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Items: 49


The adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypes.

Hill DL, Pierson W, Bolland DJ, Mkindi C, Carr EJ, Wang J, Houard S, Wingett SW, Audran R, Wallin EF, Jongo SA, Kamaka K, Zand M, Spertini F, Daubenberger C, Corcoran AE, Linterman MA.

J Exp Med. 2019 Jun 7. pii: jem.20190301. doi: 10.1084/jem.20190301. [Epub ahead of print]


Acute hypoxic exposure and prolyl-hydroxylase inhibition improves synaptic transmission recovery time from a subsequent hypoxic insult in rat hippocampus.

Lanigan S, Corcoran AE, Wall A, Mukandala G, O'Connor JJ.

Brain Res. 2018 Dec 15;1701:212-218. doi: 10.1016/j.brainres.2018.09.018. Epub 2018 Sep 20.


Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells.

Koohy H, Bolland DJ, Matheson LS, Schoenfelder S, Stellato C, Dimond A, Várnai C, Chovanec P, Chessa T, Denizot J, Manzano Garcia R, Wingett SW, Freire-Pritchett P, Nagano T, Hawkins P, Stephens L, Elderkin S, Spivakov M, Fraser P, Corcoran AE, Varga-Weisz PD.

Genome Biol. 2018 Sep 5;19(1):126. doi: 10.1186/s13059-018-1489-y.


Unbiased quantification of immunoglobulin diversity at the DNA level with VDJ-seq.

Chovanec P, Bolland DJ, Matheson LS, Wood AL, Krueger F, Andrews S, Corcoran AE.

Nat Protoc. 2018 Jun;13(6):1232-1252. doi: 10.1038/nprot.2018.021. Epub 2018 May 3.


Local Chromatin Features Including PU.1 and IKAROS Binding and H3K4 Methylation Shape the Repertoire of Immunoglobulin Kappa Genes Chosen for V(D)J Recombination.

Matheson LS, Bolland DJ, Chovanec P, Krueger F, Andrews S, Koohy H, Corcoran AE.

Front Immunol. 2017 Nov 17;8:1550. doi: 10.3389/fimmu.2017.01550. eCollection 2017.


Clonally stable Vκ allelic choice instructs Igκ repertoire.

Levin-Klein R, Fraenkel S, Lichtenstein M, Matheson LS, Bartok O, Nevo Y, Kadener S, Corcoran AE, Cedar H, Bergman Y.

Nat Commun. 2017 May 30;8:15575. doi: 10.1038/ncomms15575.


Comprehensive Cell Surface Protein Profiling Identifies Specific Markers of Human Naive and Primed Pluripotent States.

Collier AJ, Panula SP, Schell JP, Chovanec P, Plaza Reyes A, Petropoulos S, Corcoran AE, Walker R, Douagi I, Lanner F, Rugg-Gunn PJ.

Cell Stem Cell. 2017 Jun 1;20(6):874-890.e7. doi: 10.1016/j.stem.2017.02.014. Epub 2017 Mar 23.


Activity of Tachykinin1-Expressing Pet1 Raphe Neurons Modulates the Respiratory Chemoreflex.

Hennessy ML, Corcoran AE, Brust RD, Chang Y, Nattie EE, Dymecki SM.

J Neurosci. 2017 Feb 15;37(7):1807-1819. doi: 10.1523/JNEUROSCI.2316-16.2016. Epub 2017 Jan 16.


Two Mutually Exclusive Local Chromatin States Drive Efficient V(D)J Recombination.

Bolland DJ, Koohy H, Wood AL, Matheson LS, Krueger F, Stubbington MJ, Baizan-Edge A, Chovanec P, Stubbs BA, Tabbada K, Andrews SR, Spivakov M, Corcoran AE.

Cell Rep. 2016 Jun 14;15(11):2475-87. doi: 10.1016/j.celrep.2016.05.020. Epub 2016 Jun 2.


Functional link between the hypocretin and serotonin systems in the neural control of breathing and central chemosensitivity.

Corcoran AE, Richerson GB, Harris MB.

