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Heightened JNK Activation and Reduced XIAP Levels Promote TRAIL and Sunitinib-Mediated Apoptosis in Colon Cancer Models.

Mahalingam D, Carew JS, Espitia CM, Cool RH, Giles FJ, de Jong S, Nawrocki ST.

Cancers (Basel). 2019 Jun 26;11(7). pii: E895. doi: 10.3390/cancers11070895.


Creation of RANKL mutants with low affinity for decoy receptor OPG and their potential anti-fibrosis activity.

Wang Y, Michiels T, Setroikromo R, van Merkerk R, Cool RH, Quax WJ.

FEBS J. 2019 Sep;286(18):3582-3593. doi: 10.1111/febs.14925. Epub 2019 May 25.


Small-molecule inhibitors of macrophage migration inhibitory factor (MIF) as an emerging class of therapeutics for immune disorders.

Kok T, Wasiel AA, Cool RH, Melgert BN, Poelarends GJ, Dekker FJ.

Drug Discov Today. 2018 Nov;23(11):1910-1918. doi: 10.1016/j.drudis.2018.06.017. Epub 2018 Jun 21. Review.


The past and presence of gene targeting: from chemicals and DNA via proteins to RNA.

Geel TM, Ruiters MHJ, Cool RH, Halby L, Voshart DC, Andrade Ruiz L, Niezen-Koning KE, Arimondo PB, Rots MG.

Philos Trans R Soc Lond B Biol Sci. 2018 Jun 5;373(1748). pii: 20170077. doi: 10.1098/rstb.2017.0077. Review.


High yield production of human invariant chain CD74 constructs fused to solubility-enhancing peptides and characterization of their MIF-binding capacities.

Kok T, Wasiel AA, Dekker FJ, Poelarends GJ, Cool RH.

Protein Expr Purif. 2018 Aug;148:46-53. doi: 10.1016/j.pep.2018.03.008. Epub 2018 Mar 27.


Discovery of chromenes as inhibitors of macrophage migration inhibitory factor.

Kok T, Wapenaar H, Wang K, Neochoritis CG, Zarganes-Tzitzikas T, Proietti G, Eleftheriadis N, Kurpiewska K, Kalinowska-Tłuścik J, Cool RH, Poelarends GJ, Dömling A, Dekker FJ.

Bioorg Med Chem. 2018 Mar 1;26(5):999-1005. doi: 10.1016/j.bmc.2017.12.032. Epub 2017 Dec 24.


Novel RANKL DE-loop mutants antagonize RANK-mediated osteoclastogenesis.

Wang Y, van Assen AHG, Reis CR, Setroikromo R, van Merkerk R, Boersma YL, Cool RH, Quax WJ.

FEBS J. 2017 Aug;284(15):2501-2512. doi: 10.1111/febs.14142. Epub 2017 Jul 7.


Receptor-specific TRAIL as a means to achieve targeted elimination of activated hepatic stellate cells.

Arabpour M, Cool RH, Faber KN, Quax WJ, Haisma HJ.

J Drug Target. 2017 Apr;25(4):360-369. doi: 10.1080/1061186X.2016.1262867. Epub 2016 Dec 28.


Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity.

O'Leary L, van der Sloot AM, Reis CR, Deegan S, Ryan AE, Dhami SP, Murillo LS, Cool RH, Correa de Sampaio P, Thompson K, Murphy G, Quax WJ, Serrano L, Samali A, Szegezdi E.

Oncogene. 2016 Mar 10;35(10):1261-70. doi: 10.1038/onc.2015.180. Epub 2015 Jun 8.


DR4 specific TRAIL variants are more efficacious than wild-type TRAIL in pancreatic cancer.

Yu R, Albarenque SM, Cool RH, Quax WJ, Mohr A, Zwacka RM.

Cancer Biol Ther. 2014;15(12):1658-66. doi: 10.4161/15384047.2014.972183.


Deinococcus radiodurans can interfere with quorum sensing by producing an AHL-acylase and an AHL-lactonase.

