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Scientific Business Abstracts of the 112th Annual Meeting of the Association of Physicians of Great Britain and Ireland.

Chauhan A, Lalor T, Watson S, Adams D, Farrah TE, Anand A, Kimmitt R, Mills NL, Webb DJ, Dhaun N, Kalla R, Adams A, Vatn S, Bonfliglio F, Nimmo E, Kennedy N, Ventham N, Vatn M, Ricanek P, Halfvarson J, Soderhollm J, Pierik M, Torkvist L, Gomollon F, Gut I, Jahnsen J, Satsangi J, Body R, Almashali M, McDowell G, Taylor P, Lacey A, Rees A, Dayan C, Lazarus J, Nelson S, Okosieme O, Corcoran D, Young R, Ciadella P, McCartney P, Bajrangee A, Hennigan B, Collison D, Carrick D, Shaukat A, Good R, Watkins S, McEntegart M, Watt J, Welsh P, Sattar N, McConnachie A, Oldroyd K, Berry C, Parks T, Auckland K, Mentzer AJ, Kado J, Mirabel MM, Kauwe JK, Robson KJ, Mittal B, Steer AC, Hill AVS, Akbar M, Forrester M, Virlan AT, Gilmour A, Wallace C, Paterson C, Reid D, Siebert S, Porter D, Liversidge J, McInnes I, Goodyear C, Athwal V, Pritchett J, Zaitoun A, Irving W, Guha IN, Hanley NA, Hanley KP, Briggs T, Reynolds J, Rice G, Bondet V, Bruce E, Crow Y, Duffy D, Parker B, Bruce I, Martin K, Pritchett J, Aoibheann Mullan M, Llewellyn J, Athwal V, Zeef L, Farrow S, Streuli C, Henderson N, Friedman S, Hanley N, Hanley KP.

QJM. 2018 Dec 1;111(12):920-924. doi: 10.1093/qjmed/hcy193. No abstract available.


Bats in a changing landscape: Linking occupancy and traits of a diverse montane bat community to fire regime.

Blakey RV, Webb EB, Kesler DC, Siegel RB, Corcoran D, Johnson M.

Ecol Evol. 2019 Apr 12;9(9):5324-5337. doi: 10.1002/ece3.5121. eCollection 2019 May.


Comparative Loss-of-Function Screens Reveal ABCE1 as an Essential Cellular Host Factor for Efficient Translation of Paramyxoviridae and Pneumoviridae.

Anderson DE, Pfeffermann K, Kim SY, Sawatsky B, Pearson J, Kovtun M, Corcoran DL, Krebs Y, Sigmundsson K, Jamison SF, Yeo ZZJ, Rennick LJ, Wang LF, Talbot PJ, Duprex WP, Garcia-Blanco MA, von Messling V.

MBio. 2019 May 14;10(3). pii: e00826-19. doi: 10.1128/mBio.00826-19.


Histone Deacetylase 7 Inhibition in A Murine Model of Gram-Negative Pneumonia-Induced Acute Lung Injury.

Kasotakis G, Kintsurashvili E, Galvan MD, Graham C, Purves JT, Agarwal S, Corcoran DL, Sullenger BA, Palmer SM, Remick DG.

Shock. 2019 May 2. doi: 10.1097/SHK.0000000000001372. [Epub ahead of print]


The skin transcriptome in hidradenitis suppurativa uncovers an antimicrobial and sweat gland gene signature which has distinct overlap with wounded skin.

Coates M, Mariottoni P, Corcoran DL, Kirshner HF, Jaleel T, Brown DA, Brooks SR, Murray J, Morasso MI, MacLeod AS.

PLoS One. 2019 May 6;14(5):e0216249. doi: 10.1371/journal.pone.0216249. eCollection 2019.


Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults.

van Dongen J, Zilhão NR, Sugden K; BIOS Consortium, Hannon EJ, Mill J, Caspi A, Agnew-Blais J, Arseneault L, Corcoran DL, Moffitt TE, Poulton R, Franke B, Boomsma DI.

Biol Psychiatry. 2019 Mar 1. pii: S0006-3223(19)30125-8. doi: 10.1016/j.biopsych.2019.02.016. [Epub ahead of print]


Cardiovascular health technology assessment: recommendations to improve the quality of evidence.

Berry C, Corcoran D, Mangion K.

Open Heart. 2019 Feb 27;6(1):e000930. doi: 10.1136/openhrt-2018-000930. eCollection 2019. Review.


Genetics and the geography of health, behaviour and attainment.

