016 May 4;90(3):452-70. doi: 10.1016/j.neuron.2016.03.032. Review.

9.

Neurotoxic phospholipase A2 from rattlesnake as a new ligand and new regulator of prokaryotic receptor GLIC (proton-gated ion channel from G. violaceus).

Ostrowski M, Porowinska D, Prochnicki T, Prevost M, Raynal B, Baron B, Sauguet L, Corringer PJ, Faure G.

Toxicon. 2016 Jun 15;116:63-71. doi: 10.1016/j.toxicon.2016.02.002. Epub 2016 Feb 5.

PMID:
26854368
10.

Ethanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine Receptors.

Horani S, Stater EP, Corringer PJ, Trudell JR, Harris RA, Howard RJ.

Alcohol Clin Exp Res. 2015 Jun;39(6):962-8. doi: 10.1111/acer.12735. Epub 2015 May 14.

11.

The nicotinic acetylcholine receptor: From molecular biology to cognition.

Changeux JP, Corringer PJ, Maskos U.

Neuropharmacology. 2015 Sep;96(Pt B):135-6. doi: 10.1016/j.neuropharm.2015.03.024. Epub 2015 Apr 1. No abstract available.

PMID:
25842243
12.

Allosteric and hyperekplexic mutant phenotypes investigated on an α1 glycine receptor transmembrane structure.

Moraga-Cid G, Sauguet L, Huon C, Malherbe L, Girard-Blanc C, Petres S, Murail S, Taly A, Baaden M, Delarue M, Corringer PJ.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2865-70. doi: 10.1073/pnas.1417864112. Epub 2015 Feb 17.

13.

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation.

Sauguet L, Shahsavar A, Poitevin F, Huon C, Menny A, Nemecz À, Haouz A, Changeux JP, Corringer PJ, Delarue M.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):966-71. doi: 10.1073/pnas.1314997111. Epub 2013 Dec 23.

14.

Intermediate closed state for glycine receptor function revealed by cysteine cross-linking.

Prevost MS, Moraga-Cid G, Van Renterghem C, Edelstein SJ, Changeux JP, Corringer PJ.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17113-8. doi: 10.1073/pnas.1317009110. Epub 2013 Oct 1.

15.

Identification of cinnamic acid derivatives as novel antagonists of the prokaryotic proton-gated ion channel GLIC.

Prevost MS, Delarue-Cochin S, Marteaux J, Colas C, Van Renterghem C, Blondel A, Malliavin T, Corringer PJ, Joseph D.

J Med Chem. 2013 Jun 13;56(11):4619-30. doi: 10.1021/jm400374q. Epub 2013 Jun 4.

PMID:
23682762
16.

Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel.

Sauguet L, Howard RJ, Malherbe L, Lee US, Corringer PJ, Harris RA, Delarue M.

Nat Commun. 2013;4:1697. doi: 10.1038/ncomms2682.

17.

Structural sensitivity of a prokaryotic pentameric ligand-gated ion channel to its membrane environment.

Labriola JM, Pandhare A, Jansen M, Blanton MP, Corringer PJ, Baenziger JE.

J Biol Chem. 2013 Apr 19;288(16):11294-303. doi: 10.1074/jbc.M113.458133. Epub 2013 Mar 5.

18.

Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels.

Sauguet L, Poitevin F, Murail S, Van Renterghem C, Moraga-Cid G, Malherbe L, Thompson AW, Koehl P, Corringer PJ, Baaden M, Delarue M.

EMBO J. 2013 Mar 6;32(5):728-41. doi: 10.1038/emboj.2013.17. Epub 2013 Feb 12.

19.

Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines.

Spurny R, Ramerstorfer J, Price K, Brams M, Ernst M, Nury H, Verheij M, Legrand P, Bertrand D, Bertrand S, Dougherty DA, de Esch IJ, Corringer PJ, Sieghart W, Lummis SC, Ulens C.

Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):E3028-34. doi: 10.1073/pnas.1208208109. Epub 2012 Oct 3.

20.

Structure and pharmacology of pentameric receptor channels: from bacteria to brain.

Corringer PJ, Poitevin F, Prevost MS, Sauguet L, Delarue M, Changeux JP.

Structure. 2012 Jun 6;20(6):941-56. doi: 10.1016/j.str.2012.05.003. Review.

21.

A locally closed conformation of a bacterial pentameric proton-gated ion channel.

Prevost MS, Sauguet L, Nury H, Van Renterghem C, Huon C, Poitevin F, Baaden M, Delarue M, Corringer PJ.

