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A ribonucleoprotein octamer for targeted siRNA delivery.

Tai W, Li J, Corey E, Gao X.

Nat Biomed Eng. 2018;2:326-337. Epub 2018 Jul 12.


Contribution of Adrenal Glands to Intra-tumor Androgens and Growth of Castration Resistant Prostate Cancer.

Mostaghel EA, Zhang A, Hernandez S, Marck B, Zhang X, Tamae D, Biehl H, Tretiakova MS, Bartlett J, Burns JF, Dumpit RF, Ang LS, Matsumoto AM, Penning TM, Balk SP, Morrisey C, Corey E, True L, Nelson PS.

Clin Cancer Res. 2018 Sep 4. pii: clincanres.1431.2018. doi: 10.1158/1078-0432.CCR-18-1431. [Epub ahead of print]


Movember GAP1 PDX project: An international collection of serially transplantable prostate cancer patient-derived xenograft (PDX) models.

Navone NM, van Weerden WM, Vessella RL, Williams ED, Wang Y, Isaacs JT, Nguyen HM, Culig Z, van der Pluijm G, Rentsch CA, Marques RB, de Ridder CMA, Bubendorf L, Thalmann GN, Brennen WN, Santer FR, Moser PL, Shepherd P, Efstathiou E, Xue H, Lin D, Buijs J, Bosse T, Collins A, Maitland N, Buzza M, Kouspou M, Achtman A, Taylor RA, Risbridger G, Corey E.

Prostate. 2018 Aug 2. doi: 10.1002/pros.23701. [Epub ahead of print]


Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody-drug Conjugate Targeting PSMA, in Pre-clinical Models of Prostate Cancer.

Cho S, Zammarchi F, Williams DG, Havenith CE, Monks NR, Tyrer P, d'Hooge F, Fleming R, Vashisht K, Dimasi N, Bertelli F, Corbett S, Adams L, Reinert HW, Dissanayake S, Britten CE, King W, Dacosta K, Tammali R, Schifferli K, Strout P, Korade M, Masson Hinrichs MJ, Chivers S, Corey E, Liu H, Kim S, Bander NH, Howard PW, Hartley JA, Coats S, Tice DA, Herbst R, van Berkel PH.

Mol Cancer Ther. 2018 Jul 31. pii: molcanther.0982.2017. doi: 10.1158/1535-7163.MCT-17-0982. [Epub ahead of print]


Tyrosine Kinase Inhibitors Increase MCL1 Degradation and in Combination with BCLXL/BCL2 Inhibitors Drive Prostate Cancer Apoptosis.

Arai S, Jonas O, Whitman MA, Corey E, Balk SP, Chen S.

Clin Cancer Res. 2018 Jul 18. doi: 10.1158/1078-0432.CCR-18-0549. [Epub ahead of print]


Supraphysiological Testosterone Therapy as Treatment for Castration-Resistant Prostate Cancer.

Lam HM, Corey E.

Front Oncol. 2018 May 22;8:167. doi: 10.3389/fonc.2018.00167. eCollection 2018. No abstract available.


Generation of Prostate Cancer Patient-Derived Xenografts to Investigate Mechanisms of Novel Treatments and Treatment Resistance.

Lam HM, Nguyen HM, Corey E.

Methods Mol Biol. 2018;1786:1-27. doi: 10.1007/978-1-4939-7845-8_1.


A PDX/Organoid Biobank of Advanced Prostate Cancers Captures Genomic and Phenotypic Heterogeneity for Disease Modeling and Therapeutic Screening.

Beshiri ML, Tice CM, Tran C, Nguyen HM, Sowalsky AG, Agarwal S, Jansson KH, Yang Q, McGowen KM, Yin J, Alilin AN, Karzai FH, Dahut WL, Corey E, Kelly K.

Clin Cancer Res. 2018 Sep 1;24(17):4332-4345. doi: 10.1158/1078-0432.CCR-18-0409. Epub 2018 May 10.


Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate cancer.

Lee JK, Bangayan NJ, Chai T, Smith BA, Pariva TE, Yun S, Vashisht A, Zhang Q, Park JW, Corey E, Huang J, Graeber TG, Wohlschlegel J, Witte ON.

Proc Natl Acad Sci U S A. 2018 May 8;115(19):E4473-E4482. doi: 10.1073/pnas.1802354115. Epub 2018 Apr 23.


