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Progesterone receptor integrates the effects of mutated MED12 and altered DNA methylation to stimulate RANKL expression and stem cell proliferation in uterine leiomyoma.

Liu S, Yin P, Kujawa SA, Coon JS 5th, Okeigwe I, Bulun SE.

Oncogene. 2019 Apr;38(15):2722-2735. doi: 10.1038/s41388-018-0612-6. Epub 2018 Dec 11.


RANKL/RANK Pathway and Its Inhibitor RANK-Fc in Uterine Leiomyoma Growth.

Ikhena DE, Liu S, Kujawa S, Esencan E, Coon JS 5th, Robins J, Bulun SE, Yin P.

J Clin Endocrinol Metab. 2018 May 1;103(5):1842-1849. doi: 10.1210/jc.2017-01585.


Paracrine Pathways in Uterine Leiomyoma Stem Cells Involve Insulinlike Growth Factor 2 and Insulin Receptor A.

Moravek MB, Yin P, Coon JS 5th, Ono M, Druschitz SA, Malpani SS, Dyson MT, Rademaker AW, Robins JC, Wei JJ, Kim JJ, Bulun SE.

J Clin Endocrinol Metab. 2017 May 1;102(5):1588-1595. doi: 10.1210/jc.2016-3497.


Transcriptional Profiling of Human Endocervical Tissues Reveals Distinct Gene Expression in the Follicular and Luteal Phases of the Menstrual Cycle.

Yildiz-Arslan S, Coon JS, Hope TJ, Kim JJ.

Biol Reprod. 2016 Jun;94(6):138. doi: 10.1095/biolreprod.116.140327. Epub 2016 May 11.


Uterine Leiomyoma Stem Cells: Linking Progesterone to Growth.

Bulun SE, Moravek MB, Yin P, Ono M, Coon JS 5th, Dyson MT, Navarro A, Marsh EE, Zhao H, Maruyama T, Chakravarti D, Kim JJ, Wei JJ.

Semin Reprod Med. 2015 Sep;33(5):357-65. doi: 10.1055/s-0035-1558451. Epub 2015 Aug 6. Review.


Human uterine leiomyoma stem/progenitor cells expressing CD34 and CD49b initiate tumors in vivo.

Yin P, Ono M, Moravek MB, Coon JS 5th, Navarro A, Monsivais D, Dyson MT, Druschitz SA, Malpani SS, Serna VA, Qiang W, Chakravarti D, Kim JJ, Bulun SE.

J Clin Endocrinol Metab. 2015 Apr;100(4):E601-6. doi: 10.1210/jc.2014-2134. Epub 2015 Feb 6.


Fenretinide: a novel treatment for endometrial cancer.

Mittal N, Malpani S, Dyson M, Ono M, Coon JS, Kim JJ, Schink JC, Bulun SE, Pavone ME.

PLoS One. 2014 Oct 23;9(10):e110410. doi: 10.1371/journal.pone.0110410. eCollection 2014.


Ovarian steroids, stem cells and uterine leiomyoma: therapeutic implications.

Moravek MB, Yin P, Ono M, Coon JS 5th, Dyson MT, Navarro A, Marsh EE, Chakravarti D, Kim JJ, Wei JJ, Bulun SE.

Hum Reprod Update. 2015 Jan-Feb;21(1):1-12. doi: 10.1093/humupd/dmu048. Epub 2014 Sep 8. Review.


5-Hydroxymethylcytosine promotes proliferation of human uterine leiomyoma: a biological link to a new epigenetic modification in benign tumors.

Navarro A, Yin P, Ono M, Monsivais D, Moravek MB, Coon JS 5th, Dyson MT, Wei JJ, Bulun SE.

J Clin Endocrinol Metab. 2014 Nov;99(11):E2437-45. doi: 10.1210/jc.2014-2264. Epub 2014 Jul 24.


ERβ- and prostaglandin E2-regulated pathways integrate cell proliferation via Ras-like and estrogen-regulated growth inhibitor in endometriosis.

Monsivais D, Dyson MT, Yin P, Coon JS, Navarro A, Feng G, Malpani SS, Ono M, Ercan CM, Wei JJ, Pavone ME, Su E, Bulun SE.

Mol Endocrinol. 2014 Aug;28(8):1304-15. doi: 10.1210/me.2013-1421. Epub 2014 Jul 3.


Identification of FISH biomarkers to detect chromosome abnormalities associated with prostate adenocarcinoma in tumour and field effect environment.

Zhang Y, Perez T, Blondin B, Du J, Liu P, Escarzaga D, Coon JS, Morrison LE, Pestova K.

