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Items: 1 to 50 of 162

1.

Biosynthetic ganciclovir triphosphate: its isolation and characterization from ganciclovir-treated herpes simplex thymidine kinase-transduced murine cells.

Agbaria R, Candotti F, Kelley JA, Hao Z, Johns DG, Cooney DA, Blaese RM, Ford H Jr.

Biochem Biophys Res Commun. 2001 Nov 30;289(2):525-30.

PMID:
11716505
2.

Consequences of IMP dehydrogenase inhibition, and its relationship to cancer and apoptosis.

Jayaram HN, Cooney DA, Grusch M, Krupitza G.

Curr Med Chem. 1999 Jul;6(7):561-74. Review.

PMID:
10390601
3.

Carbocyclic analogues of the potent cytidine deaminase inhibitor 1-(beta-D-ribofuranosyl)-1,2-dihydropyrimidin-2-one (zebularine).

Jeong LS, Buenger G, McCormack JJ, Cooney DA, Hao Z, Marquez VE.

J Med Chem. 1998 Jul 2;41(14):2572-8.

PMID:
9651161
4.

Biochemical consequences of resistance to a recently discovered IMP dehydrogenase inhibitor, benzamide riboside, in human myelogenous leukemia K562 cells.

Jayaram HN, O'Connor A, Grant MR, Yang H, Grieco PA, Cooney DA.

J Exp Ther Oncol. 1996 Sep;1(5):278-85.

PMID:
9414415
5.

Identification of a novel inhibitor (NSC 665564) of dihydroorotate dehydrogenase with a potency equivalent to brequinar.

Cleaveland ES, Zaharevitz DW, Kelley JA, Paull K, Cooney DA, Ford H Jr.

Biochem Biophys Res Commun. 1996 Jun 25;223(3):654-9.

PMID:
8687451
6.

Studies on the mechanism of action of 1-beta-D-arabinofuranosyl-5-azacytosine (fazarabine) in mammalian lymphoblasts.

Barchi JJ Jr, Cooney DA, Ahluwalia GS, Gharehbaghi K, Covey JM, Hochman I, Paull KD, Jayaram HN.

J Exp Ther Oncol. 1996 May;1(3):191-203.

PMID:
9414404
7.

Site of action of two novel pyrimidine biosynthesis inhibitors accurately predicted by the compare program.

Cleaveland ES, Monks A, Vaigro-Wolff A, Zaharevitz DW, Paull K, Ardalan K, Cooney DA, Ford H Jr.

Biochem Pharmacol. 1995 Mar 30;49(7):947-54.

PMID:
7741767
8.

Improved synthesis of zebularine [1-(beta-D-ribofuranosyl)-dihydropyrimidin-2-one] nucleotides as inhibitors of human deoxycytidylate deaminase.

Barchi JJ Jr, Cooney DA, Hao Z, Weinberg ZH, Taft C, Marquez VE, Ford H Jr.

J Enzyme Inhib. 1995;9(2):147-62.

PMID:
8583252
9.

Quantitation of mitochondrial DNA in human lymphoblasts by a competitive polymerase chain reaction method: application to the study of inhibitors of mitochondrial DNA content.

Zhang H, Cooney DA, Sreenath A, Zhan Q, Agbaria R, Stowe EE, Fornace AJ Jr, Johns DG.

Mol Pharmacol. 1994 Dec;46(6):1063-9.

PMID:
7808425
10.
11.

Comparison of biochemical parameters of benzamide riboside, a new inhibitor of IMP dehydrogenase, with tiazofurin and selenazofurin.

Gharehbaghi K, Sreenath A, Hao Z, Paull KD, Szekeres T, Cooney DA, Krohn K, Jayaram HN.

Biochem Pharmacol. 1994 Oct 7;48(7):1413-9.

PMID:
7945441
12.

IL-3 and ribavirin induce high level expression of megakaryocytic markers and messages during long-term treatment of a megakaryocytic leukemia cell line.

Majumdar A, Kerby S, Stenberg PE, Mullikin B, Beckstead JH, Cooney DA, Seidman MM.

J Cell Physiol. 1994 Jul;160(1):29-39.

PMID:
8021297
13.

