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Antiretroviral therapy and vaginally administered contraceptive hormones: a three-arm, pharmacokinetic study.

Scarsi KK, Cramer YS, Rosenkranz SL, Aweeka F, Berzins B, Coombs RW, Coughlin K, Moran LE, Zorrilla CD, Akelo V, Aziz M, Friedman RK, Gingrich D, Swaminathan S, Godfrey C, Cohn SE; AIDS Clinical Trials Group A5316 Study Team.

Lancet HIV. 2019 Sep;6(9):e601-e612. doi: 10.1016/S2352-3018(19)30155-9.


Minority and majority pretreatment HIV-1 drug resistance associated with failure of first-line nonnucleoside reverse-transcriptase inhibitor antiretroviral therapy in Kenyan women.

Milne RS, Silverman RA, Beck IA, Mckernan-Mullin J, Deng W, Sibley TR, Dross S, Kiarie JN, Sakr SR, Coombs RW, Chung MH, Frenkel LM.

AIDS. 2019 May 1;33(6):941-951. doi: 10.1097/QAD.0000000000002134.


Phylogenetic Analyses Comparing HIV Sequences from Plasma at Virologic Failure to Cervix Versus Blood Sequences from Antecedent Antiretroviral Therapy Suppression.

Bull ME, McKernan JL, Styrchak S, Kraft K, Hitti J, Cohn SE, Tapia K, Deng W, Holte S, Mullins JI, Coombs RW, Frenkel LM.

AIDS Res Hum Retroviruses. 2019 Jun;35(6):557-566. doi: 10.1089/AID.2018.0211. Epub 2019 Apr 30.


A Randomized, Double-blinded, Placebo-controlled Trial of Sitagliptin for Reducing Inflammation and Immune Activation in Treated and Suppressed Human Immunodeficiency Virus Infection.

Dubé MP, Chan ES, Lake JE, Williams B, Kinslow J, Landay A, Coombs RW, Floris-Moore M, Ribaudo HJ, Yarasheski KE.

Clin Infect Dis. 2019 Sep 13;69(7):1165-1172. doi: 10.1093/cid/ciy1051.


HIV DNA levels and decay in a cohort of 111 long-term virally suppressed patients.

Golob JL, Stern J, Holte S, Kitahata MM, Crane HM, Coombs RW, Goecker E, Woolfrey AE, Harrington RD.

AIDS. 2018 Sep 24;32(15):2113-2118. doi: 10.1097/QAD.0000000000001948.


Comparison of Detection Limits of Fourth- and Fifth-Generation Combination HIV Antigen-Antibody, p24 Antigen, and Viral Load Assays on Diverse HIV Isolates.

Stone M, Bainbridge J, Sanchez AM, Keating SM, Pappas A, Rountree W, Todd C, Bakkour S, Manak M, Peel SA, Coombs RW, Ramos EM, Shriver MK, Contestable P, Nair SV, Wilson DH, Stengelin M, Murphy G, Hewlett I, Denny TN, Busch MP.

J Clin Microbiol. 2018 Jul 26;56(8). pii: e02045-17. doi: 10.1128/JCM.02045-17. Print 2018 Aug.


No Time to Delay! Fiebig Stages and Referral in Acute HIV infection: Seattle Primary Infection Program Experience.

Stekler JD, Tapia K, Maenza J, Stevens CE, Ure GA, O'Neal JD, Lane A, Mullins JI, Coombs RW, Holte S, Collier AC.

AIDS Res Hum Retroviruses. 2018 Aug;34(8):657-666. doi: 10.1089/AID.2017.0276. Epub 2018 Jun 13.


Monotypic low-level HIV viremias during antiretroviral therapy are associated with disproportionate production of X4 virions and systemic immune activation.

Bull ME, Mitchell C, Soria J, Styrchak S, Williams-Wietzikoski C, Legard J, McKernan-Mullin J, Kraft K, Onchiri F, Stern J, Holte S, Ryan KJ, Acosta EP, La Rosa A, Coombs RW, Ticona E, Frenkel LM.

