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J Glob Oncol. 2018 Sep;4:1-11. doi: 10.1200/JGO.17.00214.

Stage III Non-Small-Cell Lung Cancer Treated With Concurrent Chemoradiation Followed or Not by Consolidation Chemotherapy: A Survival Analysis From a Brazilian Multicentric Cohort.

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1
Vladmir C. Cordeiro de Lima and Rodrigo C. Nery, AC Camargo Cancer Center; Clarissa S. Baldotto, Mauro Zukin, and Gabriel Madeira, Instituto Nacional de Câncer, Rio de Janeiro; Carlos H. Barrios and Facundo Zaffaroni, Latin American Cooperative Oncology Group; Juliano C. Coelho and Guilherme Geib, Hospital de Clínicas de Porto Alegre, Porto Alegre; Eldsamira M. Sobrinho, Clarissa Mathias, and Maria Fernanda Simões, Núcleo de Oncologia da Bahia, Salvador, and Alex V. Amadio and Gilberto Castro Jr, Instituto de Câncer do Estado de São Paulo, São Paulo, Brazil.

Abstract

PURPOSE:

Of newly diagnosed patients with non-small-cell lung cancer (NSCLC), stage III accounts for 30%. Most patients are treated with concurrent chemoradiation therapy, but the addition of consolidation chemotherapy (CC) is debatable. We examined the effect of CC in Brazilian patients with stage III NSCLC treated in routine clinical practice.

METHODS:

We retrospectively collected data for patients from five different Brazilian cancer institutions who had stage III NSCLC and who were treated with chemoradiation therapy followed or not by CC. Eligible patients were age 18 years or older and must have been treated with cisplatin-carboplatin plus etoposide, paclitaxel, or vinorelbine, concurrently with thoracic radiation therapy (RT). Patients treated with surgery or neoadjuvant chemotherapy were excluded. The primary end point was overall survival (OS). Associations between CC and clinical variables and demographics were evaluated by using Pearson's χ2 test. Survival curves were calculated by using the Kaplan-Meier method and were compared using the log-rank test. Univariable and multivariable analysis used a Cox proportional hazards model.

RESULTS:

We collected data from 165 patients. Median age was 60 years. Most patients were male (69.1%), white (77.9%), current or former smokers (93.3%), and had stage IIIB disease (52.7%). Adenocarcinoma was the most common histology (47.9%). Weight loss of more than 5% was observed in 39.1% and Eastern Cooperative Oncology Group performance status of 2 was observed in 14.6%. The only variable associated with CC was T stage ( P = .022). We observed no statistically significant difference in OS between patients treated or not with CC ( P = .128). A total delivered RT dose ≥ 61 Gy was the only variable independently associated with improved survival ( P = .012).

CONCLUSION:

Brazilian patients with locally advanced NSCLC who were treated with standard treatment achieved OS similar to that reported in randomized trials. CC did not improve OS in patients with stage III NSCLC after concurrent chemoradiation therapy. An RT dose of less than 61 Gy had a negative effect on OS.

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