J Neurophysiol. 2015 Jul;114(1):381-9. doi: 10.1152/jn.00870.2013. Epub 2015 Apr 15.


Functional and developmental identification of a molecular subtype of brain serotonergic neuron specialized to regulate breathing dynamics.

Brust RD, Corcoran AE, Richerson GB, Nattie E, Dymecki SM.

Cell Rep. 2014 Dec 24;9(6):2152-65. doi: 10.1016/j.celrep.2014.11.027. Epub 2014 Dec 11.


CO2-inhibited neurons in the medullary raphé are GABAergic.

Iceman KE, Corcoran AE, Taylor BE, Harris MB.

Respir Physiol Neurobiol. 2014 Nov 1;203:28-34. doi: 10.1016/j.resp.2014.07.016. Epub 2014 Aug 1.


Dual effects of 5-HT(1a) receptor activation on breathing in neonatal mice.

Corcoran AE, Commons KG, Wu Y, Smith JC, Harris MB, Richerson GB.

J Neurosci. 2014 Jan 1;34(1):51-9. doi: 10.1523/JNEUROSCI.0864-13.2014.


Effects of prolyl-hydroxylase inhibition and chronic intermittent hypoxia on synaptic transmission and plasticity in the rat CA1 and dentate gyrus.

Wall AM, Corcoran AE, O'Halloran KD, O'Connor JJ.

Neurobiol Dis. 2014 Feb;62:8-17. doi: 10.1016/j.nbd.2013.08.016. Epub 2013 Sep 17.


Robust 3D DNA FISH using directly labeled probes.

Bolland DJ, King MR, Reik W, Corcoran AE, Krueger C.

J Vis Exp. 2013 Aug 15;(78). doi: 10.3791/50587.


Development of brainstem 5-HT1A receptor-binding sites in serotonin-deficient mice.

Massey CA, Kim G, Corcoran AE, Haynes RL, Paterson DS, Cummings KJ, Dymecki SM, Richerson GB, Nattie EE, Kinney HC, Commons KG.

J Neurochem. 2013 Sep;126(6):749-57. doi: 10.1111/jnc.12311. Epub 2013 Jun 10.


Serotonergic mechanisms are necessary for central respiratory chemoresponsiveness in situ.

Corcoran AE, Richerson GB, Harris MB.

Respir Physiol Neurobiol. 2013 Apr 1;186(2):214-20. doi: 10.1016/j.resp.2013.02.015. Epub 2013 Feb 27.


Non-coding transcription and large-scale nuclear organisation of immunoglobulin recombination.

Stubbington MJ, Corcoran AE.

Curr Opin Genet Dev. 2013 Apr;23(2):81-8. doi: 10.1016/j.gde.2013.01.001. Epub 2013 Feb 22. Review.


Egr2-neurons control the adult respiratory response to hypercapnia.

Ray RS, Corcoran AE, Brust RD, Soriano LP, Nattie EE, Dymecki SM.

Brain Res. 2013 May 20;1511:115-25. doi: 10.1016/j.brainres.2012.12.017. Epub 2012 Dec 19.


Developmental changes in cold tolerance and ability to autoresuscitate from hypothermic respiratory arrest are not linked in rats and hamsters.

Corcoran AE, Andrade DV, Marshall LH, Milsom WK.

Respir Physiol Neurobiol. 2012 May 31;181(3):249-58. doi: 10.1016/j.resp.2012.03.006. Epub 2012 Mar 15.


Editorial overview. Lymphocyte development.

Corcoran AE, Feeney AJ.

Curr Opin Immunol. 2012 Apr;24(2):129-31. doi: 10.1016/j.coi.2012.03.003. Epub 2012 Mar 20. No abstract available.


Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition.

Ray RS, Corcoran AE, Brust RD, Kim JC, Richerson GB, Nattie E, Dymecki SM.

Science. 2011 Jul 29;333(6042):637-42. doi: 10.1126/science.1205295.


Local and global epigenetic regulation of V(D)J recombination.

Matheson LS, Corcoran AE.

