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Items: 1 to 50 of 76

1.

LJ000328, a novel ALK2/3 kinase inhibitor, represses hepcidin and significantly improves the phenotype of IRIDA.

Belot A, Gourbeyre O, Fay A, Palin A, Besson C, Latour C, Hopkins CR, Tidmarsh GF, Coppin H, Roth MP, Ritter MR, Hong CC, Meynard D.

Haematologica. 2019 Dec 5. pii: haematol.2019.236133. doi: 10.3324/haematol.2019.236133. [Epub ahead of print]

2.

Spleen iron, molybdenum, and manganese concentrations are coregulated in hepcidin-deficient and secondary iron overload models in mice.

Cavey T, Latour C, Island ML, Leroyer P, Guggenbuhl P, Coppin H, Roth MP, Bendavid C, Brissot P, Ropert M, Loréal O.

FASEB J. 2019 Oct;33(10):11072-11081. doi: 10.1096/fj.201801381RR. Epub 2019 Jul 23.

3.

Regulators of hepcidin expression.

Roth MP, Meynard D, Coppin H.

Vitam Horm. 2019;110:101-129. doi: 10.1016/bs.vh.2019.01.005. Epub 2019 Feb 2. Review.

PMID:
30798807
4.

Shift in skin microbiota of Western European women across aging.

Jugé R, Rouaud-Tinguely P, Breugnot J, Servaes K, Grimaldi C, Roth MP, Coppin H, Closs B.

J Appl Microbiol. 2018 Sep;125(3):907-916. doi: 10.1111/jam.13929. Epub 2018 Jun 29.

PMID:
29791788
5.

Deletion of BMP6 worsens the phenotype of HJV-deficient mice and attenuates hepcidin levels reached after LPS challenge.

Latour C, Besson-Fournier C, Gourbeyre O, Meynard D, Roth MP, Coppin H.

Blood. 2017 Nov 23;130(21):2339-2343. doi: 10.1182/blood-2017-07-795658. Epub 2017 Oct 11.

6.

Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B.

Besson-Fournier C, Gineste A, Latour C, Gourbeyre O, Meynard D, Martin P, Oswald E, Coppin H, Roth MP.

Blood. 2017 Jan 26;129(4):533-536. doi: 10.1182/blood-2016-10-748541. Epub 2016 Nov 30. No abstract available.

7.

Erythroferrone contributes to hepcidin repression in a mouse model of malarial anemia.

Latour C, Wlodarczyk MF, Jung G, Gineste A, Blanchard N, Ganz T, Roth MP, Coppin H, Kautz L.

Haematologica. 2017 Jan;102(1):60-68. doi: 10.3324/haematol.2016.150227. Epub 2016 Sep 22.

8.

Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice.

Nai A, Rubio A, Campanella A, Gourbeyre O, Artuso I, Bordini J, Gineste A, Latour C, Besson-Fournier C, Lin HY, Coppin H, Roth MP, Camaschella C, Silvestri L, Meynard D.

Blood. 2016 May 12;127(19):2327-36. doi: 10.1182/blood-2015-11-681494. Epub 2016 Jan 11.

9.

Targeting iron-mediated retinal degeneration by local delivery of transferrin.

Picard E, Le Rouzic Q, Oudar A, Berdugo M, El Sanharawi M, Andrieu-Soler C, Naud MC, Jonet L, Latour C, Klein C, Galiacy S, Malecaze F, Coppin H, Roth MP, Jeanny JC, Courtois Y, Behar-Cohen F.

Free Radic Biol Med. 2015 Dec;89:1105-21. doi: 10.1016/j.freeradbiomed.2015.08.018. Epub 2015 Oct 8.

10.

Further support for the association of GNPAT variant rs11558492 with severe iron overload in hemochromatosis.

Besson-Fournier C, Martinez M, Vinel JP, Aguilar-Martinez P, Coppin H, Roth MP.

Hepatology. 2016 Jun;63(6):2054-5. doi: 10.1002/hep.28259. Epub 2015 Oct 30. No abstract available.

PMID:
26418842
11.

Differing impact of the deletion of hemochromatosis-associated molecules HFE and transferrin receptor-2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelin.

Latour C, Besson-Fournier C, Meynard D, Silvestri L, Gourbeyre O, Aguilar-Martinez P, Schmidt PJ, Fleming MD, Roth MP, Coppin H.

Hepatology. 2016 Jan;63(1):126-37. doi: 10.1002/hep.28254. Epub 2015 Nov 12.

PMID:
26406355
12.

