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Items: 1 to 50 of 53

1.

Atlastins remodel the endoplasmic reticulum for selective autophagy.

Liang JR, Lingeman E, Ahmed S, Corn JE.

J Cell Biol. 2018 Aug 24. pii: jcb.201804185. doi: 10.1083/jcb.201804185. [Epub ahead of print]

PMID:
30143524
2.

CRISPR-Cas9 genome editing in human cells occurs via the Fanconi anemia pathway.

Richardson CD, Kazane KR, Feng SJ, Zelin E, Bray NL, Schäfer AJ, Floor SN, Corn JE.

Nat Genet. 2018 Aug;50(8):1132-1139. doi: 10.1038/s41588-018-0174-0. Epub 2018 Jul 27.

PMID:
30054595
3.

In vitro-transcribed guide RNAs trigger an innate immune response via the RIG-I pathway.

Wienert B, Shin J, Zelin E, Pestal K, Corn JE.

PLoS Biol. 2018 Jul 16;16(7):e2005840. doi: 10.1371/journal.pbio.2005840. eCollection 2018 Jul.

4.

Sometimes you're the scooper, and sometimes you get scooped: How to turn both into something good.

Kim JS, Corn JE.

PLoS Biol. 2018 Jul 16;16(7):e2006843. doi: 10.1371/journal.pbio.2006843. eCollection 2018 Jul.

5.

Author Correction: Discovery of stimulation-responsive immune enhancers with CRISPR activation.

Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, Naddaf N, Chu JS, Ma H, Boyer E, Van Gool F, Huang H, Liu R, Tobin VR, Schumann K, Daly MJ, Farh KK, Ansel KM, Ye CJ, Greenleaf WJ, Anderson MS, Bluestone JA, Chang HY, Corn JE, Marson A.

Nature. 2018 Jul;559(7715):E13. doi: 10.1038/s41586-018-0227-7.

PMID:
29899441
6.

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms.

Farboud B, Jarvis E, Roth TL, Shin J, Corn JE, Marson A, Meyer BJ, Patel NH, Hochstrasser ML.

J Vis Exp. 2018 May 25;(135). doi: 10.3791/57350.

7.

BARD1 is necessary for ubiquitylation of nucleosomal histone H2A and for transcriptional regulation of estrogen metabolism genes.

Stewart MD, Zelin E, Dhall A, Walsh T, Upadhyay E, Corn JE, Chatterjee C, King MC, Klevit RE.

Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):1316-1321. doi: 10.1073/pnas.1715467115. Epub 2018 Jan 24.

8.

E Pluribus Unum ("Out of Many, One"): CRISPR Modeling of Myeloid Expansion.

Shin J, Corn JE.

Cell Stem Cell. 2017 Oct 5;21(4):415-416. doi: 10.1016/j.stem.2017.09.013.

PMID:
28985519
9.

Production of Purified CasRNPs for Efficacious Genome Editing.

Lingeman E, Jeans C, Corn JE.

Curr Protoc Mol Biol. 2017 Oct 2;120:31.10.1-31.10.19. doi: 10.1002/cpmb.43.

PMID:
28967993
10.

Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements.

Mumbach MR, Satpathy AT, Boyle EA, Dai C, Gowen BG, Cho SW, Nguyen ML, Rubin AJ, Granja JM, Kazane KR, Wei Y, Nguyen T, Greenside PG, Corces MR, Tycko J, Simeonov DR, Suliman N, Li R, Xu J, Flynn RA, Kundaje A, Khavari PA, Marson A, Corn JE, Quertermous T, Greenleaf WJ, Chang HY.

Nat Genet. 2017 Nov;49(11):1602-1612. doi: 10.1038/ng.3963. Epub 2017 Sep 25.

11.

Discovery of stimulation-responsive immune enhancers with CRISPR activation.

Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, Naddaf N, Chu JS, Ma H, Boyer E, Van Gool F, Huang H, Liu R, Tobin VR, Schumann K, Daly MJ, Farh KK, Ansel KM, Ye CJ, Greenleaf WJ, Anderson MS, Bluestone JA, Chang HY, Corn JE, Marson A.

Nature. 2017 Sep 7;549(7670):111-115. doi: 10.1038/nature23875. Epub 2017 Aug 30. Erratum in: Nature. 2018 Jul;559(7715):E13.

12.

Protein engineering to increase the potential of a therapeutic antibody Fab for long-acting delivery to the eye.

Tesar D, Luoma J, Wyatt EA, Shi C, Shatz W, Hass PE, Mathieu M, Yi L, Corn JE, Maass KF, Wang K, Dion MZ, Andersen N, Loyet KM, van Lookeren Campagne M, Rajagopal K, Dickmann L, Scheer JM, Kelley RF.

MAbs. 2017 Nov/Dec;9(8):1297-1305. doi: 10.1080/19420862.2017.1372078. Epub 2017 Aug 30.

13.

Disabling Cas9 by an anti-CRISPR DNA mimic.

Shin J, Jiang F, Liu JJ, Bray NL, Rauch BJ, Baik SH, Nogales E, Bondy-Denomy J, Corn JE, Doudna JA.

Sci Adv. 2017 Jul 12;3(7):e1701620. doi: 10.1126/sciadv.1701620. eCollection 2017 Jul.

14.

Thigmotaxis Mediates Trail Odour Disruption.

Stringer LD, Corn JE, Sik Roh H, Jiménez-Pérez A, Manning LM, Harper AR, Suckling DM.

Sci Rep. 2017 May 10;7(1):1670. doi: 10.1038/s41598-017-01958-z.

15.

Synthetically modified guide RNA and donor DNA are a versatile platform for CRISPR-Cas9 engineering.

Lee K, Mackley VA, Rao A, Chong AT, Dewitt MA, Corn JE, Murthy N.

Elife. 2017 May 2;6. pii: e25312. doi: 10.7554/eLife.25312.

16.

Flexibility and Design: Conformational Heterogeneity along the Evolutionary Trajectory of a Redesigned Ubiquitin.

Biel JT, Thompson MC, Cunningham CN, Corn JE, Fraser JS.

Structure. 2017 May 2;25(5):739-749.e3. doi: 10.1016/j.str.2017.03.009. Epub 2017 Apr 13.

17.

Genome editing via delivery of Cas9 ribonucleoprotein.

DeWitt MA, Corn JE, Carroll D.

Methods. 2017 May 15;121-122:9-15. doi: 10.1016/j.ymeth.2017.04.003. Epub 2017 Apr 12.

PMID:
28410976
18.

Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair.

Lee K, Conboy M, Park HM, Jiang F, Kim HJ, Dewitt MA, Mackley VA, Chang K, Rao A, Skinner C, Shobha T, Mehdipour M, Liu H, Huang WC, Lan F, Bray NL, Li S, Corn JE, Kataoka K, Doudna JA, Conboy I, Murthy N.

Nat Biomed Eng. 2017;1:889-901. doi: 10.1038/s41551-017-0137-2. Epub 2017 Oct 2.

19.

Cornerstones of CRISPR-Cas in drug discovery and therapy.

Fellmann C, Gowen BG, Lin PC, Doudna JA, Corn JE.

Nat Rev Drug Discov. 2017 Feb;16(2):89-100. doi: 10.1038/nrd.2016.238. Epub 2016 Dec 23. Review.

20.

Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells.

Dillon M, Yin Y, Zhou J, McCarty L, Ellerman D, Slaga D, Junttila TT, Han G, Sandoval W, Ovacik MA, Lin K, Hu Z, Shen A, Corn JE, Spiess C, Carter PJ.

MAbs. 2017 Feb/Mar;9(2):213-230. doi: 10.1080/19420862.2016.1267089. Epub 2016 Dec 8.

21.

Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation.

