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Items: 47


Ensemble of Convolutional Neural Networks Improves Automated Segmentation of Acute Ischemic Lesions Using Multiparametric Diffusion-Weighted MRI.

Winzeck S, Mocking SJT, Bezerra R, Bouts MJRJ, McIntosh EC, Diwan I, Garg P, Chutinet A, Kimberly WT, Copen WA, Schaefer PW, Ay H, Singhal AB, Kamnitsas K, Glocker B, Sorensen AG, Wu O.

AJNR Am J Neuroradiol. 2019 Jun;40(6):938-945. doi: 10.3174/ajnr.A6077. Epub 2019 May 30.


White Matter Integrity and Early Outcomes After Acute Ischemic Stroke.

Etherton MR, Wu O, Giese AK, Lauer A, Boulouis G, Mills B, Cloonan L, Donahue KL, Copen W, Schaefer P, Rost NS.

Transl Stroke Res. 2019 Jan 28. doi: 10.1007/s12975-019-0689-4. [Epub ahead of print]


Intravenous thrombolysis in unwitnessed stroke onset: MR WITNESS trial results.

Schwamm LH, Wu O, Song SS, Latour LL, Ford AL, Hsia AW, Muzikansky A, Betensky RA, Yoo AJ, Lev MH, Boulouis G, Lauer A, Cougo P, Copen WA, Harris GJ, Warach S; MR WITNESS Investigators.

Ann Neurol. 2018 May;83(5):980-993. doi: 10.1002/ana.25235. Epub 2018 Apr 27.


In patients with suspected acute stroke, CT perfusion-based cerebral blood flow maps cannot substitute for DWI in measuring the ischemic core.

Copen WA, Yoo AJ, Rost NS, Morais LT, Schaefer PW, González RG, Wu O.

PLoS One. 2017 Nov 30;12(11):e0188891. doi: 10.1371/journal.pone.0188891. eCollection 2017.


Diffuse microvascular dysfunction and loss of white matter integrity predict poor outcomes in patients with acute ischemic stroke.

Rost NS, Cougo P, Lorenzano S, Li H, Cloonan L, Bouts MJ, Lauer A, Etherton MR, Karadeli HH, Musolino PL, Copen WA, Arai K, Lo EH, Feske SK, Furie KL, Wu O.

J Cereb Blood Flow Metab. 2018 Jan;38(1):75-86. doi: 10.1177/0271678X17706449. Epub 2017 May 8.


Case 13-2017. A 41-Year-Old Man with Hearing Loss, Seizures, Weakness, and Cognitive Decline.

Reda HM, Copen WA, Karaa A, Oakley DH.

N Engl J Med. 2017 Apr 27;376(17):1668-1678. doi: 10.1056/NEJMcpc1616022. No abstract available.


Brain perfusion: computed tomography and magnetic resonance techniques.

Copen WA, Lev MH, Rapalino O.

Handb Clin Neurol. 2016;135:117-135. doi: 10.1016/B978-0-444-53485-9.00006-4. Review.


Diffusion tensor imaging in acute-to-subacute traumatic brain injury: a longitudinal analysis.

Edlow BL, Copen WA, Izzy S, Bakhadirov K, van der Kouwe A, Glenn MB, Greenberg SM, Greer DM, Wu O.

BMC Neurol. 2016 Jan 11;16:2. doi: 10.1186/s12883-015-0525-8.


Longitudinal Diffusion Tensor Imaging Detects Recovery of Fractional Anisotropy Within Traumatic Axonal Injury Lesions.

Edlow BL, Copen WA, Izzy S, van der Kouwe A, Glenn MB, Greenberg SM, Greer DM, Wu O.

Neurocrit Care. 2016 Jun;24(3):342-52. doi: 10.1007/s12028-015-0216-8.


Comparing prognostic strength of acute corticospinal tract injury measured by a new diffusion tensor imaging based template approach versus common approaches.

Hirai KK, Groisser BN, Copen WA, Singhal AB, Schaechter JD.

J Neurosci Methods. 2016 Jan 15;257:204-13. doi: 10.1016/j.jneumeth.2015.09.005. Epub 2015 Sep 16.


Role of Acute Lesion Topography in Initial Ischemic Stroke Severity and Long-Term Functional Outcomes.

Wu O, Cloonan L, Mocking SJ, Bouts MJ, Copen WA, Cougo-Pinto PT, Fitzpatrick K, Kanakis A, Schaefer PW, Rosand J, Furie KL, Rost NS.

Stroke. 2015 Sep;46(9):2438-44. doi: 10.1161/STROKEAHA.115.009643. Epub 2015 Jul 21.


In Acute Stroke, Can CT Perfusion-Derived Cerebral Blood Volume Maps Substitute for Diffusion-Weighted Imaging in Identifying the Ischemic Core?