Belsky DW, Caspi A, Arseneault L, Corcoran DL, Domingue BW, Harris KM, Houts RM, Mill JS, Moffitt TE, Prinz J, Sugden K, Wertz J, Williams B, Odgers CL.

Nat Hum Behav. 2019 Jun;3(6):576-586. doi: 10.1038/s41562-019-0562-1. Epub 2019 Apr 8.


The right ventricular response to lung resection.

McCall PJ, Arthur A, Glass A, Corcoran DS, Kirk A, Macfie A, Payne J, Johnson M, Kinsella J, Shelley BG.

J Thorac Cardiovasc Surg. 2019 Jan 26. pii: S0022-5223(19)30279-X. doi: 10.1016/j.jtcvs.2019.01.067. [Epub ahead of print]


Establishing a generalized polyepigenetic biomarker for tobacco smoking.

Sugden K, Hannon EJ, Arseneault L, Belsky DW, Broadbent JM, Corcoran DL, Hancox RJ, Houts RM, Moffitt TE, Poulton R, Prinz JA, Thomson WM, Williams BS, Wong CCY, Mill J, Caspi A.

Transl Psychiatry. 2019 Feb 15;9(1):92. doi: 10.1038/s41398-019-0430-9.


Is it important to differentiate between peri-procedural myocardial injury and persistent myocardial scar?

McEntegart M, Corcoran D, Berry C.

J Thorac Dis. 2018 Dec;10(12):E830-E831. doi: 10.21037/jtd.2018.11.84. No abstract available.


Effects of Systematic Shortening of Noncovalent C8 Side Chain on the Cytotoxicity and NF-κB Inhibitory Capacity of Pyrrolobenzodiazepines (PBDs).

Corcoran DB, Lewis T, Nahar KS, Jamshidi S, Fegan C, Pepper C, Thurston DE, Rahman KM.

J Med Chem. 2019 Feb 28;62(4):2127-2139. doi: 10.1021/acs.jmedchem.8b01849. Epub 2019 Feb 13.


Rationale and design of the Coronary Microvascular Angina Cardiac Magnetic Resonance Imaging (CorCMR) diagnostic study: the CorMicA CMR sub-study.

Corcoran D, Ford TJ, Hsu LY, Chiribiri A, Orchard V, Mangion K, McEntegart M, Rocchiccioli P, Watkins S, Good R, Brooksbank K, Padmanabhan S, Sattar N, McConnachie A, Oldroyd KG, Touyz RM, Arai A, Berry C.

Open Heart. 2018 Dec 30;5(2):e000924. doi: 10.1136/openhrt-2018-000924. eCollection 2018.


MINOCA: Requirement for Definitive Diagnostic Work-Up.

Ford TJ, Corcoran D, Sidik N, Oldroyd KG, Rocchiccioli P, McEntegart M, Berry C.

Heart Lung Circ. 2019 Feb;28(2):e4-e6. doi: 10.1016/j.hlc.2018.04.001. No abstract available.


Inhibition of Notch signaling by the p105 and p180 subunits of Drosophila chromatin assembly factor 1 is required for follicle cell proliferation.

Lo PK, Huang YC, Corcoran D, Jiao R, Deng WM.

J Cell Sci. 2019 Jan 25;132(2). pii: jcs224170. doi: 10.1242/jcs.224170.


Cannabinoid exposure and altered DNA methylation in rat and human sperm.

Murphy SK, Itchon-Ramos N, Visco Z, Huang Z, Grenier C, Schrott R, Acharya K, Boudreau MH, Price TM, Raburn DJ, Corcoran DL, Lucas JE, Mitchell JT, McClernon FJ, Cauley M, Hall BJ, Levin ED, Kollins SH.

Epigenetics. 2018;13(12):1208-1221. doi: 10.1080/15592294.2018.1554521. Epub 2018 Dec 18.



Waters HS, Corcoran DM, Waters TEA.

Monogr Soc Res Child Dev. 2018 Dec;83(4):106-120. doi: 10.1111/mono.12394.


Coronary Thermodilution Waveforms After Acute Reperfused ST-Segment-Elevation Myocardial Infarction: Relation to Microvascular Obstruction and Prognosis.

Yew SN, Carrick D, Corcoran D, Ahmed N, Carberry J, Teng Yue May V, McEntegart M, Petrie MC, Eteiba H, Lindsay M, Hood S, Watkins S, Davie A, Mahrous A, Mordi I, Ford I, Oldroyd KG, Berry C.

J Am Heart Assoc. 2018 Aug 7;7(15):e008957. doi: 10.1161/JAHA.118.008957.


Selection of marker peptides from casein phosphopeptide and application for quantification in infant formula.

