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Items: 1 to 50 of 843

1.

CRISPR-Cas9-mediated gene knockout in intestinal tumor organoids provides functional validation for colorectal cancer driver genes.

Takeda H, Kataoka S, Nakayama M, Ali MAE, Oshima H, Yamamoto D, Park JW, Takegami Y, An T, Jenkins NA, Copeland NG, Oshima M.

Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15635-15644. doi: 10.1073/pnas.1904714116. Epub 2019 Jul 12.

PMID:
31300537
2.

Author Correction: A recellularized human colon model identifies cancer driver genes.

Chen HJ, Wei Z, Sun J, Bhattacharya A, Savage DJ, Serda R, Mackeyev Y, Curley SA, Bu P, Wang L, Chen S, Cohen-Gould L, Huang E, Shen X, Lipkin SM, Copeland NG, Jenkins NA, Shuler ML.

Nat Biotechnol. 2019 Jul;37(7):820. doi: 10.1038/s41587-019-0163-6.

PMID:
31160724
3.

The Roles of Initiating Truncal Mutations in Human Cancers: The Order of Mutations and Tumor Cell Type Matters.

Levine AJ, Jenkins NA, Copeland NG.

Cancer Cell. 2019 Jan 14;35(1):10-15. doi: 10.1016/j.ccell.2018.11.009. Review.

PMID:
30645969
4.

Molecular profiling of nonalcoholic fatty liver disease-associated hepatocellular carcinoma using SB transposon mutagenesis.

Kodama T, Yi J, Newberg JY, Tien JC, Wu H, Finegold MJ, Kodama M, Wei Z, Tamura T, Takehara T, Johnson RL, Jenkins NA, Copeland NG.

Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):E10417-E10426. doi: 10.1073/pnas.1808968115. Epub 2018 Oct 16.

5.

Asymptomatic Visceral Leishmania infantum Infection in US Soldiers Deployed to Iraq.

Mody RM, Lakhal-Naouar I, Sherwood JE, Koles NL, Shaw D, Bigley DP, Co EA, Copeland NK, Jagodzinski LL, Mukbel RM, Smiley RA, Duncan RC, Kamhawi S, Jeronimo SMB, DeFraites RF, Aronson NE.

Clin Infect Dis. 2019 May 30;68(12):2036-2044. doi: 10.1093/cid/ciy811.

PMID:
30239631
6.

Methicillin-Resistant Staphylococcus aureus as a Probable Cause of Antibiotic-Associated Enterocolitis.

Lane AB, Copeland NK, Onmus-Leone F, Lawler JV.

Case Rep Infect Dis. 2018 Aug 5;2018:3106305. doi: 10.1155/2018/3106305. eCollection 2018.

7.

Creation of a myosin Va-TAP-tagged mouse and identification of potential myosin Va-interacting proteins in the cerebellum.

Alexander CJ, Wagner W, Copeland NG, Jenkins NA, Hammer JA.

Cytoskeleton (Hoboken). 2018 Sep;75(9):395-409. doi: 10.1002/cm.21474.

PMID:
29979496
8.

SB Driver Analysis: a Sleeping Beauty cancer driver analysis framework for identifying and prioritizing experimentally actionable oncogenes and tumor suppressors.

Newberg JY, Black MA, Jenkins NA, Copeland NG, Mann KM, Mann MB.

Nucleic Acids Res. 2018 Sep 19;46(16):e94. doi: 10.1093/nar/gky450.

9.

Stability and Function of Hippocampal Mossy Fiber Synapses Depend on Bcl11b/Ctip2.

De Bruyckere E, Simon R, Nestel S, Heimrich B, Kätzel D, Egorov AV, Liu P, Jenkins NA, Copeland NG, Schwegler H, Draguhn A, Britsch S.

Front Mol Neurosci. 2018 Apr 5;11:103. doi: 10.3389/fnmol.2018.00103. eCollection 2018.

10.

Concurrent treatment of aplastic anemia/paroxysmal nocturnal hemoglobinuria syndrome with immunosuppressive therapy and eculizumab: a UK experience.

