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Items: 1 to 50 of 65

1.

Cutting Edge: Protein Arginine Deiminase 2 and 4 Regulate NLRP3 Inflammasome-Dependent IL-1β Maturation and ASC Speck Formation in Macrophages.

Mishra N, Schwerdtner L, Sams K, Mondal S, Ahmad F, Schmidt RE, Coonrod SA, Thompson PR, Lerch MM, Bossaller L.

J Immunol. 2019 Jul 10. pii: ji1800720. doi: 10.4049/jimmunol.1800720. [Epub ahead of print]

PMID:
31292215
2.

Calcium Regulates the Nuclear Localization of Protein Arginine Deiminase 2.

Zheng L, Nagar M, Maurais AJ, Slade DJ, Parelkar SS, Coonrod SA, Weerapana E, Thompson PR.

Biochemistry. 2019 Jul 9;58(27):3042-3056. doi: 10.1021/acs.biochem.9b00225. Epub 2019 Jun 27.

PMID:
31243954
3.

Peptidylarginine deiminases 2 and 4 modulate innate and adaptive immune responses in TLR-7-dependent lupus.

Liu Y, Lightfoot YL, Seto N, Carmona-Rivera C, Moore E, Goel R, O'Neil L, Mistry P, Hoffmann V, Mondal S, Premnath PN, Gribbons K, Dell'Orso S, Jiang K, Thompson PR, Sun HW, Coonrod SA, Kaplan MJ.

JCI Insight. 2018 Dec 6;3(23). pii: 124729. doi: 10.1172/jci.insight.124729.

4.

BB-Cl-Amidine as a novel therapeutic for canine and feline mammary cancer via activation of the endoplasmic reticulum stress pathway.

Ledet MM, Anderson R, Harman R, Muth A, Thompson PR, Coonrod SA, Van de Walle GR.

BMC Cancer. 2018 Apr 12;18(1):412. doi: 10.1186/s12885-018-4323-8.

5.

A bi-stable feedback loop between GDNF, EGR1, and ERα contribute to endocrine resistant breast cancer.

Horibata S, Rice EJ, Zheng H, Mukai C, Chu T, Marks BA, Coonrod SA, Danko CG.

PLoS One. 2018 Apr 3;13(4):e0194522. doi: 10.1371/journal.pone.0194522. eCollection 2018.

6.

ER-positive breast cancer cells are poised for RET-mediated endocrine resistance.

Horibata S, Rice EJ, Mukai C, Marks BA, Sams K, Zheng H, Anguish LJ, Coonrod SA, Danko CG.

PLoS One. 2018 Apr 2;13(4):e0194023. doi: 10.1371/journal.pone.0194023. eCollection 2018.

7.

Dynamic evolution of regulatory element ensembles in primate CD4+ T cells.

Danko CG, Choate LA, Marks BA, Rice EJ, Wang Z, Chu T, Martins AL, Dukler N, Coonrod SA, Tait Wojno ED, Lis JT, Kraus WL, Siepel A.

Nat Ecol Evol. 2018 Mar;2(3):537-548. doi: 10.1038/s41559-017-0447-5. Epub 2018 Jan 29.

8.

PAD1 promotes epithelial-mesenchymal transition and metastasis in triple-negative breast cancer cells by regulating MEK1-ERK1/2-MMP2 signaling.

Qin H, Liu X, Li F, Miao L, Li T, Xu B, An X, Muth A, Thompson PR, Coonrod SA, Zhang X.

Cancer Lett. 2017 Nov 28;409:30-41. doi: 10.1016/j.canlet.2017.08.019. Epub 2017 Aug 24.

9.

PAD2 overexpression in transgenic mice augments malignancy and tumor-associated inflammation in chemically initiated skin tumors.

Mohanan S, Horibata S, Anguish LJ, Mukai C, Sams K, McElwee JL, McLean D, Yan A, Coonrod SA.

Cell Tissue Res. 2017 Nov;370(2):275-283. doi: 10.1007/s00441-017-2669-x. Epub 2017 Aug 2.

PMID:
28766045
10.

Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration.

Horibata S, Rogers KE, Sadegh D, Anguish LJ, McElwee JL, Shah P, Thompson PR, Coonrod SA.

BMC Cancer. 2017 May 26;17(1):378. doi: 10.1186/s12885-017-3354-x.

11.

Peptidylarginine deiminase 1-catalyzed histone citrullination is essential for early embryo development.

Zhang X, Liu X, Zhang M, Li T, Muth A, Thompson PR, Coonrod SA, Zhang X.

Sci Rep. 2016 Dec 8;6:38727. doi: 10.1038/srep38727.

12.