Fang F, Hao X, Wu Y, Ying M, He P, Corcoran D, Chen Q.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018 Nov;35(11):2077-2087. doi: 10.1080/19440049.2018.1523573. Epub 2018 Oct 10.


Stratified Medical Therapy Using Invasive Coronary Function Testing in Angina: The CorMicA Trial.

Ford TJ, Stanley B, Good R, Rocchiccioli P, McEntegart M, Watkins S, Eteiba H, Shaukat A, Lindsay M, Robertson K, Hood S, McGeoch R, McDade R, Yii E, Sidik N, McCartney P, Corcoran D, Collison D, Rush C, McConnachie A, Touyz RM, Oldroyd KG, Berry C.

J Am Coll Cardiol. 2018 Dec 11;72(23 Pt A):2841-2855. doi: 10.1016/j.jacc.2018.09.006. Epub 2018 Sep 25.


A Polygenic Score for Higher Educational Attainment is Associated with Larger Brains.

Elliott ML, Belsky DW, Anderson K, Corcoran DL, Ge T, Knodt A, Prinz JA, Sugden K, Williams B, Ireland D, Poulton R, Caspi A, Holmes A, Moffitt T, Hariri AR.

Cereb Cortex. 2018 Sep 12. doi: 10.1093/cercor/bhy219. [Epub ahead of print]


Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins.

Hannon E, Knox O, Sugden K, Burrage J, Wong CCY, Belsky DW, Corcoran DL, Arseneault L, Moffitt TE, Caspi A, Mill J.

PLoS Genet. 2018 Aug 9;14(8):e1007544. doi: 10.1371/journal.pgen.1007544. eCollection 2018 Aug.


Coronary Microvascular Dysfunction: Assessment of Both Structure and Function.

Ford TJ, Corcoran D, Sidik N, McEntegart M, Berry C.

J Am Coll Cardiol. 2018 Jul 31;72(5):584-586. doi: 10.1016/j.jacc.2018.03.545. No abstract available.


Correction of Biochemical Abnormalities and Improved Muscle Function in a Phase I/II Clinical Trial of Clenbuterol in Pompe Disease.

Koeberl DD, Case LE, Smith EC, Walters C, Han SO, Li Y, Chen W, Hornik CP, Huffman KM, Kraus WE, Thurberg BL, Corcoran DL, Bali D, Bursac N, Kishnani PS.

Mol Ther. 2018 Sep 5;26(9):2304-2314. doi: 10.1016/j.ymthe.2018.06.023. Epub 2018 Jul 5.


Magnetic Resonance Perfusion Imaging to Guide Management of Patients With Stable Ischemic Heart Disease.

Berry C, Mangion K, Corcoran D.

JACC Cardiovasc Imaging. 2018 Jul;11(7):997-999. doi: 10.1016/j.jcmg.2018.05.020. No abstract available.


Metabolic Changes with Base-Loading in CKD.

Scialla JJ, Brown L, Gurley S, Corcoran DL, Bain JR, Muehlbauer MJ, O'Neal SK, M O'Connell T, Wolf M, Melamed ML, Hostetter TH, Abramowitz MK.

Clin J Am Soc Nephrol. 2018 Aug 7;13(8):1244-1246. doi: 10.2215/CJN.01830218. Epub 2018 Jun 22. No abstract available.


Rationale and design of the British Heart Foundation (BHF) Coronary Microvascular Angina (CorMicA) stratified medicine clinical trial.

Ford TJ, Corcoran D, Oldroyd KG, McEntegart M, Rocchiccioli P, Watkins S, Brooksbank K, Padmanabhan S, Sattar N, Briggs A, McConnachie A, Touyz R, Berry C.

Am Heart J. 2018 Jul;201:86-94. doi: 10.1016/j.ahj.2018.03.010. Epub 2018 Apr 3. Review.


Single- Versus 2-Stent Strategies for Coronary Bifurcation Lesions: A Systematic Review and Meta-Analysis of Randomized Trials With Long-Term Follow-up.

Ford TJ, McCartney P, Corcoran D, Collison D, Hennigan B, McEntegart M, Hildick-Smith D, Oldroyd KG, Berry C.

J Am Heart Assoc. 2018 May 25;7(11). pii: e008730. doi: 10.1161/JAHA.118.008730. Review.


Incidence of procedural myocardial infarction and cardiac magnetic resonance imaging-detected myocardial injury following percutaneous coronary intervention with rotational atherectomy.

McEntegart M, Corcoran D, Carrick D, Clerfond G, Sidik N, Collison D, Robertson KR, Shaukat A, Watkins S, Rocchicholi PR, Eteiba H, Petrie MP, Lindsay MM, Oldroyd KG, Berry C.