Griffin M, Kulasekararaj A, Gandhi S, Munir T, Richards S, Arnold L, Benson-Quarm N, Copeland N, Duggins I, Riley K, Hillmen P, Marsh J, Hill A.

Haematologica. 2018 Aug;103(8):e345-e347. doi: 10.3324/haematol.2017.183046. Epub 2018 Mar 15. No abstract available.

11.

p120-Catenin is an obligate haploinsufficient tumor suppressor in intestinal neoplasia.

Short SP, Kondo J, Smalley-Freed WG, Takeda H, Dohn MR, Powell AE, Carnahan RH, Washington MK, Tripathi M, Payne DM, Jenkins NA, Copeland NG, Coffey RJ, Reynolds AB.

J Clin Invest. 2017 Dec 1;127(12):4462-4476. doi: 10.1172/JCI77217. Epub 2017 Nov 13.

12.

SBCDDB: Sleeping Beauty Cancer Driver Database for gene discovery in mouse models of human cancers.

Newberg JY, Mann KM, Mann MB, Jenkins NA, Copeland NG.

Nucleic Acids Res. 2018 Jan 4;46(D1):D1011-D1017. doi: 10.1093/nar/gkx956.

13.

In vivo loss-of-function screens identify KPNB1 as a new druggable oncogene in epithelial ovarian cancer.

Kodama M, Kodama T, Newberg JY, Katayama H, Kobayashi M, Hanash SM, Yoshihara K, Wei Z, Tien JC, Rangel R, Hashimoto K, Mabuchi S, Sawada K, Kimura T, Copeland NG, Jenkins NA.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):E7301-E7310. doi: 10.1073/pnas.1705441114. Epub 2017 Aug 15.

14.

Identification of new tumor suppressor genes in triple-negative breast cancer.

Rangel R, Guzman-Rojas L, Kodama T, Kodama M, Newberg JY, Copeland NG, Jenkins NA.

Cancer Res. 2017 Jul 19. pii: canres.0785.2017. doi: 10.1158/0008-5472.CAN-17-0785. [Epub ahead of print]

PMID:
28724549
15.

Transposon insertional mutagenesis in mice identifies human breast cancer susceptibility genes and signatures for stratification.

Chen L, Jenjaroenpun P, Pillai AM, Ivshina AV, Ow GS, Efthimios M, Zhiqun T, Tan TZ, Lee SC, Rogers K, Ward JM, Mori S, Adams DJ, Jenkins NA, Copeland NG, Ban KH, Kuznetsov VA, Thiery JP.

Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):E2215-E2224. doi: 10.1073/pnas.1701512114. Epub 2017 Mar 1.

16.

Emerging Roles for Ciz1 in Cell Cycle Regulation and as a Driver of Tumorigenesis.

Pauzaite T, Thacker U, Tollitt J, Copeland NA.

Biomolecules. 2016 Dec 27;7(1). pii: E1. doi: 10.3390/biom7010001. Review.

17.

Transposon mutagenesis identifies genes that cooperate with mutant Pten in breast cancer progression.

Rangel R, Lee SC, Hon-Kim Ban K, Guzman-Rojas L, Mann MB, Newberg JY, Kodama T, McNoe LA, Selvanesan L, Ward JM, Rust AG, Chin KY, Black MA, Jenkins NA, Copeland NG.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7749-E7758. Epub 2016 Nov 14.

18.

KRAS-related proteins in pancreatic cancer.

Mann KM, Ying H, Juan J, Jenkins NA, Copeland NG.

Pharmacol Ther. 2016 Dec;168:29-42. doi: 10.1016/j.pharmthera.2016.09.003. Epub 2016 Sep 3. Review.

PMID:
27595930
19.

Analyzing tumor heterogeneity and driver genes in single myeloid leukemia cells with SBCapSeq.

Mann KM, Newberg JY, Black MA, Jones DJ, Amaya-Manzanares F, Guzman-Rojas L, Kodama T, Ward JM, Rust AG, van der Weyden L, Yew CC, Waters JL, Leung ML, Rogers K, Rogers SM, McNoe LA, Selvanesan L, Navin N, Jenkins NA, Copeland NG, Mann MB.