Copen WA, Morais LT, Wu O, Schwamm LH, Schaefer PW, González RG, Yoo AJ.

PLoS One. 2015 Jul 20;10(7):e0133566. doi: 10.1371/journal.pone.0133566. eCollection 2015.


Multimodal imaging in acute ischemic stroke.

Copen WA.

Curr Treat Options Cardiovasc Med. 2015 Mar;17(3):368. doi: 10.1007/s11936-015-0368-z.


Exposing hidden truncation-related errors in acute stroke perfusion imaging.

Copen WA, Deipolyi AR, Schaefer PW, Schwamm LH, González RG, Wu O.

AJNR Am J Neuroradiol. 2015 Apr;36(4):638-45. doi: 10.3174/ajnr.A4186. Epub 2014 Dec 11.


Optimal brain MRI protocol for new neurological complaint.

Mehan WA Jr, González RG, Buchbinder BR, Chen JW, Copen WA, Gupta R, Hirsch JA, Hunter GJ, Hunter S, Johnson JM, Kelly HR, Larvie M, Lev MH, Pomerantz SR, Rapalino O, Rincon S, Romero JM, Schaefer PW, Shah V.

PLoS One. 2014 Oct 24;9(10):e110803. doi: 10.1371/journal.pone.0110803. eCollection 2014.


Combining MRI with NIHSS thresholds to predict outcome in acute ischemic stroke: value for patient selection.

Schaefer PW, Pulli B, Copen WA, Hirsch JA, Leslie-Mazwi T, Schwamm LH, Wu O, González RG, Yoo AJ.

AJNR Am J Neuroradiol. 2015 Feb;36(2):259-64. doi: 10.3174/ajnr.A4103. Epub 2014 Sep 25.


Time and diffusion lesion size in major anterior circulation ischemic strokes.

Hakimelahi R, Vachha BA, Copen WA, Papini GD, He J, Higazi MM, Lev MH, Schaefer PW, Yoo AJ, Schwamm LH, González RG.

Stroke. 2014 Oct;45(10):2936-41. doi: 10.1161/STROKEAHA.114.005644. Epub 2014 Sep 4.


Corticospinal tract diffusion abnormalities early after stroke predict motor outcome.

Groisser BN, Copen WA, Singhal AB, Hirai KK, Schaechter JD.

Neurorehabil Neural Repair. 2014 Oct;28(8):751-60. doi: 10.1177/1545968314521896. Epub 2014 Feb 11. Erratum in: Neurorehabil Neural Repair. 2015 Mar-Apr;29(3):296.


Improving door-to-needle times: a single center validation of the target stroke hypothesis.

Ruff IM, Ali SF, Goldstein JN, Lev M, Copen WA, McIntyre J, Rost NS, Schwamm LH.

Stroke. 2014 Feb;45(2):504-8. doi: 10.1161/STROKEAHA.113.004073. Epub 2014 Jan 7.


Acute Stroke Imaging Research Roadmap II.

Wintermark M, Albers GW, Broderick JP, Demchuk AM, Fiebach JB, Fiehler J, Grotta JC, Houser G, Jovin TG, Lees KR, Lev MH, Liebeskind DS, Luby M, Muir KW, Parsons MW, von Kummer R, Wardlaw JM, Wu O, Yoo AJ, Alexandrov AV, Alger JR, Aviv RI, Bammer R, Baron JC, Calamante F, Campbell BC, Carpenter TC, Christensen S, Copen WA, Derdeyn CP, Haley EC Jr, Khatri P, Kudo K, Lansberg MG, Latour LL, Lee TY, Leigh R, Lin W, Lyden P, Mair G, Menon BK, Michel P, Mikulik R, Nogueira RG, Ostergaard L, Pedraza S, Riedel CH, Rowley HA, Sanelli PC, Sasaki M, Saver JL, Schaefer PW, Schellinger PD, Tsivgoulis G, Wechsler LR, White PM, Zaharchuk G, Zaidat OO, Davis SM, Donnan GA, Furlan AJ, Hacke W, Kang DW, Kidwell C, Thijs VN, Thomalla G, Warach SJ; Stroke Imaging Research (STIR) and Virtual International Stroke Trials Archive (VISTA)-Imaging Investigators.

Stroke. 2013 Sep;44(9):2628-39. doi: 10.1161/STROKEAHA.113.002015. Epub 2013 Jul 16. Review. No abstract available.


The Massachusetts General Hospital acute stroke imaging algorithm: an experience and evidence based approach.

González RG, Copen WA, Schaefer PW, Lev MH, Pomerantz SR, Rapalino O, Chen JW, Hunter GJ, Romero JM, Buchbinder BR, Larvie M, Hirsch JA, Gupta R.