EuroIntervention. 2018 Sep 20;14(7):819-823. doi: 10.4244/EIJ-D-17-01077. No abstract available.


Coronary microvascular dysfunction in patients with stable coronary artery disease: The CE-MARC 2 coronary physiology sub-study.

Corcoran D, Young R, Adlam D, McConnachie A, Mangion K, Ripley D, Cairns D, Brown J, Bucciarelli-Ducci C, Baumbach A, Kharbanda R, Oldroyd KG, McCann GP, Greenwood JP, Berry C.

Int J Cardiol. 2018 Sep 1;266:7-14. doi: 10.1016/j.ijcard.2018.04.061. Epub 2018 Apr 19.


Genetics and Crime: Integrating New Genomic Discoveries Into Psychological Research About Antisocial Behavior.

Wertz J, Caspi A, Belsky DW, Beckley AL, Arseneault L, Barnes JC, Corcoran DL, Hogan S, Houts RM, Morgan N, Odgers CL, Prinz JA, Sugden K, Williams BS, Poulton R, Moffitt TE.

Psychol Sci. 2018 May;29(5):791-803. doi: 10.1177/0956797617744542. Epub 2018 Mar 7.


Transcriptional profiling reveals distinct classes of parathyroid tumors in PHPT.

Koh J, Hogue JA, Roman SA, Scheri RP, Fradin H, Corcoran DL, Sosa JA.

Endocr Relat Cancer. 2018 Apr;25(4):407-420. doi: 10.1530/ERC-17-0470.


Analysis of DNA Methylation in Young People: Limited Evidence for an Association Between Victimization Stress and Epigenetic Variation in Blood.

Marzi SJ, Sugden K, Arseneault L, Belsky DW, Burrage J, Corcoran DL, Danese A, Fisher HL, Hannon E, Moffitt TE, Odgers CL, Pariante C, Poulton R, Williams BS, Wong CCY, Mill J, Caspi A.

Am J Psychiatry. 2018 Jun 1;175(6):517-529. doi: 10.1176/appi.ajp.2017.17060693. Epub 2018 Jan 12.


Trials and Tribulations of Enteric Parasitology in the Molecular Era.

O' Leary JK, Blake L, Corcoran D, Sleator RD, Lucey B.

J Med Microbiol. 2018 Feb;67(2):145-147. doi: 10.1099/jmm.0.000670. Epub 2017 Dec 21. No abstract available.


The effects of remote ischaemic preconditioning on coronary artery function in patients with stable coronary artery disease.

Corcoran D, Young R, Cialdella P, McCartney P, Bajrangee A, Hennigan B, Collison D, Carrick D, Shaukat A, Good R, Watkins S, McEntegart M, Watt J, Welsh P, Sattar N, McConnachie A, Oldroyd KG, Berry C.

Int J Cardiol. 2018 Feb 1;252:24-30. doi: 10.1016/j.ijcard.2017.10.082.


How to: identify non-tuberculous Mycobacterium species using MALDI-TOF mass spectrometry.

Alcaide F, Amlerová J, Bou G, Ceyssens PJ, Coll P, Corcoran D, Fangous MS, González-Álvarez I, Gorton R, Greub G, Hery-Arnaud G, Hrábak J, Ingebretsen A, Lucey B, Marekoviċ I, Mediavilla-Gradolph C, Monté MR, O'Connor J, O'Mahony J, Opota O, O'Reilly B, Orth-Höller D, Oviaño M, Palacios JJ, Palop B, Pranada AB, Quiroga L, Rodríguez-Temporal D, Ruiz-Serrano MJ, Tudó G, Van den Bossche A, van Ingen J, Rodriguez-Sanchez B; European Study Group on Genomics and Molecular Diagnosis (ESGMD).

Clin Microbiol Infect. 2018 Jun;24(6):599-603. doi: 10.1016/j.cmi.2017.11.012. Epub 2017 Nov 22. Review.


Eleven Telomere, Epigenetic Clock, and Biomarker-Composite Quantifications of Biological Aging: Do They Measure the Same Thing?

Belsky DW, Moffitt TE, Cohen AA, Corcoran DL, Levine ME, Prinz JA, Schaefer J, Sugden K, Williams B, Poulton R, Caspi A.

Am J Epidemiol. 2018 Jun 1;187(6):1220-1230. doi: 10.1093/aje/kwx346.


Stable coronary syndromes: pathophysiology, diagnostic advances and therapeutic need.

Ford TJ, Corcoran D, Berry C.