Horlbeck MA, Gilbert LA, Villalta JE, Adamson B, Pak RA, Chen Y, Fields AP, Park CY, Corn JE, Kampmann M, Weissman JS.

Elife. 2016 Sep 23;5. pii: e19760. doi: 10.7554/eLife.19760.

22.

Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells.

DeWitt MA, Magis W, Bray NL, Wang T, Berman JR, Urbinati F, Heo SJ, Mitros T, Muñoz DP, Boffelli D, Kohn DB, Walters MC, Carroll D, Martin DI, Corn JE.

Sci Transl Med. 2016 Oct 12;8(360):360ra134.

23.

Non-homologous DNA increases gene disruption efficiency by altering DNA repair outcomes.

Richardson CD, Ray GJ, Bray NL, Corn JE.

Nat Commun. 2016 Aug 17;7:12463. doi: 10.1038/ncomms12463.

24.

Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA.

Richardson CD, Ray GJ, DeWitt MA, Curie GL, Corn JE.

Nat Biotechnol. 2016 Mar;34(3):339-44. doi: 10.1038/nbt.3481. Epub 2016 Jan 20.

PMID:
26789497
25.

Using protein motion to read, write, and erase ubiquitin signals.

Phillips AH, Corn JE.

J Biol Chem. 2015 Oct 30;290(44):26437-44. doi: 10.1074/jbc.R115.653675. Epub 2015 Sep 9. Review.

26.

Co-opting CRISPR to deliver functional RNAs.

Lin PC, Corn JE.

Nat Methods. 2015 Jul;12(7):613-4. doi: 10.1038/nmeth.3452. No abstract available.

PMID:
26125593
27.

Biotechnology. A prudent path forward for genomic engineering and germline gene modification.

Baltimore D, Berg P, Botchan M, Carroll D, Charo RA, Church G, Corn JE, Daley GQ, Doudna JA, Fenner M, Greely HT, Jinek M, Martin GS, Penhoet E, Puck J, Sternberg SH, Weissman JS, Yamamoto KR.

Science. 2015 Apr 3;348(6230):36-8. doi: 10.1126/science.aab1028. Epub 2015 Mar 19. No abstract available.

28.

USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria.

Cunningham CN, Baughman JM, Phu L, Tea JS, Yu C, Coons M, Kirkpatrick DS, Bingol B, Corn JE.

Nat Cell Biol. 2015 Feb;17(2):160-9. doi: 10.1038/ncb3097. Epub 2015 Jan 26.

PMID:
25621951
29.

Ubiquitin in inflammation: the right linkage makes all the difference.

Corn JE, Vucic D.

Nat Struct Mol Biol. 2014 Apr;21(4):297-300. doi: 10.1038/nsmb.2808. Review. No abstract available.

PMID:
24699077
30.

Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor.

Mukund S, Shang Y, Clarke HJ, Madjidi A, Corn JE, Kates L, Kolumam G, Chiang V, Luis E, Murray J, Zhang Y, Hötzel I, Koth CM, Allan BB.

J Biol Chem. 2013 Dec 13;288(50):36168-78. doi: 10.1074/jbc.M113.496984. Epub 2013 Nov 4.

31.

Decoding a chain letter for degradation.

Cunningham CN, Corn JE.

Structure. 2013 Jul 2;21(7):1068-70. doi: 10.1016/j.str.2013.06.009.

32.

Conformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signaling.

Phillips AH, Zhang Y, Cunningham CN, Zhou L, Forrest WF, Liu PS, Steffek M, Lee J, Tam C, Helgason E, Murray JM, Kirkpatrick DS, Fairbrother WJ, Corn JE.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11379-84. doi: 10.1073/pnas.1302407110. Epub 2013 Jun 25.

33.

Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7.

Zhang Y, Zhou L, Rouge L, Phillips AH, Lam C, Liu P, Sandoval W, Helgason E, Murray JM, Wertz IE, Corn JE.

