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Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy.

Misra C, Bangru S, Lin F, Lam K, Koenig SN, Lubbers ER, Hedhli J, Murphy NP, Parker DJ, Dobrucki LW, Cooper TA, Tajkhorshid E, Mohler PJ, Kalsotra A.

Dev Cell. 2020 Mar 23;52(6):748-763.e6. doi: 10.1016/j.devcel.2020.01.037. Epub 2020 Feb 27.


Endurance exercise leads to beneficial molecular and physiological effects in a mouse model of myotonic dystrophy type 1.

Sharp L, Cox DC, Cooper TA.

Muscle Nerve. 2019 Dec;60(6):779-789. doi: 10.1002/mus.26709. Epub 2019 Oct 23.


Harnessing Heat Beyond 200 °C from Unconcentrated Sunlight with Nonevacuated Transparent Aerogels.

Zhao L, Bhatia B, Yang S, Strobach E, Weinstein LA, Cooper TA, Chen G, Wang EN.

ACS Nano. 2019 Jul 23;13(7):7508-7516. doi: 10.1021/acsnano.9b02976. Epub 2019 Jun 14.


Contactless steam generation and superheating under one sun illumination.

Cooper TA, Zandavi SH, Ni GW, Tsurimaki Y, Huang Y, Boriskina SV, Chen G.

Nat Commun. 2018 Dec 11;9(1):5086. doi: 10.1038/s41467-018-07494-2.


Alu insertion variants alter mRNA splicing.

Payer LM, Steranka JP, Ardeljan D, Walker J, Fitzgerald KC, Calabresi PA, Cooper TA, Burns KH.

Nucleic Acids Res. 2019 Jan 10;47(1):421-431. doi: 10.1093/nar/gky1086.


CRISPR -Mediated Expression of the Fetal Scn5a Isoform in Adult Mice Causes Conduction Defects and Arrhythmias.

Pang PD, Alsina KM, Cao S, Koushik AB, Wehrens XHT, Cooper TA.

J Am Heart Assoc. 2018 Oct 2;7(19):e010393. doi: 10.1161/JAHA.118.010393.


Modulation of alternative splicing of trafficking genes by genome editing reveals functional consequences in muscle biology.

Blue RE, Koushik A, Engels NM, Wiedner HJ, Cooper TA, Giudice J.

Int J Biochem Cell Biol. 2018 Dec;105:134-143. doi: 10.1016/j.biocel.2018.10.004. Epub 2018 Oct 11.


Rbfox-Splicing Factors Maintain Skeletal Muscle Mass by Regulating Calpain3 and Proteostasis.

Singh RK, Kolonin AM, Fiorotto ML, Cooper TA.

Cell Rep. 2018 Jul 3;24(1):197-208. doi: 10.1016/j.celrep.2018.06.017.


Mechanisms of skeletal muscle wasting in a mouse model for myotonic dystrophy type 1.

Morriss GR, Rajapakshe K, Huang S, Coarfa C, Cooper TA.

Hum Mol Genet. 2018 Aug 15;27(16):2789-2804. doi: 10.1093/hmg/ddy192.


Correction: Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress.

Jaiswal M, Haelterman NA, Sandoval H, Xiong B, Donti T, Kalsotra A, Yamamoto S, Cooper TA, Graham BH, Bellen HJ.

PLoS Biol. 2018 Mar 6;16(3):e1002622. doi: 10.1371/journal.pbio.1002622. eCollection 2018 Mar.


A Therapeutic Double Whammy: Transcriptional or Post-transcriptional Suppression of Microsatellite Repeat Toxicity by Cas9.

Rao AN, Cooper TA.

Mol Cell. 2017 Nov 2;68(3):473-475. doi: 10.1016/j.molcel.2017.10.023.


BNANC Gapmers Revert Splicing and Reduce RNA Foci with Low Toxicity in Myotonic Dystrophy Cells.

Manning KS, Rao AN, Castro M, Cooper TA.

ACS Chem Biol. 2017 Oct 20;12(10):2503-2509. doi: 10.1021/acschembio.7b00416. Epub 2017 Sep 5.


Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions.

Brinegar AE, Xia Z, Loehr JA, Li W, Rodney GG, Cooper TA.