From the morphological to the transcriptomic characterization of a compromised three-dimensional in vitro model mimicking atopic dermatitis.

Rouaud-Tinguely P, Boudier D, Marchand L, Barruche V, Bordes S, Coppin H, Roth MP, Closs B.

Br J Dermatol. 2015 Oct;173(4):1006-14. doi: 10.1111/bjd.14012. Epub 2015 Oct 8.

PMID:
26147950
13.

Evidence for IL-6/STAT3-independent induction of lipocalin-2 in the liver of mice infected with Escherichia coli.

Gineste A, Martin P, Oswald E, Coppin H, Roth MP.

Hepatology. 2016 Feb;63(2):673-4. doi: 10.1002/hep.27845. Epub 2015 May 20. No abstract available.

PMID:
25865824
14.

Genome-wide association study identifies TF as a significant modifier gene of iron metabolism in HFE hemochromatosis.

de Tayrac M, Roth MP, Jouanolle AM, Coppin H, le Gac G, Piperno A, Férec C, Pelucchi S, Scotet V, Bardou-Jacquet E, Ropert M, Bouvet R, Génin E, Mosser J, Deugnier Y.

J Hepatol. 2015 Mar;62(3):664-72. doi: 10.1016/j.jhep.2014.10.017. Epub 2014 Oct 18.

15.

Glycol-split nonanticoagulant heparins are inhibitors of hepcidin expression in vitro and in vivo.

Poli M, Asperti M, Naggi A, Campostrini N, Girelli D, Corbella M, Benzi M, Besson-Fournier C, Coppin H, Maccarinelli F, Finazzi D, Arosio P.

Blood. 2014 Mar 6;123(10):1564-73. doi: 10.1182/blood-2013-07-515221. Epub 2014 Jan 7.

16.

Testosterone perturbs systemic iron balance through activation of epidermal growth factor receptor signaling in the liver and repression of hepcidin.

Latour C, Kautz L, Besson-Fournier C, Island ML, Canonne-Hergaux F, Loréal O, Ganz T, Coppin H, Roth MP.

Hepatology. 2014 Feb;59(2):683-94. doi: 10.1002/hep.26648. Epub 2013 Dec 16.

PMID:
23907767
17.

Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling.

Besson-Fournier C, Latour C, Kautz L, Bertrand J, Ganz T, Roth MP, Coppin H.

Blood. 2012 Jul 12;120(2):431-9. doi: 10.1182/blood-2012-02-411470. Epub 2012 May 18.

PMID:
22611157
18.

Iron overload induces BMP6 expression in the liver but not in the duodenum.

Kautz L, Besson-Fournier C, Meynard D, Latour C, Roth MP, Coppin H.

Haematologica. 2011 Feb;96(2):199-203. doi: 10.3324/haematol.2010.031963. Epub 2010 Oct 15.

19.

[BMP6: a key player in iron metabolism].

Roth MP, Coppin H.

Med Sci (Paris). 2009 Aug-Sep;25(8-9):678-80. doi: 10.1051/medsci/2009258-9678. French. No abstract available.

20.

BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression.

Kautz L, Meynard D, Besson-Fournier C, Darnaud V, Al Saati T, Coppin H, Roth MP.

Blood. 2009 Sep 17;114(12):2515-20. doi: 10.1182/blood-2009-02-206771. Epub 2009 Jul 21.

PMID:
19622835
21.

Iron speciation study in Hfe knockout mice tissues: magnetic and ultrastructural characterisation.

Gutiérrez L, Quintana C, Patiño C, Bueno J, Coppin H, Roth MP, Lázaro FJ.

Biochim Biophys Acta. 2009 Jun;1792(6):541-7. doi: 10.1016/j.bbadis.2009.03.007. Epub 2009 Apr 5.

22.

Lack of the bone morphogenetic protein BMP6 induces massive iron overload.

Meynard D, Kautz L, Darnaud V, Canonne-Hergaux F, Coppin H, Roth MP.

Nat Genet. 2009 Apr;41(4):478-81. doi: 10.1038/ng.320. Epub 2009 Mar 1.

PMID:
19252488
23.

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver.

Kautz L, Meynard D, Monnier A, Darnaud V, Bouvet R, Wang RH, Deng C, Vaulont S, Mosser J, Coppin H, Roth MP.

Blood. 2008 Aug 15;112(4):1503-9. doi: 10.1182/blood-2008-03-143354. Epub 2008 Jun 6.

PMID:
18539898
25.