Supraphysiologic Testosterone Therapy in the Treatment of Prostate Cancer: Models, Mechanisms and Questions.

Mohammad OS, Nyquist MD, Schweizer MT, Balk SP, Corey E, Plymate S, Nelson PS, Mostaghel EA.

Cancers (Basel). 2017 Dec 6;9(12). pii: E166. doi: 10.3390/cancers9120166. Review.


Highly Diastereoselective Cationic Cyclization Reactions Convert a Common Monocyclic Enone to Bicyclic Precursors for the Synthesis of Retigeranic Acids A and B.

Breitler S, Han Y, Corey EJ.

Org Lett. 2017 Dec 15;19(24):6686-6687. doi: 10.1021/acs.orglett.7b03412. Epub 2017 Dec 1.


Rapid Loss of RNA Detection by In Situ Hybridization in Stored Tissue Blocks and Preservation by Cold Storage of Unstained Slides.

Baena-Del Valle JA, Zheng Q, Hicks JL, Fedor H, Trock BJ, Morrissey C, Corey E, Cornish TC, Sfanos KS, De Marzo AM.

Am J Clin Pathol. 2017 Nov 2;148(5):398-415. doi: 10.1093/ajcp/aqx094.


Gambogic acid inhibits thioredoxin activity and induces ROS-mediated cell death in castration-resistant prostate cancer.

Pan H, Jansson KH, Beshiri ML, Yin J, Fang L, Agarwal S, Nguyen H, Corey E, Zhang Y, Liu J, Fan H, Lin H, Kelly K.

Oncotarget. 2017 Aug 24;8(44):77181-77194. doi: 10.18632/oncotarget.20424. eCollection 2017 Sep 29.


Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling.

Bluemn EG, Coleman IM, Lucas JM, Coleman RT, Hernandez-Lopez S, Tharakan R, Bianchi-Frias D, Dumpit RF, Kaipainen A, Corella AN, Yang YC, Nyquist MD, Mostaghel E, Hsieh AC, Zhang X, Corey E, Brown LG, Nguyen HM, Pienta K, Ittmann M, Schweizer M, True LD, Wise D, Rennie PS, Vessella RL, Morrissey C, Nelson PS.

Cancer Cell. 2017 Oct 9;32(4):474-489.e6. doi: 10.1016/j.ccell.2017.09.003.


Identifying Dysregulated Epigenetic Enzyme Activity in Castrate-Resistant Prostate Cancer Development.

Lee JH, Yang B, Lindahl AJ, Damaschke N, Boersma MD, Huang W, Corey E, Jarrard DF, Denu JM.

ACS Chem Biol. 2017 Nov 17;12(11):2804-2814. doi: 10.1021/acschembio.6b01035. Epub 2017 Oct 11.


Simple Enantioselective Syntheses of (2R,6R)-Hydroxynorketamine and Related Potential Rapid-Onset Antidepressants.

Han Y, Mahender Reddy K, Corey EJ.

Org Lett. 2017 Oct 6;19(19):5224-5227. doi: 10.1021/acs.orglett.7b02498. Epub 2017 Sep 11.


Delivering Emotions.

Corey E.

JAMA. 2017 Sep 5;318(9):797-798. doi: 10.1001/jama.2017.7129. No abstract available.


Useful Applications of Enantioselective (4 + 2)-Cycloaddition Reactions to the Synthesis of Chiral 1,2-Amino Alcohols, 1,2-Diamines, and β-Amino Acids.

Mahender Reddy K, Thirupathi B, Corey EJ.

Org Lett. 2017 Sep 15;19(18):4956-4959. doi: 10.1021/acs.orglett.7b02437. Epub 2017 Aug 31.


Method for Highly Enantioselective Ligation of Two Chiral C(sp3) Stereocenters.

Bhimireddy E, Corey EJ.

J Am Chem Soc. 2017 Aug 16;139(32):11044-11047. doi: 10.1021/jacs.7b07366. Epub 2017 Aug 7.


A New, Short, and Stereocontrolled Synthesis of C2-Symmetric 1,2-Diamines.

Vemula R, Wilde NC, Goreti R, Corey EJ.

Org Lett. 2017 Jul 21;19(14):3883-3886. doi: 10.1021/acs.orglett.7b01768. Epub 2017 Jul 11.


Inhibition of ERG Activity in Patient-derived Prostate Cancer Xenografts by YK-4-279.

