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Items: 1 to 50 of 71

1.

An essential role for the Zn2+ transporter ZIP7 in B cell development.

Anzilotti C, Swan DJ, Boisson B, Deobagkar-Lele M, Oliveira C, Chabosseau P, Engelhardt KR, Xu X, Chen R, Alvarez L, Berlinguer-Palmini R, Bull KR, Cawthorne E, Cribbs AP, Crockford TL, Dang TS, Fearn A, Fenech EJ, de Jong SJ, Lagerholm BC, Ma CS, Sims D, van den Berg B, Xu Y, Cant AJ, Kleiner G, Leahy TR, de la Morena MT, Puck JM, Shapiro RS, van der Burg M, Chapman JR, Christianson JC, Davies B, McGrath JA, Przyborski S, Santibanez Koref M, Tangye SG, Werner A, Rutter GA, Padilla-Parra S, Casanova JL, Cornall RJ, Conley ME, Hambleton S.

Nat Immunol. 2019 Mar;20(3):350-361. doi: 10.1038/s41590-018-0295-8. Epub 2019 Feb 4.

PMID:
30718914
2.

Immune Checkpoints as Therapeutic Targets in Autoimmunity.

Paluch C, Santos AM, Anzilotti C, Cornall RJ, Davis SJ.

Front Immunol. 2018 Oct 8;9:2306. doi: 10.3389/fimmu.2018.02306. eCollection 2018. Review.

3.

53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ.

Ghezraoui H, Oliveira C, Becker JR, Bilham K, Moralli D, Anzilotti C, Fischer R, Deobagkar-Lele M, Sanchiz-Calvo M, Fueyo-Marcos E, Bonham S, Kessler BM, Rottenberg S, Cornall RJ, Green CM, Chapman JR.

Nature. 2018 Aug;560(7716):122-127. doi: 10.1038/s41586-018-0362-1. Epub 2018 Jul 25.

PMID:
30046110
4.

Partial retinal photoreceptor loss in a transgenic mouse model associated with reduced levels of interphotoreceptor retinol binding protein (IRBP, RBP3).

Liu YH, Corbett C, Klaska IP, Makinen K, Nickerson JM, Cornall RJ, Kuffova L, Forrester JV.

Exp Eye Res. 2018 Jul;172:54-65. doi: 10.1016/j.exer.2018.03.020. Epub 2018 Mar 21.

PMID:
29571629
5.

Capturing resting T cells: the perils of PLL.

Santos AM, Ponjavic A, Fritzsche M, Fernandes RA, de la Serna JB, Wilcock MJ, Schneider F, Urbančič I, McColl J, Anzilotti C, Ganzinger KA, Aßmann M, Depoil D, Cornall RJ, Dustin ML, Klenerman D, Davis SJ, Eggeling C, Lee SF.

Nat Immunol. 2018 Mar;19(3):203-205. doi: 10.1038/s41590-018-0048-8. Epub 2018 Feb 23. No abstract available.

PMID:
29476188
6.

B1a B cells require autophagy for metabolic homeostasis and self-renewal.

Clarke AJ, Riffelmacher T, Braas D, Cornall RJ, Simon AK.

J Exp Med. 2018 Feb 5;215(2):399-413. doi: 10.1084/jem.20170771. Epub 2018 Jan 11.

7.

Mammalian γ2 AMPK regulates intrinsic heart rate.

Yavari A, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV, Sharpe EJ, Wolfien M, Czibik G, Steeples V, Ghaffari S, Nguyen C, Stockenhuber A, Clair JRS, Rimmbach C, Okamoto Y, Yang D, Wang M, Ziman BD, Moen JM, Riordon DR, Ramirez C, Paina M, Lee J, Zhang J, Ahmet I, Matt MG, Tarasova YS, Baban D, Sahgal N, Lockstone H, Puliyadi R, de Bono J, Siggs OM, Gomes J, Muskett H, Maguire ML, Beglov Y, Kelly M, Dos Santos PPN, Bright NJ, Woods A, Gehmlich K, Isackson H, Douglas G, Ferguson DJP, Schneider JE, Tinker A, Wolkenhauer O, Channon KM, Cornall RJ, Sternick EB, Paterson DJ, Redwood CS, Carling D, Proenza C, David R, Baruscotti M, DiFrancesco D, Lakatta EG, Watkins H, Ashrafian H.

