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Guide Swap enables genome-scale pooled CRISPR-Cas9 screening in human primary cells.

Ting PY, Parker AE, Lee JS, Trussell C, Sharif O, Luna F, Federe G, Barnes SW, Walker JR, Vance J, Gao MY, Klock HE, Clarkson S, Russ C, Miraglia LJ, Cooke MP, Boitano AE, McNamara P, Lamb J, Schmedt C, Snead JL.

Nat Methods. 2018 Nov;15(11):941-946. doi: 10.1038/s41592-018-0149-1. Epub 2018 Oct 8.


Identification of a xenobiotic as a potential environmental trigger in primary biliary cholangitis.

Probert PM, Leitch AC, Dunn MP, Meyer SK, Palmer JM, Abdelghany TM, Lakey AF, Cooke MP, Talbot H, Wills C, McFarlane W, Blake LI, Rosenmai AK, Oskarsson A, Figueiredo R, Wilson C, Kass GE, Jones DE, Blain PG, Wright MC.

J Hepatol. 2018 Nov;69(5):1123-1135. doi: 10.1016/j.jhep.2018.06.027. Epub 2018 Jul 11.


Environmental Xenoestrogens Super-Activate a Variant Murine ER Beta in Cholangiocytes.

Meyer SK, Probert PM, Lakey AK, Leitch AC, Blake LI, Jowsey PA, Cooke MP, Blain PG, Wright MC.

Toxicol Sci. 2017 Mar 1;156(1):54-71. doi: 10.1093/toxsci/kfw234.


Incorporation of Phosphonate into Benzonaphthyridine Toll-like Receptor 7 Agonists for Adsorption to Aluminum Hydroxide.

Cortez A, Li Y, Miller AT, Zhang X, Yue K, Maginnis J, Hampton J, Hall de S, Shapiro M, Nayak B, D'Oro U, Li C, Skibinski D, Mbow ML, Singh M, O'Hagan DT, Cooke MP, Valiante NM, Wu TY.

J Med Chem. 2016 Jun 23;59(12):5868-78. doi: 10.1021/acs.jmedchem.6b00489. Epub 2016 Jun 13.


Phase I/II Trial of StemRegenin-1 Expanded Umbilical Cord Blood Hematopoietic Stem Cells Supports Testing as a Stand-Alone Graft.

Wagner JE Jr, Brunstein CG, Boitano AE, DeFor TE, McKenna D, Sumstad D, Blazar BR, Tolar J, Le C, Jones J, Cooke MP, Bleul CC.

Cell Stem Cell. 2016 Jan 7;18(1):144-55. doi: 10.1016/j.stem.2015.10.004. Epub 2015 Dec 5.


Inhibition of the Inositol Kinase Itpkb Augments Calcium Signaling in Lymphocytes and Reveals a Novel Strategy to Treat Autoimmune Disease.

Miller AT, Dahlberg C, Sandberg ML, Wen BG, Beisner DR, Hoerter JA, Parker A, Schmedt C, Stinson M, Avis J, Cienfuegos C, McPate M, Tranter P, Gosling M, Groot-Kormelink PJ, Dawson J, Pan S, Tian SS, Seidel HM, Cooke MP.

PLoS One. 2015 Jun 29;10(6):e0131071. doi: 10.1371/journal.pone.0131071. eCollection 2015.


A comparison of methods used to calculate normal background concentrations of potentially toxic elements for urban soil.

Rothwell KA, Cooke MP.

Sci Total Environ. 2015 Nov 1;532:625-34. doi: 10.1016/j.scitotenv.2015.06.083. Epub 2015 Jun 25.


A new TLR2 agonist promotes cross-presentation by mouse and human antigen presenting cells.

Santone M, Aprea S, Wu TY, Cooke MP, Mbow ML, Valiante NM, Rush JS, Dougan S, Avalos A, Ploegh H, De Gregorio E, Buonsanti C, D'Oro U.

Hum Vaccin Immunother. 2015;11(8):2038-50. doi: 10.1080/21645515.2015.1027467.


Using Poly I:C as an adjuvant does not induce or exacerbate models of systemic lupus erythematosus.

Annable T, Tomassian T, Jain S, Leibbrandt M, Cooke MP, Deane JA.

Autoimmunity. 2015 Feb;48(1):29-39. doi: 10.3109/08916934.2014.959166. Epub 2014 Dec 8.


Rational design of small molecules as vaccine adjuvants.

Wu TY, Singh M, Miller AT, De Gregorio E, Doro F, D'Oro U, Skibinski DA, Mbow ML, Bufali S, Herman AE, Cortez A, Li Y, Nayak BP, Tritto E, Filippi CM, Otten GR, Brito LA, Monaci E, Li C, Aprea S, Valentini S, Calabrό S, Laera D, Brunelli B, Caproni E, Malyala P, Panchal RG, Warren TK, Bavari S, O'Hagan DT, Cooke MP, Valiante NM.