Heart. 2018 Feb;104(4):284-292. doi: 10.1136/heartjnl-2017-311446. Epub 2017 Oct 13. Review.


Genome Architecture and Evolution of a Unichromosomal Asexual Nematode.

Fradin H, Kiontke K, Zegar C, Gutwein M, Lucas J, Kovtun M, Corcoran DL, Baugh LR, Fitch DHA, Piano F, Gunsalus KC.

Curr Biol. 2017 Oct 9;27(19):2928-2939.e6. doi: 10.1016/j.cub.2017.08.038. Epub 2017 Sep 21.


Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity.

Suwanpradid J, Shih M, Pontius L, Yang B, Birukova A, Guttman-Yassky E, Corcoran DL, Que LG, Tighe RM, MacLeod AS.

J Immunol. 2017 Sep 1;199(5):1827-1834. doi: 10.4049/jimmunol.1700739. Epub 2017 Jul 26.


Collagen induces activation of DDR1 through lateral dimer association and phosphorylation between dimers.

Juskaite V, Corcoran DS, Leitinger B.

Elife. 2017 Jun 7;6. pii: e25716. doi: 10.7554/eLife.25716.


Fractional flow reserve: a clinical perspective.

Corcoran D, Hennigan B, Berry C.

Int J Cardiovasc Imaging. 2017 Jul;33(7):961-974. doi: 10.1007/s10554-017-1159-2. Epub 2017 Jun 2. Review.


Coronary artery disease: physiology and prognosis.

Ford TJ, Corcoran D, Berry C.

Eur Heart J. 2017 Jul 1;38(25):1990-1992. doi: 10.1093/eurheartj/ehx226. No abstract available.


Validation of the "smart" minimum FFR Algorithm in an unselected all comer population of patients with intermediate coronary stenoses.

Hennigan B, Johnson N, McClure J, Corcoran D, Watkins S, Berry C, Oldroyd KG.

Int J Cardiovasc Imaging. 2017 Jul;33(7):991-997. doi: 10.1007/s10554-017-1126-y. Epub 2017 Mar 29.


Overlap Extension Barcoding for the Next Generation Sequencing and Genotyping of Plasmodium falciparum in Individual Patients in Western Kenya.

Levitt B, Obala A, Langdon S, Corcoran D, O'Meara WP, Taylor SM.

Sci Rep. 2017 Jan 24;7:41108. doi: 10.1038/srep41108.


Mega-Cecum: An Unrecognized Cause of Symptoms in Some Female Patients with Uro-Gynecological Symptoms and Severe Slow Transit Constipation.

Chey WY, Chang V, Hoellrich CM, Lee KY, Lubkin M, Corcoran D, Chang TM, Chey WD.

Dig Dis Sci. 2017 Jan;62(1):217-223. doi: 10.1007/s10620-016-4392-y. Epub 2016 Dec 2.


miR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy.

Badal SS, Wang Y, Long J, Corcoran DL, Chang BH, Truong LD, Kanwar YS, Overbeek PA, Danesh FR.

Nat Commun. 2016 Jun 28;7:12076. doi: 10.1038/ncomms12076.


The Genetics of Success: How Single-Nucleotide Polymorphisms Associated With Educational Attainment Relate to Life-Course Development.

Belsky DW, Moffitt TE, Corcoran DL, Domingue B, Harrington H, Hogan S, Houts R, Ramrakha S, Sugden K, Williams BS, Poulton R, Caspi A.

Psychol Sci. 2016 Jul;27(7):957-72. doi: 10.1177/0956797616643070. Epub 2016 Jun 1.


Stool consistency: no hard and fast rules for the diagnosis of VTEC infection.

Ross S, O'Callaghan I, Jermy R, Blake L, Corcoran D, Sleator RD, Lucey B.

J Clin Pathol. 2016 Sep;69(9):837. doi: 10.1136/jclinpath-2016-203792. Epub 2016 May 4. No abstract available.


Non-invasive versus invasive management in patients with prior coronary artery bypass surgery with a non-ST segment elevation acute coronary syndrome: study design of the pilot randomised controlled trial and registry (CABG-ACS).

Lee MM, Petrie MC, Rocchiccioli P, Simpson J, Jackson C, Brown A, Corcoran D, Mangion K, McEntegart M, Shaukat A, Rae A, Hood S, Peat E, Findlay I, Murphy C, Cormack A, Bukov N, Balachandran K, Papworth R, Ford I, Briggs A, Berry C.

Open Heart. 2016 Apr 20;3(1):e000371. doi: 10.1136/openhrt-2015-000371. eCollection 2016.

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