Curr Top Microbiol Immunol. 2012;356:65-89. doi: 10.1007/82_2011_137. Review.


Modeling the evolution of ETV6-RUNX1-induced B-cell precursor acute lymphoblastic leukemia in mice.

van der Weyden L, Giotopoulos G, Rust AG, Matheson LS, van Delft FW, Kong J, Corcoran AE, Greaves MF, Mullighan CG, Huntly BJ, Adams DJ.

Blood. 2011 Jul 28;118(4):1041-51. doi: 10.1182/blood-2011-02-338848. Epub 2011 May 31.


ATMIN is required for maintenance of genomic stability and suppression of B cell lymphoma.

Loizou JI, Sancho R, Kanu N, Bolland DJ, Yang F, Rada C, Corcoran AE, Behrens A.

Cancer Cell. 2011 May 17;19(5):587-600. doi: 10.1016/j.ccr.2011.03.022.


RUNX transcription factor-mediated association of Cd4 and Cd8 enables coordinate gene regulation.

Collins A, Hewitt SL, Chaumeil J, Sellars M, Micsinai M, Allinne J, Parisi F, Nora EP, Bolland DJ, Corcoran AE, Kluger Y, Bosselut R, Ellmeier W, Chong MM, Littman DR, Skok JA.

Immunity. 2011 Mar 25;34(3):303-14. doi: 10.1016/j.immuni.2011.03.004.


The epigenetic role of non-coding RNA transcription and nuclear organization in immunoglobulin repertoire generation.

Corcoran AE.

Semin Immunol. 2010 Dec;22(6):353-61. doi: 10.1016/j.smim.2010.08.001. Epub 2010 Sep 21. Review.


The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development.

Ramadani F, Bolland DJ, Garcon F, Emery JL, Vanhaesebroeck B, Corcoran AE, Okkenhaug K.

Sci Signal. 2010 Aug 10;3(134):ra60. doi: 10.1126/scisignal.2001104.


The mouse immunoglobulin heavy chain V-D intergenic sequence contains insulators that may regulate ordered V(D)J recombination.

Featherstone K, Wood AL, Bowen AJ, Corcoran AE.

J Biol Chem. 2010 Mar 26;285(13):9327-38. doi: 10.1074/jbc.M109.098251. Epub 2010 Jan 25.


Large-scale chromatin remodeling at the immunoglobulin heavy chain locus: a paradigm for multigene regulation.

Bolland DJ, Wood AL, Corcoran AE.

Adv Exp Med Biol. 2009;650:59-72. Review.


Medullary serotonin neurons and central CO2 chemoreception.

Corcoran AE, Hodges MR, Wu Y, Wang W, Wylie CJ, Deneris ES, Richerson GB.

Respir Physiol Neurobiol. 2009 Aug 31;168(1-2):49-58. doi: 10.1016/j.resp.2009.04.014. Epub 2009 Apr 24. Review.


Maturational changes in pontine and medullary alpha-adrenoceptor influences on respiratory rhythm generation in neonatal rats.

Corcoran AE, Milsom WK.

Respir Physiol Neurobiol. 2009 Feb 28;165(2-3):195-201. doi: 10.1016/j.resp.2008.11.009. Epub 2008 Dec 6.


AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations.

Robbiani DF, Bothmer A, Callen E, Reina-San-Martin B, Dorsett Y, Difilippantonio S, Bolland DJ, Chen HT, Corcoran AE, Nussenzweig A, Nussenzweig MC.

Cell. 2008 Dec 12;135(6):1028-38. doi: 10.1016/j.cell.2008.09.062.


Respiratory rhythm of brainstem-spinal cord preparations: Effects of maturation, age, mass and oxygenation.

Fong AY, Corcoran AE, Zimmer MB, Andrade DV, Milsom WK.

Respir Physiol Neurobiol. 2008 Dec 31;164(3):429-40. doi: 10.1016/j.resp.2008.09.008. Epub 2008 Oct 2.


How chromatin remodelling allows shuffling of immunoglobulin heavy chain genes.