Nat Struct Mol Biol. 2012 May 13;19(6):642-9. doi: 10.1038/nsmb.2307.

PMID:
22580559
22.

[X-ray structures of general anesthetics bound to their molecular targets].

Nury H, Delarue M, Corringer PJ.

Med Sci (Paris). 2011 Dec;27(12):1056-7. doi: 10.1051/medsci/20112712006. Epub 2011 Dec 23. Review. French. No abstract available.

23.

Unravelling the conformational plasticity of the extracellular domain of a prokaryotic nAChR homologue in solution by NMR.

Chasapis CT, Argyriou AI, Corringer PJ, Bentrop D, Spyroulias GA.

Biochemistry. 2011 Nov 15;50(45):9681-3. doi: 10.1021/bi201223u. Epub 2011 Oct 20.

PMID:
22007668
24.

Discrimination of agonists versus antagonists of nicotinic ligands based on docking onto AChBP structures.

Taly A, Colas C, Malliavin T, Blondel A, Nilges M, Corringer PJ, Joseph D.

J Mol Graph Model. 2011 Sep;30:100-9. doi: 10.1016/j.jmgm.2011.06.008. Epub 2011 Jun 29.

PMID:
21764343
25.

Structural basis for alcohol modulation of a pentameric ligand-gated ion channel.

Howard RJ, Murail S, Ondricek KE, Corringer PJ, Lindahl E, Trudell JR, Harris RA.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12149-54. doi: 10.1073/pnas.1104480108. Epub 2011 Jul 5.

26.

Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family.

Duret G, Van Renterghem C, Weng Y, Prevost M, Moraga-Cid G, Huon C, Sonner JM, Corringer PJ.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12143-8. doi: 10.1073/pnas.1104494108. Epub 2011 Jul 5.

27.

Smoke extracts and nicotine, but not tobacco extracts, potentiate firing and burst activity of ventral tegmental area dopaminergic neurons in mice.

Marti F, Arib O, Morel C, Dufresne V, Maskos U, Corringer PJ, de Beaurepaire R, Faure P.

Neuropsychopharmacology. 2011 Oct;36(11):2244-57. doi: 10.1038/npp.2011.112. Epub 2011 Jun 29.

28.

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel.

Nury H, Van Renterghem C, Weng Y, Tran A, Baaden M, Dufresne V, Changeux JP, Sonner JM, Delarue M, Corringer PJ.

Nature. 2011 Jan 20;469(7330):428-31. doi: 10.1038/nature09647.

PMID:
21248852
29.

3D structure and allosteric modulation of the transmembrane domain of pentameric ligand-gated ion channels.

Baenziger JE, Corringer PJ.

Neuropharmacology. 2011 Jan;60(1):116-25. doi: 10.1016/j.neuropharm.2010.08.007. Epub 2010 Aug 14. Review.

PMID:
20713066
30.

One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue.

Nury H, Poitevin F, Van Renterghem C, Changeux JP, Corringer PJ, Delarue M, Baaden M.

Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6275-80. doi: 10.1073/pnas.1001832107. Epub 2010 Mar 22.

31.

Atomic structure and dynamics of pentameric ligand-gated ion channels: new insight from bacterial homologues.

Corringer PJ, Baaden M, Bocquet N, Delarue M, Dufresne V, Nury H, Prevost M, Van Renterghem C.

J Physiol. 2010 Feb 15;588(Pt 4):565-72. doi: 10.1113/jphysiol.2009.183160. Epub 2009 Dec 7. Review.

32.

Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel.

Weng Y, Yang L, Corringer PJ, Sonner JM.

Anesth Analg. 2010 Jan 1;110(1):59-63. doi: 10.1213/ANE.0b013e3181c4bc69. Epub 2009 Nov 21.

33.

Crystal structure of the extracellular domain of a bacterial ligand-gated ion channel.

Nury H, Bocquet N, Le Poupon C, Raynal B, Haouz A, Corringer PJ, Delarue M.

J Mol Biol. 2010 Feb 5;395(5):1114-27. doi: 10.1016/j.jmb.2009.11.024. Epub 2009 Nov 13.

PMID:
19917292
34.

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system.

Taly A, Corringer PJ, Guedin D, Lestage P, Changeux JP.

Nat Rev Drug Discov. 2009 Sep;8(9):733-50. doi: 10.1038/nrd2927. Review.

PMID:
19721446
35.

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation.

Bocquet N, Nury H, Baaden M, Le Poupon C, Changeux JP, Delarue M, Corringer PJ.