AIDS. 2018 Jul 17;32(11):1389-1401. doi: 10.1097/QAD.0000000000001824.


A Randomized, Placebo-Controlled Trial of the Quadrivalent Human Papillomavirus Vaccine in Human Immunodeficiency Virus-Infected Adults Aged 27 Years or Older: AIDS Clinical Trials Group Protocol A5298.

Wilkin TJ, Chen H, Cespedes MS, Leon-Cruz JT, Godfrey C, Chiao EY, Bastow B, Webster-Cyriaque J, Feng Q, Dragavon J, Coombs RW, Presti RM, Saah A, Cranston RD.

Clin Infect Dis. 2018 Oct 15;67(9):1339-1346. doi: 10.1093/cid/ciy274.


Use of External Quality Control Material for HIV-1 RNA Testing To Assess the Comparability of Data Generated in Separate Laboratories and the Stability of HIV-1 RNA in Samples after Prolonged Storage.

Jennings C, Wager CG, Scianna SR, Zaccaro DJ, Couzens A, Mellors JW, Coombs RW, Bremer JW.

J Clin Microbiol. 2018 May 25;56(6). pii: e00120-18. doi: 10.1128/JCM.00120-18. Print 2018 Jun.


High Baseline Anal Human Papillomavirus and Abnormal Anal Cytology in a Phase 3 Trial of the Quadrivalent Human Papillomavirus Vaccine in Human Immunodeficiency Virus-Infected Individuals Older Than 26 Years: ACTG 5298.

Cranston RD, Cespedes MS, Paczuski P, Yang M, Coombs RW, Dragavon J, Saah A, Godfrey C, Webster-Cyriaque JY, Chiao EY, Bastow B, Wilkin T; ACTG 5298 Study Team.

Sex Transm Dis. 2018 Apr;45(4):266-271. doi: 10.1097/OLQ.0000000000000745.


Simultaneous quantitation of multiple contraceptive hormones in human serum by LC-MS/MS.

Blue SW, Winchell AJ, Kaucher AV, Lieberman RA, Gilles CT, Pyra MN, Heffron R, Hou X, Coombs RW, Nanda K, Davis NL, Kourtis AP, Herbeck JT, Baeten JM, Lingappa JR, Erikson DW.

Contraception. 2018 Apr;97(4):363-369. doi: 10.1016/j.contraception.2018.01.015. Epub 2018 Jan 31.


Prevalence, Magnitude, and Correlates of HIV-1 Genital Shedding in Women on Antiretroviral Therapy.

King CC, Ellington SR, Davis NL, Coombs RW, Pyra M, Hong T, Mugo N, Patel RC, Lingappa JR, Baeten JM, Kourtis AP; Partners in Prevention HSV/HIV Transmission Study and Partners PrEP Study Teams.

J Infect Dis. 2017 Dec 19;216(12):1534-1540. doi: 10.1093/infdis/jix550.


Detection and differentiation of HIV-2 using the point-of-care Alere q HIV-1/2 Detect nucleic acid test.

Chang M, Steinmetzer K, Raugi DN, Smith RA, Ba S, Sall F, Seydi M, Niang A, Sall EI, Cisse O, Rödel K, Coombs RW, Gottlieb GS.

J Clin Virol. 2017 Dec;97:22-25. doi: 10.1016/j.jcv.2017.10.013. Epub 2017 Oct 24.


The effect of oral preexposure prophylaxis on the progression of HIV-1 seroconversion.

Donnell D, Ramos E, Celum C, Baeten J, Dragavon J, Tappero J, Lingappa JR, Ronald A, Fife K, Coombs RW; Partners PrEP Study Team.

AIDS. 2017 Sep 10;31(14):2007-2016. doi: 10.1097/QAD.0000000000001577.