Erratum to: A Comparative Study on the In Vitro Effects of the DNA Methyltransferase Inhibitor 5-Azacytidine (5-AzaC) in Breast/Mammary Cancer of Different Mammalian Species.

Harman RM, Curtis TM, Argyle DJ, Coonrod SA, Van de Walle GR.

J Mammary Gland Biol Neoplasia. 2016 Jun;21(1-2):67-68. No abstract available.

PMID:
27116467
13.

A Comparative Study on the In Vitro Effects of the DNA Methyltransferase Inhibitor 5-Azacytidine (5-AzaC) in Breast/Mammary Cancer of Different Mammalian Species.

Harman RM, Curtis TM, Argyle DJ, Coonrod SA, Van de Walle GR.

J Mammary Gland Biol Neoplasia. 2016 Jun;21(1-2):51-66. doi: 10.1007/s10911-016-9350-y. Epub 2016 Mar 22. Review. Erratum in: J Mammary Gland Biol Neoplasia. 2016 Jun;21(1-2):67-8.

PMID:
27002722
14.

Utilization of the Soft Agar Colony Formation Assay to Identify Inhibitors of Tumorigenicity in Breast Cancer Cells.

Horibata S, Vo TV, Subramanian V, Thompson PR, Coonrod SA.

J Vis Exp. 2015 May 20;(99):e52727. doi: 10.3791/52727.

15.

Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design.

Slade DJ, Fang P, Dreyton CJ, Zhang Y, Fuhrmann J, Rempel D, Bax BD, Coonrod SA, Lewis HD, Guo M, Gross ML, Thompson PR.

ACS Chem Biol. 2015 Apr 17;10(4):1043-53. doi: 10.1021/cb500933j. Epub 2015 Jan 26.

16.

Design, synthesis, and biological evaluation of tetrazole analogs of Cl-amidine as protein arginine deiminase inhibitors.

Subramanian V, Knight JS, Parelkar S, Anguish L, Coonrod SA, Kaplan MJ, Thompson PR.

J Med Chem. 2015 Feb 12;58(3):1337-44. doi: 10.1021/jm501636x. Epub 2015 Jan 16.

17.

PAD2 overexpression in transgenic mice promotes spontaneous skin neoplasia.

McElwee JL, Mohanan S, Horibata S, Sams KL, Anguish LJ, McLean D, Cvitaš I, Wakshlag JJ, Coonrod SA.

Cancer Res. 2014 Nov 1;74(21):6306-17. doi: 10.1158/0008-5472.CAN-14-0749. Epub 2014 Sep 11.

18.

Targeted H3R26 deimination specifically facilitates estrogen receptor binding by modifying nucleosome structure.

Guertin MJ, Zhang X, Anguish L, Kim S, Varticovski L, Lis JT, Hager GL, Coonrod SA.

PLoS Genet. 2014 Sep 11;10(9):e1004613. doi: 10.1371/journal.pgen.1004613. eCollection 2014 Sep.

19.

Transient estrogen receptor binding and p300 redistribution support a squelching mechanism for estradiol-repressed genes.

Guertin MJ, Zhang X, Coonrod SA, Hager GL.

Mol Endocrinol. 2014 Sep;28(9):1522-33. doi: 10.1210/me.2014-1130. Epub 2014 Jul 22.

20.

A novel role for protein arginine deiminase 4 in pluripotency: the emerging role of citrullinated histone H1 in cellular programming.

Slade DJ, Horibata S, Coonrod SA, Thompson PR.

Bioessays. 2014 Aug;36(8):736-40. doi: 10.1002/bies.201400057. Epub 2014 May 30.

21.

The role of MATER in endoplasmic reticulum distribution and calcium homeostasis in mouse oocytes.

Kim B, Zhang X, Kan R, Cohen R, Mukai C, Travis AJ, Coonrod SA.

Dev Biol. 2014 Feb 15;386(2):331-9. doi: 10.1016/j.ydbio.2013.12.025. Epub 2013 Dec 25.

22.

Dysregulation of PAD4-mediated citrullination of nuclear GSK3β activates TGF-β signaling and induces epithelial-to-mesenchymal transition in breast cancer cells.

Stadler SC, Vincent CT, Fedorov VD, Patsialou A, Cherrington BD, Wakshlag JJ, Mohanan S, Zee BM, Zhang X, Garcia BA, Condeelis JS, Brown AM, Coonrod SA, Allis CD.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11851-6. doi: 10.1073/pnas.1308362110. Epub 2013 Jul 1. Erratum in: Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16283.

23.

Identification of macrophage extracellular trap-like structures in mammary gland adipose tissue: a preliminary study.

Mohanan S, Horibata S, McElwee JL, Dannenberg AJ, Coonrod SA.

Front Immunol. 2013 Mar 18;4:67. doi: 10.3389/fimmu.2013.00067. eCollection 2013.