Koch G, Nadal-Jimenez P, Cool RH, Quax WJ.

FEMS Microbiol Lett. 2014 Jul;356(1):62-70. doi: 10.1111/1574-6968.12479. Epub 2014 Jun 26.


Assessing Pseudomonas virulence with nonmammalian host: Galleria mellonella.

Koch G, Nadal-Jimenez P, Cool RH, Quax WJ.

Methods Mol Biol. 2014;1149:681-8. doi: 10.1007/978-1-4939-0473-0_52.


PvdP is a tyrosinase that drives maturation of the pyoverdine chromophore in Pseudomonas aeruginosa.

Nadal-Jimenez P, Koch G, Reis CR, Muntendam R, Raj H, Jeronimus-Stratingh CM, Cool RH, Quax WJ.

J Bacteriol. 2014 Jul;196(14):2681-90. doi: 10.1128/JB.01376-13. Epub 2014 May 9.


Reducing virulence of the human pathogen Burkholderia by altering the substrate specificity of the quorum-quenching acylase PvdQ.

Koch G, Nadal-Jimenez P, Reis CR, Muntendam R, Bokhove M, Melillo E, Dijkstra BW, Cool RH, Quax WJ.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1568-73. doi: 10.1073/pnas.1311263111. Epub 2014 Jan 13.


The multiple signaling systems regulating virulence in Pseudomonas aeruginosa.

Jimenez PN, Koch G, Thompson JA, Xavier KB, Cool RH, Quax WJ.

Microbiol Mol Biol Rev. 2012 Mar;76(1):46-65. doi: 10.1128/MMBR.05007-11. Review.


Lipase A gene transcription in Pseudomonas alcaligenes is under control of RNA polymerase σ54 and response regulator LipR.

Krzeslak J, Papaioannou E, van Merkerk R, Paal KA, Bischoff R, Cool RH, Quax WJ.

FEMS Microbiol Lett. 2012 Apr;329(2):146-53. doi: 10.1111/j.1574-6968.2012.02516.x. Epub 2012 Feb 24.


Kinetics in signal transduction pathways involving promiscuous oligomerizing receptors can be determined by receptor specificity: apoptosis induction by TRAIL.

Szegezdi E, van der Sloot AM, Mahalingam D, O'Leary L, Cool RH, Muñoz IG, Montoya G, Quax WJ, de Jong S, Samali A, Serrano L.

Mol Cell Proteomics. 2012 Mar;11(3):M111.013730. doi: 10.1074/mcp.M111.013730. Epub 2012 Jan 2.


PA0305 of Pseudomonas aeruginosa is a quorum quenching acylhomoserine lactone acylase belonging to the Ntn hydrolase superfamily.

Wahjudi M, Papaioannou E, Hendrawati O, van Assen AHG, van Merkerk R, Cool RH, Poelarends GJ, Quax WJ.

Microbiology. 2011 Jul;157(Pt 7):2042-2055. doi: 10.1099/mic.0.043935-0. Epub 2011 Mar 3.


Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants.

Reis CR, van der Sloot AM, Natoni A, Szegezdi E, Setroikromo R, Meijer M, Sjollema K, Stricher F, Cool RH, Samali A, Serrano L, Quax WJ.

Cell Death Dis. 2010 Oct 21;1:e83. doi: 10.1038/cddis.2010.61.


Targeting AML through DR4 with a novel variant of rhTRAIL.

Szegezdi E, Reis CR, van der Sloot AM, Natoni A, O'Reilly A, Reeve J, Cool RH, O'Dwyer M, Knapper S, Serrano L, Quax WJ, Samali A.

J Cell Mol Med. 2011 Oct;15(10):2216-31. doi: 10.1111/j.1582-4934.2010.01211.x.


Unraveling the binding mechanism of trivalent tumor necrosis factor ligands and their receptors.

Reis CR, van Assen AH, Quax WJ, Cool RH.