Nat Chem Biol. 2013 Jan;9(1):51-8. doi: 10.1038/nchembio.1134. Epub 2012 Nov 25. Erratum in: Nat Chem Biol. 2013 Mar;9(3):192.

PMID:
23178935
34.

Aerosol delivery of trail pheromone disrupts the foraging of the red imported fire ant, Solenopsis invicta.

Suckling DM, Stringer LD, Corn JE, Bunn B, El-Sayed AM, Vander Meer RK.

Pest Manag Sci. 2012 Dec;68(12):1572-8. doi: 10.1002/ps.3349. Epub 2012 Jul 19.

PMID:
22815260
35.

Binding mechanism of metal⋅NTP substrates and stringent-response alarmones to bacterial DnaG-type primases.

Rymer RU, Solorio FA, Tehranchi AK, Chu C, Corn JE, Keck JL, Wang JD, Berger JM.

Structure. 2012 Sep 5;20(9):1478-89. doi: 10.1016/j.str.2012.05.017. Epub 2012 Jul 12.

36.

Community-wide assessment of protein-interface modeling suggests improvements to design methodology.

Fleishman SJ, Whitehead TA, Strauch EM, Corn JE, Qin S, Zhou HX, Mitchell JC, Demerdash ON, Takeda-Shitaka M, Terashi G, Moal IH, Li X, Bates PA, Zacharias M, Park H, Ko JS, Lee H, Seok C, Bourquard T, Bernauer J, Poupon A, Azé J, Soner S, Ovali SK, Ozbek P, Tal NB, Haliloglu T, Hwang H, Vreven T, Pierce BG, Weng Z, Pérez-Cano L, Pons C, Fernández-Recio J, Jiang F, Yang F, Gong X, Cao L, Xu X, Liu B, Wang P, Li C, Wang C, Robert CH, Guharoy M, Liu S, Huang Y, Li L, Guo D, Chen Y, Xiao Y, London N, Itzhaki Z, Schueler-Furman O, Inbar Y, Potapov V, Cohen M, Schreiber G, Tsuchiya Y, Kanamori E, Standley DM, Nakamura H, Kinoshita K, Driggers CM, Hall RG, Morgan JL, Hsu VL, Zhan J, Yang Y, Zhou Y, Kastritis PL, Bonvin AM, Zhang W, Camacho CJ, Kilambi KP, Sircar A, Gray JJ, Ohue M, Uchikoga N, Matsuzaki Y, Ishida T, Akiyama Y, Khashan R, Bush S, Fouches D, Tropsha A, Esquivel-Rodríguez J, Kihara D, Stranges PB, Jacak R, Kuhlman B, Huang SY, Zou X, Wodak SJ, Janin J, Baker D.

J Mol Biol. 2011 Nov 25;414(2):289-302. doi: 10.1016/j.jmb.2011.09.031. Epub 2011 Sep 29.

37.

Argentine ant trail pheromone disruption is mediated by trail concentration.

Suckling DM, Stringer LD, Corn JE.

J Chem Ecol. 2011 Oct;37(10):1143-9. doi: 10.1007/s10886-011-0019-0. Epub 2011 Oct 1.

PMID:
21964852
38.

Hotspot-centric de novo design of protein binders.

Fleishman SJ, Corn JE, Strauch EM, Whitehead TA, Karanicolas J, Baker D.

J Mol Biol. 2011 Nov 11;413(5):1047-62. doi: 10.1016/j.jmb.2011.09.001. Epub 2011 Sep 10.

39.

Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex.

Bentley ML, Corn JE, Dong KC, Phung Q, Cheung TK, Cochran AG.

EMBO J. 2011 Jul 19;30(16):3285-97. doi: 10.1038/emboj.2011.243.

40.

RosettaScripts: a scripting language interface to the Rosetta macromolecular modeling suite.

Fleishman SJ, Leaver-Fay A, Corn JE, Strauch EM, Khare SD, Koga N, Ashworth J, Murphy P, Richter F, Lemmon G, Meiler J, Baker D.