Nat Commun. 2017 Nov 2;8(1):1258. doi: 10.1038/s41467-017-01342-5.

8.

Themis2: setting the threshold for B-cell selection.

Deobagkar-Lele M, Anzilotti C, Cornall RJ.

Cell Mol Immunol. 2017 Aug;14(8):643-645. doi: 10.1038/cmi.2017.27. Epub 2017 Jun 19. No abstract available.

9.

Themis2 lowers the threshold for B cell activation during positive selection.

Cheng D, Deobagkar-Lele M, Zvezdova E, Choi S, Uehara S, Baup D, Bennett SC, Bull KR, Crockford TL, Ferry H, Warzecha C, Marcellin M, de Peredo AG, Lesourne R, Anzilotti C, Love PE, Cornall RJ.

Nat Immunol. 2017 Feb;18(2):205-213. doi: 10.1038/ni.3642. Epub 2016 Dec 19.

PMID:
27992403
10.

Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity.

Siggs OM, Stockenhuber A, Deobagkar-Lele M, Bull KR, Crockford TL, Kingston BL, Crawford G, Anzilotti C, Steeples V, Ghaffari S, Czibik G, Bellahcene M, Watkins H, Ashrafian H, Davies B, Woods A, Carling D, Yavari A, Beutler B, Cornall RJ.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3706-15. doi: 10.1073/pnas.1607592113. Epub 2016 Jun 14.

11.

Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection.

Siggs OM, Popkin DL, Krebs P, Li X, Tang M, Zhan X, Zeng M, Lin P, Xia Y, Oldstone MB, Cornall RJ, Beutler B.

Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):E5706-14. doi: 10.1073/pnas.1515619112. Epub 2015 Oct 5.

12.

Two types of BCR interactions are positively selected during leukemia development in the Eμ-TCL1 transgenic mouse model of CLL.

Iacovelli S, Hug E, Bennardo S, Duehren-von Minden M, Gobessi S, Rinaldi A, Suljagic M, Bilbao D, Bolasco G, Eckl-Dorna J, Niederberger V, Autore F, Sica S, Laurenti L, Wang H, Cornall RJ, Clarke SH, Croce CM, Bertoni F, Jumaa H, Efremov DG.

Blood. 2015 Mar 5;125(10):1578-88. doi: 10.1182/blood-2014-07-587790. Epub 2015 Jan 6.

13.

DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity.

Zhang Q, Dove CG, Hor JL, Murdock HM, Strauss-Albee DM, Garcia JA, Mandl JN, Grodick RA, Jing H, Chandler-Brown DB, Lenardo TE, Crawford G, Matthews HF, Freeman AF, Cornall RJ, Germain RN, Mueller SN, Su HC.

J Exp Med. 2014 Dec 15;211(13):2549-66. doi: 10.1084/jem.20141307. Epub 2014 Nov 24.

14.

Genetic analysis of autoimmune type 1 diabetes mellitus in mice. 1991.

Todd JA, Aitman TJ, Cornall RJ, Ghosh S, Hall JR, Hearne CM, Knight AM, Love JM, McAleer MA, Prins JB, Rodrigues N, Lathrop M, Pressey A, DeLarato NH, Peterson LB, Wicker LS.

J Immunol. 2014 Jul 1;193(1):7-12. No abstract available.

15.

Next-generation sequencing to dissect hereditary nephrotic syndrome in mice identifies a hypomorphic mutation in Lamb2 and models Pierson's syndrome.

Bull KR, Mason T, Rimmer AJ, Crockford TL, Silver KL, Bouriez-Jones T, Hough TA, Chaudhry S, Roberts IS, Goodnow CC, Cornall RJ.

J Pathol. 2014 May;233(1):18-26. doi: 10.1002/path.4308. Epub 2014 Feb 6.

16.

DOCK8 is critical for the survival and function of NKT cells.

Crawford G, Enders A, Gileadi U, Stankovic S, Zhang Q, Lambe T, Crockford TL, Lockstone HE, Freeman A, Arkwright PD, Smart JM, Ma CS, Tangye SG, Goodnow CC, Cerundolo V, Godfrey DI, Su HC, Randall KL, Cornall RJ.

Blood. 2013 Sep 19;122(12):2052-61. doi: 10.1182/blood-2013-02-482331. Epub 2013 Aug 8.

