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Items: 1 to 50 of 103


MTA3 Represses Cancer Stemness by Targeting the SOX2OT/SOX2 Axis.

Du L, Wang L, Gan J, Yao Z, Lin W, Li J, Guo Y, Chen Y, Zhou F, Jim Yeung SC, Coppes RP, Zhang D, Zhang H.

iScience. 2019 Dec 20;22:353-368. doi: 10.1016/j.isci.2019.11.009. Epub 2019 Nov 11.


MTA3-SOX2 Module Regulates Cancer Stemness and Contributes to Clinical Outcomes of Tongue Carcinoma.

Yao Z, Du L, Xu M, Li K, Guo H, Ye G, Zhang D, Coppes RP, Zhang H.

Front Oncol. 2019 Aug 27;9:816. doi: 10.3389/fonc.2019.00816. eCollection 2019.


FLASH radiotherapy International Workshop.

Vozenin MC, Baumann M, Coppes RP, Bourhis J.

Radiother Oncol. 2019 Oct;139:1-3. doi: 10.1016/j.radonc.2019.07.020. Epub 2019 Aug 21. No abstract available.


Hedgehog Pathway as a Potential Intervention Target in Esophageal Cancer.

Wang D, Nagle PW, Wang HH, Smit JK, Faber H, Baanstra M, Karrenbeld A, Chiu RK, Plukker JTM, Coppes RP.

Cancers (Basel). 2019 Jun 13;11(6). pii: E821. doi: 10.3390/cancers11060821.


Micro cone beam computed tomography for sensitive assessment of radiation-induced late lung toxicity in preclinical models.

van Berlo D, Khmelinskii A, Gasparini A, Salguero FJ, Floot B, de Wit N, van de Ven M, Song JY, Coppes RP, Verheij M, Sonke JJ, Vens C.

Radiother Oncol. 2019 Sep;138:17-24. doi: 10.1016/j.radonc.2019.05.007. Epub 2019 May 27.


In vitro biological response of cancer and normal tissue cells to proton irradiation not affected by an added magnetic field.

Nagle PW, van Goethem MJ, Kempers M, Kiewit H, Knopf A, Langendijk JA, Brandenburg S, van Luijk P, Coppes RP.

Radiother Oncol. 2019 Aug;137:125-129. doi: 10.1016/j.radonc.2019.04.028. Epub 2019 May 11.


Lack of DNA Damage Response at Low Radiation Doses in Adult Stem Cells Contributes to Organ Dysfunction.

Nagle PW, Hosper NA, Barazzuol L, Jellema AL, Baanstra M, van Goethem MJ, Brandenburg S, Giesen U, Langendijk JA, van Luijk P, Coppes RP.

Clin Cancer Res. 2018 Dec 15;24(24):6583-6593. doi: 10.1158/1078-0432.CCR-18-0533. Epub 2018 Aug 22.


Salivary Gland Stem Cells Age Prematurely in Primary Sjögren's Syndrome.

Pringle S, Wang X, Verstappen GMPJ, Terpstra JH, Zhang CK, He A, Patel V, Jones RE, Baird DM, Spijkervet FKL, Vissink A, Bootsma H, Coppes RP, Kroese FGM.

Arthritis Rheumatol. 2019 Jan;71(1):133-142. doi: 10.1002/art.40659.


Patient-derived tumor organoids for prediction of cancer treatment response.

Nagle PW, Plukker JTM, Muijs CT, van Luijk P, Coppes RP.

Semin Cancer Biol. 2018 Dec;53:258-264. doi: 10.1016/j.semcancer.2018.06.005. Epub 2018 Jun 30. Review.


Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion.

Mauthe M, Orhon I, Rocchi C, Zhou X, Luhr M, Hijlkema KJ, Coppes RP, Engedal N, Mari M, Reggiori F.

Autophagy. 2018;14(8):1435-1455. doi: 10.1080/15548627.2018.1474314. Epub 2018 Jul 20.


Role of glial-cell-derived neurotrophic factor in salivary gland stem cell response to irradiation.

Peng X, Varendi K, Maimets M, Andressoo JO, Coppes RP.

Radiother Oncol. 2017 Sep;124(3):448-454. doi: 10.1016/j.radonc.2017.07.008. Epub 2017 Aug 4.


Cancer stem cells with increased metastatic potential as a therapeutic target for esophageal cancer.

Wang D, Plukker JTM, Coppes RP.

Semin Cancer Biol. 2017 Jun;44:60-66. doi: 10.1016/j.semcancer.2017.03.010. Epub 2017 Mar 30. Review.


Targeting Stem Cells in Radiation Oncology.

