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Items: 18

1.

Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty.

Large JM, Birchall K, Bouloc NS, Merritt AT, Smiljanic-Hurley E, Tsagris DJ, Wheldon MC, Ansell KH, Coombs PJ, Kettleborough CA, Whalley D, Stewart LB, Bowyer PW, Baker DA, Osborne SA.

Bioorg Med Chem Lett. 2019 Aug 9:126610. doi: 10.1016/j.bmcl.2019.08.014. [Epub ahead of print]

2.

Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines.

Large JM, Birchall K, Bouloc NS, Merritt AT, Smiljanic-Hurley E, Tsagris DJ, Wheldon MC, Ansell KH, Coombs PJ, Kettleborough CA, Whalley D, Stewart LB, Bowyer PW, Baker DA, Osborne SA.

Bioorg Med Chem Lett. 2019 Feb 1;29(3):509-514. doi: 10.1016/j.bmcl.2018.11.039. Epub 2018 Nov 20.

3.

Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.

McIntyre PJ, Collins PM, Vrzal L, Birchall K, Arnold LH, Mpamhanga C, Coombs PJ, Burgess SG, Richards MW, Winter A, Veverka V, Delft FV, Merritt A, Bayliss R.

ACS Chem Biol. 2017 Nov 17;12(11):2906-2914. doi: 10.1021/acschembio.7b00537. Epub 2017 Oct 30.

4.

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.

Baker DA, Stewart LB, Large JM, Bowyer PW, Ansell KH, Jiménez-Díaz MB, El Bakkouri M, Birchall K, Dechering KJ, Bouloc NS, Coombs PJ, Whalley D, Harding DJ, Smiljanic-Hurley E, Wheldon MC, Walker EM, Dessens JT, Lafuente MJ, Sanz LM, Gamo FJ, Ferrer SB, Hui R, Bousema T, Angulo-Barturén I, Merritt AT, Croft SL, Gutteridge WE, Kettleborough CA, Osborne SA.

Nat Commun. 2017 Sep 5;8(1):430. doi: 10.1038/s41467-017-00572-x.

5.

N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF.

Chapman TM, Wallace C, Gillen KJ, Bakrania P, Khurana P, Coombs PJ, Fox S, Bureau EA, Brownlees J, Melton DW, Saxty B.

Bioorg Med Chem Lett. 2015 Oct 1;25(19):4104-8. doi: 10.1016/j.bmcl.2015.08.024. Epub 2015 Aug 14.

PMID:
26321360
6.

Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF.

Chapman TM, Gillen KJ, Wallace C, Lee MT, Bakrania P, Khurana P, Coombs PJ, Stennett L, Fox S, Bureau EA, Brownlees J, Melton DW, Saxty B.

Bioorg Med Chem Lett. 2015 Oct 1;25(19):4097-103. doi: 10.1016/j.bmcl.2015.08.031. Epub 2015 Aug 17.

PMID:
26318993
7.

Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid lattice.

Goldstone DC, Walker PA, Calder LJ, Coombs PJ, Kirkpatrick J, Ball NJ, Hilditch L, Yap MW, Rosenthal PB, Stoye JP, Taylor IA.

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9609-14. doi: 10.1073/pnas.1402448111. Epub 2014 Jun 16.

8.

Enhanced human receptor binding by H5 haemagglutinins.

Xiong X, Xiao H, Martin SR, Coombs PJ, Liu J, Collins PJ, Vachieri SG, Walker PA, Lin YP, McCauley JW, Gamblin SJ, Skehel JJ.

Virology. 2014 May;456-457:179-87. doi: 10.1016/j.virol.2014.03.008. Epub 2014 Apr 12.

9.

A phospha-oseltamivir-biotin conjugate as a strong and selective adhesive for the influenza virus.

Streicher H, Martin SR, Coombs PJ, McCauley J, Neill-Hall D, Stanley M.