BMC Cancer. 2014 Feb 25;14:129. doi: 10.1186/1471-2407-14-129.


Estrogen-dependent sushi domain containing 3 regulates cytoskeleton organization and migration in breast cancer cells.

Moy I, Todorović V, Dubash AD, Coon JS, Parker JB, Buranapramest M, Huang CC, Zhao H, Green KJ, Bulun SE.

Oncogene. 2015 Jan 15;34(3):323-33. doi: 10.1038/onc.2013.553. Epub 2014 Jan 13.


Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth.

Ono M, Yin P, Navarro A, Moravek MB, Coon JS 5th, Druschitz SA, Serna VA, Qiang W, Brooks DC, Malpani SS, Ma J, Ercan CM, Mittal N, Monsivais D, Dyson MT, Yemelyanov A, Maruyama T, Chakravarti D, Kim JJ, Kurita T, Gottardi CJ, Bulun SE.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17053-8. doi: 10.1073/pnas.1313650110. Epub 2013 Sep 30.


Ligand-activated peroxisome proliferator-activated receptor β/δ modulates human endometrial cancer cell survival.

Ma JJ, Monsivais D, Dyson MT, Coon JS, Malpani S, Ono M, Zhao H, Xin H, Pavone ME, Kim JJ, Chakravarti D, Bulun SE.

Horm Cancer. 2013 Dec;4(6):358-70. doi: 10.1007/s12672-013-0157-7. Epub 2013 Aug 14.


Role of stem cells in human uterine leiomyoma growth.

Ono M, Qiang W, Serna VA, Yin P, Coon JS 5th, Navarro A, Monsivais D, Kakinuma T, Dyson M, Druschitz S, Unno K, Kurita T, Bulun SE.

PLoS One. 2012;7(5):e36935. doi: 10.1371/journal.pone.0036935. Epub 2012 May 3.


A humanized pattern of aromatase expression is associated with mammary hyperplasia in mice.

Zhao H, Pearson EK, Brooks DC, Coon JS 5th, Chen D, Demura M, Zhang M, Clevenger CV, Xu X, Veenstra TD, Chatterton RT, DeMayo FJ, Bulun SE.

Endocrinology. 2012 Jun;153(6):2701-13. doi: 10.1210/en.2011-1761. Epub 2012 Apr 16.


PKCα and ERβ Are Associated with Triple-Negative Breast Cancers in African American and Caucasian Patients.

Tonetti DA, Gao W, Escarzaga D, Walters K, Szafran A, Coon JS.

Int J Breast Cancer. 2012;2012:740353. doi: 10.1155/2012/740353. Epub 2012 Feb 26.


Weight gain increases human aromatase expression in mammary gland.

Chen D, Zhao H, Coon JS 5th, Ono M, Pearson EK, Bulun SE.

Mol Cell Endocrinol. 2012 May 15;355(1):114-20. doi: 10.1016/j.mce.2012.01.027. Epub 2012 Feb 10.


Genome-wide progesterone receptor binding: cell type-specific and shared mechanisms in T47D breast cancer cells and primary leiomyoma cells.

Yin P, Roqueiro D, Huang L, Owen JK, Xie A, Navarro A, Monsivais D, Coon JS 5th, Kim JJ, Dai Y, Bulun SE.

PLoS One. 2012;7(1):e29021. doi: 10.1371/journal.pone.0029021. Epub 2012 Jan 17.


Biomarkers of the insulin-like growth factor pathway predict progression and outcome in lung cancer.

Shersher DD, Vercillo MS, Fhied C, Basu S, Rouhi O, Mahon B, Coon JS, Warren WH, Faber LP, Hong E, Bonomi P, Liptay MJ, Borgia JA.

Ann Thorac Surg. 2011 Nov;92(5):1805-11; discussion 1811. doi: 10.1016/j.athoracsur.2011.06.058. Epub 2011 Sep 25.


Early growth response-2 expression in uterine leiomyoma cells: regulation and function.

Yin P, Navarro A, Fang F, Xie A, Coon JS, Richardson C, Bulun SE.

Fertil Steril. 2011 Aug;96(2):439-44. doi: 10.1016/j.fertnstert.2011.05.062. Epub 2011 Jun 24.


A multi-analyte serum test for the detection of non-small cell lung cancer.

Farlow EC, Vercillo MS, Coon JS, Basu S, Kim AW, Faber LP, Warren WH, Bonomi P, Liptay MJ, Borgia JA.

Br J Cancer. 2010 Oct 12;103(8):1221-8. doi: 10.1038/sj.bjc.6605865. Epub 2010 Sep 21.


Knockdown of splicing factor SRp20 causes apoptosis in ovarian cancer cells and its expression is associated with malignancy of epithelial ovarian cancer.

