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Items: 33


Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice.

López-Tello J, Pérez-García V, Khaira J, Kusinski LC, Cooper WN, Andreani A, Grant I, Fernández de Liger E, Lam BY, Hemberger M, Sandovici I, Constancia M, Sferruzzi-Perri AN.

Elife. 2019 Jun 26;8. pii: e45282. doi: 10.7554/eLife.45282.


Enhanced detection of circulating tumor DNA by fragment size analysis.

Mouliere F, Chandrananda D, Piskorz AM, Moore EK, Morris J, Ahlborn LB, Mair R, Goranova T, Marass F, Heider K, Wan JCM, Supernat A, Hudecova I, Gounaris I, Ros S, Jimenez-Linan M, Garcia-Corbacho J, Patel K, Østrup O, Murphy S, Eldridge MD, Gale D, Stewart GD, Burge J, Cooper WN, van der Heijden MS, Massie CE, Watts C, Corrie P, Pacey S, Brindle KM, Baird RD, Mau-Sørensen M, Parkinson CA, Smith CG, Brenton JD, Rosenfeld N.

Sci Transl Med. 2018 Nov 7;10(466). pii: eaat4921. doi: 10.1126/scitranslmed.aat4921.


Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p'-DDE.

Pestana D, Teixeira D, Meireles M, Marques C, Norberto S, Sá C, Fernandes VC, Correia-Sá L, Faria A, Guardão L, Guimarães JT, Cooper WN, Sandovici I, Domingues VF, Delerue-Matos C, Monteiro R, Constância M, Calhau C.

Sci Rep. 2017 Jun 1;7(1):2738. doi: 10.1038/s41598-017-02885-9.


Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets.

Sandovici I, Hammerle CM, Cooper WN, Smith NH, Tarry-Adkins JL, Dunmore BJ, Bauer J, Andrews SR, Yeo GS, Ozanne SE, Constância M.

Diabetologia. 2016 Mar;59(3):502-11. doi: 10.1007/s00125-015-3837-8. Epub 2015 Dec 23.


Impact on offspring methylation patterns of maternal gestational diabetes mellitus and intrauterine growth restraint suggest common genes and pathways linked to subsequent type 2 diabetes risk.

Quilter CR, Cooper WN, Cliffe KM, Skinner BM, Prentice PM, Nelson L, Bauer J, Ong KK, Constância M, Lowe WL, Affara NA, Dunger DB.

FASEB J. 2014 Nov;28(11):4868-79. doi: 10.1096/fj.14-255240. Epub 2014 Aug 21.


Maternal diet amplifies the hepatic aging trajectory of Cidea in male mice and leads to the development of fatty liver.

Carr SK, Chen JH, Cooper WN, Constância M, Yeo GS, Ozanne SE.

FASEB J. 2014 May;28(5):2191-201. doi: 10.1096/fj.13-242727. Epub 2014 Jan 30.


An obesogenic diet during mouse pregnancy modifies maternal nutrient partitioning and the fetal growth trajectory.

Sferruzzi-Perri AN, Vaughan OR, Haro M, Cooper WN, Musial B, Charalambous M, Pestana D, Ayyar S, Ferguson-Smith AC, Burton GJ, Constancia M, Fowden AL.

FASEB J. 2013 Oct;27(10):3928-37. doi: 10.1096/fj.13-234823. Epub 2013 Jun 27.


Periconceptional maternal micronutrient supplementation is associated with widespread gender related changes in the epigenome: a study of a unique resource in the Gambia.

Khulan B, Cooper WN, Skinner BM, Bauer J, Owens S, Prentice AM, Belteki G, Constancia M, Dunger D, Affara NA.

Hum Mol Genet. 2012 May 1;21(9):2086-101. doi: 10.1093/hmg/dds026. Epub 2012 Feb 3.


Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility.

Astuti D, Morris MR, Cooper WN, Staals RH, Wake NC, Fews GA, Gill H, Gentle D, Shuib S, Ricketts CJ, Cole T, van Essen AJ, van Lingen RA, Neri G, Opitz JM, Rump P, Stolte-Dijkstra I, Müller F, Pruijn GJ, Latif F, Maher ER.