Brief Report: Hormonal Contraception Is Not Associated With Reduced ART Effectiveness Among Women Initiating ART: Evidence From Longitudinal Data.

Patel RC, Baeten JM, Heffron R, Hong T, Davis NL, Nanda K, Coombs RW, Lingappa JR, Bukusi EA, Hurst S, Thomas KK, Kourtis AP, Mugo N; Partners in Prevention HSVHIV Transmission Study and Partners PrEP Study Teams.

J Acquir Immune Defic Syndr. 2017 May 1;75(1):91-96. doi: 10.1097/QAI.0000000000001339.


Detection of HIV RNA in dried blood spots and oral fluids.

Stekler JD, Ure G, Dragavon J, Chang M, Coombs RW.

AIDS. 2017 May 15;31(8):1191-1193. doi: 10.1097/QAD.0000000000001477.


Clinical validation of a novel diagnostic HIV-2 total nucleic acid qualitative assay using the Abbott m2000 platform: Implications for complementary HIV-2 nucleic acid testing for the CDC 4th generation HIV diagnostic testing algorithm.

Chang M, Wong AJ, Raugi DN, Smith RA, Seilie AM, Ortega JP, Bogusz KM, Sall F, Ba S, Seydi M, Gottlieb GS, Coombs RW.

J Clin Virol. 2017 Jan;86:56-61. doi: 10.1016/j.jcv.2016.11.011. Epub 2016 Nov 23.


Semen Bacterial Concentrations and HIV-1 RNA Shedding Among HIV-1-Seropositive Kenyan Men.

Korhonen CJ, Srinivasan S, Huang D, Ko DL, Sanders EJ, Peshu NM, Krieger JN, Muller CH, Coombs RW, Fredricks DN, Graham SM.

J Acquir Immune Defic Syndr. 2017 Mar 1;74(3):250-257. doi: 10.1097/QAI.0000000000001244.


Herpes Simplex Virus Suppressive Therapy in Herpes Simplex Virus-2/Human Immunodeficiency Virus-1 Coinfected Women Is Associated With Reduced Systemic CXCL10 But Not Genital Cytokines.

Andersen-Nissen E, Chang JT, Thomas KK, Adams D, Celum C, Sanchez J, Coombs RW, McElrath MJ, Baeten JM.

Sex Transm Dis. 2016 Dec;43(12):761-764.


Exploring the anatomical HIV reservoirs: role of the testicular tissue.

Darcis G, Coombs RW, Van Lint C.

AIDS. 2016 Nov 28;30(18):2891-2893. No abstract available.


Semen as the Way Forward to Understand HIV-1 Transmission.

Coombs RW, Krieger JN.

J Infect Dis. 2016 Nov 15;214(10):1473-1474. Epub 2016 Aug 30. No abstract available.


Criminal justice involvement history is associated with better HIV care continuum metrics among a population-based sample of young black MSM.

Schneider JA, Kozloski M, Michaels S, Skaathun B, Voisin D, Lancki N, Morgan E, Khanna A, Green K, Coombs RW, Friedman SR, Laumann E, Schumm P; uConnectand BARS study teams.

AIDS. 2017 Jan 2;31(1):159-165.


Marijuana Use Among Young Black Men Who Have Sex With Men and the HIV Care Continuum: Findings From the uConnect Cohort.

Morgan E, Khanna AS, Skaathun B, Michaels S, Young L, Duvoisin R, Chang M, Voisin D, Cornwell B, Coombs RW, Friedman SR, Schneider JA.

Subst Use Misuse. 2016 Nov 9;51(13):1751-9. doi: 10.1080/10826084.2016.1197265. Epub 2016 Aug 11.


Human Immunodeficiency Virus (HIV) Separation and Enrichment via the Combination of Antiviral Lectin Recognition and a Thermoresponsive Reagent System.

Phan JC, Nehilla BJ, Srinivasan S, Coombs RW, Woodrow KA, Lai JJ.

