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β-Cell Failure or β-Cell Abuse?

Erion K, Corkey BE.

Front Endocrinol (Lausanne). 2018 Sep 13;9:532. doi: 10.3389/fendo.2018.00532. eCollection 2018. Review.


Cohort profile: The MULTI sTUdy Diabetes rEsearch (MULTITUDE) consortium.

Pino EC, Zuo Y, Maciel De Olivera C, Mahalingaiah S, Keiser O, Moore LL, Li F, Vasan RS, Corkey BE, Kalesan B.

BMJ Open. 2018 May 5;8(5):e020640. doi: 10.1136/bmjopen-2017-020640.


Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion.

Benador IY, Veliova M, Mahdaviani K, Petcherski A, Wikstrom JD, Assali EA, Acín-Pérez R, Shum M, Oliveira MF, Cinti S, Sztalryd C, Barshop WD, Wohlschlegel JA, Corkey BE, Liesa M, Shirihai OS.

Cell Metab. 2018 Apr 3;27(4):869-885.e6. doi: 10.1016/j.cmet.2018.03.003.


Type 1 diabetes alters lipid handling and metabolism in human fibroblasts and peripheral blood mononuclear cells.

Jones AR IV, Coleman EL, Husni NR, Deeney JT, Raval F, Steenkamp D, Dooms H, Nikolajczyk BS, Corkey BE.

PLoS One. 2017 Dec 4;12(12):e0188474. doi: 10.1371/journal.pone.0188474. eCollection 2017.


Identification of the signals for glucose-induced insulin secretion in INS1 (832/13) β-cells using metformin-induced metabolic deceleration as a model.

Lamontagne J, Al-Mass A, Nolan CJ, Corkey BE, Madiraju SRM, Joly E, Prentki M.

J Biol Chem. 2017 Nov 24;292(47):19458-19468. doi: 10.1074/jbc.M117.808105. Epub 2017 Oct 2.


A Unified Pathophysiological Construct of Diabetes and its Complications.

Schwartz SS, Epstein S, Corkey BE, Grant SFA, Gavin Iii JR, Aguilar RB, Herman ME.

Trends Endocrinol Metab. 2017 Sep;28(9):645-655. doi: 10.1016/j.tem.2017.05.005. Epub 2017 Jun 16. Review.


Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis.

Mahdaviani K, Benador IY, Su S, Gharakhanian RA, Stiles L, Trudeau KM, Cardamone M, Enríquez-Zarralanga V, Ritou E, Aprahamian T, Oliveira MF, Corkey BE, Perissi V, Liesa M, Shirihai OS.

EMBO Rep. 2017 Jul;18(7):1123-1138. doi: 10.15252/embr.201643827. Epub 2017 May 24.


Hyperinsulinemia: a Cause of Obesity?

Erion KA, Corkey BE.

Curr Obes Rep. 2017 Jun;6(2):178-186. doi: 10.1007/s13679-017-0261-z. Review.


Metabolic fate of glucose and candidate signaling and excess-fuel detoxification pathways in pancreatic β-cells.

Mugabo Y, Zhao S, Lamontagne J, Al-Mass A, Peyot ML, Corkey BE, Joly E, Madiraju SRM, Prentki M.

J Biol Chem. 2017 May 5;292(18):7407-7422. doi: 10.1074/jbc.M116.763060. Epub 2017 Mar 9.


Metabolomics-guided insights on bariatric surgery versus behavioral interventions for weight loss.

Tulipani S, Griffin J, Palau-Rodriguez M, Mora-Cubillos X, Bernal-Lopez RM, Tinahones FJ, Corkey BE, Andres-Lacueva C.

Obesity (Silver Spring). 2016 Dec;24(12):2451-2466. doi: 10.1002/oby.21686. Review.


Direct Stimulation of Islet Insulin Secretion by Glycolytic and Mitochondrial Metabolites in KCl-Depolarized Islets.

Pizarro-Delgado J, Deeney JT, Corkey BE, Tamarit-Rodriguez J.

PLoS One. 2016 Nov 16;11(11):e0166111. doi: 10.1371/journal.pone.0166111. eCollection 2016.


Extracellular Redox Regulation of Intracellular Reactive Oxygen Generation, Mitochondrial Function and Lipid Turnover in Cultured Human Adipocytes.