17.

The high-risk corneal regraft model: a justification for tissue matching in humans.

Vitova A, Kuffová L, Klaska IP, Holan V, Cornall RJ, Forrester JV.

Transpl Int. 2013 Apr;26(4):453-61. doi: 10.1111/tri.12055. Epub 2013 Feb 11. Erratum in: Transpl Int. 2013 Aug;26(8):e74. Transpl Int. 2013 May;26(5):562.

18.

Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations.

Bull KR, Rimmer AJ, Siggs OM, Miosge LA, Roots CM, Enders A, Bertram EM, Crockford TL, Whittle B, Potter PK, Simon MM, Mallon AM, Brown SD, Beutler B, Goodnow CC, Lunter G, Cornall RJ.

PLoS Genet. 2013;9(1):e1003219. doi: 10.1371/journal.pgen.1003219. Epub 2013 Jan 31.

19.

Mutations in TCF12, encoding a basic helix-loop-helix partner of TWIST1, are a frequent cause of coronal craniosynostosis.

Sharma VP, Fenwick AL, Brockop MS, McGowan SJ, Goos JA, Hoogeboom AJ, Brady AF, Jeelani NO, Lynch SA, Mulliken JB, Murray DJ, Phipps JM, Sweeney E, Tomkins SE, Wilson LC, Bennett S, Cornall RJ, Broxholme J, Kanapin A; 500 Whole-Genome Sequences (WGS500) Consortium, Johnson D, Wall SA, van der Spek PJ, Mathijssen IM, Maxson RE, Twigg SR, Wilkie AO.

Nat Genet. 2013 Mar;45(3):304-7. doi: 10.1038/ng.2531. Epub 2013 Jan 27. Erratum in: Nat Genet. 2013 Oct;45(10):1261.

20.

B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A.

Bergmann H, Yabas M, Short A, Miosge L, Barthel N, Teh CE, Roots CM, Bull KR, Jeelall Y, Horikawa K, Whittle B, Balakishnan B, Sjollema G, Bertram EM, Mackay F, Rimmer AJ, Cornall RJ, Field MA, Andrews TD, Goodnow CC, Enders A.

J Exp Med. 2013 Jan 14;210(1):31-40. doi: 10.1084/jem.20121076. Epub 2012 Dec 24.

21.

The phenotype of circulating follicular-helper T cells in patients with rheumatoid arthritis defines CD200 as a potential therapeutic target.

Chakera A, Bennett SC, Morteau O, Bowness P, Luqmani RA, Cornall RJ.

Clin Dev Immunol. 2012;2012:948218. doi: 10.1155/2012/948218. Epub 2012 Oct 4.

22.

DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice.

Randall KL, Chan SS, Ma CS, Fung I, Mei Y, Yabas M, Tan A, Arkwright PD, Al Suwairi W, Lugo Reyes SO, Yamazaki-Nakashimada MA, Garcia-Cruz Mde L, Smart JM, Picard C, Okada S, Jouanguy E, Casanova JL, Lambe T, Cornall RJ, Russell S, Oliaro J, Tangye SG, Bertram EM, Goodnow CC.

J Exp Med. 2011 Oct 24;208(11):2305-20. doi: 10.1084/jem.20110345. Epub 2011 Oct 17.

23.

DOCK8 is essential for T-cell survival and the maintenance of CD8+ T-cell memory.

Lambe T, Crawford G, Johnson AL, Crockford TL, Bouriez-Jones T, Smyth AM, Pham TH, Zhang Q, Freeman AF, Cyster JG, Su HC, Cornall RJ.

Eur J Immunol. 2011 Dec;41(12):3423-35. doi: 10.1002/eji.201141759. Epub 2011 Nov 10.

24.

A whole blood monokine-based reporter assay provides a sensitive and robust measurement of the antigen-specific T cell response.

Chakera A, Bennett SC, Cornall RJ.

J Transl Med. 2011 Aug 26;9:143. doi: 10.1186/1479-5876-9-143.

25.

Antigen-specific T cell responses to BK polyomavirus antigens identify functional anti-viral immunity and may help to guide immunosuppression following renal transplantation.

Chakera A, Bennett S, Lawrence S, Morteau O, Mason PD, O'Callaghan CA, Cornall RJ.