Winters B, Brown L, Coleman I, Nguyen H, Minas TZ, Kollath L, Vasioukhin V, Nelson P, Corey E, Üren A, Morrissey C.

Anticancer Res. 2017 Jul;37(7):3385-3396.


A novel iterative mixed model to remap three complex orthopedic traits in dogs.

Huang M, Hayward JJ, Corey E, Garrison SJ, Wagner GR, Krotscheck U, Hayashi K, Schweitzer PA, Lust G, Boyko AR, Todhunter RJ.

PLoS One. 2017 Jun 14;12(6):e0176932. doi: 10.1371/journal.pone.0176932. eCollection 2017.


Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer.

Urbanucci A, Barfeld SJ, Kytölä V, Itkonen HM, Coleman IM, Vodák D, Sjöblom L, Sheng X, Tolonen T, Minner S, Burdelski C, Kivinummi KK, Kohvakka A, Kregel S, Takhar M, Alshalalfa M, Davicioni E, Erho N, Lloyd P, Karnes RJ, Ross AE, Schaeffer EM, Vander Griend DJ, Knapp S, Corey E, Feng FY, Nelson PS, Saatcioglu F, Knudsen KE, Tammela TLJ, Sauter G, Schlomm T, Nykter M, Visakorpi T, Mills IG.

Cell Rep. 2017 Jun 6;19(10):2045-2059. doi: 10.1016/j.celrep.2017.05.049.


Exploiting AR-Regulated Drug Transport to Induce Sensitivity to the Survivin Inhibitor YM155.

Nyquist MD, Corella A, Burns J, Coleman I, Gao S, Tharakan R, Riggan L, Cai C, Corey E, Nelson PS, Mostaghel EA.

Mol Cancer Res. 2017 May;15(5):521-531. doi: 10.1158/1541-7786.MCR-16-0315-T.


Physiological effects of environmentally relevant, multi-day thermal stress on wild juvenile Atlantic salmon (Salmo salar).

Corey E, Linnansaari T, Cunjak RA, Currie S.

Conserv Physiol. 2017 Feb 27;5(1):cox014. doi: 10.1093/conphys/cox014. eCollection 2017.


Radium-223 Inhibits Osseous Prostate Cancer Growth by Dual Targeting of Cancer Cells and Bone Microenvironment in Mouse Models.

Suominen MI, Fagerlund KM, Rissanen JP, Konkol YM, Morko JP, Peng Z, Alhoniemi EJ, Laine SK, Corey E, Mumberg D, Ziegelbauer K, Käkönen SM, Halleen JM, Vessella RL, Scholz A.

Clin Cancer Res. 2017 Aug 1;23(15):4335-4346. doi: 10.1158/1078-0432.CCR-16-2955. Epub 2017 Mar 31.


LuCaP Prostate Cancer Patient-Derived Xenografts Reflect the Molecular Heterogeneity of Advanced Disease an--d Serve as Models for Evaluating Cancer Therapeutics.

Nguyen HM, Vessella RL, Morrissey C, Brown LG, Coleman IM, Higano CS, Mostaghel EA, Zhang X, True LD, Lam HM, Roudier M, Lange PH, Nelson PS, Corey E.

Prostate. 2017 May;77(6):654-671. doi: 10.1002/pros.23313. Epub 2017 Feb 3.


Candidate pheromone receptors of codling moth Cydia pomonella respond to pheromones and kairomones.

Cattaneo AM, Gonzalez F, Bengtsson JM, Corey EA, Jacquin-Joly E, Montagné N, Salvagnin U, Walker WB, Witzgall P, Anfora G, Bobkov YV.

Sci Rep. 2017 Jan 24;7:41105. doi: 10.1038/srep41105.


Characterization of an Abiraterone Ultraresponsive Phenotype in Castration-Resistant Prostate Cancer Patient-Derived Xenografts.

Lam HM, McMullin R, Nguyen HM, Coleman I, Gormley M, Gulati R, Brown LG, Holt SK, Li W, Ricci DS, Verstraeten K, Thomas S, Mostaghel EA, Nelson PS, Vessella RL, Corey E.

Clin Cancer Res. 2017 May 1;23(9):2301-2312. doi: 10.1158/1078-0432.CCR-16-2054. Epub 2016 Dec 19.


Enantioselective Conversion of Achiral Cyclohexadienones to Chiral Cyclohexenones by Desymmetrization.

Han Y, Breitler S, Zheng SL, Corey EJ.

