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Impaired folate one-carbon metabolism causes formate-preventable hydrocephalus in glycine decarboxylase-deficient mice.

Santos C, Pai YJ, Mahmood MR, Leung KY, Savery D, Waddington SN, Copp AJ, Greene N.

J Clin Invest. 2019 Dec 3. pii: 132360. doi: 10.1172/JCI132360. [Epub ahead of print]


Refinement of inducible gene deletion in embryos of pregnant mice.

Savery D, Maniou E, Culshaw LH, Greene NDE, Copp AJ, Galea GL.

Birth Defects Res. 2019 Dec 3. doi: 10.1002/bdr2.1628. [Epub ahead of print]


Dynamic acetylation profile during mammalian neurulation.

Massa V, Avagliano L, Grazioli P, De Castro SCP, Parodi C, Savery D, Vergani P, Cuttin S, Doi P, Bulfamante G, Copp AJ, Greene NDE.

Birth Defects Res. 2019 Nov 23. doi: 10.1002/bdr2.1618. [Epub ahead of print]


Cellular mechanisms underlying Pax3-related neural tube defects and their prevention by folic acid.

Sudiwala S, Palmer A, Massa V, Burns AJ, Dunlevy LPE, de Castro SCP, Savery D, Leung KY, Copp AJ, Greene NDE.

Dis Model Mech. 2019 Nov 22;12(11). pii: dmm042234. doi: 10.1242/dmm.042234.


Novel mouse model of encephalocele: post-neurulation origin and relationship to open neural tube defects.

Rolo A, Galea GL, Savery D, Greene NDE, Copp AJ.

Dis Model Mech. 2019 Nov 14;12(11). pii: dmm040683. doi: 10.1242/dmm.040683.


Mouse whole embryo culture: Evaluating the requirement for rat serum as culture medium.

Culshaw LH, Savery D, Greene NDE, Copp AJ.

Birth Defects Res. 2019 Oct 1;111(16):1165-1177. doi: 10.1002/bdr2.1538. Epub 2019 Jun 24.


Rho kinase-dependent apical constriction counteracts M-phase apical expansion to enable mouse neural tube closure.

Butler MB, Short NE, Maniou E, Alexandre P, Greene NDE, Copp AJ, Galea GL.

J Cell Sci. 2019 Jul 1;132(13). pii: jcs230300. doi: 10.1242/jcs.230300.


Spinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by Grhl2.

Nikolopoulou E, Hirst CS, Galea G, Venturini C, Moulding D, Marshall AR, Rolo A, De Castro SCP, Copp AJ, Greene NDE.

Nat Commun. 2019 Jun 6;10(1):2487. doi: 10.1038/s41467-019-10164-6.


Association of Functional Screening Tests and Noncontact Injuries in Division I Women Student-Athletes.

Warren M, Lininger MR, Smith CA, Copp AJ, Chimera NJ.

J Strength Cond Res. 2019 Feb 7. doi: 10.1519/JSC.0000000000003004. [Epub ahead of print]


Overexpression of Grainyhead-like 3 causes spina bifida and interacts genetically with mutant alleles of Grhl2 and Vangl2 in mice.

De Castro SCP, Gustavsson P, Marshall AR, Gordon WM, Galea G, Nikolopoulou E, Savery D, Rolo A, Stanier P, Andersen B, Copp AJ, Greene NDE.

Hum Mol Genet. 2018 Dec 15;27(24):4218-4230. doi: 10.1093/hmg/ddy313.


Vangl2 disruption alters the biomechanics of late spinal neurulation leading to spina bifida in mouse embryos.

Galea GL, Nychyk O, Mole MA, Moulding D, Savery D, Nikolopoulou E, Henderson DJ, Greene NDE, Copp AJ.

Dis Model Mech. 2018 Mar 21;11(3). pii: dmm032219. doi: 10.1242/dmm.032219.


Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice.

Orriss IR, Lanham S, Savery D, Greene NDE, Stanier P, Oreffo R, Copp AJ, Galea GL.

Sci Rep. 2018 Feb 20;8(1):3325. doi: 10.1038/s41598-018-21718-x.


Neural tube closure depends on expression of Grainyhead-like 3 in multiple tissues.