Clin Exp Immunol. 2011 Sep;165(3):401-9. doi: 10.1111/j.1365-2249.2011.04429.x. Epub 2011 Jun 14.

26.

The essential role of DOCK8 in humoral immunity.

Randall KL, Lambe T, Goodnow CC, Cornall RJ.

Dis Markers. 2010;29(3-4):141-50. doi: 10.3233/DMA-2010-0739. Review.

27.

Renal transplant immunosuppression impairs natural killer cell function in vitro and in vivo.

Morteau O, Blundell S, Chakera A, Bennett S, Christou CM, Mason PD, Cornall RJ, O'Callaghan CA.

PLoS One. 2010 Oct 12;5(10):e13294. doi: 10.1371/journal.pone.0013294.

28.

Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.

Randall KL, Lambe T, Johnson AL, Treanor B, Kucharska E, Domaschenz H, Whittle B, Tze LE, Enders A, Crockford TL, Bouriez-Jones T, Alston D, Cyster JG, Lenardo MJ, Mackay F, Deenick EK, Tangye SG, Chan TD, Camidge T, Brink R, Vinuesa CG, Batista FD, Cornall RJ, Goodnow CC.

Nat Immunol. 2009 Dec;10(12):1283-91. doi: 10.1038/ni.1820. Epub 2009 Nov 8. Erratum in: Nat Immunol. 2010 Jul;11(7):644. Johnson, Andy [corrected to Johnson, Andy L].

29.

Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection.

Johnson AL, Aravind L, Shulzhenko N, Morgun A, Choi SY, Crockford TL, Lambe T, Domaschenz H, Kucharska EM, Zheng L, Vinuesa CG, Lenardo MJ, Goodnow CC, Cornall RJ, Schwartz RH.

Nat Immunol. 2009 Aug;10(8):831-9. doi: 10.1038/ni.1769. Epub 2009 Jul 13. Erratum in: Nat Immunol. 2010 Jan;11(1):97.

30.

Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome.

Nijnik A, Dawson S, Crockford TL, Woodbine L, Visetnoi S, Bennett S, Jones M, Turner GD, Jeggo PA, Goodnow CC, Cornall RJ.

J Clin Invest. 2009 Jun;119(6):1696-705. doi: 10.1172/JCI32743. Epub 2009 May 18.

31.

HO-1 extends to stem cells.

Cornall RJ.

Blood. 2008 Dec 1;112(12):4363-4. doi: 10.1182/blood-2008-06-163055. No abstract available.

32.

Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism.

Lambe T, Simpson RJ, Dawson S, Bouriez-Jones T, Crockford TL, Lepherd M, Latunde-Dada GO, Robinson H, Raja KB, Campagna DR, Villarreal G Jr, Ellory JC, Goodnow CC, Fleming MD, McKie AT, Cornall RJ.

Blood. 2009 Feb 19;113(8):1805-8. doi: 10.1182/blood-2007-11-120402. Epub 2008 Oct 27.

34.

Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis.

Heazlewood CK, Cook MC, Eri R, Price GR, Tauro SB, Taupin D, Thornton DJ, Png CW, Crockford TL, Cornall RJ, Adams R, Kato M, Nelms KA, Hong NA, Florin TH, Goodnow CC, McGuckin MA.

PLoS Med. 2008 Mar 4;5(3):e54. doi: 10.1371/journal.pmed.0050054.

35.

Vitiligo pathogenesis: autoimmune disease, genetic defect, excessive reactive oxygen species, calcium imbalance, or what else?

Schallreuter KU, Bahadoran P, Picardo M, Slominski A, Elassiuty YE, Kemp EH, Giachino C, Liu JB, Luiten RM, Lambe T, Le Poole IC, Dammak I, Onay H, Zmijewski MA, Dell'Anna ML, Zeegers MP, Cornall RJ, Paus R, Ortonne JP, Westerhof W.

Exp Dermatol. 2008 Feb;17(2):139-40; discussion 141-60. doi: 10.1111/j.1600-0625.2007.00666_1.x.

PMID:
18205713
36.

MyD88-dependent autoimmune disease in Lyn-deficient mice.

Silver KL, Crockford TL, Bouriez-Jones T, Milling S, Lambe T, Cornall RJ.

Eur J Immunol. 2007 Oct;37(10):2734-43.

37.

DNA repair is limiting for haematopoietic stem cells during ageing.