Tyrphostin induced growth inhibition: correlation with effect on p210bcr-abl autokinase activity in K562 chronic myelogenous leukemia.

Kaur G, Gazit A, Levitzki A, Stowe E, Cooney DA, Sausville EA.

Anticancer Drugs. 1994 Apr;5(2):213-22.

PMID:
8049505
14.

Effects of IMP dehydrogenase inhibitors on the phosphorylation of ganciclovir in MOLT-4 cells before and after herpes simplex virus thymidine kinase gene transduction.

Agbaria R, Mullen CA, Hartman NR, Cooney DA, Hao Z, Blaese RM, Johns DG.

Mol Pharmacol. 1994 Apr;45(4):777-82.

PMID:
7910373
15.

Cytotoxicity and characterization of an active metabolite of benzamide riboside, a novel inhibitor of IMP dehydrogenase.

Gharehbaghi K, Paull KD, Kelley JA, Barchi JJ Jr, Marquez VE, Cooney DA, Monks A, Scudiero D, Krohn K, Jayaram HN.

Int J Cancer. 1994 Mar 15;56(6):892-9.

PMID:
7907081
16.

Resistance to cyclopentenylcytosine in murine leukemia L1210 cells.

Zhang H, Cooney DA, Zhang MH, Ahluwalia G, Ford H Jr, Johns DG.

Cancer Res. 1993 Dec 1;53(23):5714-20.

17.
18.

Measurement of cyclopentenyl cytosine 5'-triphosphate in vitro and in vivo by multidimensional high-performance liquid chromatography.

Agbaria R, Ford H Jr, Kelley JA, Xie F, Politi P, Grem JL, Cooney DA, Marquez VE, Allegra CJ, Johns DG.

Anal Biochem. 1993 Aug 15;213(1):90-6.

PMID:
8238887
19.

Anomalous accumulation and decay of 2',3'-dideoxyadenosine-5'-triphosphate in human T-cell cultures exposed to the anti-HIV drug 2',3'-dideoxyinosine.

Ahluwalia G, Cooney DA, Hartman NR, Mitsuya H, Yarchoan R, Fridland A, Broder S, Johns DG.

Drug Metab Dispos. 1993 Mar-Apr;21(2):369-76.

PMID:
8097711
20.

Metabolic pathways for the activation of the antiviral agent 2',3'-dideoxyguanosine in human lymphoid cells.

Bondoc LL Jr, Ahluwalia G, Cooney DA, Hartman NR, Johns DG, Fridland A.

Mol Pharmacol. 1992 Sep;42(3):525-30.

PMID:
1328848
21.

Effects of bone marrow stimulatory cytokines on human immunodeficiency virus replication and the antiviral activity of dideoxynucleosides in cultures of monocyte/macrophages.

Perno CF, Cooney DA, Gao WY, Hao Z, Johns DG, Foli A, Hartman NR, CaliĆ² R, Broder S, Yarchoan R.

Blood. 1992 Aug 15;80(4):995-1003.

PMID:
1379854
22.

In vitro inhibition of hepatitis B virus replication by 2',3'-dideoxyguanosine, 2',3'-dideoxyinosine, and 3'-azido-2',3'-dideoxythymidine in 2.2.15 (PR) cells.

Aoki-Sei S, O'Brien MC, Ford H, Fujii H, Gilbert DA, Cooney DA, Johns DG, Broder S, Mitsuya H.

J Infect Dis. 1991 Nov;164(5):843-51.

PMID:
1940465
23.

Cytotoxicity of tiazofurin and its arabinose and xylose analogues in K562 cells.

Zhen W, Jayaram HN, Marquez VE, Goldstein BM, Cooney DA, Weber G.

Biochem Biophys Res Commun. 1991 Oct 31;180(2):933-8.

PMID:
1683233
24.

Cellular pharmacology of cyclopentenyl cytosine in Molt-4 lymphoblasts.

Ford H Jr, Cooney DA, Ahluwalia GS, Hao Z, Rommel ME, Hicks L, Dobyns KA, Tomaszewski JE, Johns DG.

Cancer Res. 1991 Jul 15;51(14):3733-40.

25.

Inhibitors of IMP dehydrogenase stimulate the phosphorylation of the anti-human immunodeficiency virus nucleosides 2',3'-dideoxyadenosine and 2',3'-dideoxyinosine.

