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Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance.

Gilleron J, Bouget G, Ivanov S, Meziat C, Ceppo F, Vergoni B, Djedaini M, Soprani A, Dumas K, Jacquel A, Yvan-Charvet L, Venteclef N, Tanti JF, Cormont M.

Cell Rep. 2018 Dec 18;25(12):3329-3341.e5. doi: 10.1016/j.celrep.2018.11.083.


Decrease in αβ/γδ T-cell ratio is accompanied by a reduction in high-fat diet-induced weight gain, insulin resistance, and inflammation.

Le Menn G, Sibille B, Murdaca J, Rousseau AS, Squillace R, Vergoni B, Cormont M, Niot I, Grimaldi PA, Mothe-Satney I, Neels JG.

FASEB J. 2019 Feb;33(2):2553-2562. doi: 10.1096/fj.201800696RR. Epub 2018 Oct 4.


Implication of REDD1 in the activation of inflammatory pathways.

Pastor F, Dumas K, Barthélémy MA, Regazzetti C, Druelle N, Peraldi P, Cormont M, Tanti JF, Giorgetti-Peraldi S.

Sci Rep. 2017 Aug 1;7(1):7023. doi: 10.1038/s41598-017-07182-z.


The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells.

Loubiere C, Clavel S, Gilleron J, Harisseh R, Fauconnier J, Ben-Sahra I, Kaminski L, Laurent K, Herkenne S, Lacas-Gervais S, Ambrosetti D, Alcor D, Rocchi S, Cormont M, Michiels JF, Mari B, Mazure NM, Scorrano L, Lacampagne A, Gharib A, Tanti JF, Bost F.

Sci Rep. 2017 Jul 11;7(1):5040. doi: 10.1038/s41598-017-05052-2.


Transfer of dysbiotic gut microbiota has beneficial effects on host liver metabolism.

Nicolas S, Blasco-Baque V, Fournel A, Gilleron J, Klopp P, Waget A, Ceppo F, Marlin A, Padmanabhan R, Iacovoni JS, Tercé F, Cani PD, Tanti JF, Burcelin R, Knauf C, Cormont M, Serino M.

Mol Syst Biol. 2017 Mar 16;13(3):921. doi: 10.15252/msb.20167356.


DNA Damage and the Activation of the p53 Pathway Mediate Alterations in Metabolic and Secretory Functions of Adipocytes.

Vergoni B, Cornejo PJ, Gilleron J, Djedaini M, Ceppo F, Jacquel A, Bouget G, Ginet C, Gonzalez T, Maillet J, Dhennin V, Verbanck M, Auberger P, Froguel P, Tanti JF, Cormont M.

Diabetes. 2016 Oct;65(10):3062-74. doi: 10.2337/db16-0014. Epub 2016 Jul 7.


The Tpl2 Kinase Regulates the COX-2/Prostaglandin E2 Axis in Adipocytes in Inflammatory Conditions.

Berthou F, Ceppo F, Dumas K, Massa F, Vergoni B, Alemany S, Cormont M, Tanti JF.

Mol Endocrinol. 2015 Jul;29(7):1025-36. Epub 2015 May 28.


Inhibition of the GTPase Rac1 mediates the antimigratory effects of metformin in prostate cancer cells.

Dirat B, Ader I, Golzio M, Massa F, Mettouchi A, Laurent K, Larbret F, Malavaud B, Cormont M, Lemichez E, Cuvillier O, Tanti JF, Bost F.

Mol Cancer Ther. 2015 Feb;14(2):586-96. doi: 10.1158/1535-7163.MCT-14-0102. Epub 2014 Dec 19.


Hypoxia inhibits Cavin-1 and Cavin-2 expression and down-regulates caveolae in adipocytes.

Regazzetti C, Dumas K, Lacas-Gervais S, Pastor F, Peraldi P, Bonnafous S, Dugail I, Le Lay S, Valet P, Le Marchand-Brustel Y, Tran A, Gual P, Tanti JF, Cormont M, Giorgetti-Peraldi S.

Endocrinology. 2015 Mar;156(3):789-801. doi: 10.1210/en.2014-1656. Epub 2014 Dec 18.


[Implication of MAP kinases in obesity-induced inflammation and insulin resistance].

Ceppo F, Jager J, Berthou F, Giorgetti-Peraldi S, Cormont M, Bost F, Tanti JF.

Biol Aujourdhui. 2014;208(2):97-107. doi: 10.1051/jbio/2014014. Epub 2014 Sep 8. Review. French.