Nijnik A, Woodbine L, Marchetti C, Dawson S, Lambe T, Liu C, Rodrigues NP, Crockford TL, Cabuy E, Vindigni A, Enver T, Bell JI, Slijepcevic P, Goodnow CC, Jeggo PA, Cornall RJ.

Nature. 2007 Jun 7;447(7145):686-90.

PMID:
17554302
38.

Limited peripheral T cell anergy predisposes to retinal autoimmunity.

Lambe T, Leung JC, Ferry H, Bouriez-Jones T, Makinen K, Crockford TL, Jiang HR, Nickerson JM, Peltonen L, Forrester JV, Cornall RJ.

J Immunol. 2007 Apr 1;178(7):4276-83.

39.

Increased positive selection of B1 cells and reduced B cell tolerance to intracellular antigens in c1q-deficient mice.

Ferry H, Potter PK, Crockford TL, Nijnik A, Ehrenstein MR, Walport MJ, Botto M, Cornall RJ.

J Immunol. 2007 Mar 1;178(5):2916-22.

40.

Spontaneous class switching and B cell hyperactivity increase autoimmunity against intracellular self antigen in Lyn-deficient mice.

Silver K, Bouriez-Jones T, Crockford T, Ferry H, Tang HL, Cyster JG, Cornall RJ.

Eur J Immunol. 2006 Nov;36(11):2920-7.

41.

CD4 T cell-dependent autoimmunity against a melanocyte neoantigen induces spontaneous vitiligo and depends upon Fas-Fas ligand interactions.

Lambe T, Leung JC, Bouriez-Jones T, Silver K, Makinen K, Crockford TL, Ferry H, Forrester JV, Cornall RJ.

J Immunol. 2006 Sep 1;177(5):3055-62.

42.

Signals from a self-antigen induce positive selection in early B cell ontogeny but are tolerogenic in adults.

Ferry H, Crockford TL, Leung JC, Cornall RJ.

J Immunol. 2006 Jun 15;176(12):7402-11.

43.

Spontaneous B cell hyperactivity in autoimmune-prone MRL mice.

Nijnik A, Ferry H, Lewis G, Rapsomaniki E, Leung JC, Daser A, Lambe T, Goodnow CC, Cornall RJ.

Int Immunol. 2006 Jul;18(7):1127-37. Epub 2006 May 30.

PMID:
16735376
44.

TLR4, TLR9 and MyD88 are not required for the positive selection of autoreactive B cells into the primary repertoire.

Silver K, Ferry H, Crockford T, Cornall RJ.

Eur J Immunol. 2006 Jun;36(6):1404-12.

45.

B-cell tolerance.

Ferry H, Leung JC, Lewis G, Nijnik A, Silver K, Lambe T, Cornall RJ.

Transplantation. 2006 Feb 15;81(3):308-15. Review.

PMID:
16477212
46.

Analysis of Lyn/CD22 double-deficient B cells in vivo demonstrates Lyn- and CD22-independent pathways affecting BCR regulation and B cell survival.

Ferry H, Crockford TL, Silver K, Rust N, Goodnow CC, Cornall RJ.

Eur J Immunol. 2005 Dec;35(12):3655-63. Erratum in: Eur J Immunol. 2005 Dec;35(12):3714. Cockford, Tanya L [corrected to Crockford, Tanya L].

47.

A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity.

Vinuesa CG, Cook MC, Angelucci C, Athanasopoulos V, Rui L, Hill KM, Yu D, Domaschenz H, Whittle B, Lambe T, Roberts IS, Copley RR, Bell JI, Cornall RJ, Goodnow CC.

Nature. 2005 May 26;435(7041):452-8.

PMID:
15917799
48.

Analysis of B-cell immune tolerance induction using transgenic mice.

Ferry H, Cornall RJ.

Methods Mol Biol. 2004;271:239-60.

PMID:
15146125
49.

Tolerance and autoimmunity in the eye: a role for CD8 T cells in organ-specific autoimmunity in the retina.

Forrester JV, Cornall RJ.

Immunology. 2003 Nov;110(3):293-5. Review. No abstract available.

50.

The cellular location of self-antigen determines the positive and negative selection of autoreactive B cells.

Ferry H, Jones M, Vaux DJ, Roberts IS, Cornall RJ.

J Exp Med. 2003 Nov 3;198(9):1415-25.

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