24.

D-amino acid based protein arginine deiminase inhibitors: Synthesis, pharmacokinetics, and in cellulo efficacy.

Bicker KL, Anguish L, Chumanevich AA, Cameron MD, Cui X, Witalison E, Subramanian V, Zhang X, Chumanevich AP, Hofseth LJ, Coonrod SA, Thompson PR.

ACS Med Chem Lett. 2012 Oct 26;3(12):1081-1085.

25.

Identification of PADI2 as a potential breast cancer biomarker and therapeutic target.

McElwee JL, Mohanan S, Griffith OL, Breuer HC, Anguish LJ, Cherrington BD, Palmer AM, Howe LR, Subramanian V, Causey CP, Thompson PR, Gray JW, Coonrod SA.

BMC Cancer. 2012 Oct 30;12:500. doi: 10.1186/1471-2407-12-500.

26.

Potential role of peptidylarginine deiminase enzymes and protein citrullination in cancer pathogenesis.

Mohanan S, Cherrington BD, Horibata S, McElwee JL, Thompson PR, Coonrod SA.

Biochem Res Int. 2012;2012:895343. Epub 2012 Sep 16.

27.

Potential role for PAD2 in gene regulation in breast cancer cells.

Cherrington BD, Zhang X, McElwee JL, Morency E, Anguish LJ, Coonrod SA.

PLoS One. 2012;7(7):e41242. doi: 10.1371/journal.pone.0041242. Epub 2012 Jul 24.

28.

Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor α target gene activation.

Zhang X, Bolt M, Guertin MJ, Chen W, Zhang S, Cherrington BD, Slade DJ, Dreyton CJ, Subramanian V, Bicker KL, Thompson PR, Mancini MA, Lis JT, Coonrod SA.

Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13331-6. doi: 10.1073/pnas.1203280109. Epub 2012 Aug 1.

29.

Role for peptidylarginine deiminase enzymes in disease and female reproduction.

Horibata S, Coonrod SA, Cherrington BD.

J Reprod Dev. 2012;58(3):274-82. Review.

30.

Potential role for PADI-mediated histone citrullination in preimplantation development.

Kan R, Jin M, Subramanian V, Causey CP, Thompson PR, Coonrod SA.

BMC Dev Biol. 2012 Jun 19;12:19. doi: 10.1186/1471-213X-12-19.

31.

Comparative analysis of peptidylarginine deiminase-2 expression in canine, feline and human mammary tumours.

Cherrington BD, Mohanan S, Diep AN, Fleiss R, Sudilovsky D, Anguish LJ, Coonrod SA, Wakshlag JJ.

J Comp Pathol. 2012 Aug-Oct;147(2-3):139-46. doi: 10.1016/j.jcpa.2012.01.021. Epub 2012 Apr 19.

PMID:
22520816
32.

Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors.

Jones JE, Slack JL, Fang P, Zhang X, Subramanian V, Causey CP, Coonrod SA, Guo M, Thompson PR.

ACS Chem Biol. 2012 Jan 20;7(1):160-5. doi: 10.1021/cb200258q. Epub 2011 Oct 21.

33.

Genome-wide analysis reveals PADI4 cooperates with Elk-1 to activate c-Fos expression in breast cancer cells.

Zhang X, Gamble MJ, Stadler S, Cherrington BD, Causey CP, Thompson PR, Roberson MS, Kraus WL, Coonrod SA.

PLoS Genet. 2011 Jun;7(6):e1002112. doi: 10.1371/journal.pgen.1002112. Epub 2011 Jun 2.

34.

Regulation of mouse oocyte microtubule and organelle dynamics by PADI6 and the cytoplasmic lattices.

Kan R, Yurttas P, Kim B, Jin M, Wo L, Lee B, Gosden R, Coonrod SA.

Dev Biol. 2011 Feb 15;350(2):311-22. doi: 10.1016/j.ydbio.2010.11.033. Epub 2010 Dec 11.

35.

Potential role for MATER in cytoplasmic lattice formation in murine oocytes.

Kim B, Kan R, Anguish L, Nelson LM, Coonrod SA.

PLoS One. 2010 Sep 7;5(9):e12587. doi: 10.1371/journal.pone.0012587.

36.

Potential role for peptidylarginine deiminase 2 (PAD2) in citrullination of canine mammary epithelial cell histones.

Cherrington BD, Morency E, Struble AM, Coonrod SA, Wakshlag JJ.

PLoS One. 2010 Jul 26;5(7):e11768. doi: 10.1371/journal.pone.0011768.

37.

Use of proteomics to identify highly abundant maternal factors that drive the egg-to-embryo transition.

Yurttas P, Morency E, Coonrod SA.