Nat Genet. 2012 Feb 5;44(3):277-84. doi: 10.1038/ng.1071.


DNA methylation profiling at imprinted loci after periconceptional micronutrient supplementation in humans: results of a pilot randomized controlled trial.

Cooper WN, Khulan B, Owens S, Elks CE, Seidel V, Prentice AM, Belteki G, Ong KK, Affara NA, Constância M, Dunger DB.

FASEB J. 2012 May;26(5):1782-90. doi: 10.1096/fj.11-192708. Epub 2012 Jan 20.


How genome-wide approaches can be used to unravel the remaining secrets of the imprintome.

Cooper WN, Constância M.

Brief Funct Genomics. 2010 Jul;9(4):315-28. doi: 10.1093/bfgp/elq018. Review.


Human RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis.

Recino A, Sherwood V, Flaxman A, Cooper WN, Latif F, Ward A, Chalmers AD.

Biochem J. 2010 Sep 1;430(2):207-13. doi: 10.1042/BJ20100883.


The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias.

Hesson LB, Dunwell TL, Cooper WN, Catchpoole D, Brini AT, Chiaramonte R, Griffiths M, Chalmers AD, Maher ER, Latif F.

Mol Cancer. 2009 Jul 1;8:42. doi: 10.1186/1476-4598-8-42.


RAN GTPase is a RASSF1A effector involved in controlling microtubule organization.

Dallol A, Hesson LB, Matallanas D, Cooper WN, O'Neill E, Maher ER, Kolch W, Latif F.

Curr Biol. 2009 Jul 28;19(14):1227-32. doi: 10.1016/j.cub.2009.05.064. Epub 2009 Jun 25.


RASSF2 associates with and stabilizes the proapoptotic kinase MST2.

Cooper WN, Hesson LB, Matallanas D, Dallol A, von Kriegsheim A, Ward R, Kolch W, Latif F.

Oncogene. 2009 Aug 20;28(33):2988-98. doi: 10.1038/onc.2009.152. Epub 2009 Jun 15.


Beckwith Weidemann syndrome: a behavioral phenotype-genotype study.

Kent L, Bowdin S, Kirby GA, Cooper WN, Maher ER.

Am J Med Genet B Neuropsychiatr Genet. 2008 Oct 5;147B(7):1295-7. doi: 10.1002/ajmg.b.30729.


Epigenetic regulation of the ras effector/tumour suppressor RASSF2 in breast and lung cancer.

Cooper WN, Dickinson RE, Dallol A, Grigorieva EV, Pavlova TV, Hesson LB, Bieche I, Broggini M, Maher ER, Zabarovsky ER, Clark GJ, Latif F.

Oncogene. 2008 Mar 13;27(12):1805-11. Epub 2007 Sep 24.


Evaluation of the 3p21.3 tumour-suppressor gene cluster.

Hesson LB, Cooper WN, Latif F.

Oncogene. 2007 Nov 15;26(52):7283-301. Epub 2007 May 28. Review.


Mitotic recombination and uniparental disomy in Beckwith-Wiedemann syndrome.

Cooper WN, Curley R, Macdonald F, Maher ER.

Genomics. 2007 May;89(5):613-7. Epub 2007 Mar 6.


The role of RASSF1A methylation in cancer.

Hesson LB, Cooper WN, Latif F.

Dis Markers. 2007;23(1-2):73-87. Review.


Depletion of the Ras association domain family 1, isoform A-associated novel microtubule-associated protein, C19ORF5/MAP1S, causes mitotic abnormalities.

Dallol A, Cooper WN, Al-Mulla F, Agathanggelou A, Maher ER, Latif F.

Cancer Res. 2007 Jan 15;67(2):492-500.


Molecular subtypes and phenotypic expression of Beckwith-Wiedemann syndrome.