Bowen AJ, Corcoran AE.

Mol Biosyst. 2008 Aug;4(8):790-8. doi: 10.1039/b719771n. Epub 2008 May 14. Review.


Heavy chain-only antibodies are spontaneously produced in light chain-deficient mice.

Zou X, Osborn MJ, Bolland DJ, Smith JA, Corcos D, Hamon M, Oxley D, Hutchings A, Morgan G, Santos F, Kilshaw PJ, Taussig MJ, Corcoran AE, Brüggemann M.

J Exp Med. 2007 Dec 24;204(13):3271-83. Epub 2007 Dec 17.


Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy.

Clapp J, Mitchell LM, Bolland DJ, Fantes J, Corcoran AE, Scotting PJ, Armour JA, Hewitt JE.

Am J Hum Genet. 2007 Aug;81(2):264-79. Epub 2007 Jun 27.


Myc dynamically and preferentially relocates to a transcription factory occupied by Igh.

Osborne CS, Chakalova L, Mitchell JA, Horton A, Wood AL, Bolland DJ, Corcoran AE, Fraser P.

PLoS Biol. 2007 Aug;5(8):e192.


Antisense intergenic transcription precedes Igh D-to-J recombination and is controlled by the intronic enhancer Emu.

Bolland DJ, Wood AL, Afshar R, Featherstone K, Oltz EM, Corcoran AE.

Mol Cell Biol. 2007 Aug;27(15):5523-33. Epub 2007 May 25.


Complete sequence assembly and characterization of the C57BL/6 mouse Ig heavy chain V region.

Johnston CM, Wood AL, Bolland DJ, Corcoran AE.

J Immunol. 2006 Apr 1;176(7):4221-34.


Both the pre-BCR and the IL-7Ralpha are essential for expansion at the pre-BII cell stage in vivo.

Erlandsson L, Licence S, Gaspal F, Lane P, Corcoran AE, Mårtensson IL.

Eur J Immunol. 2005 Jun;35(6):1969-76.


Immunoglobulin locus silencing and allelic exclusion.

Corcoran AE.

Semin Immunol. 2005 Apr;17(2):141-54. Review.


Impaired B-1 and B-2 B cell development and atypical splenic B cell structures in IL-7 receptor-deficient mice.

Erlandsson L, Licence S, Gaspal F, Bell S, Lane P, Corcoran AE, Mårtensson IL.

Eur J Immunol. 2004 Dec;34(12):3595-603.


Antisense intergenic transcription in V(D)J recombination.

Bolland DJ, Wood AL, Johnston CM, Bunting SF, Morgan G, Chakalova L, Fraser PJ, Corcoran AE.

Nat Immunol. 2004 Jun;5(6):630-7. Epub 2004 Apr 25.


Minimal tumor necrosis factor receptor binding protein: optimum biological activity of a truncated p55 soluble tumor necrosis factor receptor-IgG fusion protein.

Corcoran AE, Scallon BJ, Trinh H, Chernajovsky Y, Ghrayeb J, Feldmann M.

Eur Cytokine Netw. 1998 Sep;9(3):255-62.


Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor.

Corcoran AE, Riddell A, Krooshoop D, Venkitaraman AR.

Nature. 1998 Feb 26;391(6670):904-7.


The interleukin-7 receptor alpha chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis.

Corcoran AE, Smart FM, Cowling RJ, Crompton T, Owen MJ, Venkitaraman AR.

EMBO J. 1996 Apr 15;15(8):1924-32.


Characterization of ligand binding by the human p55 tumour-necrosis-factor receptor. Involvement of individual cysteine-rich repeats.

Corcoran AE, Barrett K, Turner M, Brown A, Kissonerghis AM, Gadnell M, Gray PW, Chernajovsky Y, Feldmann M.

Eur J Biochem. 1994 Aug 1;223(3):831-40.


Autoantigen recognition by thyroid-infiltrating T cells in Graves disease.

Dayan CM, Londei M, Corcoran AE, Grubeck-Loebenstein B, James RF, Rapoport B, Feldmann M.

Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7415-9.

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