Pharm Res. 2016 Oct;33(10):2411-20. doi: 10.1007/s11095-016-1980-7. Epub 2016 Jul 11.


Bloodborne Viral Pathogen Contamination in the Era of Laboratory Automation.

Bryan A, Cook L, Atienza EE, Kuypers J, Cent A, Baird GS, Coombs RW, Jerome KR, Wener MH, Butler-Wu SM.

Clin Chem. 2016 Jul;62(7):973-81. doi: 10.1373/clinchem.2016.255349. Epub 2016 May 19.


HIV Transmission Risk Persists During the First 6 Months of Antiretroviral Therapy.

Mujugira A, Celum C, Coombs RW, Campbell JD, Ndase P, Ronald A, Were E, Bukusi EA, Mugo N, Kiarie J, Baeten JM; Partners PrEP Study Team.

J Acquir Immune Defic Syndr. 2016 Aug 15;72(5):579-84. doi: 10.1097/QAI.0000000000001019.


Seminal HIV-1 RNA Detection in Heterosexual African Men Initiating Antiretroviral Therapy.

Mujugira A, Coombs RW, Heffron R, Celum C, Ronald A, Mugo N, Baeten JM; Partners PrEP Study Team.

J Infect Dis. 2016 Jul 15;214(2):212-5. doi: 10.1093/infdis/jiw131. Epub 2016 Apr 6.



Sha BE, Tierney C, Sun X, Stek A, Cohn SE, Coombs RW, Bastow B, Aweeka FT; AIDS Clinical Trials Group (ACTG) 5153s Team.

Jacobs J AIDS HIV. 2015;1(1). pii: 003. Epub 2015 May 16.


A Pilot Study of Raltegravir Plus Combination Antiretroviral Therapy in Early Human Immunodeficiency Virus Infection: Challenges and Lessons Learned.

Collier AC, Chun TW, Maenza J, Coombs RW, Tapia K, Chang M, Stevens CE, Justement JS, Murray D, Stekler JD, Mullins JI, Holte SE.

Biores Open Access. 2016 Jan 1;5(1):15-21. doi: 10.1089/biores.2015.0038. eCollection 2016.


Acute Infections, Cost per Infection and Turnaround Time in Three United States Hospital Laboratories Using Fourth-Generation Antigen-Antibody Human Immunodeficiency Virus Immunoassays.

Wesolowski LG, Nasrullah M, Coombs RW, Rosenberg E, Ethridge SF, Hutchinson AB, Dragavon J, Rychert J, Nolte FS, Madory JE, Werner BG.

Open Forum Infect Dis. 2015 Dec 9;3(1):ofv188. doi: 10.1093/ofid/ofv188. eCollection 2016 Jan.


Performance of Determine Combo and other point-of-care HIV tests among Seattle MSM.

Stekler JD, Ure G, O'Neal JD, Lane A, Swanson F, Maenza J, Stevens C, Coombs RW, Dragavon J, Swenson PD, Golden MR.

J Clin Virol. 2016 Mar;76:8-13. doi: 10.1016/j.jcv.2015.12.011. Epub 2016 Jan 2.


Virologic and immunologic effects of adding maraviroc to suppressive antiretroviral therapy in individuals with suboptimal CD4+ T-cell recovery.

Cillo AR, Hilldorfer BB, Lalama CM, McKinnon JE, Coombs RW, Tenorio AR, Fox L, Gandhi RT, Ribaudo H, Currier JS, Gulick RM, Wilkin TJ, Mellors JW.

AIDS. 2015 Oct 23;29(16):2121-9. doi: 10.1097/QAD.0000000000000810.


Short Communication: Analysis of Minor Populations of Human Immunodeficiency Virus by Primer Identification and Insertion-Deletion and Carry Forward Correction Pipelines.

Hughes P, Deng W, Olson SC, Coombs RW, Chung MH, Frenkel LM.