Reproduction. 2010 May;139(5):809-23. doi: 10.1530/REP-09-0538. Epub 2010 Jan 27. Review.

PMID:
20106898
38.

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation.

Wang Y, Li M, Stadler S, Correll S, Li P, Wang D, Hayama R, Leonelli L, Han H, Grigoryev SA, Allis CD, Coonrod SA.

J Cell Biol. 2009 Jan 26;184(2):205-13. doi: 10.1083/jcb.200806072. Epub 2009 Jan 19.

39.

Role for PADI6 and the cytoplasmic lattices in ribosomal storage in oocytes and translational control in the early mouse embryo.

Yurttas P, Vitale AM, Fitzhenry RJ, Cohen-Gould L, Wu W, Gossen JA, Coonrod SA.

Development. 2008 Aug;135(15):2627-36. doi: 10.1242/dev.016329. Epub 2008 Jul 3.

40.

Antibodies to two ZP3 B cell epitopes affect zona pellucida assembly.

Borillo J, Coonrod SA, Wu J, Zhou C, Lou Y.

J Reprod Immunol. 2008 Jul;78(2):149-57. doi: 10.1016/j.jri.2008.02.002. Epub 2008 Apr 16.

41.

Peptidylarginine deiminase (PAD) is a mouse cortical granule protein that plays a role in preimplantation embryonic development.

Liu M, Oh A, Calarco P, Yamada M, Coonrod SA, Talbot P.

Reprod Biol Endocrinol. 2005 Sep 1;3:42.

42.

Linking covalent histone modifications to epigenetics: the rigidity and plasticity of the marks.

Wang Y, Wysocka J, Perlin JR, Leonelli L, Allis CD, Coonrod SA.

Cold Spring Harb Symp Quant Biol. 2004;69:161-9. Review. No abstract available.

PMID:
16117646
43.

Mouse SLLP1, a sperm lysozyme-like protein involved in sperm-egg binding and fertilization.

Herrero MB, Mandal A, Digilio LC, Coonrod SA, Maier B, Herr JC.

Dev Biol. 2005 Aug 1;284(1):126-42.

44.

Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination.

Lee YH, Coonrod SA, Kraus WL, Jelinek MA, Stallcup MR.

Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3611-6. Epub 2005 Feb 24.

45.

Human PAD4 regulates histone arginine methylation levels via demethylimination.

Wang Y, Wysocka J, Sayegh J, Lee YH, Perlin JR, Leonelli L, Sonbuchner LS, McDonald CH, Cook RG, Dou Y, Roeder RG, Clarke S, Stallcup MR, Allis CD, Coonrod SA.

Science. 2004 Oct 8;306(5694):279-83. Epub 2004 Sep 2.

46.

Dynamic alterations of specific histone modifications during early murine development.

Sarmento OF, Digilio LC, Wang Y, Perlin J, Herr JC, Allis CD, Coonrod SA.

J Cell Sci. 2004 Sep 1;117(Pt 19):4449-59. Epub 2004 Aug 17.

47.

Oocyte proteomics: localisation of mouse zona pellucida protein 3 to the plasma membrane of ovulated mouse eggs.

Coonrod SA, Calvert ME, Reddi PP, Kasper EN, Digilio LC, Herr JC.

Reprod Fertil Dev. 2004;16(1-2):69-78.

PMID:
14972104
48.

Structural requirements for the inhibitory action of the CD9 large extracellular domain in sperm/oocyte binding and fusion.

Higginbottom A, Takahashi Y, Bolling L, Coonrod SA, White JM, Partridge LJ, Monk PN.

Biochem Biophys Res Commun. 2003 Nov 7;311(1):208-14.

PMID:
14575715
49.

SAMP14, a novel, acrosomal membrane-associated, glycosylphosphatidylinositol-anchored member of the Ly-6/urokinase-type plasminogen activator receptor superfamily with a role in sperm-egg interaction.

Shetty J, Wolkowicz MJ, Digilio LC, Klotz KL, Jayes FL, Diekman AB, Westbrook VA, Farris EM, Hao Z, Coonrod SA, Flickinger CJ, Herr JC.

J Biol Chem. 2003 Aug 15;278(33):30506-15. Epub 2003 Jun 4.

50.

ePAD, an oocyte and early embryo-abundant peptidylarginine deiminase-like protein that localizes to egg cytoplasmic sheets.

Wright PW, Bolling LC, Calvert ME, Sarmento OF, Berkeley EV, Shea MC, Hao Z, Jayes FC, Bush LA, Shetty J, Shore AN, Reddi PP, Tung KS, Samy E, Allietta MM, Sherman NE, Herr JC, Coonrod SA.

Dev Biol. 2003 Apr 1;256(1):73-88.

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