Nat Biotechnol. 2016 Sep;34(9):962-72. doi: 10.1038/nbt.3637. Epub 2016 Aug 1.

20.

A recellularized human colon model identifies cancer driver genes.

Chen HJ, Wei Z, Sun J, Bhattacharya A, Savage DJ, Serda R, Mackeyev Y, Curley SA, Bu P, Wang L, Chen S, Cohen-Gould L, Huang E, Shen X, Lipkin SM, Copeland NG, Jenkins NA, Shuler ML.

Nat Biotechnol. 2016 Aug;34(8):845-51. doi: 10.1038/nbt.3586. Epub 2016 Jul 11. Erratum in: Nat Biotechnol. 2019 Jul;37(7):820.

21.

Transposon mutagenesis identifies genes and cellular processes driving epithelial-mesenchymal transition in hepatocellular carcinoma.

Kodama T, Newberg JY, Kodama M, Rangel R, Yoshihara K, Tien JC, Parsons PH, Wu H, Finegold MJ, Copeland NG, Jenkins NA.

Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):E3384-93. doi: 10.1073/pnas.1606876113. Epub 2016 May 31.

22.

Two-Step Forward Genetic Screen in Mice Identifies Ral GTPase-Activating Proteins as Suppressors of Hepatocellular Carcinoma.

Kodama T, Bard-Chapeau EA, Newberg JY, Kodama M, Rangel R, Yoshihara K, Ward JM, Jenkins NA, Copeland NG.

Gastroenterology. 2016 Aug;151(2):324-337.e12. doi: 10.1053/j.gastro.2016.04.040. Epub 2016 May 10.

PMID:
27178121
23.

NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes.

Marriott AS, Vasieva O, Fang Y, Copeland NA, McLennan AG, Jones NJ.

PLoS One. 2016 May 4;11(5):e0154674. doi: 10.1371/journal.pone.0154674. eCollection 2016.

24.

Other sexually transmitted diseases chancroid and donovanosis.

Copeland NK, Decker CF.

Dis Mon. 2016 Aug;62(8):306-13. doi: 10.1016/j.disamonth.2016.03.016. Epub 2016 Apr 20. Review. No abstract available.

PMID:
27107782
25.

Sleeping Beauty transposon mutagenesis identifies genes that cooperate with mutant Smad4 in gastric cancer development.

Takeda H, Rust AG, Ward JM, Yew CC, Jenkins NA, Copeland NG.

Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2057-65. doi: 10.1073/pnas.1603223113. Epub 2016 Mar 22.

26.

Structure-function integrity of the adult hippocampus depends on the transcription factor Bcl11b/Ctip2.

Simon R, Baumann L, Fischer J, Seigfried FA, De Bruyckere E, Liu P, Jenkins NA, Copeland NG, Schwegler H, Britsch S.

Genes Brain Behav. 2016 Apr;15(4):405-19. doi: 10.1111/gbb.12287. Epub 2016 Mar 30.

27.

Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death.

Bouilloux F, Thireau J, Ventéo S, Farah C, Karam S, Dauvilliers Y, Valmier J, Copeland NG, Jenkins NA, Richard S, Marmigère F.

Elife. 2016 Feb 8;5. pii: e11627. doi: 10.7554/eLife.11627.

28.

An Adverse Drug Reaction to Trimethoprim-Sulfamethoxazole Revealing Primary HIV: A Case Report and Literature Review.

Meyer C, Behm N, Brown E, Copeland NK, Sklar MJ.

Case Rep Infect Dis. 2015;2015:691010. doi: 10.1155/2015/691010. Epub 2015 Dec 21.

29.

Cardiomyocyte-specific overexpression of the ubiquitin ligase Wwp1 contributes to reduction in Connexin 43 and arrhythmogenesis.

Basheer WA, Harris BS, Mentrup HL, Abreha M, Thames EL, Lea JB, Swing DA, Copeland NG, Jenkins NA, Price RL, Matesic LE.

J Mol Cell Cardiol. 2015 Nov;88:1-13. doi: 10.1016/j.yjmcc.2015.09.004. Epub 2015 Sep 16.