Coppes RP, Dubrovska A.

Clin Oncol (R Coll Radiol). 2017 Jun;29(6):329-334. doi: 10.1016/j.clon.2017.03.005. Epub 2017 Mar 28. No abstract available.


Understanding mechanisms yields novel approaches to reduce radiotherapy-related xerostomia.

van Luijk P, Langendijk JA, Coppes RP.

Ann Transl Med. 2017 Feb;5(3):63. doi: 10.21037/atm.2017.02.02. No abstract available.


Effects of Radioiodine Treatment on Salivary Gland Function in Patients with Differentiated Thyroid Carcinoma: A Prospective Study.

Klein Hesselink EN, Brouwers AH, de Jong JR, van der Horst-Schrivers AN, Coppes RP, Lefrandt JD, Jager PL, Vissink A, Links TP.

J Nucl Med. 2016 Nov;57(11):1685-1691. Epub 2016 Jun 23.


The In Vitro Response of Tissue Stem Cells to Irradiation With Different Linear Energy Transfers.

Nagle PW, Hosper NA, Ploeg EM, van Goethem MJ, Brandenburg S, Langendijk JA, Chiu RK, Coppes RP.

Int J Radiat Oncol Biol Phys. 2016 May 1;95(1):103-111. doi: 10.1016/j.ijrobp.2016.02.020. Epub 2016 Feb 12.


Human Salivary Gland Stem Cells Functionally Restore Radiation Damaged Salivary Glands.

Pringle S, Maimets M, van der Zwaag M, Stokman MA, van Gosliga D, Zwart E, Witjes MJ, de Haan G, van Os R, Coppes RP.

Stem Cells. 2016 Mar;34(3):640-52. doi: 10.1002/stem.2278.


Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals.

Maimets M, Rocchi C, Bron R, Pringle S, Kuipers J, Giepmans BN, Vries RG, Clevers H, de Haan G, van Os R, Coppes RP.

Stem Cell Reports. 2016 Jan 12;6(1):150-62. doi: 10.1016/j.stemcr.2015.11.009. Epub 2015 Dec 24.


Decreasing Irradiated Rat Lung Volume Changes Dose-Limiting Toxicity From Early to Late Effects.

van der Veen SJ, Faber H, Ghobadi G, Brandenburg S, Langendijk JA, Coppes RP, van Luijk P.

Int J Radiat Oncol Biol Phys. 2016 Jan 1;94(1):163-171. doi: 10.1016/j.ijrobp.2015.09.034. Epub 2015 Sep 28.


Sparing the region of the salivary gland containing stem cells preserves saliva production after radiotherapy for head and neck cancer.

van Luijk P, Pringle S, Deasy JO, Moiseenko VV, Faber H, Hovan A, Baanstra M, van der Laan HP, Kierkels RG, van der Schaaf A, Witjes MJ, Schippers JM, Brandenburg S, Langendijk JA, Wu J, Coppes RP.

Sci Transl Med. 2015 Sep 16;7(305):305ra147. doi: 10.1126/scitranslmed.aac4441.


A new CT-based method to quantify radiation-induced lung damage in patients.

Ghobadi G, Wiegman EM, Langendijk JA, Widder J, Coppes RP, van Luijk P.

Radiother Oncol. 2015 Oct;117(1):4-8. doi: 10.1016/j.radonc.2015.07.017. Epub 2015 Aug 4.


Similar ex vivo expansion and post-irradiation regenerative potential of juvenile and aged salivary gland stem cells.

Maimets M, Bron R, de Haan G, van Os R, Coppes RP.

Radiother Oncol. 2015 Sep;116(3):443-8. doi: 10.1016/j.radonc.2015.06.022. Epub 2015 Jun 29.


ACE inhibition attenuates radiation-induced cardiopulmonary damage.

van der Veen SJ, Ghobadi G, de Boer RA, Faber H, Cannon MV, Nagle PW, Brandenburg S, Langendijk JA, van Luijk P, Coppes RP.

Radiother Oncol. 2015 Jan;114(1):96-103. doi: 10.1016/j.radonc.2014.11.017. Epub 2014 Nov 25.


Purification and ex vivo expansion of fully functional salivary gland stem cells.

Nanduri LS, Baanstra M, Faber H, Rocchi C, Zwart E, de Haan G, van Os R, Coppes RP.

Stem Cell Reports. 2014 Dec 9;3(6):957-64. doi: 10.1016/j.stemcr.2014.09.015. Epub 2014 Oct 23.


Thalidomide ameliorates inflammation and vascular injury but aggravates tubular damage in the irradiated mouse kidney.