De Castro SCP, Hirst CS, Savery D, Rolo A, Lickert H, Andersen B, Copp AJ, Greene NDE.

Dev Biol. 2018 Mar 15;435(2):130-137. doi: 10.1016/j.ydbio.2018.01.016. Epub 2018 Feb 2.


Valproic acid disrupts the biomechanics of late spinal neural tube closure in mouse embryos.

Hughes A, Greene NDE, Copp AJ, Galea GL.

Mech Dev. 2018 Feb;149:20-26. doi: 10.1016/j.mod.2017.12.001. Epub 2017 Dec 7.


A targeted sequencing panel identifies rare damaging variants in multiple genes in the cranial neural tube defect, anencephaly.

Ishida M, Cullup T, Boustred C, James C, Docker J, English C; GOSgene, Lench N, Copp AJ, Moore GE, Greene NDE, Stanier P.

Clin Genet. 2018 Apr;93(4):870-879. doi: 10.1111/cge.13189. Epub 2018 Feb 11.


Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure.

Leung KY, Pai YJ, Chen Q, Santos C, Calvani E, Sudiwala S, Savery D, Ralser M, Gross SS, Copp AJ, Greene NDE.

Cell Rep. 2017 Nov 14;21(7):1795-1808. doi: 10.1016/j.celrep.2017.10.072.


Infectious causes of microcephaly: epidemiology, pathogenesis, diagnosis, and management.

Devakumar D, Bamford A, Ferreira MU, Broad J, Rosch RE, Groce N, Breuer J, Cardoso MA, Copp AJ, Alexandre P, Rodrigues LC, Abubakar I.

Lancet Infect Dis. 2018 Jan;18(1):e1-e13. doi: 10.1016/S1473-3099(17)30398-5. Epub 2017 Aug 30. Review.


Biomechanical coupling facilitates spinal neural tube closure in mouse embryos.

Galea GL, Cho YJ, Galea G, Molè MA, Rolo A, Savery D, Moulding D, Culshaw LH, Nikolopoulou E, Greene NDE, Copp AJ.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5177-E5186. doi: 10.1073/pnas.1700934114. Epub 2017 Jun 12.


Neural tube closure: cellular, molecular and biomechanical mechanisms.

Nikolopoulou E, Galea GL, Rolo A, Greene ND, Copp AJ.

Development. 2017 Feb 15;144(4):552-566. doi: 10.1242/dev.145904. Review.


Perturbation of Retinoid Homeostasis Increases Malformation Risk in Embryos Exposed to Pregestational Diabetes.

Lee LM, Leung MB, Kwok RC, Leung YC, Wang CC, McCaffery PJ, Copp AJ, Shum AS.

Diabetes. 2017 Apr;66(4):1041-1051. doi: 10.2337/db15-1570. Epub 2017 Jan 13.


Use of high-frequency ultrasound to study the prenatal development of cranial neural tube defects and hydrocephalus in Gldc-deficient mice.

Autuori MC, Pai YJ, Stuckey DJ, Savery D, Marconi AM, Massa V, Lythgoe MF, Copp AJ, David AL, Greene ND.

Prenat Diagn. 2017 Mar;37(3):273-281. doi: 10.1002/pd.5004. Epub 2017 Feb 17.


HDBR Expression: A Unique Resource for Global and Individual Gene Expression Studies during Early Human Brain Development.

Lindsay SJ, Xu Y, Lisgo SN, Harkin LF, Copp AJ, Gerrelli D, Clowry GJ, Talbot A, Keogh MJ, Coxhead J, Santibanez-Koref M, Chinnery PF.

Front Neuroanat. 2016 Oct 26;10:86. eCollection 2016. No abstract available.


Rho GTPases in mammalian spinal neural tube closure.

Rolo A, Escuin S, Greene NDE, Copp AJ.

Small GTPases. 2018 Jul 4;9(4):283-289. doi: 10.1080/21541248.2016.1235388. Epub 2016 Oct 21. Review.


Inositol, neural tube closure and the prevention of neural tube defects.

Greene ND, Leung KY, Copp AJ.

Birth Defects Res. 2017 Jan 30;109(2):68-80. doi: 10.1002/bdra.23533. Review.


Regulation of cell protrusions by small GTPases during fusion of the neural folds.