Cooper WN, Luharia A, Evans GA, Raza H, Haire AC, Grundy R, Bowdin SC, Riccio A, Sebastio G, Bliek J, Schofield PN, Reik W, Macdonald F, Maher ER.

Eur J Hum Genet. 2005 Sep;13(9):1025-32.


Role of the Ras-association domain family 1 tumor suppressor gene in human cancers.

Agathanggelou A, Cooper WN, Latif F.

Cancer Res. 2005 May 1;65(9):3497-508. Review. Erratum in: Cancer Res. 2005 Jun 15;65(12):5480.


Epigenetic alteration at the DLK1-GTL2 imprinted domain in human neoplasia: analysis of neuroblastoma, phaeochromocytoma and Wilms' tumour.

Astuti D, Latif F, Wagner K, Gentle D, Cooper WN, Catchpoole D, Grundy R, Ferguson-Smith AC, Maher ER.

Br J Cancer. 2005 Apr 25;92(8):1574-80.


Epigenetic analysis of HIC1, CASP8, FLIP, TSP1, DCR1, DCR2, DR4, DR5, KvDMR1, H19 and preferential 11p15.5 maternal-allele loss in von Hippel-Lindau and sporadic phaeochromocytomas.

Margetts CD, Astuti D, Gentle DC, Cooper WN, Cascon A, Catchpoole D, Robledo M, Neumann HP, Latif F, Maher ER.

Endocr Relat Cancer. 2005 Mar;12(1):161-72.


Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome.

Gissen P, Johnson CA, Morgan NV, Stapelbroek JM, Forshew T, Cooper WN, McKiernan PJ, Klomp LW, Morris AA, Wraith JE, McClean P, Lynch SA, Thompson RJ, Lo B, Quarrell OW, Di Rocco M, Trembath RC, Mandel H, Wali S, Karet FE, Knisely AS, Houwen RH, Kelly DA, Maher ER.

Nat Genet. 2004 Apr;36(4):400-4. Epub 2004 Mar 28.


An association between variants in the IGF2 gene and Beckwith-Wiedemann syndrome: interaction between genotype and epigenotype.

Murrell A, Heeson S, Cooper WN, Douglas E, Apostolidou S, Moore GE, Maher ER, Reik W.

Hum Mol Genet. 2004 Jan 15;13(2):247-55. Epub 2003 Nov 25.


Multigene methylation analysis of Wilms' tumour and adult renal cell carcinoma.

Morris MR, Hesson LB, Wagner KJ, Morgan NV, Astuti D, Lees RD, Cooper WN, Lee J, Gentle D, Macdonald F, Kishida T, Grundy R, Yao M, Latif F, Maher ER.

Oncogene. 2003 Oct 2;22(43):6794-801.


Frequent RASSF1A tumour suppressor gene promoter methylation in Wilms' tumour and colorectal cancer.

Wagner KJ, Cooper WN, Grundy RG, Caldwell G, Jones C, Wadey RB, Morton D, Schofield PN, Reik W, Latif F, Maher ER.

Oncogene. 2002 Oct 17;21(47):7277-82.


Mapping the multiple self-healing squamous epithelioma (MSSE) gene and investigation of xeroderma pigmentosum group A (XPA) and PATCHED (PTCH) as candidate genes.

Richards FM, Goudie DR, Cooper WN, Jene Q, Barroso I, Wicking C, Wainwright BJ, Ferguson-Smith MA.

Hum Genet. 1997 Dec;101(3):317-22.


Hemoglobin Westmead alpha 2 122(H5)His replaced by Gln beta 2: a new hemoglobin variant with the substitution in the alpha 1 beta 1 contact area.

Fleming PJ, Hughes WG, Farmilo RK, Wyatt K, Cooper WN.

Hemoglobin. 1980;4(1):39-52. No abstract available.


Lack of relationship between hypoprothrombinemia and transvascular protein exchange.

Nelson TE Jr, Cooper WN.

Am J Physiol. 1966 Jul;211(1):105-16. No abstract available.


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