Bioorg Med Chem Lett. 2014 Apr 1;24(7):1805-7. doi: 10.1016/j.bmcl.2014.02.021. Epub 2014 Feb 18.

10.

Changes in the hemagglutinin of H5N1 viruses during human infection--influence on receptor binding.

Crusat M, Liu J, Palma AS, Childs RA, Liu Y, Wharton SA, Lin YP, Coombs PJ, Martin SR, Matrosovich M, Chen Z, Stevens DJ, Hien VM, Thanh TT, Nhu le NT, Nguyet LA, Ha do Q, van Doorn HR, Hien TT, Conradt HS, Kiso M, Gamblin SJ, Chai W, Skehel JJ, Hay AJ, Farrar J, de Jong MD, Feizi T.

Virology. 2013 Dec;447(1-2):326-37. doi: 10.1016/j.virol.2013.08.010. Epub 2013 Sep 17.

11.

Recognition of sulphated and fucosylated receptor sialosides by A/Vietnam/1194/2004 (H5N1) influenza virus.

Xiong X, Tuzikov A, Coombs PJ, Martin SR, Walker PA, Gamblin SJ, Bovin N, Skehel JJ.

Virus Res. 2013 Dec 5;178(1):12-4. doi: 10.1016/j.virusres.2013.08.007. Epub 2013 Sep 10. No abstract available.

PMID:
24036174
12.

Receptor binding by a ferret-transmissible H5 avian influenza virus.

Xiong X, Coombs PJ, Martin SR, Liu J, Xiao H, McCauley JW, Locher K, Walker PA, Collins PJ, Kawaoka Y, Skehel JJ, Gamblin SJ.

Nature. 2013 May 16;497(7449):392-6. doi: 10.1038/nature12144. Epub 2013 Apr 24.

PMID:
23615615
13.

Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin.

Lin YP, Xiong X, Wharton SA, Martin SR, Coombs PJ, Vachieri SG, Christodoulou E, Walker PA, Liu J, Skehel JJ, Gamblin SJ, Hay AJ, Daniels RS, McCauley JW.

Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21474-9. doi: 10.1073/pnas.1218841110. Epub 2012 Dec 10. Erratum in: Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2677.

14.

Identification of novel contributions to high-affinity glycoprotein-receptor interactions using engineered ligands.

Coombs PJ, Harrison R, Pemberton S, Quintero-Martinez A, Parry S, Haslam SM, Dell A, Taylor ME, Drickamer K.

J Mol Biol. 2010 Feb 26;396(3):685-96. doi: 10.1016/j.jmb.2009.11.073. Epub 2009 Dec 7.

15.

Structures of receptor complexes formed by hemagglutinins from the Asian Influenza pandemic of 1957.

Liu J, Stevens DJ, Haire LF, Walker PA, Coombs PJ, Russell RJ, Gamblin SJ, Skehel JJ.

Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17175-80. doi: 10.1073/pnas.0906849106. Epub 2009 Sep 28.

16.

Lewis x antigen mediates adhesion of human breast carcinoma cells to activated endothelium. Possible involvement of the endothelial scavenger receptor C-type lectin.

Elola MT, Capurro MI, Barrio MM, Coombs PJ, Taylor ME, Drickamer K, Mordoh J.

Breast Cancer Res Treat. 2007 Jan;101(2):161-74. Epub 2006 Jul 19.

17.

Two categories of mammalian galactose-binding receptors distinguished by glycan array profiling.

Coombs PJ, Taylor ME, Drickamer K.

Glycobiology. 2006 Aug;16(8):1C-7C. Epub 2006 May 2.

18.

Selective binding of the scavenger receptor C-type lectin to Lewisx trisaccharide and related glycan ligands.

Coombs PJ, Graham SA, Drickamer K, Taylor ME.

J Biol Chem. 2005 Jun 17;280(24):22993-9. Epub 2005 Apr 21.

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