Scharpfenecker M, Floot B, Russell NS, Coppes RP, Stewart FA.

Int J Radiat Oncol Biol Phys. 2014 Jul 1;89(3):599-606. doi: 10.1016/j.ijrobp.2014.03.039.


Bone marrow-derived macrophages incorporate into the endothelium and influence vascular and renal function after irradiation.

de Cortie K, Russell NS, Coppes RP, Stewart FA, Scharpfenecker M.

Int J Radiat Biol. 2014 Sep;90(9):769-77. doi: 10.3109/09553002.2014.920967. Epub 2014 Jun 25.


Current ideas to reduce or salvage radiation damage to salivary glands.

Vissink A, van Luijk P, Langendijk JA, Coppes RP.

Oral Dis. 2015 Jan;21(1):e1-10. doi: 10.1111/odi.12222. Epub 2014 Feb 28. Review.


Stem cell therapies for the treatment of radiation-induced normal tissue side effects.

Benderitter M, Caviggioli F, Chapel A, Coppes RP, Guha C, Klinger M, Malard O, Stewart F, Tamarat R, van Luijk P, Limoli CL.

Antioxid Redox Signal. 2014 Jul 10;21(2):338-55. doi: 10.1089/ars.2013.5652. Epub 2014 Feb 3. Review.


Endoglin haploinsufficiency attenuates radiation-induced deterioration of kidney function in mice.

Scharpfenecker M, Floot B, Russell NS, Coppes RP, Stewart FA.

Radiother Oncol. 2013 Sep;108(3):464-8. doi: 10.1016/j.radonc.2013.06.016. Epub 2013 Jul 9.


Salisphere derived c-Kit+ cell transplantation restores tissue homeostasis in irradiated salivary gland.

Nanduri LS, Lombaert IM, van der Zwaag M, Faber H, Brunsting JF, van Os RP, Coppes RP.

Radiother Oncol. 2013 Sep;108(3):458-63. doi: 10.1016/j.radonc.2013.05.020. Epub 2013 Jun 13.


Prediction of response to radiotherapy in the treatment of esophageal cancer using stem cell markers.

Smit JK, Faber H, Niemantsverdriet M, Baanstra M, Bussink J, Hollema H, van Os RP, Plukker JT, Coppes RP.

Radiother Oncol. 2013 Jun;107(3):434-41. doi: 10.1016/j.radonc.2013.03.027. Epub 2013 May 14.


Concise review: Adult salivary gland stem cells and a potential therapy for xerostomia.

Pringle S, Van Os R, Coppes RP.

Stem Cells. 2013 Apr;31(4):613-9. doi: 10.1002/stem.1327. Review.


ΔNp73 enhances promoter activity of TGF-β induced genes.

Niemantsverdriet M, Nagle P, Chiu RK, Langendijk JA, Kampinga HH, Coppes RP.

PLoS One. 2012;7(12):e50815. doi: 10.1371/journal.pone.0050815. Epub 2012 Dec 7.


Physiological interaction of heart and lung in thoracic irradiation.

Ghobadi G, van der Veen S, Bartelds B, de Boer RA, Dickinson MG, de Jong JR, Faber H, Niemantsverdriet M, Brandenburg S, Berger RM, Langendijk JA, Coppes RP, van Luijk P.

Int J Radiat Oncol Biol Phys. 2012 Dec 1;84(5):e639-46. doi: 10.1016/j.ijrobp.2012.07.2362. Epub 2012 Sep 11.


High and low LET radiation differentially induce normal tissue damage signals.

Niemantsverdriet M, van Goethem MJ, Bron R, Hogewerf W, Brandenburg S, Langendijk JA, van Luijk P, Coppes RP.

Int J Radiat Oncol Biol Phys. 2012 Jul 15;83(4):1291-7. doi: 10.1016/j.ijrobp.2011.09.057. Epub 2012 Jan 13.


Lung irradiation induces pulmonary vascular remodelling resembling pulmonary arterial hypertension.

Ghobadi G, Bartelds B, van der Veen SJ, Dickinson MG, Brandenburg S, Berger RM, Langendijk JA, Coppes RP, van Luijk P.

Thorax. 2012 Apr;67(4):334-41. doi: 10.1136/thoraxjnl-2011-200346. Epub 2011 Dec 26.


Regeneration of irradiated salivary glands with stem cell marker expressing cells.

Nanduri LS, Maimets M, Pringle SA, van der Zwaag M, van Os RP, Coppes RP.

Radiother Oncol. 2011 Jun;99(3):367-72. doi: 10.1016/j.radonc.2011.05.085. Epub 2011 Jun 28.