30.

Leishmaniasis: treatment updates and clinical practice guidelines review.

Copeland NK, Aronson NE.

Curr Opin Infect Dis. 2015 Oct;28(5):426-37. doi: 10.1097/QCO.0000000000000194. Review.

PMID:
26312442
31.

Functional features of EVI1 and EVI1Δ324 isoforms of MECOM gene in genome-wide transcription regulation and oncogenicity.

Sayadi A, Jeyakani J, Seet SH, Wei CL, Bourque G, Bard FA, Jenkins NA, Copeland NG, Bard-Chapeau EA.

Oncogene. 2016 May 5;35(18):2311-21. doi: 10.1038/onc.2015.286. Epub 2015 Aug 3.

PMID:
26234679
32.

Diadenosine 5', 5'''-P(1),P(4)-tetraphosphate (Ap4A) is synthesized in response to DNA damage and inhibits the initiation of DNA replication.

Marriott AS, Copeland NA, Cunningham R, Wilkinson MC, McLennan AG, Jones NJ.

DNA Repair (Amst). 2015 Sep;33:90-100. doi: 10.1016/j.dnarep.2015.06.008. Epub 2015 Jun 29.

PMID:
26204256
33.

Bcl11a (Ctip1) Controls Migration of Cortical Projection Neurons through Regulation of Sema3c.

Wiegreffe C, Simon R, Peschkes K, Kling C, Strehle M, Cheng J, Srivatsa S, Liu P, Jenkins NA, Copeland NG, Tarabykin V, Britsch S.

Neuron. 2015 Jul 15;87(2):311-25. doi: 10.1016/j.neuron.2015.06.023.

34.

Omental Infarction: An Unusual Cause of Left-Sided Abdominal Pain.

Walia R, Verma R, Copeland N, Goubeaux D, Pabby S, Khan R.

ACG Case Rep J. 2014 Jul 8;1(4):223-4. doi: 10.14309/crj.2014.60. eCollection 2014 Jul.

35.

Supramolecular assemblies underpin turnover of outer membrane proteins in bacteria.

Rassam P, Copeland NA, Birkholz O, Tóth C, Chavent M, Duncan AL, Cross SJ, Housden NG, Kaminska R, Seger U, Quinn DM, Garrod TJ, Sansom MS, Piehler J, Baumann CG, Kleanthous C.

Nature. 2015 Jul 16;523(7560):333-6. doi: 10.1038/nature14461. Epub 2015 Jun 10.

36.

The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development.

Yu Y, Wang C, Clare S, Wang J, Lee SC, Brandt C, Burke S, Lu L, He D, Jenkins NA, Copeland NG, Dougan G, Liu P.

J Exp Med. 2015 Jun 1;212(6):865-74. doi: 10.1084/jem.20142318. Epub 2015 May 11.

37.

Transposon mutagenesis identifies genetic drivers of Braf(V600E) melanoma.

Mann MB, Black MA, Jones DJ, Ward JM, Yew CC, Newberg JY, Dupuy AJ, Rust AG, Bosenberg MW, McMahon M, Print CG, Copeland NG, Jenkins NA.

Nat Genet. 2015 May;47(5):486-95. doi: 10.1038/ng.3275. Epub 2015 Apr 13.

38.

Cyclin-A-CDK2-mediated phosphorylation of CIZ1 blocks replisome formation and initiation of mammalian DNA replication.

Copeland NA, Sercombe HE, Wilson RH, Coverley D.

J Cell Sci. 2015 Apr 15;128(8):1518-27. doi: 10.1242/jcs.161919. Epub 2015 Mar 3.

39.

BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells.

Khaled WT, Choon Lee S, Stingl J, Chen X, Raza Ali H, Rueda OM, Hadi F, Wang J, Yu Y, Chin SF, Stratton M, Futreal A, Jenkins NA, Aparicio S, Copeland NG, Watson CJ, Caldas C, Liu P.

Nat Commun. 2015 Jan 9;6:5987. doi: 10.1038/ncomms6987.

40.

Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression.