Jones AR IV, Meshulam T, Oliveira MF, Burritt N, Corkey BE.

PLoS One. 2016 Oct 14;11(10):e0164011. doi: 10.1371/journal.pone.0164011. eCollection 2016.


Response to Comment on Schwartz et al. The Time Is Right for a New Classification System for Diabetes: Rationale and Implications of the β-Cell-Centric Classification Schema. Diabetes Care 2016;39:179-186.

Schwartz SS, Epstein S, Corkey BE, Grant SF, Gavin JR 3rd, Aguilar RB.

Diabetes Care. 2016 Aug;39(8):e129-30. doi: 10.2337/dci16-0011. No abstract available.


BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic β-Cell.

Deeney JT, Belkina AC, Shirihai OS, Corkey BE, Denis GV.

PLoS One. 2016 Mar 23;11(3):e0151329. doi: 10.1371/journal.pone.0151329. eCollection 2016.


Inhibition of Monoacylglycerol Lipase Activity Decreases Glucose-Stimulated Insulin Secretion in INS-1 (832/13) Cells and Rat Islets.

Berdan CA, Erion KA, Burritt NE, Corkey BE, Deeney JT.

PLoS One. 2016 Feb 11;11(2):e0149008. doi: 10.1371/journal.pone.0149008. eCollection 2016.


The Time Is Right for a New Classification System for Diabetes: Rationale and Implications of the β-Cell-Centric Classification Schema.

Schwartz SS, Epstein S, Corkey BE, Grant SF, Gavin JR 3rd, Aguilar RB.

Diabetes Care. 2016 Feb;39(2):179-86. doi: 10.2337/dc15-1585.


KCl -Permeabilized Pancreatic Islets: An Experimental Model to Explore the Messenger Role of ATP in the Mechanism of Insulin Secretion.

Pizarro-Delgado J, Deeney JT, Martín-del-Río R, Corkey BE, Tamarit-Rodriguez J.

PLoS One. 2015 Oct 7;10(10):e0140096. doi: 10.1371/journal.pone.0140096. eCollection 2015.


The Intra- or Extracellular Redox State Was Not Affected by a High vs. Low Glycemic Response Diet in Mice.

Kleckner AS, Wong S, Corkey BE.

PLoS One. 2015 Jun 1;10(6):e0128380. doi: 10.1371/journal.pone.0128380. eCollection 2015.


Chronic Exposure to Excess Nutrients Left-shifts the Concentration Dependence of Glucose-stimulated Insulin Secretion in Pancreatic β-Cells.

Erion KA, Berdan CA, Burritt NE, Corkey BE, Deeney JT.

J Biol Chem. 2015 Jun 26;290(26):16191-201. doi: 10.1074/jbc.M114.620351. Epub 2015 May 1.


The extracellular redox state modulates mitochondrial function, gluconeogenesis, and glycogen synthesis in murine hepatocytes.

Nocito L, Kleckner AS, Yoo EJ, Jones Iv AR, Liesa M, Corkey BE.

PLoS One. 2015 Mar 27;10(3):e0122818. doi: 10.1371/journal.pone.0122818. eCollection 2015.


What Are We Putting in Our Food That Is Making Us Fat? Food Additives, Contaminants, and Other Putative Contributors to Obesity.

Simmons AL, Schlezinger JJ, Corkey BE.

Curr Obes Rep. 2014 Jun 1;3(2):273-85. doi: 10.1007/s13679-014-0094-y.


Effects of thiol antioxidant β-mercaptoethanol on diet-induced obese mice.

Wong S, Kirkland JL, Schwanz HA, Simmons AL, Hamilton JA, Corkey BE, Guo W.

Life Sci. 2014 Jun 27;107(1-2):32-41. doi: 10.1016/j.lfs.2014.04.031. Epub 2014 May 5.


Fibroblasts from type 1 diabetics exhibit enhanced Ca(2+) mobilization after TNF or fat exposure.

Husni NR, Jones AR 4th, Simmons AL, Corkey BE.

PLoS One. 2014 Jan 23;9(1):e87068. doi: 10.1371/journal.pone.0087068. eCollection 2014.


Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure.