Direct recognition by alphabeta cytolytic T cells of Hfe, a MHC class Ib molecule without antigen-presenting function.

Rohrlich PS, Fazilleau N, Ginhoux F, Firat H, Michel F, Cochet M, Laham N, Roth MP, Pascolo S, Nato F, Coppin H, Charneau P, Danos O, Acuto O, Ehrlich R, Kanellopoulos J, Lemonnier FA.

Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12855-60. Epub 2005 Aug 25.

26.

Multigenic control of hepatic iron loading in a murine model of hemochromatosis.

Bensaid M, Fruchon S, Mazères C, Bahram S, Roth MP, Coppin H.

Gastroenterology. 2004 May;126(5):1400-8.

PMID:
15131800
27.

Strain and gender modulate hepatic hepcidin 1 and 2 mRNA expression in mice.

Courselaud B, Troadec MB, Fruchon S, Ilyin G, Borot N, Leroyer P, Coppin H, Brissot P, Roth MP, Loréal O.

Blood Cells Mol Dis. 2004 Mar-Apr;32(2):283-9.

PMID:
15003819
28.

A vulnerability locus to multiple sclerosis maps to 7p15 in a region syntenic to an EAE locus in the rat.

Coppin H, Ribouchon MT, Fontaine B, Edan G, Clanet M, Roth MP; French Multiple Sclerosis Genetics Group.

Genes Immun. 2004 Jan;5(1):72-5.

PMID:
14735153
29.

Investigation of seven proposed regions of linkage in multiple sclerosis: an American and French collaborative study.

Pericak-Vance MA, Rimmler JB, Haines JL, Garcia ME, Oksenberg JR, Barcellos LF, Lincoln R, Hauser SL, Cournu-Rebeix I, Azoulay-Cayla A, Lyon-Caen O, Fontaine B, Duhamel E, Coppin H, Brassat D, Roth MP, Clanet M, Alizadeh M, Yaouanq J, Quelvennec E, Semana G, Edan G, Babron MC, Genin E, Clerget-Darpoux F.

Neurogenetics. 2004 Feb;5(1):45-8. Epub 2003 Nov 1.

PMID:
14595552
30.

Longevity and carrying the C282Y mutation for haemochromatosis on the HFE gene: case control study of 492 French centenarians.

Coppin H, Bensaid M, Fruchon S, Borot N, Blanché H, Roth MP.

BMJ. 2003 Jul 19;327(7407):132-3. No abstract available.

31.

Use of denaturing HPLC and a heteroduplex generator to detect the HFE C282Y mutation associated with genetic hemochromatosis.

Fruchon S, Bensaid M, Borot N, Roth MP, Coppin H.

Clin Chem. 2003 May;49(5):822-4. No abstract available.

PMID:
12709380
32.

Cytokine and cytokine receptor genes in the susceptibility and resistance to organ-specific autoimmune diseases.

Coppin H, Roth MP, Liblau RS.

Adv Exp Med Biol. 2003;520:33-65. Review. No abstract available.

PMID:
12613571
33.

Duodenal mRNA expression of iron related genes in response to iron loading and iron deficiency in four strains of mice.

Dupic F, Fruchon S, Bensaid M, Loreal O, Brissot P, Borot N, Roth MP, Coppin H.

Gut. 2002 Nov;51(5):648-53.

34.

Inactivation of the hemochromatosis gene differentially regulates duodenal expression of iron-related mRNAs between mouse strains.

Dupic F, Fruchon S, Bensaid M, Borot N, Radosavljevic M, Loreal O, Brissot P, Gilfillan S, Bahram S, Coppin H, Roth MP.

Gastroenterology. 2002 Mar;122(3):745-51.

PMID:
11875007
35.

No evidence for transmission disequilibrium between a new marker at the myelin basic protein locus and multiple sclerosis in French patients.

Coppin H, Ribouchon MT, Bausero P, Pessac B, Fontaine B, Semana G, Clanet M, Roth MP; French Multiple Sclerosis Genetics Group.

Genes Immun. 2000 Dec;1(8):478-82.

36.

Polymorphism in intron 4 of HFE does not compromise haemochromatosis mutation results. The European Haemochromatosis Consortium.

Merryweather-Clarke AT, Pointon JJ, Shearman JD, Robson KJ, Jouanolle AM, Mosser A, David V, Le Gall JY, Halsall DJ, Elsey TS, Kelly A, Cox TM, Clare M, Bomford A, Vandwalle JL, Rochette J, Borot N, Coppin H, Roth MP, Ryan E, Crowe J, Totaro A, Gasparini P, Roetto A, Walker AP, et al.