J Neurointerv Surg. 2013 May;5 Suppl 1:i7-12. doi: 10.1136/neurintsurg-2013-010715. Epub 2013 Mar 14. Review.


Dynamic contrast-enhanced MRA at 1.5 T for detection of arteriovenous shunting before and after Onyx embolization of cerebral arteriovenous malformations.

Nogueira RG, Bayrlee A, Hirsch JA, Yoo AJ, Copen WA.

J Neuroimaging. 2013 Oct;23(4):514-7. doi: 10.1111/j.1552-6569.2012.00780.x. Epub 2013 Jan 14.


Reliability of cerebral blood volume maps as a substitute for diffusion-weighted imaging in acute ischemic stroke.

Deipolyi AR, Wu O, Macklin EA, Schaefer PW, Schwamm LH, Gilberto Gonzalez R, Copen WA.

J Magn Reson Imaging. 2012 Nov;36(5):1083-7. doi: 10.1002/jmri.23740. Epub 2012 Jul 3.


Comparison of wideband steady-state free precession and T₂-weighted fast spin echo in spine disorder assessment at 1.5 and 3 T.

Danagoulian GS, Qin L, Nayak KS, Colen RR, Mukundan S Jr, Harris MB, Jolesz FA, Shankaranarayanan A, Copen WA, Schmidt EJ.

Magn Reson Med. 2012 Nov;68(5):1527-35. doi: 10.1002/mrm.24163. Epub 2012 Jan 27.


MR perfusion imaging in acute ischemic stroke.

Copen WA, Schaefer PW, Wu O.

Neuroimaging Clin N Am. 2011 May;21(2):259-83, x. doi: 10.1016/j.nic.2011.02.007. Review.


Time-resolved contrast-enhanced magnetic resonance angiography in the investigation of suspected intracranial dural arteriovenous fistula.

Schanker BD, Walcott BP, Nahed BV, Ogilvy CS, Kiruluta AJ, Rabinov JD, Copen WA.

J Clin Neurosci. 2011 Jun;18(6):837-9. doi: 10.1016/j.jocn.2010.12.003. Epub 2011 Apr 19.


Cerebral blood flow thresholds for tissue infarction in patients with acute ischemic stroke treated with intra-arterial revascularization therapy depend on timing of reperfusion.

Mui K, Yoo AJ, Verduzco L, Copen WA, Hirsch JA, González RG, Schaefer PW.

AJNR Am J Neuroradiol. 2011 May;32(5):846-51. doi: 10.3174/ajnr.A2415. Epub 2011 Apr 7.


Outcome in patients with H1N1 influenza and cerebrovascular injury treated with extracorporeal membrane oxygenation.

Chow FC, Edlow BL, Frosch MP, Copen WA, Greer DM.

Neurocrit Care. 2011 Aug;15(1):156-60. doi: 10.1007/s12028-011-9534-7.


Early experience of translating pH-weighted MRI to image human subjects at 3 Tesla.

Sun PZ, Benner T, Copen WA, Sorensen AG.

Stroke. 2010 Oct;41(10 Suppl):S147-51. doi: 10.1161/STROKEAHA.110.595777.


Combining acute diffusion-weighted imaging and mean transmit time lesion volumes with National Institutes of Health Stroke Scale Score improves the prediction of acute stroke outcome.

Yoo AJ, Barak ER, Copen WA, Kamalian S, Gharai LR, Pervez MA, Schwamm LH, González RG, Schaefer PW.

Stroke. 2010 Aug;41(8):1728-35. doi: 10.1161/STROKEAHA.110.582874. Epub 2010 Jul 1.


Posterior circulation stroke after C1-C2 intraarticular facet steroid injection: evidence for diffuse microvascular injury.

Edlow BL, Wainger BJ, Frosch MP, Copen WA, Rathmell JP, Rost NS.

Anesthesiology. 2010 Jun;112(6):1532-5. doi: 10.1097/ALN.0b013e3181d7b15a. No abstract available.


Case records of the Massachusetts General Hospital. Case 9-2010. A 37-year-old woman with paresthesias and ataxia.

Pless ML, Chen YB, Copen WA, Frosch MP.

N Engl J Med. 2010 Mar 25;362(12):1129-38. doi: 10.1056/NEJMcpc0910092. No abstract available.


Case Records of the Massachusetts General Hospital. Case 38-2009 - a 16-year-old boy with paroxysmal headaches and visual changes.

Brass SD, Dinkin MJ, Williams Z, Krishnamoorthy KS, Copen WA, Freeman SH.

N Engl J Med. 2009 Dec 10;361(24):2367-78. doi: 10.1056/NEJMcpc0905547. No abstract available.


Case records of the Massachusetts General Hospital. Case 12-2009. A 46-year-old man with migraine, aphasia, and hemiparesis and similarly affected family members.