Rolo A, Savery D, Escuin S, de Castro SC, Armer HE, Munro PM, Molè MA, Greene ND, Copp AJ.

Elife. 2016 Apr 26;5:e13273. doi: 10.7554/eLife.13273.


Microtubules, polarity and vertebrate neural tube morphogenesis.

Cearns MD, Escuin S, Alexandre P, Greene ND, Copp AJ.

J Anat. 2016 Jul;229(1):63-74. doi: 10.1111/joa.12468. Epub 2016 Mar 29. Review.


Formate supplementation enhances folate-dependent nucleotide biosynthesis and prevents spina bifida in a mouse model of folic acid-resistant neural tube defects.

Sudiwala S, De Castro SC, Leung KY, Brosnan JT, Brosnan ME, Mills K, Copp AJ, Greene ND.

Biochimie. 2016 Jul;126:63-70. doi: 10.1016/j.biochi.2016.02.010. Epub 2016 Feb 23.


Inositol for prevention of neural tube defects: a pilot randomised controlled trial - CORRIGENDUM.

Greene ND, Leung KY, Gay V, Burren K, Mills K, Chitty LS, Copp AJ.

Br J Nutr. 2016 May;115(9):1697. doi: 10.1017/S0007114516000659. Epub 2016 Feb 26. No abstract available.


Inositol for the prevention of neural tube defects: a pilot randomised controlled trial.

Greene ND, Leung KY, Gay V, Burren K, Mills K, Chitty LS, Copp AJ.

Br J Nutr. 2016 Mar 28;115(6):974-83. doi: 10.1017/S0007114515005322. Epub 2016 Feb 5. Erratum in: Br J Nutr. 2016 May;115(9):1697.


Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion.

Quétier I, Marshall JJT, Spencer-Dene B, Lachmann S, Casamassima A, Franco C, Escuin S, Worrall JT, Baskaran P, Rajeeve V, Howell M, Copp AJ, Stamp G, Rosewell I, Cutillas P, Gerhardt H, Parker PJ, Cameron AJM.

Cell Rep. 2016 Jan 26;14(3):440-448. doi: 10.1016/j.celrep.2015.12.049. Epub 2016 Jan 7.


Enabling research with human embryonic and fetal tissue resources.

Gerrelli D, Lisgo S, Copp AJ, Lindsay S.

Development. 2015 Sep 15;142(18):3073-6. doi: 10.1242/dev.122820.


Cellular basis of neuroepithelial bending during mouse spinal neural tube closure.

McShane SG, Molè MA, Savery D, Greene ND, Tam PP, Copp AJ.

Dev Biol. 2015 Aug 15;404(2):113-24. doi: 10.1016/j.ydbio.2015.06.003. Epub 2015 Jun 12.


Rho-kinase-dependent actin turnover and actomyosin disassembly are necessary for mouse spinal neural tube closure.

Escuin S, Vernay B, Savery D, Gurniak CB, Witke W, Greene ND, Copp AJ.

J Cell Sci. 2015 Jul 15;128(14):2468-81. doi: 10.1242/jcs.164574. Epub 2015 Jun 3.


Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice.

Pai YJ, Leung KY, Savery D, Hutchin T, Prunty H, Heales S, Brosnan ME, Brosnan JT, Copp AJ, Greene ND.

Nat Commun. 2015 Mar 4;6:6388. doi: 10.1038/ncomms7388.


Spina bifida.

Copp AJ, Adzick NS, Chitty LS, Fletcher JM, Holmbeck GN, Shaw GM.

Nat Rev Dis Primers. 2015 Apr 30;1:15007. doi: 10.1038/nrdp.2015.7. Review.


Planar cell polarity aligns osteoblast division in response to substrate strain.

Galea GL, Meakin LB, Savery D, Taipaleenmaki H, Delisser P, Stein GS, Copp AJ, van Wijnen AJ, Lanyon LE, Price JS.

J Bone Miner Res. 2015 Mar;30(3):423-35. doi: 10.1002/jbmr.2377.


Genetic interactions between planar cell polarity genes cause diverse neural tube defects in mice.

Murdoch JN, Damrau C, Paudyal A, Bogani D, Wells S, Greene ND, Stanier P, Copp AJ.