Nat Genet. 1999 Nov;23(3):271. No abstract available.

PMID:
10545942
37.

Biased T-cell receptor usage is associated with allelic variation in the MHC class II peptide binding groove.

Yassine-Diab B, Carmichael P, L'Faqihi FE, Lombardi G, Deacock S, de Préval C, Coppin H, Lechler RI.

Immunogenetics. 1999 Jun;49(6):532-40.

PMID:
10380698
38.

A genome-wide search identifies two susceptibility loci for experimental autoimmune encephalomyelitis on rat chromosomes 4 and 10.

Roth MP, Viratelle C, Dolbois L, Delverdier M, Borot N, Pelletier L, Druet P, Clanet M, Coppin H.

J Immunol. 1999 Feb 15;162(4):1917-22.

39.

Human collagen II peptide 256-271 preferentially binds to HLA-DR molecules associated with susceptibility to rheumatoid arthritis.

Diab BY, Lambert NC, L'Faqihi FE, Loubet-Lescoulié P, de Préval C, Coppin H.

Immunogenetics. 1999 Jan;49(1):36-44.

PMID:
9811967
40.

Residue 67 in the DRbeta1*0101 and DRbeta1*0103 chains strongly influences antigen presentation and DR-peptide molecular complex conformation.

L'Faqihi FE, Praud C, Yassine-Diab B, Enault G, Lakhdar-Ghazal F, de Préval C, Coppin H.

Tissue Antigens. 1998 Jan;51(1):10-9.

PMID:
9459499
41.

Heterogeneity in rates of recombination in the 6-Mb region telomeric to the human major histocompatibility complex.

Malfroy L, Roth MP, Carrington M, Borot N, Volz A, Ziegler A, Coppin H.

Genomics. 1997 Jul 15;43(2):226-31.

PMID:
9244441
42.

Hereditary hemochromatosis: a HpaI polymorphism within the HLA-H gene.

Totaro A, Grifa A, Carella M, D'Ambrosio L, Valentino M, Roth MP, Borot N, Coppin H, Roetto A, Camaschella C, Gasparini P.

Mol Cell Probes. 1997 Jun;11(3):229-30. No abstract available.

PMID:
9232622
43.

Dominant clones in immortalized T-cell lines from rheumatoid arthritis synovial membranes.

Saadawi AM, L'Faqihi F, Diab BY, Sol MA, Enault G, Coppin H, Cantagrel A, Biesinger B, Fleckenstein B, Thomsen M.

Tissue Antigens. 1997 May;49(5):431-7.

PMID:
9174133
44.

Absence of the hemochromatosis gene Cys282Tyr mutation in three ethnic groups from Algeria (Mzab), Ethiopia, and Senegal.

Roth M, Giraldo P, Hariti G, Poloni ES, Sanchez-Mazas A, Stefano GF, Dugoujon JM, Coppin H.

Immunogenetics. 1997;46(3):222-5.

PMID:
9211748
45.

Mutations in the MHC class I-like candidate gene for hemochromatosis in French patients.

Borot N, Roth M, Malfroy L, Demangel C, Vinel JP, Pascal JP, Coppin H.

Immunogenetics. 1997;45(5):320-4.

PMID:
9038104
46.

Persistence of dominant T cell clones in synovial tissues during rheumatoid arthritis.

Alam A, Lambert N, Lulé J, Coppin H, Mazières B, de Préval C, Cantagrel A.

J Immunol. 1996 May 1;156(9):3480-5.

PMID:
8617976
47.

Role of polymorphic residues of human leucocyte antigen-DR molecules on the binding of human immunodeficiency virus peptides.

Jurcevic S, Praud C, Coppin HL, Bertrand A, Ricard S, Thomsen M, Lakhdar-Ghazal F, De Preval C.

Immunology. 1996 Mar;87(3):414-20.

48.

Polymorphic tri- and tetranucleotide repeats in exons 1 and 8 of the myelin oligodendrocyte glycoprotein (MOG) gene.

Malfroy L, Viratelle C, Coppin H, Borot N, Roth MP.

Hum Genet. 1995 Dec;96(6):737-8.

PMID:
8522338
49.

Myelin oligodendrocyte glycoprotein (MOG) gene polymorphisms and multiple sclerosis: no evidence of disease association with MOG.

Roth MP, Dolbois L, Borot N, Pontarotti P, Clanet M, Coppin H.

J Neuroimmunol. 1995 Sep;61(2):117-22.

PMID:
7593547
50.

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