Implication of the Tpl2 kinase in inflammatory changes and insulin resistance induced by the interaction between adipocytes and macrophages.

Ceppo F, Berthou F, Jager J, Dumas K, Cormont M, Tanti JF.

Endocrinology. 2014 Mar;155(3):951-64. doi: 10.1210/en.2013-1815. Epub 2014 Jan 1.


Rab4b controls an early endosome sorting event by interacting with the γ-subunit of the clathrin adaptor complex 1.

Perrin L, Lacas-Gervais S, Gilleron J, Ceppo F, Prodon F, Benmerah A, Tanti JF, Cormont M.

J Cell Sci. 2013 Nov 1;126(Pt 21):4950-62. doi: 10.1242/jcs.130575. Epub 2013 Sep 4. Erratum in: J Cell Sci. 2014 Jan 1;127(Pt 1):258. Laura, Perrin [corrected to Perrin, Laura]; Sandra, Lacas-Gervais [corrected to Lacas-Gervais, Sandra]; Jérôme, Gilleron [corrected to Gilleron, Jérôme]; Franck, Ceppo [corrected to Ceppo, Franck]; François, Prodon [corrected to Prodon, François]; Al.


Adipose tissue microRNAs as regulators of CCL2 production in human obesity.

Arner E, Mejhert N, Kulyté A, Balwierz PJ, Pachkov M, Cormont M, Lorente-Cebrián S, Ehrlund A, Laurencikiene J, Hedén P, Dahlman-Wright K, Tanti JF, Hayashizaki Y, Rydén M, Dahlman I, van Nimwegen E, Daub CO, Arner P.

Diabetes. 2012 Aug;61(8):1986-93. doi: 10.2337/db11-1508. Epub 2012 Jun 11.


Hemojuvelin: a new link between obesity and iron homeostasis.

Luciani N, Brasse-Lagnel C, Poli M, Anty R, Lesueur C, Cormont M, Laquerriere A, Folope V, LeMarchand-Brustel Y, Gugenheim J, Gual P, Tran A, Bekri S.

Obesity (Silver Spring). 2011 Aug;19(8):1545-51. doi: 10.1038/oby.2011.12. Epub 2011 Feb 10.


Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma.

Strub T, Giuliano S, Ye T, Bonet C, Keime C, Kobi D, Le Gras S, Cormont M, Ballotti R, Bertolotto C, Davidson I.

Oncogene. 2011 May 19;30(20):2319-32. doi: 10.1038/onc.2010.612. Epub 2011 Jan 24.


Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells.

Ben Sahra I, Laurent K, Giuliano S, Larbret F, Ponzio G, Gounon P, Le Marchand-Brustel Y, Giorgetti-Peraldi S, Cormont M, Bertolotto C, Deckert M, Auberger P, Tanti JF, Bost F.

Cancer Res. 2010 Mar 15;70(6):2465-75. doi: 10.1158/0008-5472.CAN-09-2782. Epub 2010 Mar 9.


Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis.

Jager J, Grémeaux T, Gonzalez T, Bonnafous S, Debard C, Laville M, Vidal H, Tran A, Gual P, Le Marchand-Brustel Y, Cormont M, Tanti JF.

Diabetes. 2010 Jan;59(1):61-70. doi: 10.2337/db09-0470. Epub 2009 Oct 6.


Helicobacter pylori counteracts the apoptotic action of its VacA toxin by injecting the CagA protein into gastric epithelial cells.

Oldani A, Cormont M, Hofman V, Chiozzi V, Oregioni O, Canonici A, Sciullo A, Sommi P, Fabbri A, Ricci V, Boquet P.

PLoS Pathog. 2009 Oct;5(10):e1000603. doi: 10.1371/journal.ppat.1000603. Epub 2009 Oct 2.


Rab4b is a small GTPase involved in the control of the glucose transporter GLUT4 localization in adipocyte.

Kaddai V, Gonzalez T, Keslair F, Grémeaux T, Bonnafous S, Gugenheim J, Tran A, Gual P, Le Marchand-Brustel Y, Cormont M.

PLoS One. 2009 Apr 17;4(4):e5257. doi: 10.1371/journal.pone.0005257.


Involvement of TNF-alpha in abnormal adipocyte and muscle sortilin expression in obese mice and humans.

Kaddai V, Jager J, Gonzalez T, Najem-Lendom R, Bonnafous S, Tran A, Le Marchand-Brustel Y, Gual P, Tanti JF, Cormont M.