Org Lett. 2016 Dec 2;18(23):6172-6175. Epub 2016 Nov 18.


Paracrine sonic hedgehog signaling contributes significantly to acquired steroidogenesis in the prostate tumor microenvironment.

Lubik AA, Nouri M, Truong S, Ghaffari M, Adomat HH, Corey E, Cox ME, Li N, Guns ES, Yenki P, Pham S, Buttyan R.

Int J Cancer. 2017 Jan 15;140(2):358-369. doi: 10.1002/ijc.30450. Epub 2016 Oct 20.


Acceleration of Enantioselective Cycloadditions Catalyzed by Second-Generation Chiral Oxazaborolidinium Triflimidates by Biscoordinating Lewis Acids.

Thirupathi B, Breitler S, Mahender Reddy K, Corey EJ.

J Am Chem Soc. 2016 Aug 31;138(34):10842-5. doi: 10.1021/jacs.6b08018. Epub 2016 Aug 19.


GRM1 is An Androgen-Regulated Gene and its Expression Correlates with Prostate Cancer Progression in Pre-Clinical Models.

Shourideh M, Azabdaftari G, Attwood K, DePriest A, Wadosky KM, Gillard BM, Karasik E, Heemers H, Kyprianou N, Gelman IH, Corey E, Vessella RL, Mohler JL, Koochekpour S.

Clin Cancer Res. 2016 Jul 25. pii: clincanres.0137.2016. doi: 10.1158/1078-0432.CCR-16-0137. [Epub ahead of print] Retraction in: Clin Cancer Res. 2017 Jul 15;23 (14 ):3973.


Androgen deprivation leads to increased carbohydrate metabolism and hexokinase 2-mediated survival in Pten/Tp53-deficient prostate cancer.

Martin PL, Yin JJ, Seng V, Casey O, Corey E, Morrissey C, Simpson RM, Kelly K.

Oncogene. 2017 Jan 26;36(4):525-533. doi: 10.1038/onc.2016.223. Epub 2016 Jul 4.


Phosphoinositide-3-Kinase Is the Primary Mediator of Phosphoinositide-Dependent Inhibition in Mammalian Olfactory Receptor Neurons.

Ukhanov K, Corey E, Ache BW.

Front Cell Neurosci. 2016 Apr 11;10:97. doi: 10.3389/fncel.2016.00097. eCollection 2016.


Reply to Wang et al.: Sequencing datasets do not refute Central Asian domestication origin of dogs.

Shannon LM, Boyko RH, Castelhano M, Corey E, Hayward JJ, McLean C, White ME, Abi Said MR, Anita BA, Bondjengo NI, Calero J, Galov A, Hedimbi M, Imam B, Khalap R, Lally D, Masta A, Oliveira KC, Pérez L, Randall J, Tam NM, Trujillo-Cornejo FJ, Valeriano C, Sutter NB, Todhunter RJ, Bustamante CD, Boyko AR.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2556-7. doi: 10.1073/pnas.1600618113. Epub 2016 Apr 20. No abstract available.


Characterizing the molecular features of ERG-positive tumors in primary and castration resistant prostate cancer.

Roudier MP, Winters BR, Coleman I, Lam HM, Zhang X, Coleman R, Chéry L, True LD, Higano CS, Montgomery B, Lange PH, Snyder LA, Srivastava S, Corey E, Vessella RL, Nelson PS, Üren A, Morrissey C.

Prostate. 2016 Jun;76(9):810-22. doi: 10.1002/pros.23171. Epub 2016 Mar 16.


Spheroid culture of LuCaP 136 patient-derived xenograft enables versatile preclinical models of prostate cancer.

Valta MP, Zhao H, Saar M, Tuomela J, Nolley R, Linxweiler J, Sandholm J, Lehtimäki J, Härkönen P, Coleman I, Nelson PS, Corey E, Peehl DM.

Clin Exp Metastasis. 2016 Apr;33(4):325-37. doi: 10.1007/s10585-016-9781-2. Epub 2016 Feb 12.


Cationic Chiral Fluorinated Oxazaborolidines. More Potent, Second-Generation Catalysts for Highly Enantioselective Cycloaddition Reactions.

Mahender Reddy K, Bhimireddy E, Thirupathi B, Breitler S, Yu S, Corey EJ.

J Am Chem Soc. 2016 Feb 24;138(7):2443-53. doi: 10.1021/jacs.6b00100. Epub 2016 Feb 10.


Complex disease and phenotype mapping in the domestic dog.