PLoS One. 2011;6(6):e20161. doi: 10.1371/journal.pone.0020161. Epub 2011 Jun 24.

41.

Computational design of proteins targeting the conserved stem region of influenza hemagglutinin.

Fleishman SJ, Whitehead TA, Ekiert DC, Dreyfus C, Corn JE, Strauch EM, Wilson IA, Baker D.

Science. 2011 May 13;332(6031):816-21. doi: 10.1126/science.1202617.

42.

A de novo protein binding pair by computational design and directed evolution.

Karanicolas J, Corn JE, Chen I, Joachimiak LA, Dym O, Peck SH, Albeck S, Unger T, Hu W, Liu G, Delbecq S, Montelione GT, Spiegel CP, Liu DR, Baker D.

Mol Cell. 2011 Apr 22;42(2):250-60. doi: 10.1016/j.molcel.2011.03.010. Epub 2011 Mar 31.

43.

Molecular determinants of origin discrimination by Orc1 initiators in archaea.

Dueber EC, Costa A, Corn JE, Bell SD, Berger JM.

Nucleic Acids Res. 2011 May;39(9):3621-31. doi: 10.1093/nar/gkq1308. Epub 2011 Jan 11.

44.

ROSETTA3: an object-oriented software suite for the simulation and design of macromolecules.

Leaver-Fay A, Tyka M, Lewis SM, Lange OF, Thompson J, Jacak R, Kaufman K, Renfrew PD, Smith CA, Sheffler W, Davis IW, Cooper S, Treuille A, Mandell DJ, Richter F, Ban YE, Fleishman SJ, Corn JE, Kim DE, Lyskov S, Berrondo M, Mentzer S, Popović Z, Havranek JJ, Karanicolas J, Das R, Meiler J, Kortemme T, Gray JJ, Kuhlman B, Baker D, Bradley P.

Methods Enzymol. 2011;487:545-74. doi: 10.1016/B978-0-12-381270-4.00019-6.

45.

Rosetta in CAPRI rounds 13-19.

Fleishman SJ, Corn JE, Strauch EM, Whitehead TA, Andre I, Thompson J, Havranek JJ, Das R, Bradley P, Baker D.

Proteins. 2010 Nov 15;78(15):3212-8. doi: 10.1002/prot.22784.

46.

Automated electron-density sampling reveals widespread conformational polymorphism in proteins.

Lang PT, Ng HL, Fraser JS, Corn JE, Echols N, Sales M, Holton JM, Alber T.

Protein Sci. 2010 Jul;19(7):1420-31. doi: 10.1002/pro.423.

47.

THAP proteins target specific DNA sites through bipartite recognition of adjacent major and minor grooves.

Sabogal A, Lyubimov AY, Corn JE, Berger JM, Rio DC.

Nat Struct Mol Biol. 2010 Jan;17(1):117-23. doi: 10.1038/nsmb.1742. Epub 2009 Dec 13.

48.

Hyperthermophilic Aquifex aeolicus initiates primer synthesis on a limited set of trinucleotides comprised of cytosines and guanines.

Larson MA, Bressani R, Sayood K, Corn JE, Berger JM, Griep MA, Hinrichs SH.

Nucleic Acids Res. 2008 Sep;36(16):5260-9. doi: 10.1093/nar/gkn461. Epub 2008 Aug 6.

49.

Identification of a DNA primase template tracking site redefines the geometry of primer synthesis.

Corn JE, Pelton JG, Berger JM.

Nat Struct Mol Biol. 2008 Feb;15(2):163-9. doi: 10.1038/nsmb.1373. Epub 2008 Jan 13.

PMID:
18193061
50.

Replication origin recognition and deformation by a heterodimeric archaeal Orc1 complex.

Dueber EL, Corn JE, Bell SD, Berger JM.

Science. 2007 Aug 31;317(5842):1210-3.

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