Dis Model Mech. 2014 Oct;7(10):1153-63. doi: 10.1242/dmm.016758. Epub 2014 Aug 15.


Vangl-dependent planar cell polarity signalling is not required for neural crest migration in mammals.

Pryor SE, Massa V, Savery D, Andre P, Yang Y, Greene ND, Copp AJ.

Development. 2014 Aug;141(16):3153-8. doi: 10.1242/dev.111427. Epub 2014 Jul 18.


Neural tube defects.

Greene ND, Copp AJ.

Annu Rev Neurosci. 2014;37:221-42. doi: 10.1146/annurev-neuro-062012-170354. Review.


Diffusion microscopic MRI of the mouse embryo: Protocol and practical implementation in the splotch mouse model.

Norris FC, Siow BM, Cleary JO, Wells JA, De Castro SC, Ordidge RJ, Greene ND, Copp AJ, Scambler PJ, Alexander DC, Lythgoe MF.

Magn Reson Med. 2015 Feb;73(2):731-9. doi: 10.1002/mrm.25145. Epub 2014 Mar 13.


Planar cell polarity and the kidney.

Papakrivopoulou E, Dean CH, Copp AJ, Long DA.

Nephrol Dial Transplant. 2014 Jul;29(7):1320-6. doi: 10.1093/ndt/gft484. Epub 2013 Nov 28. Review.


Novel exomphalos genetic mouse model: the importance of accurate phenotypic classification.

Carnaghan H, Roberts T, Savery D, Norris FC, McCann CJ, Copp AJ, Scambler PJ, Lythgoe MF, Greene ND, Decoppi P, Burns AJ, Pierro A, Eaton S.

J Pediatr Surg. 2013 Oct;48(10):2036-42. doi: 10.1016/j.jpedsurg.2013.04.010.


Neural tube defects--disorders of neurulation and related embryonic processes.

Copp AJ, Greene ND.

Wiley Interdiscip Rev Dev Biol. 2013 Mar-Apr;2(2):213-27. doi: 10.1002/wdev.71. Epub 2012 May 29. Review.


Nucleotide precursors prevent folic acid-resistant neural tube defects in the mouse.

Leung KY, De Castro SC, Savery D, Copp AJ, Greene ND.

Brain. 2013 Sep;136(Pt 9):2836-41. doi: 10.1093/brain/awt209. Epub 2013 Aug 8.


Knowledge and periconceptional use of folic acid for the prevention of neural tube defects in ethnic communities in the United Kingdom: systematic review and meta-analysis.

Peake JN, Copp AJ, Shawe J.

Birth Defects Res A Clin Mol Teratol. 2013 Jul;97(7):444-51. doi: 10.1002/bdra.23154. Review.


Neural tube defects: recent advances, unsolved questions, and controversies.

Copp AJ, Stanier P, Greene ND.

Lancet Neurol. 2013 Aug;12(8):799-810. doi: 10.1016/S1474-4422(13)70110-8. Epub 2013 Jun 19. Review.


Syndecan 4 interacts genetically with Vangl2 to regulate neural tube closure and planar cell polarity.

Escobedo N, Contreras O, Muñoz R, Farías M, Carrasco H, Hill C, Tran U, Pryor SE, Wessely O, Copp AJ, Larraín J.

Development. 2013 Jul;140(14):3008-17. doi: 10.1242/dev.091173. Epub 2013 Jun 12.


Is LMNB1 a susceptibility gene for neural tube defects in humans?

Robinson A, Partridge D, Malhas A, De Castro SC, Gustavsson P, Thompson DN, Vaux DJ, Copp AJ, Stanier P, Bassuk AG, Greene ND.

Birth Defects Res A Clin Mol Teratol. 2013 Jun;97(6):398-402. doi: 10.1002/bdra.23141. Epub 2013 Jun 3.


Deciphering the Mechanisms of Developmental Disorders (DMDD): a new programme for phenotyping embryonic lethal mice.

Mohun T, Adams DJ, Baldock R, Bhattacharya S, Copp AJ, Hemberger M, Houart C, Hurles ME, Robertson E, Smith JC, Weaver T, Weninger W.

Dis Model Mech. 2013 May;6(3):562-6. doi: 10.1242/dmm.011957. Epub 2013 Mar 18.

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