Hayward JJ, Castelhano MG, Oliveira KC, Corey E, Balkman C, Baxter TL, Casal ML, Center SA, Fang M, Garrison SJ, Kalla SE, Korniliev P, Kotlikoff MI, Moise NS, Shannon LM, Simpson KW, Sutter NB, Todhunter RJ, Boyko AR.

Nat Commun. 2016 Jan 22;7:10460. doi: 10.1038/ncomms10460.


Screening for Postpartum Depression and Associated Factors among Women who Deliver at a University Hospital, Nepal.

Kumwar D, Corey EK, Sharma P, Risal A.

Kathmandu Univ Med J (KUMJ). 2015 Jan-Mar;13(49):44-8.


Addition of PSMA ADC to enzalutamide therapy significantly improves survival in in vivo model of castration resistant prostate cancer.

DiPippo VA, Nguyen HM, Brown LG, Olson WC, Vessella RL, Corey E.

Prostate. 2016 Feb 15;76(3):325-34. doi: 10.1002/pros.23124. Epub 2015 Nov 20.


Genetic structure in village dogs reveals a Central Asian domestication origin.

Shannon LM, Boyko RH, Castelhano M, Corey E, Hayward JJ, McLean C, White ME, Abi Said M, Anita BA, Bondjengo NI, Calero J, Galov A, Hedimbi M, Imam B, Khalap R, Lally D, Masta A, Oliveira KC, Pérez L, Randall J, Tam NM, Trujillo-Cornejo FJ, Valeriano C, Sutter NB, Todhunter RJ, Bustamante CD, Boyko AR.

Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13639-44. doi: 10.1073/pnas.1516215112. Epub 2015 Oct 19.


Rapid modification of the bone microenvironment following short-term treatment with Cabozantinib in vivo.

Haider MT, Hunter KD, Robinson SP, Graham TJ, Corey E, Dear TN, Hughes R, Brown NJ, Holen I.

Bone. 2015 Dec;81:581-592. doi: 10.1016/j.bone.2015.08.003. Epub 2015 Aug 14.


Cellular Adhesion Promotes Prostate Cancer Cells Escape from Dormancy.

Ruppender N, Larson S, Lakely B, Kollath L, Brown L, Coleman I, Coleman R, Nguyen H, Nelson PS, Corey E, Snyder LA, Vessella RL, Morrissey C, Lam HM.

PLoS One. 2015 Jun 19;10(6):e0130565. doi: 10.1371/journal.pone.0130565. eCollection 2015.


SRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer.

Zhang X, Coleman IM, Brown LG, True LD, Kollath L, Lucas JM, Lam HM, Dumpit R, Corey E, Chéry L, Lakely B, Higano CS, Montgomery B, Roudier M, Lange PH, Nelson PS, Vessella RL, Morrissey C.

Clin Cancer Res. 2015 Oct 15;21(20):4698-708. doi: 10.1158/1078-0432.CCR-15-0157. Epub 2015 Jun 12.


A systematic study of functionalized oxiranes as initiating groups for cationic polycyclization reactions.

Rajendar G, Corey EJ.

J Am Chem Soc. 2015 May 6;137(17):5837-44. doi: 10.1021/jacs.5b03229. Epub 2015 Apr 24.


Reversal of the importance of steric and electronic effects in the base-promoted α-silylation of sulfides.

Surendra K, Vemula R, Han Y, Corey EJ.

Org Lett. 2015 Apr 3;17(7):1621-3. doi: 10.1021/acs.orglett.5b00521. Epub 2015 Mar 11.


CH5137291, an androgen receptor nuclear translocation-inhibiting compound, inhibits the growth of castration-resistant prostate cancer cells.

Ishikura N, Kawata H, Nishimoto A, Nakamura R, Tsunenari T, Watanabe M, Tachibana K, Shiraishi T, Yoshino H, Honma A, Emura T, Ohta M, Nakagawa T, Houjo T, Corey E, Vessella RL, Aoki Y, Sato H.

Int J Oncol. 2015 Apr;46(4):1560-72. doi: 10.3892/ijo.2015.2860. Epub 2015 Jan 30.


A case of ruptured splenic artery aneurysm in pregnancy.

Corey EK, Harvey SA, Sauvage LM, Bohrer JC.

Case Rep Obstet Gynecol. 2014;2014:793735. doi: 10.1155/2014/793735. Epub 2014 Dec 9.

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