Diabetologia. 2009 May;52(5):932-40. doi: 10.1007/s00125-009-1273-3. Epub 2009 Feb 14.


Hypoxia decreases insulin signaling pathways in adipocytes.

Regazzetti C, Peraldi P, Grémeaux T, Najem-Lendom R, Ben-Sahra I, Cormont M, Bost F, Le Marchand-Brustel Y, Tanti JF, Giorgetti-Peraldi S.

Diabetes. 2009 Jan;58(1):95-103. doi: 10.2337/db08-0457. Epub 2008 Nov 4.


The nitric oxide-donating derivative of acetylsalicylic acid, NCX 4016, stimulates glucose transport and glucose transporters translocation in 3T3-L1 adipocytes.

Kaddai V, Gonzalez T, Bolla M, Le Marchand-Brustel Y, Cormont M.

Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E162-9. doi: 10.1152/ajpendo.00622.2007. Epub 2008 May 20.


Rab proteins in endocytosis and Glut4 trafficking.

Kaddai V, Le Marchand-Brustel Y, Cormont M.

Acta Physiol (Oxf). 2008 Jan;192(1):75-88. doi: 10.1111/j.1748-1716.2007.01787.x. Review. Erratum in: Acta Physiol (Oxf). 2008 Jun;193(2): 201-2.


p38MAP Kinase activity is required for human primary adipocyte differentiation.

Aouadi M, Jager J, Laurent K, Gonzalez T, Cormont M, Binétruy B, Le Marchand-Brustel Y, Tanti JF, Bost F.

FEBS Lett. 2007 Dec 11;581(29):5591-6. Epub 2007 Nov 13.


Early endosomes associated with dynamic F-actin structures are required for late trafficking of H. pylori VacA toxin.

Gauthier NC, Monzo P, Gonzalez T, Doye A, Oldani A, Gounon P, Ricci V, Cormont M, Boquet P.

J Cell Biol. 2007 Apr 23;177(2):343-54. Epub 2007 Apr 16.


Hepatocyte growth factor induces glucose uptake in 3T3-L1 adipocytes through A Gab1/phosphatidylinositol 3-kinase/Glut4 pathway.

Bertola A, Bonnafous S, Cormont M, Anty R, Tanti JF, Tran A, Le Marchand-Brustel Y, Gual P.

J Biol Chem. 2007 Apr 6;282(14):10325-32. Epub 2007 Feb 6.


Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression.

Jager J, Grémeaux T, Cormont M, Le Marchand-Brustel Y, Tanti JF.

Endocrinology. 2007 Jan;148(1):241-51. Epub 2006 Oct 12.


The Rab4A effector protein Rabip4 is involved in migration of NIH 3T3 fibroblasts.

Vukmirica J, Monzo P, Le Marchand-Brustel Y, Cormont M.

J Biol Chem. 2006 Nov 24;281(47):36360-8. Epub 2006 Sep 25.


The Rab4 effector Rabip4 plays a role in the endocytotic trafficking of Glut 4 in 3T3-L1 adipocytes.

Mari M, Monzo P, Kaddai V, Keslair F, Gonzalez T, Le Marchand-Brustel Y, Cormont M.

J Cell Sci. 2006 Apr 1;119(Pt 7):1297-306. Epub 2006 Mar 7.


CD2AP, Rabip4, and Rabip4': analysis of interaction with Rab4a and regulation of endosomes morphology.

Monzo P, Mari M, Kaddai V, Gonzalez T, Le Marchand-Brustel Y, Cormont M.

Methods Enzymol. 2005;403:107-18.


[CD2AP, a molecule adaptator between endocytosis and actin cytoskeleton in the cell in interphase and during cytokinesis?].

Monzo P, Cormont M.

Med Sci (Paris). 2005 Dec;21(12):1036-7. French. No abstract available.


Clues to CD2-associated protein involvement in cytokinesis.

Monzo P, Gauthier NC, Keslair F, Loubat A, Field CM, Le Marchand-Brustel Y, Cormont M.

Mol Biol Cell. 2005 Jun;16(6):2891-902. Epub 2005 Mar 30.


CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl.

Cormont M, Metón I, Mari M, Monzo P, Keslair F, Gaskin C, McGraw TE, Le Marchand-Brustel Y.

Traffic. 2003 Feb;4(2):97-112.


The role of small G-proteins in the regulation of glucose transport (review).