Elife. 2017 Aug 11;6. pii: e27192. doi: 10.7554/eLife.27192.


Unexpected consequences: exon skipping caused by CRISPR-generated mutations.

Sharpe JJ, Cooper TA.

Genome Biol. 2017 Jun 14;18(1):109. doi: 10.1186/s13059-017-1240-0.


Protein sequestration as a normal function of long noncoding RNAs and a pathogenic mechanism of RNAs containing nucleotide repeat expansions.

Morriss GR, Cooper TA.

Hum Genet. 2017 Sep;136(9):1247-1263. doi: 10.1007/s00439-017-1807-6. Epub 2017 May 8. Review.


Alternative Splicing of Four Trafficking Genes Regulates Myofiber Structure and Skeletal Muscle Physiology.

Giudice J, Loehr JA, Rodney GG, Cooper TA.

Cell Rep. 2016 Nov 15;17(8):1923-1933. doi: 10.1016/j.celrep.2016.10.072.


The roles of RNA processing in translating genotype to phenotype.

Manning KS, Cooper TA.

Nat Rev Mol Cell Biol. 2017 Feb;18(2):102-114. doi: 10.1038/nrm.2016.139. Epub 2016 Nov 16. Review.


Cow genotyping strategies for genomic selection in a small dairy cattle population.

Jenko J, Wiggans GR, Cooper TA, Eaglen SAE, Luff WGL, Bichard M, Pong-Wong R, Woolliams JA.

J Dairy Sci. 2017 Jan;100(1):439-452. doi: 10.3168/jds.2016-11479. Epub 2016 Nov 9.


Neonatal cardiac dysfunction and transcriptome changes caused by the absence of Celf1.

Giudice J, Xia Z, Li W, Cooper TA.

Sci Rep. 2016 Oct 19;6:35550. doi: 10.1038/srep35550.


Genomic evaluation, breed identification, and population structure of Guernsey cattle in North America, Great Britain, and the Isle of Guernsey.

Cooper TA, Eaglen SAE, Wiggans GR, Jenko J, Huson HJ, Morrice DR, Bichard M, Luff WGL, Woolliams JA.

J Dairy Sci. 2016 Jul;99(7):5508-5515. doi: 10.3168/jds.2015-10445. Epub 2016 May 11.


Non-canonical RAN Translation of CGG Repeats Has Canonical Requirements.

Cox DC, Cooper TA.

Mol Cell. 2016 Apr 21;62(2):155-156. doi: 10.1016/j.molcel.2016.04.004.


Increasing the number of single nucleotide polymorphisms used in genomic evaluation of dairy cattle.

Wiggans GR, Cooper TA, VanRaden PM, Van Tassell CP, Bickhart DM, Sonstegard TS.

J Dairy Sci. 2016 Jun;99(6):4504-4511. doi: 10.3168/jds.2015-10456. Epub 2016 Mar 31.


Roles for RNA-binding proteins in development and disease.

Brinegar AE, Cooper TA.

Brain Res. 2016 Sep 15;1647:1-8. doi: 10.1016/j.brainres.2016.02.050. Epub 2016 Mar 10. Review.


Using genomics to enhance selection of novel traits in North American dairy cattle.

Chesnais JP, Cooper TA, Wiggans GR, Sargolzaei M, Pryce JE, Miglior F.

J Dairy Sci. 2016 Mar;99(3):2413-2427. doi: 10.3168/jds.2015-9970. Epub 2016 Jan 6.


The spliceosome is a therapeutic vulnerability in MYC-driven cancer.

Hsu TY, Simon LM, Neill NJ, Marcotte R, Sayad A, Bland CS, Echeverria GV, Sun T, Kurley SJ, Tyagi S, Karlin KL, Dominguez-Vidaña R, Hartman JD, Renwick A, Scorsone K, Bernardi RJ, Skinner SO, Jain A, Orellana M, Lagisetti C, Golding I, Jung SY, Neilson JR, Zhang XH, Cooper TA, Webb TR, Neel BG, Shaw CA, Westbrook TF.

Nature. 2015 Sep 17;525(7569):384-8. doi: 10.1038/nature14985. Epub 2015 Sep 2.


Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress.

Jaiswal M, Haelterman NA, Sandoval H, Xiong B, Donti T, Kalsotra A, Yamamoto S, Cooper TA, Graham BH, Bellen HJ.

PLoS Biol. 2015 Jul 15;13(7):e1002197. doi: 10.1371/journal.pbio.1002197. eCollection 2015 Jul. Erratum in: PLoS Biol. 2018 Mar 6;16(3):e1002622.


Antagonistic regulation of mRNA expression and splicing by CELF and MBNL proteins.

Wang ET, Ward AJ, Cherone JM, Giudice J, Wang TT, Treacy DJ, Lambert NJ, Freese P, Saxena T, Cooper TA, Burge CB.

Genome Res. 2015 Jun;25(6):858-71. doi: 10.1101/gr.184390.114. Epub 2015 Apr 16.


Short communication: Improving accuracy of Jersey genomic evaluations in the United States and Denmark by sharing reference population bulls.

Wiggans GR, Su G, Cooper TA, Nielsen US, Aamand GP, Guldbrandtsen B, Lund MS, VanRaden PM.

J Dairy Sci. 2015 May;98(5):3508-13. doi: 10.3168/jds.2014-8874. Epub 2015 Mar 12.


Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels.

Gennarino VA, Singh RK, White JJ, De Maio A, Han K, Kim JY, Jafar-Nejad P, di Ronza A, Kang H, Sayegh LS, Cooper TA, Orr HT, Sillitoe RV, Zoghbi HY.

Cell. 2015 Mar 12;160(6):1087-98. doi: 10.1016/j.cell.2015.02.012.


Short communication: Analysis of genomic predictor population for Holstein dairy cattle in the United States--Effects of sex and age.

Cooper TA, Wiggans GR, VanRaden PM.

J Dairy Sci. 2015 Apr;98(4):2785-8. doi: 10.3168/jds.2014-8894. Epub 2015 Jan 31.


The RNA-binding protein Rbfox1 regulates splicing required for skeletal muscle structure and function.

Pedrotti S, Giudice J, Dagnino-Acosta A, Knoblauch M, Singh RK, Hanna A, Mo Q, Hicks J, Hamilton S, Cooper TA.

Hum Mol Genet. 2015 Apr 15;24(8):2360-74. doi: 10.1093/hmg/ddv003. Epub 2015 Jan 9.


Technical note: Rapid calculation of genomic evaluations for new animals.

Wiggans GR, VanRaden PM, Cooper TA.

J Dairy Sci. 2015 Mar;98(3):2039-42. doi: 10.3168/jds.2014-8868. Epub 2014 Dec 31.


Decreased efficacy of twice-weekly intravaginal dehydroepiandrosterone on vulvovaginal atrophy.

Bouchard C, Labrie F, Archer DF, Portman DJ, Koltun W, Elfassi É, Grainger DA, Ayotte N, Cooper TA, Martens M, Waldbaum AS, Labrie C, Côté I, Lavoie L, Martel C, Balser J; VVA Prasterone Group.

Climacteric. 2015;18(4):590-607. doi: 10.3109/13697137.2014.992012. Epub 2015 Mar 3.


Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3'-UTR landscape across seven tumour types.

Xia Z, Donehower LA, Cooper TA, Neilson JR, Wheeler DA, Wagner EJ, Li W.

Nat Commun. 2014 Nov 20;5:5274. doi: 10.1038/ncomms6274.


RNA-binding proteins in heart development.

Giudice J, Cooper TA.

Adv Exp Med Biol. 2014;825:389-429. doi: 10.1007/978-1-4939-1221-6_11. Review.


Rbfox2-coordinated alternative splicing of Mef2d and Rock2 controls myoblast fusion during myogenesis.

Singh RK, Xia Z, Bland CS, Kalsotra A, Scavuzzo MA, Curk T, Ule J, Li W, Cooper TA.

Mol Cell. 2014 Aug 21;55(4):592-603. doi: 10.1016/j.molcel.2014.06.035. Epub 2014 Jul 31.


Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development.

Giudice J, Xia Z, Wang ET, Scavuzzo MA, Ward AJ, Kalsotra A, Wang W, Wehrens XH, Burge CB, Li W, Cooper TA.