AIDS Res Hum Retroviruses. 2016 Mar;32(3):296-302. doi: 10.1089/AID.2015.0202. Epub 2015 Dec 15.


Biomarkers of inflammation in HIV-infected Peruvian men and women before and during suppressive antiretroviral therapy.

Ticona E, Bull ME, Soria J, Tapia K, Legard J, Styrchak SM, Williams C, Mitchell C, La Rosa A, Rosa AL, Coombs RW, Frenkel LM.

AIDS. 2015 Aug 24;29(13):1617-22. doi: 10.1097/QAD.0000000000000758. Erratum in: AIDS. 2015 Sep 24;29(15):2065. Rosa, Alberto L A [corrected to La Rosa, Alberto].


Comparison of Three Different FDA-Approved Plasma HIV-1 RNA Assay Platforms Confirms the Virologic Failure Endpoint of 200 Copies per Milliliter Despite Improved Assay Sensitivity.

Lalama CM, Jennings C, Johnson VA, Coombs RW, McKinnon JE, Bremer JW, Cobb BR, Cloherty GA, Mellors JW, Ribaudo HJ; AIDS Clinical Trials Group.

J Clin Microbiol. 2015 Aug;53(8):2659-66. doi: 10.1128/JCM.00801-15. Epub 2015 Jun 10.


Single-agent tenofovir versus combination emtricitabine plus tenofovir for pre-exposure prophylaxis for HIV-1 acquisition: an update of data from a randomised, double-blind, phase 3 trial.

Baeten JM, Donnell D, Mugo NR, Ndase P, Thomas KK, Campbell JD, Wangisi J, Tappero JW, Bukusi EA, Cohen CR, Katabira E, Ronald A, Tumwesigye E, Were E, Fife KH, Kiarie J, Farquhar C, John-Stewart G, Kidoguchi L, Coombs RW, Hendrix C, Marzinke MA, Frenkel L, Haberer JE, Bangsberg D, Celum C; Partners PrEP Study Team.

Lancet Infect Dis. 2014 Nov;14(11):1055-1064. doi: 10.1016/S1473-3099(14)70937-5. Epub 2014 Oct 7.


HIV-1 shedding from the female genital tract is associated with increased Th1 cytokines/chemokines that maintain tissue homeostasis and proportions of CD8+FOXP3+ T cells.

Bull ME, Legard J, Tapia K, Sorensen B, Cohn SE, Garcia R, Holte SE, Coombs RW, Hitti JE.

J Acquir Immune Defic Syndr. 2014 Dec 1;67(4):357-64. doi: 10.1097/QAI.0000000000000336.


Sevelamer does not decrease lipopolysaccharide or soluble CD14 levels but decreases soluble tissue factor, low-density lipoprotein (LDL) cholesterol, and oxidized LDL cholesterol levels in individuals with untreated HIV infection.

Sandler NG, Zhang X, Bosch RJ, Funderburg NT, Choi AI, Robinson JK, Fine DM, Coombs RW, Jacobson JM, Landay AL, Douek DC, Tressler R, Read SW, Wilson CC, Deeks SG, Lederman MM, Gandhi RT; AIDS Clinical Trials Group A5296 Team.

J Infect Dis. 2014 Nov 15;210(10):1549-54. doi: 10.1093/infdis/jiu305. Epub 2014 May 26.


Relative accuracy of serum, whole blood, and oral fluid HIV tests among Seattle men who have sex with men.

Stekler JD, O'Neal JD, Lane A, Swanson F, Maenza J, Stevens CE, Coombs RW, Dragavon JA, Swenson PD, Golden MR, Branson BM.

J Clin Virol. 2013 Dec;58 Suppl 1:e119-22. doi: 10.1016/j.jcv.2013.09.018.


Improving diagnostic capability for HPV disease internationally within the NIH-NIAID Division of AIDS Clinical Trial Networks.