Takeda H, Wei Z, Koso H, Rust AG, Yew CC, Mann MB, Ward JM, Adams DJ, Copeland NG, Jenkins NA.

Nat Genet. 2015 Feb;47(2):142-50. doi: 10.1038/ng.3175. Epub 2015 Jan 5.

PMID:
25559195
41.

Ciguatera fish poisoning in Hawai'i and the Pacific.

Copeland NK, Palmer WR, Bienfang PK.

Hawaii J Med Public Health. 2014 Nov;73(11 Suppl 2):24-7.

42.

Mutation of murine Sox4 untranslated regions results in partially penetrant perinatal lethality.

Wiles WG 4th, Mou Z, Du Y, Long AB, Scharer CD, Bilir B, Spyropoulos DD, Jenkins NA, Copeland NG, Martin WD, Moreno CS.

In Vivo. 2014 Sep-Oct;28(5):709-18.

43.

Sleeping Beauty mutagenesis: exploiting forward genetic screens for cancer gene discovery.

Mann MB, Jenkins NA, Copeland NG, Mann KM.

Curr Opin Genet Dev. 2014 Feb;24:16-22. doi: 10.1016/j.gde.2013.11.004. Epub 2013 Dec 20. Review.

PMID:
24657532
44.

Identification of FoxR2 as an oncogene in medulloblastoma.

Koso H, Tsuhako A, Lyons E, Ward JM, Rust AG, Adams DJ, Jenkins NA, Copeland NG, Watanabe S.

Cancer Res. 2014 Apr 15;74(8):2351-61. doi: 10.1158/0008-5472.CAN-13-1523. Epub 2014 Mar 5.

45.

Transposon insertional mutagenesis models of cancer.

Mann KM, Jenkins NA, Copeland NG, Mann MB.

Cold Spring Harb Protoc. 2014 Mar 1;2014(3):235-47. doi: 10.1101/pdb.top069849.

PMID:
24591685
46.

Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

Bard-Chapeau EA, Szumska D, Jacob B, Chua BQ, Chatterjee GC, Zhang Y, Ward JM, Urun F, Kinameri E, Vincent SD, Ahmed S, Bhattacharya S, Osato M, Perkins AS, Moore AW, Jenkins NA, Copeland NG.

PLoS One. 2014 Feb 27;9(2):e89397. doi: 10.1371/journal.pone.0089397. eCollection 2014.

47.

LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.

Smith S, Tripathi R, Goodings C, Cleveland S, Mathias E, Hardaway JA, Elliott N, Yi Y, Chen X, Downing J, Mullighan C, Swing DA, Tessarollo L, Li L, Love P, Jenkins NA, Copeland NG, Thompson MA, Du Y, Davé UP.

PLoS One. 2014 Jan 21;9(1):e85883. doi: 10.1371/journal.pone.0085883. eCollection 2014.

48.

Mycobacterium haemophilum Masquerading as Leprosy in a Renal Transplant Patient.

Copeland NK, Arora NS, Ferguson TM.

Case Rep Dermatol Med. 2013;2013:793127. doi: 10.1155/2013/793127. Epub 2013 Nov 28.

49.

Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model.

Bard-Chapeau EA, Nguyen AT, Rust AG, Sayadi A, Lee P, Chua BQ, New LS, de Jong J, Ward JM, Chin CK, Chew V, Toh HC, Abastado JP, Benoukraf T, Soong R, Bard FA, Dupuy AJ, Johnson RL, Radda GK, Chan EC, Wessels LF, Adams DJ, Jenkins NA, Copeland NG.

Nat Genet. 2014 Jan;46(1):24-32. doi: 10.1038/ng.2847. Epub 2013 Dec 8.

50.

Sleeping Beauty mutagenesis in a mouse medulloblastoma model defines networks that discriminate between human molecular subgroups.

Genovesi LA, Ng CG, Davis MJ, Remke M, Taylor MD, Adams DJ, Rust AG, Ward JM, Ban KH, Jenkins NA, Copeland NG, Wainwright BJ.

Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):E4325-34. doi: 10.1073/pnas.1318639110. Epub 2013 Oct 28.

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