Nat Commun. 2014 Apr 22;5:3603. doi: 10.1038/ncomms4603.


Genomic evaluation, breed identification, and discovery of a haplotype affecting fertility for Ayrshire dairy cattle.

Cooper TA, Wiggans GR, Null DJ, Hutchison JL, Cole JB.

J Dairy Sci. 2014;97(6):3878-82. doi: 10.3168/jds.2013-7427. Epub 2014 Mar 27.


In Brief: (mis)splicing in disease.

Pedrotti S, Cooper TA.

J Pathol. 2014 May;233(1):1-3. doi: 10.1002/path.4337.


The Mef2 transcription network is disrupted in myotonic dystrophy heart tissue, dramatically altering miRNA and mRNA expression.

Kalsotra A, Singh RK, Gurha P, Ward AJ, Creighton CJ, Cooper TA.

Cell Rep. 2014 Jan 30;6(2):336-45. doi: 10.1016/j.celrep.2013.12.025. Epub 2014 Jan 9.


A single nucleotide polymorphism in the dopamine receptor D2 gene may be informative for resistance to fescue toxicosis in angus-based cattle.

Campbell BT, Kojima CJ, Cooper TA, Bastin BC, Wojakiewicz L, Kallenbach RL, Schrick FN, Waller JC.

Anim Biotechnol. 2014;25(1):1-12. doi: 10.1080/10495398.2013.796960.


Muscleblind-like 1 activates insulin receptor exon 11 inclusion by enhancing U2AF65 binding and splicing of the upstream intron.

Echeverria GV, Cooper TA.

Nucleic Acids Res. 2014 Feb;42(3):1893-903. doi: 10.1093/nar/gkt1020. Epub 2013 Oct 31.


Reexpression of pyruvate kinase M2 in type 1 myofibers correlates with altered glucose metabolism in myotonic dystrophy.

Gao Z, Cooper TA.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13570-5. doi: 10.1073/pnas.1308806110. Epub 2013 Jul 30.


Short communication: relationship of call rate and accuracy of single nucleotide polymorphism genotypes in dairy cattle.

Cooper TA, Wiggans GR, VanRaden PM.

J Dairy Sci. 2013 May;96(5):3336-9. doi: 10.3168/jds.2012-6208. Epub 2013 Mar 15.


Wheelchair skill performance of manual wheelchair users with spinal cord injury.

Oyster ML, Smith IJ, Kirby RL, Cooper TA, Groah SL, Pedersen JP, Boninger ML.

Top Spinal Cord Inj Rehabil. 2012 Spring;18(2):138-9. doi: 10.1310/sci1802-138. No abstract available.


Confirmation and discovery of maternal grandsires and great-grandsires in dairy cattle.

VanRaden PM, Cooper TA, Wiggans GR, O'Connell JR, Bacheller LR.

J Dairy Sci. 2013 Mar;96(3):1874-9. doi: 10.3168/jds.2012-6176. Epub 2013 Jan 16.


Technical note: Characteristics and use of the Illumina BovineLD and GeneSeek Genomic Profiler low-density bead chips for genomic evaluation.

Wiggans GR, Cooper TA, Van Tassell CP, Sonstegard TS, Simpson EB.

J Dairy Sci. 2013 Feb;96(2):1258-63. doi: 10.3168/jds.2012-6192. Epub 2012 Dec 20.


Antisense oligonucleotides: rising stars in eliminating RNA toxicity in myotonic dystrophy.

Gao Z, Cooper TA.

Hum Gene Ther. 2013 May;24(5):499-507. doi: 10.1089/hum.2012.212. Epub 2013 Jan 30. Review.


Implications of widespread covalent modification of mRNA.

Cooper TA.

Circ Res. 2012 Dec 7;111(12):1491-3. doi: 10.1161/CIRCRESAHA.112.281071. No abstract available.


Pre-mRNA splicing in disease and therapeutics.

Singh RK, Cooper TA.

Trends Mol Med. 2012 Aug;18(8):472-82. doi: 10.1016/j.molmed.2012.06.006. Epub 2012 Jul 18. Review.

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