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Items: 12


Depletion of mitochondria in mammalian cells through enforced mitophagy.

Correia-Melo C, Ichim G, Tait SW, Passos JF.

Nat Protoc. 2017 Jan;12(1):183-194. doi: 10.1038/nprot.2016.159. Epub 2016 Dec 22.


Powering senescence: The ugly side of mitochondria.

Correia-Melo C, Birch J, Passos JF.

Cell Cycle. 2016 Oct;15(19):2541-2542. Epub 2016 Jul 11. No abstract available.


Demystifying the role of mitochondria in senescence.

Correia-Melo C, Passos JF.

Mol Cell Oncol. 2016 Mar 28;3(4):e1162896. doi: 10.1080/23723556.2016.1162896. eCollection 2016 Jul.


SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair.

Hewitt G, Carroll B, Sarallah R, Correia-Melo C, Ogrodnik M, Nelson G, Otten EG, Manni D, Antrobus R, Morgan BA, von Zglinicki T, Jurk D, Seluanov A, Gorbunova V, Johansen T, Passos JF, Korolchuk VI.

Autophagy. 2016 Oct 2;12(10):1917-1930. Epub 2016 Jul 8.


Mitochondria are required for pro-ageing features of the senescent phenotype.

Correia-Melo C, Marques FD, Anderson R, Hewitt G, Hewitt R, Cole J, Carroll BM, Miwa S, Birch J, Merz A, Rushton MD, Charles M, Jurk D, Tait SW, Czapiewski R, Greaves L, Nelson G, Bohlooly-Y M, Rodriguez-Cuenca S, Vidal-Puig A, Mann D, Saretzki G, Quarato G, Green DR, Adams PD, von Zglinicki T, Korolchuk VI, Passos JF.

EMBO J. 2016 Apr 1;35(7):724-42. doi: 10.15252/embj.201592862. Epub 2016 Feb 4.


DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease.

Birch J, Anderson RK, Correia-Melo C, Jurk D, Hewitt G, Marques FM, Green NJ, Moisey E, Birrell MA, Belvisi MG, Black F, Taylor JJ, Fisher AJ, De Soyza A, Passos JF.

Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15;309(10):L1124-37. doi: 10.1152/ajplung.00293.2015. Epub 2015 Sep 18.


Mitochondria: Are they causal players in cellular senescence?

Correia-Melo C, Passos JF.

Biochim Biophys Acta. 2015 Nov;1847(11):1373-9. doi: 10.1016/j.bbabio.2015.05.017. Epub 2015 May 28. Review.


Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.

Jurk D, Wilson C, Passos JF, Oakley F, Correia-Melo C, Greaves L, Saretzki G, Fox C, Lawless C, Anderson R, Hewitt G, Pender SL, Fullard N, Nelson G, Mann J, van de Sluis B, Mann DA, von Zglinicki T.

Nat Commun. 2014 Jun 24;2:4172. doi: 10.1038/ncomms5172.


Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence?

Correia-Melo C, Hewitt G, Passos JF.

Longev Healthspan. 2014 Jan 16;3(1):1. doi: 10.1186/2046-2395-3-1.


Robust multiparametric assessment of cellular senescence.

Correia-Melo C, Jurk D, Passos JF.

Methods Mol Biol. 2013;965:409-19. doi: 10.1007/978-1-62703-239-1_27.


Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence.

Hewitt G, Jurk D, Marques FD, Correia-Melo C, Hardy T, Gackowska A, Anderson R, Taschuk M, Mann J, Passos JF.

Nat Commun. 2012 Feb 28;3:708. doi: 10.1038/ncomms1708.


CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity.

Manning AL, Bakhoum SF, Maffini S, Correia-Melo C, Maiato H, Compton DA.

EMBO J. 2010 Oct 20;29(20):3531-43. doi: 10.1038/emboj.2010.230. Epub 2010 Sep 17.

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