Wikstrom JD, Mahdaviani K, Liesa M, Sereda SB, Si Y, Las G, Twig G, Petrovic N, Zingaretti C, Graham A, Cinti S, Corkey BE, Cannon B, Nedergaard J, Shirihai OS.

EMBO J. 2014 Mar 3;33(5):418-36. doi: 10.1002/embj.201385014. Epub 2014 Jan 15.


Self-report-based estimates of energy intake offer an inadequate basis for scientific conclusions.

Schoeller DA, Thomas D, Archer E, Heymsfield SB, Blair SN, Goran MI, Hill JO, Atkinson RL, Corkey BE, Foreyt J, Dhurandhar NV, Kral JG, Hall KD, Hansen BC, Heitmann BL, Ravussin E, Allison DB.

Am J Clin Nutr. 2013 Jun;97(6):1413-5. doi: 10.3945/ajcn.113.062125. No abstract available.


Diabetes: have we got it all wrong? Insulin hypersecretion and food additives: cause of obesity and diabetes?

Corkey BE.

Diabetes Care. 2012 Dec;35(12):2432-7. doi: 10.2337/dc12-0825. No abstract available.


Metabolic master regulators: sharing information among multiple systems.

Corkey BE, Shirihai O.

Trends Endocrinol Metab. 2012 Dec;23(12):594-601. doi: 10.1016/j.tem.2012.07.006. Epub 2012 Aug 30.


Beta-mecaptoethanol suppresses inflammation and induces adipogenic differentiation in 3T3-F442A murine preadipocytes.

Guo W, Li Y, Liang W, Wong S, Apovian C, Kirkland JL, Corkey BE.

PLoS One. 2012;7(7):e40958. doi: 10.1371/journal.pone.0040958. Epub 2012 Jul 23.


Reactive oxygen species facilitate translocation of hormone sensitive lipase to the lipid droplet during lipolysis in human differentiated adipocytes.

Krawczyk SA, Haller JF, Ferrante T, Zoeller RA, Corkey BE.

PLoS One. 2012;7(4):e34904. doi: 10.1371/journal.pone.0034904. Epub 2012 Apr 6.


Reactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerol.

Saadeh M, Ferrante TC, Kane A, Shirihai O, Corkey BE, Deeney JT.

PLoS One. 2012;7(1):e30200. doi: 10.1371/journal.pone.0030200. Epub 2012 Jan 17.


Banting lecture 2011: hyperinsulinemia: cause or consequence?

Corkey BE.

Diabetes. 2012 Jan;61(1):4-13. doi: 10.2337/db11-1483.


Glucose-6-phosphate isomerase deficiency results in mTOR activation, failed translocation of lipin 1α to the nucleus and hypersensitivity to glucose: Implications for the inherited glycolytic disease.

Haller JF, Krawczyk SA, Gostilovitch L, Corkey BE, Zoeller RA.

Biochim Biophys Acta. 2011 Nov;1812(11):1393-402. doi: 10.1016/j.bbadis.2011.07.007. Epub 2011 Jul 21.


Temporal profiling of the secretome during adipogenesis in humans.

Zhong J, Krawczyk SA, Chaerkady R, Huang H, Goel R, Bader JS, Wong GW, Corkey BE, Pandey A.

J Proteome Res. 2010 Oct 1;9(10):5228-38. doi: 10.1021/pr100521c.


Respiration in adipocytes is inhibited by reactive oxygen species.

Wang T, Si Y, Shirihai OS, Si H, Schultz V, Corkey RF, Hu L, Deeney JT, Guo W, Corkey BE.

Obesity (Silver Spring). 2010 Aug;18(8):1493-502. doi: 10.1038/oby.2009.456. Epub 2009 Dec 24.


The CB1 antagonist rimonabant decreases insulin hypersecretion in rat pancreatic islets.

Getty-Kaushik L, Richard AM, Deeney JT, Krawczyk S, Shirihai O, Corkey BE.

Obesity (Silver Spring). 2009 Oct;17(10):1856-60. doi: 10.1038/oby.2009.234. Epub 2009 Jul 30.


Mitochondrial networking protects beta-cells from nutrient-induced apoptosis.

Molina AJ, Wikstrom JD, Stiles L, Las G, Mohamed H, Elorza A, Walzer G, Twig G, Katz S, Corkey BE, Shirihai OS.