He X, Arslan AD, Pool MD, Ho TT, Darcy KM, Coon JS, Beck WT.

Oncogene. 2011 Jan 20;30(3):356-65. doi: 10.1038/onc.2010.426. Epub 2010 Sep 20.


Enhancement of a multianalyte serum biomarker panel to identify lymph node metastases in non-small cell lung cancer with circulating autoantibody biomarkers.

Patel K, Farlow EC, Kim AW, Lee BS, Basu S, Coon JS, DeCresce D, Thimothy L, Walters KA, Fhied C, Chang C, Chen SH, Faber LP, Bonomi P, Liptay MJ, Borgia JA.

Int J Cancer. 2011 Jul 1;129(1):133-42. doi: 10.1002/ijc.25644. Epub 2010 Nov 9.


LAT1 regulates growth of uterine leiomyoma smooth muscle cells.

Xia Luo, Coon JS 5th, Su E, Pearson EK, Ping Yin, Ishikawa H, Bulun SE.

Reprod Sci. 2010 Sep;17(9):791-7. doi: 10.1177/1933719110372419. Epub 2010 Jul 2.


Development of a multiplexed tumor-associated autoantibody-based blood test for the detection of non-small cell lung cancer.

Farlow EC, Patel K, Basu S, Lee BS, Kim AW, Coon JS, Faber LP, Bonomi P, Liptay MJ, Borgia JA.

Clin Cancer Res. 2010 Jul 1;16(13):3452-62. doi: 10.1158/1078-0432.CCR-09-3192. Epub 2010 Jun 22.


Transcription factor KLF11 integrates progesterone receptor signaling and proliferation in uterine leiomyoma cells.

Yin P, Lin Z, Reierstad S, Wu J, Ishikawa H, Marsh EE, Innes J, Cheng Y, Pearson K, Coon JS 5th, Kim JJ, Chakravarti D, Bulun SE.

Cancer Res. 2010 Feb 15;70(4):1722-30. doi: 10.1158/0008-5472.CAN-09-2612. Epub 2010 Feb 2.


Establishment of a multi-analyte serum biomarker panel to identify lymph node metastases in non-small cell lung cancer.

Borgia JA, Basu S, Faber LP, Kim AW, Coon JS, Kaiser-Walters KA, Fhied C, Thomas S, Rouhi O, Warren WH, Bonomi P, Liptay MJ.

J Thorac Oncol. 2009 Mar;4(3):338-47. doi: 10.1097/JTO.0b013e3181982abf.


Topoisomerase II alpha gene copy loss has adverse prognostic significance in ERBB2-amplified breast cancer: a retrospective study of paraffin-embedded tumor specimens and medical charts.

Usha L, Tabesh B, Morrison LE, Rao RD, Jacobson K, Zhu A, Basu S, Coon JS.

J Hematol Oncol. 2008 Aug 14;1:12. doi: 10.1186/1756-8722-1-12.


The prognostic value of chromosome 7 polysomy in non-small cell lung cancer patients treated with gefitinib.

Buckingham LE, Coon JS, Morrison LE, Jacobson KK, Jewell SS, Kaiser KA, Mauer AM, Muzzafar T, Polowy C, Basu S, Gale M, Villaflor VM, Bonomi P.

J Thorac Oncol. 2007 May;2(5):414-22.


Knockdown of polypyrimidine tract-binding protein suppresses ovarian tumor cell growth and invasiveness in vitro.

He X, Pool M, Darcy KM, Lim SB, Auersperg N, Coon JS, Beck WT.

Oncogene. 2007 Jul 26;26(34):4961-8. Epub 2007 Feb 19.


Effects of ERBB2 amplicon size and genomic alterations of chromosomes 1, 3, and 10 on patient response to trastuzumab in metastatic breast cancer.

Morrison LE, Jewell SS, Usha L, Blondin BA, Rao RD, Tabesh B, Kemper M, Batus M, Coon JS.

Genes Chromosomes Cancer. 2007 Apr;46(4):397-405.


X-ray structure of the T. aquaticus FtsY:GDP complex suggests functional roles for the C-terminal helix of the SRP GTPases.

Gawronski-Salerno J, Coon JS 5th, Focia PJ, Freymann DM.

Proteins. 2007 Mar 1;66(4):984-95.


Structure of a GDP:AlF4 complex of the SRP GTPases Ffh and FtsY, and identification of a peripheral nucleotide interaction site.

Focia PJ, Gawronski-Salerno J, Coon JS 5th, Freymann DM.

J Mol Biol. 2006 Jul 14;360(3):631-43. Epub 2006 May 26.