Mol Cell Proteomics. 2011 Jan;10(1):M110.002808. doi: 10.1074/mcp.M110.002808. Epub 2010 Sep 17.


The acylase PvdQ has a conserved function among fluorescent Pseudomonas spp.

Koch G, Nadal Jimenez P, Muntendam R, Chen Y, Papaioannou E, Heeb S, Cámara M, Williams P, Cool RH, Quax WJ.

Environ Microbiol Rep. 2010 Jun;2(3):433-9. doi: 10.1111/j.1758-2229.2010.00157.x. Epub 2010 Mar 30.


Role of PvdQ in Pseudomonas aeruginosa virulence under iron-limiting conditions.

Nadal Jimenez P, Koch G, Papaioannou E, Wahjudi M, Krzeslak J, Coenye T, Cool RH, Quax WJ.

Microbiology. 2010 Jan;156(Pt 1):49-59. doi: 10.1099/mic.0.030973-0. Epub 2009 Sep 24.


Heterologous production of Escherichia coli penicillin G acylase in Pseudomonas aeruginosa.

Krzeslak J, Braun P, Voulhoux R, Cool RH, Quax WJ.

J Biotechnol. 2009 Jul 15;142(3-4):250-8. doi: 10.1016/j.jbiotec.2009.05.005. Epub 2009 May 27.


Enhanced antitumor efficacy of a DR5-specific TRAIL variant over recombinant human TRAIL in a bioluminescent ovarian cancer xenograft model.

Duiker EW, de Vries EG, Mahalingam D, Meersma GJ, Boersma-van Ek W, Hollema H, Lub-de Hooge MN, van Dam GM, Cool RH, Quax WJ, Samali A, van der Zee AG, de Jong S.

Clin Cancer Res. 2009 Mar 15;15(6):2048-57. doi: 10.1158/1078-0432.CCR-08-1535. Epub 2009 Mar 10.


Enhancement of antitumor properties of rhTRAIL by affinity increase toward its death receptors.

Reis CR, van der Sloot AM, Szegezdi E, Natoni A, Tur V, Cool RH, Samali A, Serrano L, Quax WJ.

Biochemistry. 2009 Mar 17;48(10):2180-91. doi: 10.1021/bi801927x.


DR4-selective tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) variants obtained by structure-based design.

Tur V, van der Sloot AM, Reis CR, Szegezdi E, Cool RH, Samali A, Serrano L, Quax WJ.

J Biol Chem. 2008 Jul 18;283(29):20560-8. doi: 10.1074/jbc.M800457200. Epub 2008 May 12.


A novel genetic selection system for improved enantioselectivity of Bacillus subtilis lipase A.

Boersma YL, Dröge MJ, van der Sloot AM, Pijning T, Cool RH, Dijkstra BW, Quax WJ.

Chembiochem. 2008 May 5;9(7):1110-5. doi: 10.1002/cbic.200700754.


Lipase expression in Pseudomonas alcaligenes is under the control of a two-component regulatory system.

Krzeslak J, Gerritse G, van Merkerk R, Cool RH, Quax WJ.

Appl Environ Microbiol. 2008 Mar;74(5):1402-11. doi: 10.1128/AEM.01632-07. Epub 2008 Jan 11.


A highly active adipyl-cephalosporin acylase obtained via rational randomization.

Otten LG, Sio CF, Reis CR, Koch G, Cool RH, Quax WJ.

FEBS J. 2007 Nov;274(21):5600-10. Epub 2007 Oct 8.


Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor.

van der Sloot AM, Tur V, Szegezdi E, Mullally MM, Cool RH, Samali A, Serrano L, Quax WJ.

Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8634-9. Epub 2006 May 26.


Quorum quenching by an N-acyl-homoserine lactone acylase from Pseudomonas aeruginosa PAO1.

Sio CF, Otten LG, Cool RH, Diggle SP, Braun PG, Bos R, Daykin M, Cámara M, Williams P, Quax WJ.

Infect Immun. 2006 Mar;74(3):1673-82.