Brass SD, Smith EE, Arboleda-Velasquez JF, Copen WA, Frosch MP.

N Engl J Med. 2009 Apr 16;360(16):1656-65. doi: 10.1056/NEJMcpc0810839. No abstract available.


Existence of the diffusion-perfusion mismatch within 24 hours after onset of acute stroke: dependence on proximal arterial occlusion.

Copen WA, Rezai Gharai L, Barak ER, Schwamm LH, Wu O, Kamalian S, Gonzalez RG, Schaefer PW.

Radiology. 2009 Mar;250(3):878-86. doi: 10.1148/radiol.2503080811. Epub 2009 Jan 21.


Neurological disorders in pregnancy from a neuroimaging perspective.

Brass SD, Copen WA.

Semin Neurol. 2007 Nov;27(5):411-24. Update in: Semin Neurol. 2011 Sep;31(4):361-73.


Diffusion-weighted imaging in acute stroke.

Schaefer PW, Copen WA, Lev MH, Gonzalez RG.

Magn Reson Imaging Clin N Am. 2006 May;14(2):141-68.


Diffusion-weighted imaging in acute stroke.

Schaefer PW, Copen WA, Lev MH, Gonzalez RG.

Neuroimaging Clin N Am. 2005 Aug;15(3):503-30, ix-x. Review.


Magnetic resonance perfusion-weighted imaging of acute cerebral infarction: effect of the calculation methods and underlying vasculopathy.

Yamada K, Wu O, Gonzalez RG, Bakker D, Østergaard L, Copen WA, Weisskoff RM, Rosen BR, Yagi K, Nishimura T, Sorensen AG.

Stroke. 2002 Jan;33(1):87-94.


Ischemic stroke: effects of etiology and patient age on the time course of the core apparent diffusion coefficient.

Copen WA, Schwamm LH, González RG, Wu O, Harmath CB, Schaefer PW, Koroshetz WJ, Sorensen AG.

Radiology. 2001 Oct;221(1):27-34.


Predicting tissue outcome in acute human cerebral ischemia using combined diffusion- and perfusion-weighted MR imaging.

Wu O, Koroshetz WJ, Ostergaard L, Buonanno FS, Copen WA, Gonzalez RG, Rordorf G, Rosen BR, Schwamm LH, Weisskoff RM, Sorensen AG.

Stroke. 2001 Apr;32(4):933-42.


Human acute cerebral ischemia: detection of changes in water diffusion anisotropy by using MR imaging.

Sorensen AG, Wu O, Copen WA, Davis TL, Gonzalez RG, Koroshetz WJ, Reese TG, Rosen BR, Wedeen VJ, Weisskoff RM.

Radiology. 1999 Sep;212(3):785-92.


Hyperacute stroke: simultaneous measurement of relative cerebral blood volume, relative cerebral blood flow, and mean tissue transit time.

Sorensen AG, Copen WA, Ostergaard L, Buonanno FS, Gonzalez RG, Rordorf G, Rosen BR, Schwamm LH, Weisskoff RM, Koroshetz WJ.

Radiology. 1999 Feb;210(2):519-27.


Diffusion- and perfusion-weighted imaging in vasospasm after subarachnoid hemorrhage.

Rordorf G, Koroshetz WJ, Copen WA, Gonzalez G, Yamada K, Schaefer PW, Schwamm LH, Ogilvy CS, Sorensen AG.

Stroke. 1999 Mar;30(3):599-605.


Time course of lesion development in patients with acute stroke: serial diffusion- and hemodynamic-weighted magnetic resonance imaging.

Schwamm LH, Koroshetz WJ, Sorensen AG, Wang B, Copen WA, Budzik R, Rordorf G, Buonanno FS, Schaefer PW, Gonzalez RG.

Stroke. 1998 Nov;29(11):2268-76.


Regional ischemia and ischemic injury in patients with acute middle cerebral artery stroke as defined by early diffusion-weighted and perfusion-weighted MRI.

Rordorf G, Koroshetz WJ, Copen WA, Cramer SC, Schaefer PW, Budzik RF Jr, Schwamm LH, Buonanno F, Sorensen AG, Gonzalez G.

Stroke. 1998 May;29(5):939-43.


Hyperacute stroke: evaluation with combined multisection diffusion-weighted and hemodynamically weighted echo-planar MR imaging.

Sorensen AG, Buonanno FS, Gonzalez RG, Schwamm LH, Lev MH, Huang-Hellinger FR, Reese TG, Weisskoff RM, Davis TL, Suwanwela N, Can U, Moreira JA, Copen WA, Look RB, Finklestein SP, Rosen BR, Koroshetz WJ.

Radiology. 1996 May;199(2):391-401.


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