Aberrant EGFR and chromosome 7 associate with outcome in laryngeal cancer.

Morrison LE, Jacobson KK, Friedman M, Schroeder JW, Coon JS.

Laryngoscope. 2005 Jul;115(7):1212-8.


Gene copy mapping of the ERBB2/TOP2A region in breast cancer.

Jacobson KK, Morrison LE, Henderson BT, Blondin BA, Wilber KA, Legator MS, O'Hare A, Van Stedum SC, Proffitt JH, Seelig SA, Coon JS.

Genes Chromosomes Cancer. 2004 May;40(1):19-31.


Temperature alters lipopolysaccharide-induced cytokine secretion by RAW 264.7 cells.

Kirkley JE, Thompson BJ, Coon JS.

Scand J Immunol. 2003 Jul;58(1):51-8.


Amplification and overexpression of topoisomerase IIalpha predict response to anthracycline-based therapy in locally advanced breast cancer.

Coon JS, Marcus E, Gupta-Burt S, Seelig S, Jacobson K, Chen S, Renta V, Fronda G, Preisler HD.

Clin Cancer Res. 2002 Apr;8(4):1061-7.


Abnormalities of molecular regulators of proliferation and apoptosis in carcinoma of the oral cavity and oropharynx.

Kuropkat C, Venkatesan TK, Caldarelli DD, Panje WR, Hutchinson J, Preisler HD, Coon JS, Werner JA.

Auris Nasus Larynx. 2002 Apr;29(2):165-74.


Prognostic significance of Bcl-2 and p53 expression in advanced laryngeal squamous cell carcinoma.

Friedman M, Lim JW, Manders E, Schaffner AD, Kirshenbaum GL, Tanyeri HM, Caldarelli DD, Coon JS.

Head Neck. 2001 Apr;23(4):280-5.


A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy.

Komarov PG, Komarova EA, Kondratov RV, Christov-Tselkov K, Coon JS, Chernov MV, Gudkov AV.

Science. 1999 Sep 10;285(5434):1733-7.


Prognostic significance of p27 expression in carcinoma of the oral cavity and oropharynx.

Venkatesan TK, Kuropkat C, Caldarelli DD, Panje WR, Hutchinson JC Jr, Chen S, Coon JS.

Laryngoscope. 1999 Aug;109(8):1329-33.


Activation of the LRP (lung resistance-related protein) gene by short-term exposure of human leukemia cells to phorbol ester and cytarabine.

Komarov PG, Shtil AA, Holian O, Tee L, Buckingham L, Mechetner EB, Roninson IB, Coon JS.

Oncol Res. 1998;10(4):185-92.


Regulators of proliferation and apoptosis in carcinoma of the larynx.

Whisler LC, Wood NB, Caldarelli DD, Hutchinson JC, Panje WR, Friedman M, Preisler HD, Leurgans S, Nowak J, Coon JS.

Laryngoscope. 1998 May;108(5):630-8.


Tumor angiogenesis and p53 mutations: prognosis in head and neck cancer.

Hegde PU, Brenski AC, Caldarelli DD, Hutchinson J, Panje WR, Wood NB, Leurgans S, Preisler HD, Taylor SG 4th, Caldarelli L, Coon JS.

Arch Otolaryngol Head Neck Surg. 1998 Jan;124(1):80-5.


Prognostic significance of Bcl-2 expression in localized squamous cell carcinoma of the head and neck.

Friedman M, Grey P, Venkatesan TK, Bloch I, Chawla P, Caldarelli DD, Coon JS.

Ann Otol Rhinol Laryngol. 1997 Jun;106(6):445-50.


Mutation of p53 in squamous cell cancer of the head and neck: relationship to tumor cell proliferation.

Wood NB, Kotelnikov V, Caldarelli DD, Hutchinson J, Panje WR, Hegde P, Leurgans S, LaFollette S, Taylor SG 4th, Preisler HD, Coon JS.

Laryngoscope. 1997 Jun;107(6):827-33.


Accuracy of histone H3 messenger RNA in situ hybridization for the assessment of cell proliferation in human tissues.

Kotelnikov V, Cass L, Coon JS, Spaulding D, Preisler HD.

Clin Cancer Res. 1997 May;3(5):669-73.


Cyclin D1 expression in squamous cell carcinomas of the head and neck and in oral mucosa in relation to proliferation and apoptosis.

Kotelnikov VM, Coon JS 4th, Mundle S, Kelanic S, LaFollette S, Taylor S IV, Hutchinson J, Panje W, Caldarelli DD, Preisler HD.

Clin Cancer Res. 1997 Jan;3(1):95-101.

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