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Items: 8


Increased susceptibility to develop spontaneous and post-traumatic osteoarthritis in Dot1l-deficient mice.

Cornelis FMF, de Roover A, Storms L, Hens A, Lories RJ, Monteagudo S.

Osteoarthritis Cartilage. 2019 Mar;27(3):513-525. doi: 10.1016/j.joca.2018.11.008. Epub 2018 Dec 1.


ANP32A regulates ATM expression and prevents oxidative stress in cartilage, brain, and bone.

Cornelis FMF, Monteagudo S, Guns LKA, den Hollander W, Nelissen RGHH, Storms L, Peeters T, Jonkers I, Meulenbelt I, Lories RJ.

Sci Transl Med. 2018 Sep 12;10(458). pii: eaar8426. doi: 10.1126/scitranslmed.aar8426.


DOT1L safeguards cartilage homeostasis and protects against osteoarthritis.

Monteagudo S, Cornelis FMF, Aznar-Lopez C, Yibmantasiri P, Guns LA, Carmeliet P, Cailotto F, Lories RJ.

Nat Commun. 2017 Jun 19;8:15889. doi: 10.1038/ncomms15889.


Aberrant Calreticulin Expression in Articular Cartilage of Dio2 Deficient Mice.

Bomer N, Cornelis FM, Ramos YF, den Hollander W, Lakenberg N, van der Breggen R, Storms L, Slagboom PE, Lories RJ, Meulenbelt I.

PLoS One. 2016 May 10;11(5):e0154999. doi: 10.1371/journal.pone.0154999. eCollection 2016.


The effect of forced exercise on knee joints in Dio2(-/-) mice: type II iodothyronine deiodinase-deficient mice are less prone to develop OA-like cartilage damage upon excessive mechanical stress.

Bomer N, Cornelis FM, Ramos YF, den Hollander W, Storms L, van der Breggen R, Lakenberg N, Slagboom PE, Meulenbelt I, Lories RJ.

Ann Rheum Dis. 2016 Mar;75(3):571-7. doi: 10.1136/annrheumdis-2014-206608. Epub 2014 Dec 30.


Antagonism of Nodal signaling by BMP/Smad5 prevents ectopic primitive streak formation in the mouse amnion.

Pereira PN, Dobreva MP, Maas E, Cornelis FM, Moya IM, Umans L, Verfaillie CM, Camus A, de Sousa Lopes SM, Huylebroeck D, Zwijsen A.

Development. 2012 Sep;139(18):3343-54. doi: 10.1242/dev.075465.


Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis.

CastaƱo Betancourt MC, Cailotto F, Kerkhof HJ, Cornelis FM, Doherty SA, Hart DJ, Hofman A, Luyten FP, Maciewicz RA, Mangino M, Metrustry S, Muir K, Peters MJ, Rivadeneira F, Wheeler M, Zhang W, Arden N, Spector TD, Uitterlinden AG, Doherty M, Lories RJ, Valdes AM, van Meurs JB.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8218-23. doi: 10.1073/pnas.1119899109. Epub 2012 May 7.


Functional effects of susceptibility genes in osteoarthritis.

Cornelis FM, Luyten FP, Lories RJ.

Discov Med. 2011 Aug;12(63):129-39. Review.

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