Hartman NR, Ahluwalia GS, Cooney DA, Mitsuya H, Kageyama S, Fridland A, Broder S, Johns DG.

Mol Pharmacol. 1991 Jul;40(1):118-24.

PMID:
1677450
26.

Inhibitors of IMP dehydrogenase stimulate the phosphorylation of the antiviral nucleoside 2' ,3'-dideoxyguanosine.

Ahluwalia G, Cooney DA, Bondoc LL Jr, Currens MJ, Ford H, Johns DG, Mitsuya H, Fridland A.

Biochem Biophys Res Commun. 1990 Sep 28;171(3):1297-303. Erratum in: Biochem Biophys Res Commun 1990 Nov 30;173(1):481.

PMID:
1977386
27.

Ability of anti-HIV agents to inhibit HIV replication in monocyte/macrophages or U937 monocytoid cells under conditions of enhancement by GM-CSF or anti-HIV antibody.

Perno CF, Cooney DA, Currens MJ, Rocchi G, Johns DG, Broder S, Yarchoan R.

AIDS Res Hum Retroviruses. 1990 Aug;6(8):1051-5.

PMID:
2223241
28.

2'-Fluoro-2',3'-dideoxyarabinosyladenine: a metabolically stable analogue of the antiretroviral agent 2',3'-dideoxyadenosine.

Masood R, Ahluwalia GS, Cooney DA, Fridland A, Marquez VE, Driscoll JS, Hao Z, Mitsuya H, Perno CF, Broder S, et al.

Mol Pharmacol. 1990 Apr;37(4):590-6.

PMID:
2109183
29.

Potent DNA chain termination activity and selective inhibition of human immunodeficiency virus reverse transcriptase by 2',3'-dideoxyuridine-5'-triphosphate.

Hao Z, Cooney DA, Farquhar D, Perno CF, Zhang K, Masood R, Wilson Y, Hartman NR, Balzarini J, Johns DG.

Mol Pharmacol. 1990 Feb;37(2):157-63.

PMID:
1689452
30.

Metabolism and action of amino acid analog anti-cancer agents.

Ahluwalia GS, Grem JL, Hao Z, Cooney DA.

Pharmacol Ther. 1990;46(2):243-71. Review.

PMID:
2108451
31.

Metabolism in human leukocytes of anti-HIV dideoxypurine nucleosides.

Fridland A, Johnson MA, Cooney DA, Ahluwalia G, Marquez VE, Driscoll JS, Johns DG.

Ann N Y Acad Sci. 1990;616:205-16.

PMID:
2078020
33.

Cyclopentenylcytosine triphosphate. Formation and inhibition of CTP synthetase.

Kang GJ, Cooney DA, Moyer JD, Kelley JA, Kim HY, Marquez VE, Johns DG.

J Biol Chem. 1989 Jan 15;264(2):713-8.

34.

Nucleoside uptake in Trypanosoma cruzi: analysis of a mutant resistant to tubercidin.

Finley RW, Cooney DA, Dvorak JA.

Mol Biochem Parasitol. 1988 Nov;31(2):133-40.

PMID:
3054542
35.

Metabolic pathways for the activation of the antiretroviral agent 2',3'-dideoxyadenosine in human lymphoid cells.

Johnson MA, Ahluwalia G, Connelly MC, Cooney DA, Broder S, Johns DG, Fridland A.

J Biol Chem. 1988 Oct 25;263(30):15354-7.

36.

Factors determining the activity of 2',3'-dideoxynucleosides in suppressing human immunodeficiency virus in vitro.

Hao Z, Cooney DA, Hartman NR, Perno CF, Fridland A, DeVico AL, Sarngadharan MG, Broder S, Johns DG.

Mol Pharmacol. 1988 Oct;34(4):431-5.

PMID:
2459590
37.

Inhibition of human immunodeficiency virus (HIV-1/HTLV-IIIBa-L) replication in fresh and cultured human peripheral blood monocytes/macrophages by azidothymidine and related 2',3'-dideoxynucleosides.

Perno CF, Yarchoan R, Cooney DA, Hartman NR, Gartner S, Popovic M, Hao Z, Gerrard TL, Wilson YA, Johns DG, et al.