Cormont M, Le Marchand-Brustel Y.

Mol Membr Biol. 2001 Jul-Sep;18(3):213-20. Review.


Role of the FYVE finger and the RUN domain for the subcellular localization of Rabip4.

Mari M, Macia E, Le Marchand-Brustel Y, Cormont M.

J Biol Chem. 2001 Nov 9;276(45):42501-8. Epub 2001 Aug 16.


Assays of glucose entry, glucose transporter amount, and translocation.

Tanti JF, Cormont M, Grémeaux T, Le Marchand-Brustel Y.

Methods Mol Biol. 2001;155:157-65. Review. No abstract available.


A FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved in early endosomal traffic.

Cormont M, Mari M, Galmiche A, Hofman P, Le Marchand-Brustel Y.

Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1637-42. Epub 2001 Jan 30.


From insulin receptor signalling to Glut 4 translocation abnormalities in obesity and insulin resistance.

Le Marchand-Brustel Y, Tanti JF, Cormont M, Ricort JM, Grémeaux T, Grillo S.

J Recept Signal Transduct Res. 1999 Jan-Jul;19(1-4):217-28. Review.


Insulin promotes phosphorylation and activation of geranylgeranyltransferase II. Studies with geranylgeranylation of rab-3 and rab-4.

Goalstone ML, Leitner JW, Golovchenko I, Stjernholm MR, Cormont M, Le Marchand-Brustel Y, Draznin B.

J Biol Chem. 1999 Jan 29;274(5):2880-4.


The small guanosine triphosphate-binding protein Rab4 is involved in insulin-induced GLUT4 translocation and actin filament rearrangement in 3T3-L1 cells.

Vollenweider P, Martin SS, Haruta T, Morris AJ, Nelson JG, Cormont M, Le Marchand-Brustel Y, Rose DW, Olefsky JM.

Endocrinology. 1997 Nov;138(11):4941-9.


Potential role of Rab4 in the regulation of subcellular localization of Glut4 in adipocytes.

Cormont M, Bortoluzzi MN, Gautier N, Mari M, van Obberghen E, Le Marchand-Brustel Y.

Mol Cell Biol. 1996 Dec;16(12):6879-86.


GTPase activating protein activity for Rab4 is enriched in the plasma membrane of 3T3-L1 adipocytes. Possible involvement in the regulation of Rab4 subcellular localization.

Bortoluzzi MN, Cormont M, Gautier N, Van Obberghen E, Le Marchand-Brustel Y.

Diabetologia. 1996 Aug;39(8):899-906.


Insulin induces a change in Rab5 subcellular localization in adipocytes independently of phosphatidylinositol 3-kinase activation.

Cormont M, Van Obberghen E, Zerial M, Le Marchand-Brustel Y.

Endocrinology. 1996 Aug;137(8):3408-15.


Differential effects of insulin and exercise on Rab4 distribution in rat skeletal muscle.

Sherman LA, Hirshman MF, Cormont M, Le Marchand-Brustel Y, Goodyear LJ.

Endocrinology. 1996 Jan;137(1):266-73.


Wortmannin inhibits the action of insulin but not that of okadaic acid in skeletal muscle: comparison with fat cells.

Le Marchand-Brustel Y, Gautier N, Cormont M, Van Obberghen E.

Endocrinology. 1995 Aug;136(8):3564-70.


Parallel changes in Glut 4 and Rab4 movements in two insulin-resistant states.

Ricort JM, Tanti JF, Cormont M, Van Obberghen E, Le Marchand-Brustel Y.

FEBS Lett. 1994 Jun 20;347(1):42-4.


Expression of guanine-nucleotide-binding proteins in lean and obese insulin-resistant mice.

Cormont M, Tanti JF, Van Obberghen E, Le Marchand-Brustel Y.

Mol Cell Endocrinol. 1994 Mar;99(2):169-76.


Rab4 is phosphorylated by the insulin-activated extracellular-signal-regulated kinase ERK1.

Cormont M, Tanti JF, Zahraoui A, Van Obberghen E, Le Marchand-Brustel Y.

Eur J Biochem. 1994 Feb 1;219(3):1081-5.


Insulin and okadaic acid induce Rab4 redistribution in adipocytes.

Cormont M, Tanti JF, Zahraoui A, Van Obberghen E, Tavitian A, Le Marchand-Brustel Y.

J Biol Chem. 1993 Sep 15;268(26):19491-7.

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