Godfrey CC, Michelow PM, Godard M, Sahasrabuddhe VV, Darden J, Firnhaber CS, Wetherall NT, Bremer J, Coombs RW, Wilkin T; A5282 Study Team.

Am J Clin Pathol. 2013 Dec;140(6):881-9. doi: 10.1309/AJCPIBIS19QIYHJY.


Performance of an alternative HIV diagnostic algorithm using the ARCHITECT HIV Ag/Ab Combo assay and potential utility of sample-to-cutoff ratio to discriminate primary from established infection.

Ramos EM, Harb S, Dragavon J, Swenson P, Stekler JD, Coombs RW.

J Clin Virol. 2013 Dec;58 Suppl 1:e38-43. doi: 10.1016/j.jcv.2013.08.014. Epub 2013 Aug 26.


Finding those at risk: acute HIV infection in Newark, NJ.

Martin EG, Salaru G, Mohammed D, Coombs RW, Paul SM, Cadoff EM.

J Clin Virol. 2013 Dec;58 Suppl 1:e24-8. doi: 10.1016/j.jcv.2013.07.016. Epub 2013 Aug 13.


Changes in HIV-1 subtypes B and C genital tract RNA in women and men after initiation of antiretroviral therapy.

Fiscus SA, Cu-Uvin S, Eshete AT, Hughes MD, Bao Y, Hosseinipour M, Grinsztejn B, Badal-Faesen S, Dragavon J, Coombs RW, Braun K, Moran L, Hakim J, Flanigan T, Kumarasamy N, Campbell TB; A5185s Team.

Clin Infect Dis. 2013 Jul;57(2):290-7. doi: 10.1093/cid/cit195. Epub 2013 Mar 26.


Effect of the levonorgestrel intrauterine device on genital HIV-1 RNA shedding among HIV-1-infected women not taking antiretroviral therapy in Nairobi, Kenya.

Coleman JS, Mwachari C, Balkus J, Sanguli L, Muliro A, Agnew K, Coombs RW, Cohen CR, Hitti J.

J Acquir Immune Defic Syndr. 2013 Jun 1;63(2):245-8. doi: 10.1097/QAI.0b013e31828decf8.


Development of a novel codon-specific polymerase chain reaction for the detection of CXCR4-utilizing HIV type 1 subtype B.

McLaughlin S, Swenson LC, Hu S, Hughes P, Harrigan PR, Coombs RW, Frenkel LM.

AIDS Res Hum Retroviruses. 2013 May;29(5):814-25. doi: 10.1089/AID.2012.0024. Epub 2013 Mar 6.


Human immunodeficiency viruses appear compartmentalized to the female genital tract in cross-sectional analyses but genital lineages do not persist over time.

Bull ME, Heath LM, McKernan-Mullin JL, Kraft KM, Acevedo L, Hitti JE, Cohn SE, Tapia KA, Holte SE, Dragavon JA, Coombs RW, Mullins JI, Frenkel LM.

J Infect Dis. 2013 Apr 15;207(8):1206-15. doi: 10.1093/infdis/jit016. Epub 2013 Jan 11.


Reply to Richie and Villasante.

Duerr A, Huang Y, Buchbinder S, Coombs RW, Sanchez J, del Rio C, Casapia M, Santiago S, Huang Y, Gilbert P, Corey L, Robertson MN.

J Infect Dis. 2013 Feb 15;207(4):690-2. doi: 10.1093/infdis/jis738. Epub 2012 Nov 29. No abstract available.


HIV-1 RNA may decline more slowly in semen than in blood following initiation of efavirenz-based antiretroviral therapy.

Graham SM, Holte SE, Dragavon JA, Ramko KM, Mandaliya KN, McClelland RS, Peshu NM, Sanders EJ, Krieger JN, Coombs RW.

PLoS One. 2012;7(8):e43086. doi: 10.1371/journal.pone.0043086. Epub 2012 Aug 13.

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