Volume-dependent expression of in-field and out-of-field effects in the proton-irradiated rat lung.

Coppes RP, Muijs CT, Faber H, Gross S, Schippers JM, Brandenburg S, Langendijk JA, van Luijk P.

Int J Radiat Oncol Biol Phys. 2011 Sep 1;81(1):262-9. doi: 10.1016/j.ijrobp.2011.03.021. Epub 2011 May 24.


Development of a facility for high-precision irradiation of cells with carbon ions.

van Goethem MJ, Niemantsverdriet M, Brandenburg S, Langendijk JA, Coppes RP, van Luijk P.

Med Phys. 2011 Jan;38(1):256-63.


Isolation of mouse salivary gland stem cells.

Pringle S, Nanduri LS, van der Zwaag M, van Os R, Coppes RP.

J Vis Exp. 2011 Feb 8;(48). pii: 2484. doi: 10.3791/2484.


Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers.

Vissink A, Mitchell JB, Baum BJ, Limesand KH, Jensen SB, Fox PC, Elting LS, Langendijk JA, Coppes RP, Reyland ME.

Int J Radiat Oncol Biol Phys. 2010 Nov 15;78(4):983-91. doi: 10.1016/j.ijrobp.2010.06.052. Review.


Stem cells and the repair of radiation-induced salivary gland damage.

Coppes RP, Stokman MA.

Oral Dis. 2011 Mar;17(2):143-53. doi: 10.1111/j.1601-0825.2010.01723.x. Epub 2010 Aug 27. Review.


Synergistic induction of profibrotic PAI-1 by TGF-β and radiation depends on p53.

Niemantsverdriet M, de Jong E, Langendijk JA, Kampinga HH, Coppes RP.

Radiother Oncol. 2010 Oct;97(1):33-5. doi: 10.1016/j.radonc.2010.04.002.


Quantifying local radiation-induced lung damage from computed tomography.

Ghobadi G, Hogeweg LE, Faber H, Tukker WG, Schippers JM, Brandenburg S, Langendijk JA, Coppes RP, van Luijk P.

Int J Radiat Oncol Biol Phys. 2010 Feb 1;76(2):548-56. doi: 10.1016/j.ijrobp.2009.08.058.


Isolation and characterization of human salivary gland cells for stem cell transplantation to reduce radiation-induced hyposalivation.

Feng J, van der Zwaag M, Stokman MA, van Os R, Coppes RP.

Radiother Oncol. 2009 Sep;92(3):466-71. doi: 10.1016/j.radonc.2009.06.023. Epub 2009 Jul 20.


Bath and shower effects in the rat parotid gland explain increased relative risk of parotid gland dysfunction after intensity-modulated radiotherapy.

van Luijk P, Faber H, Schippers JM, Brandenburg S, Langendijk JA, Meertens H, Coppes RP.

Int J Radiat Oncol Biol Phys. 2009 Jul 15;74(4):1002-5. doi: 10.1016/j.ijrobp.2009.03.039.


Radiation Therapy Oncology Group translational research program stem cell symposium: incorporating stem cell hypotheses into clinical trials.

Woodward WA, Bristow RG, Clarke MF, Coppes RP, Cristofanilli M, Duda DG, Fike JR, Hambardzumyan D, Hill RP, Jordan CT, Milas L, Pajonk F, Curran WJ, Dicker AP, Chen Y.

Int J Radiat Oncol Biol Phys. 2009 Aug 1;74(5):1580-91. doi: 10.1016/j.ijrobp.2009.03.047. Epub 2009 Jun 17.


Stem cell therapy to reduce radiation-induced normal tissue damage.

Coppes RP, van der Goot A, Lombaert IM.

Semin Radiat Oncol. 2009 Apr;19(2):112-21. doi: 10.1016/j.semradonc.2008.11.005. Review.


Enhanced proliferation of acinar and progenitor cells by prophylactic pilocarpine treatment underlies the observed amelioration of radiation injury to parotid glands.

Burlage FR, Faber H, Kampinga HH, Langendijk JA, Vissink A, Coppes RP.

Radiother Oncol. 2009 Feb;90(2):253-6. doi: 10.1016/j.radonc.2008.11.011. Epub 2009 Jan 10.


Cytokine treatment improves parenchymal and vascular damage of salivary glands after irradiation.

Lombaert IM, Brunsting JF, Wierenga PK, Kampinga HH, de Haan G, Coppes RP.

Clin Cancer Res. 2008 Dec 1;14(23):7741-50. doi: 10.1158/1078-0432.CCR-08-1449.

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