J Exp Med. 1988 Sep 1;168(3):1111-25.

38.

2',3'-Dideoxycytidine: regulation of its metabolism and anti-retroviral potency by natural pyrimidine nucleosides and by inhibitors of pyrimidine nucleotide synthesis.

Balzarini J, Cooney DA, Dalal M, Kang GJ, Cupp JE, DeClercq E, Broder S, Johns DG.

Mol Pharmacol. 1987 Dec;32(6):798-806.

PMID:
2826994
39.

Initial studies on the cellular pharmacology of 2',3'-dideoxyinosine, an inhibitor of HIV infectivity.

Ahluwalia G, Cooney DA, Mitsuya H, Fridland A, Flora KP, Hao Z, Dalal M, Broder S, Johns DG.

Biochem Pharmacol. 1987 Nov 15;36(22):3797-800. No abstract available.

PMID:
3120727
40.

The disposition and metabolism of 2',3'-dideoxycytidine, an in vitro inhibitor of human T-lymphotrophic virus type III infectivity, in mice and monkeys.

Kelley JA, Litterst CL, Roth JS, Vistica DT, Poplack DG, Cooney DA, Nadkarni M, Balis FM, Broder S, Johns DG.

Drug Metab Dispos. 1987 Sep-Oct;15(5):595-601.

PMID:
2891473
41.

Initial studies on the cellular pharmacology of 2',3'-dideoxyadenosine, an inhibitor of HTLV-III infectivity.

Cooney DA, Ahluwalia G, Mitsuya H, Fridland A, Johnson M, Hao Z, Dalal M, Balzarini J, Broder S, Johns DG.

Biochem Pharmacol. 1987 Jun 1;36(11):1765-8. No abstract available.

PMID:
3107569
42.

Inosine monophosphate dehydrogenase and myeloid cell maturation.

Knight RD, Mangum J, Lucas DL, Cooney DA, Khan EC, Wright DG.

Blood. 1987 Feb;69(2):634-9.

PMID:
2879579
43.

Merbarone: an antitumor agent entering clinical trials.

Glover A, Chun HG, Kleinman LM, Cooney DA, Plowman J, Grieshaber CK, Malspeis L, Leyland-Jones B.

Invest New Drugs. 1987;5(2):137-43. Review.

PMID:
3308762
45.

Potent and selective anti-HTLV-III/LAV activity of 2',3'-dideoxycytidinene, the 2',3'-unsaturated derivative of 2',3'-dideoxycytidine.

Balzarini J, Pauwels R, Herdewijn P, De Clercq E, Cooney DA, Kang GJ, Dalal M, Johns DG, Broder S.

Biochem Biophys Res Commun. 1986 Oct 30;140(2):735-42.

PMID:
3022729
46.

Thiazole-4-carboxamide adenine dinucleotide (TAD). Analogues stable to phosphodiesterase hydrolysis.

Marquez VE, Tseng CK, Gebeyehu G, Cooney DA, Ahluwalia GS, Kelley JA, Dalal M, Fuller RW, Wilson YA, Johns DG.

J Med Chem. 1986 Sep;29(9):1726-31.

PMID:
2875185
47.

Arabinosyl-5-azacytosine: mechanisms of native and acquired resistance.

Ahluwalia GS, Cohen MB, Kang GJ, Arnold ST, McMahon JB, Dalal M, Wilson YA, Cooney DA, Balzarini J, Johns DG.

Cancer Res. 1986 Sep;46(9):4479-85.

48.

Initial studies on the cellular pharmacology of 2',3-dideoxycytidine, an inhibitor of HTLV-III infectivity.

Cooney DA, Dalal M, Mitsuya H, McMahon JB, Nadkarni M, Balzarini J, Broder S, Johns DG.

Biochem Pharmacol. 1986 Jul 1;35(13):2065-8. No abstract available.

PMID:
3015143
49.

Arabinofuranosyl-5-azacytosine: antitumor and cytotoxic properties.

Dalal M, Plowman J, Breitman TR, Schuller HM, del Campo AA, Vistica DT, Driscoll JS, Cooney DA, Johns DG.

Cancer Res. 1986 Feb;46(2):831-8.

50.

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