Mutational analysis of a key residue in the substrate specificity of a cephalosporin acylase.

Otten LG, Sio CF, van der Sloot AM, Cool RH, Quax WJ.

Chembiochem. 2004 Jun 7;5(6):820-5.


Analysis of a substrate specificity switch residue of cephalosporin acylase.

Sio CF, Otten LG, Cool RH, Quax WJ.

Biochem Biophys Res Commun. 2003 Dec 19;312(3):755-60.


Reactive oxygen species modulate HIF-1 mediated PAI-1 expression: involvement of the GTPase Rac1.

Görlach A, Berchner-Pfannschmidt U, Wotzlaw C, Cool RH, Fandrey J, Acker H, Jungermann K, Kietzmann T.

Thromb Haemost. 2003 May;89(5):926-35.


Altering the substrate specificity of cephalosporin acylase by directed evolution of the Beta -subunit.

Otten LG, Sio CF, Vrielink J, Cool RH, Quax WJ.

J Biol Chem. 2002 Nov 1;277(44):42121-7. Epub 2002 Aug 26.


S-decyl-glutathione nonspecifically stimulates the ATPase activity of the nucleotide-binding domains of the human multidrug resistance-associated protein, MRP1 (ABCC1).

Cool RH, Veenstra MK, van Klompenburg W, Heyne RI, Müller M, de Vries EG, van Veen HW, Konings WN.

Eur J Biochem. 2002 Jul;269(14):3470-8.


An ABC-type multidrug transporter of Lactococcus lactis possesses an exceptionally broad substrate specificity.

Poelarends GJ, Mazurkiewicz P, Putman M, Cool RH, Veen HW, Konings WN.

Drug Resist Updat. 2000 Dec;3(6):330-334.


Dynamic interaction of cAMP with the Rap guanine-nucleotide exchange factor Epac1.

Kraemer A, Rehmann HR, Cool RH, Theiss C, de Rooij J, Bos JL, Wittinghofer A.

J Mol Biol. 2001 Mar 9;306(5):1167-77.


RalGEF2, a pleckstrin homology domain containing guanine nucleotide exchange factor for Ral.

de Bruyn KM, de Rooij J, Wolthuis RM, Rehmann H, Wesenbeek J, Cool RH, Wittinghofer AH, Bos JL.

J Biol Chem. 2000 Sep 22;275(38):29761-6.


Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs.

de Rooij J, Rehmann H, van Triest M, Cool RH, Wittinghofer A, Bos JL.

J Biol Chem. 2000 Jul 7;275(27):20829-36.


PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2.

de Rooij J, Boenink NM, van Triest M, Cool RH, Wittinghofer A, Bos JL.

J Biol Chem. 1999 Dec 31;274(53):38125-30.


Phospholipase D stimulation by receptor tyrosine kinases mediated by protein kinase C and a Ras/Ral signaling cascade.

Voss M, Weernink PA, Haupenthal S, Möller U, Cool RH, Bauer B, Camonis JH, Jakobs KH, Schmidt M.

J Biol Chem. 1999 Dec 3;274(49):34691-8.


The Ras mutant D119N is both dominant negative and activated.

Cool RH, Schmidt G, Lenzen CU, Prinz H, Vogt D, Wittinghofer A.

Mol Cell Biol. 1999 Sep;19(9):6297-305.


Effector recognition by the small GTP-binding proteins Ras and Ral.

Bauer B, Mirey G, Vetter IR, García-Ranea JA, Valencia A, Wittinghofer A, Camonis JH, Cool RH.

J Biol Chem. 1999 Jun 18;274(25):17763-70.


Discriminatory residues in Ras and Rap for guanine nucleotide exchange factor recognition.

van den Berghe N, Cool RH, Wittinghofer A.

J Biol Chem. 1999 Apr 16;274(16):11078-85.


Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP.

de Rooij J, Zwartkruis FJ, Verheijen MH, Cool RH, Nijman SM, Wittinghofer A, Bos JL.

Nature. 1998 Dec 3;396(6710):474-7.


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