Diabetes. 2009 Oct;58(10):2303-15. doi: 10.2337/db07-1781. Epub 2009 Jul 6.


ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function.

Pi J, Zhang Q, Fu J, Woods CG, Hou Y, Corkey BE, Collins S, Andersen ME.

Toxicol Appl Pharmacol. 2010 Apr 1;244(1):77-83. doi: 10.1016/j.taap.2009.05.025. Epub 2009 Jun 6. Review.


Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function.

Pi J, Bai Y, Daniel KW, Liu D, Lyght O, Edelstein D, Brownlee M, Corkey BE, Collins S.

Endocrinology. 2009 Jul;150(7):3040-8. doi: 10.1210/en.2008-1642. Epub 2009 Feb 26.


Dual role of proapoptotic BAD in insulin secretion and beta cell survival.

Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ.

Nat Med. 2008 Feb;14(2):144-53. doi: 10.1038/nm1717. Epub 2008 Jan 27.


Fission and selective fusion govern mitochondrial segregation and elimination by autophagy.

Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, Alroy J, Wu M, Py BF, Yuan J, Deeney JT, Corkey BE, Shirihai OS.

EMBO J. 2008 Jan 23;27(2):433-46. doi: 10.1038/sj.emboj.7601963. Epub 2008 Jan 17.


Glucose-dependent insulinotropic polypeptide enhances adipocyte development and glucose uptake in part through Akt activation.

Song DH, Getty-Kaushik L, Tseng E, Simon J, Corkey BE, Wolfe MM.

Gastroenterology. 2007 Dec;133(6):1796-805. Epub 2007 Sep 14.


The L-type voltage-gated Ca2+ channel is the Ca2+ sensor protein of stimulus-secretion coupling in pancreatic beta cells.

Trus M, Corkey RF, Nesher R, Richard AM, Deeney JT, Corkey BE, Atlas D.

Biochemistry. 2007 Dec 18;46(50):14461-7. Epub 2007 Nov 21.


beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels.

Wikstrom JD, Katzman SM, Mohamed H, Twig G, Graf SA, Heart E, Molina AJ, Corkey BE, de Vargas LM, Danial NN, Collins S, Shirihai OS.

Diabetes. 2007 Oct;56(10):2569-78. Epub 2007 Aug 8.


3H-serotonin as a marker of oscillatory insulin secretion in clonal beta-cells (INS-1).

Deeney JT, Bränström R, Corkey BE, Larsson O, Berggren PO.

FEBS Lett. 2007 Aug 21;581(21):4080-4. Epub 2007 Jul 30.


New scanning electron microscopic method for determination of adipocyte size in humans and mice.

Guo W, Bigornia S, Leizerman I, Xie W, McDonnell M, Clemente K, Pirtskhalava T, Kirkland JL, Gokce N, Corkey BE, Sullivan LM, Apovian CM.

Obesity (Silver Spring). 2007 Jul;15(7):1657-65.


Single residue (K332A) substitution in Kir6.2 abolishes the stimulatory effect of long-chain acyl-CoA esters: indications for a long-chain acyl-CoA ester binding motif.

Bränström R, Leibiger IB, Leibiger B, Klement G, Nilsson J, Arhem P, Aspinwall CA, Corkey BE, Larsson O, Berggren PO.

Diabetologia. 2007 Aug;50(8):1670-7. Epub 2007 May 24.


Reactive oxygen species as a signal in glucose-stimulated insulin secretion.

Pi J, Bai Y, Zhang Q, Wong V, Floering LM, Daniel K, Reece JM, Deeney JT, Andersen ME, Corkey BE, Collins S.

Diabetes. 2007 Jul;56(7):1783-91. Epub 2007 Mar 30.


Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose.

Heart E, Yaney GC, Corkey RF, Schultz V, Luc E, Liu L, Deeney JT, Shirihai O, Tornheim K, Smith PJ, Corkey BE.

Biochem J. 2007 Apr 1;403(1):197-205.


Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity.

Guo W, Pirtskhalava T, Tchkonia T, Xie W, Thomou T, Han J, Wang T, Wong S, Cartwright A, Hegardt FG, Corkey BE, Kirkland JL.

Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1041-51. Epub 2006 Dec 5.

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