Nature. 2009 Jan 1;457(7225):111-4. doi: 10.1038/nature07462. Epub 2008 Nov 5.

PMID:
18987633
36.

Regional differential effects of chronic nicotine on brain alpha 4-containing and alpha 6-containing receptors.

Even N, Cardona A, Soudant M, Corringer PJ, Changeux JP, Cloëz-Tayarani I.

Neuroreport. 2008 Oct 8;19(15):1545-50. doi: 10.1097/WNR.0b013e3283112703.

PMID:
18797314
37.

A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family.

Bocquet N, Prado de Carvalho L, Cartaud J, Neyton J, Le Poupon C, Taly A, Grutter T, Changeux JP, Corringer PJ.

Nature. 2007 Jan 4;445(7123):116-9. Epub 2006 Dec 10.

PMID:
17167423
38.

Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors.

Taly A, Corringer PJ, Grutter T, Prado de Carvalho L, Karplus M, Changeux JP.

Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16965-70. Epub 2006 Oct 31.

39.

Nicotine enhances intracellular nicotinic receptor maturation: a novel mechanism of neural plasticity?

Corringer PJ, Sallette J, Changeux JP.

J Physiol Paris. 2006 Mar-May;99(2-3):162-71. Epub 2006 Feb 3. Review.

PMID:
16458492
40.

Nicotine upregulates its own receptors through enhanced intracellular maturation.

Sallette J, Pons S, Devillers-Thiery A, Soudant M, Prado de Carvalho L, Changeux JP, Corringer PJ.

Neuron. 2005 May 19;46(4):595-607.

41.

Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism.

Taly A, Delarue M, Grutter T, Nilges M, Le Novère N, Corringer PJ, Changeux JP.

Biophys J. 2005 Jun;88(6):3954-65. Epub 2005 Apr 1.

42.

Distinct subcellular targeting of fluorescent nicotinic alpha 3 beta 4 and serotoninergic 5-HT3A receptors in hippocampal neurons.

Grailhe R, de Carvalho LP, Paas Y, Le Poupon C, Soudant M, Bregestovski P, Changeux JP, Corringer PJ.

Eur J Neurosci. 2004 Feb;19(4):855-62.

PMID:
15009132
43.

An extracellular protein microdomain controls up-regulation of neuronal nicotinic acetylcholine receptors by nicotine.

Sallette J, Bohler S, Benoit P, Soudant M, Pons S, Le Novère N, Changeux JP, Corringer PJ.

J Biol Chem. 2004 Apr 30;279(18):18767-75. Epub 2004 Feb 5.

44.

An H-bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism of nicotinic receptors.

Grutter T, Prado de Carvalho L, Le Novère N, Corringer PJ, Edelstein S, Changeux JP.

EMBO J. 2003 May 1;22(9):1990-2003.

45.

The diversity of subunit composition in nAChRs: evolutionary origins, physiologic and pharmacologic consequences.

Le Novère N, Corringer PJ, Changeux JP.

J Neurobiol. 2002 Dec;53(4):447-56. Review.

46.

Allosteric transitions of Torpedo acetylcholine receptor in lipids, detergent and amphipols: molecular interactions vs. physical constraints.

Martinez KL, Gohon Y, Corringer PJ, Tribet C, Mérola F, Changeux JP, Popot JL.

FEBS Lett. 2002 Sep 25;528(1-3):251-6.

47.

Experimentally based model of a complex between a snake toxin and the alpha 7 nicotinic receptor.

Fruchart-Gaillard C, Gilquin B, Antil-Delbeke S, Le Novère N, Tamiya T, Corringer PJ, Changeux JP, Ménez A, Servent D.

Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3216-21. Epub 2002 Feb 26.

48.

Desensitization of neuronal nicotinic acetylcholine receptors conferred by N-terminal segments of the beta 2 subunit.

Bohler S, Gay S, Bertrand S, Corringer PJ, Edelstein SJ, Changeux JP, Bertrand D.

Biochemistry. 2001 Feb 20;40(7):2066-74.

PMID:
11329274
49.

A method for soluble overexpression of the alpha7 nicotinic acetylcholine receptor extracellular domain.

Fischer M, Corringer PJ, Schott K, Bacher A, Changeux JP.

Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3567-70.

50.

Molecular determinants by which a long chain toxin from snake venom interacts with the neuronal alpha 7-nicotinic acetylcholine receptor.

Antil-Delbeke S, Gaillard C, Tamiya T, Corringer PJ, Changeux JP, Servent D, Ménez A.

J Biol Chem. 2000 Sep 22;275(38):29594-601.

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