Sci Transl Med. 2014 Nov 19;6(263):263ra160. doi: 10.1126/scitranslmed.3009980.


Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration.

Xu X, Jaeger ER, Wang X, Lagler-Ferrez E, Batalov S, Mathis NL, Wiltshire T, Walker JR, Cooke MP, Sauer K, Huang YH.

PLoS One. 2014 Aug 18;9(8):e105561. doi: 10.1371/journal.pone.0105561. eCollection 2014.


Eupalinilide E inhibits erythropoiesis and promotes the expansion of hematopoietic progenitor cells.

de Lichtervelde L, Boitano AE, Wang Y, Krastel P, Petersen F, Cooke MP, Schultz PG.

ACS Chem Biol. 2013 May 17;8(5):866-70. doi: 10.1021/cb4000234. Epub 2013 Mar 15.


The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain.

Beisner DR, Langerak P, Parker AE, Dahlberg C, Otero FJ, Sutton SE, Poirot L, Barnes W, Young MA, Niessen S, Wiltshire T, Bodendorf U, Martoglio B, Cravatt B, Cooke MP.

J Exp Med. 2013 Jan 14;210(1):23-30. doi: 10.1084/jem.20121072. Epub 2012 Dec 24.


Topical SMIP-7.7, a toll-like receptor 7 agonist, protects against genital herpes simplex virus type-2 disease in the guinea pig model of genital herpes.

Bernstein DI, Cardin RD, Bravo FJ, Earwood J, Clark JR, Li Y, Mishra P, Li C, Nayak BP, Miller AT, Wu TY, Cooke MP, Valiante NM.

Antivir Chem Chemother. 2014 Apr 11;23(5):189-96. doi: 10.3851/IMP2499.


Euphohelioscopin A is a PKC activator capable of inducing macrophage differentiation.

de Lichtervelde L, Antal CE, Boitano AE, Wang Y, Krastel P, Petersen F, Newton AC, Cooke MP, Schultz PG.

Chem Biol. 2012 Aug 24;19(8):994-1000. doi: 10.1016/j.chembiol.2012.06.010.


An image-based screen identifies a small molecule regulator of megakaryopoiesis.

Boitano AE, de Lichtervelde L, Snead JL, Cooke MP, Schultz PG.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14019-23. doi: 10.1073/pnas.1212545109. Epub 2012 Aug 13.


Rapid expansion of human hematopoietic stem cells by automated control of inhibitory feedback signaling.

Csaszar E, Kirouac DC, Yu M, Wang W, Qiao W, Cooke MP, Boitano AE, Ito C, Zandstra PW.

Cell Stem Cell. 2012 Feb 3;10(2):218-29. doi: 10.1016/j.stem.2012.01.003.


Identification of a high-affinity ligand that exhibits complete aryl hydrocarbon receptor antagonism.

Smith KJ, Murray IA, Tanos R, Tellew J, Boitano AE, Bisson WH, Kolluri SK, Cooke MP, Perdew GH.

J Pharmacol Exp Ther. 2011 Jul;338(1):318-27. doi: 10.1124/jpet.110.178392. Epub 2011 Apr 14.


Small-molecule regulators of human stem cell self-renewal.

Bouchez LC, Boitano AE, de Lichtervelde L, Romeo R, Cooke MP, Schultz PG.

Chembiochem. 2011 Apr 11;12(6):854-7. doi: 10.1002/cbic.201000734. Epub 2011 Mar 4. No abstract available.


Tonic BCR signaling represses receptor editing via Raf- and calcium-dependent signaling pathways.

Ramsey LB, Vegoe AL, Miller AT, Cooke MP, Farrar MA.

Immunol Lett. 2011 Mar 30;135(1-2):74-7. doi: 10.1016/j.imlet.2010.09.018. Epub 2010 Oct 7.


Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells.

Boitano AE, Wang J, Romeo R, Bouchez LC, Parker AE, Sutton SE, Walker JR, Flaveny CA, Perdew GH, Denison MS, Schultz PG, Cooke MP.

Science. 2010 Sep 10;329(5997):1345-8. doi: 10.1126/science.1191536. Epub 2010 Aug 5. Erratum in: Science. 2011 May 6;332(6030):664.


Regulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphate.

Sauer K, Cooke MP.

Nat Rev Immunol. 2010 Apr;10(4):257-71. doi: 10.1038/nri2745. Review.


Inositol 1,4,5-trisphosphate 3-kinase B is a negative regulator of BCR signaling that controls B cell selection and tolerance induction.

Miller AT, Beisner DR, Liu D, Cooke MP.

J Immunol. 2009 Apr 15;182(8):4696-704. doi: 10.4049/jimmunol.0802850.


A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function.

Barouch-Bentov R, Che J, Lee CC, Yang Y, Herman A, Jia Y, Velentza A, Watson J, Sternberg L, Kim S, Ziaee N, Miller A, Jackson C, Fujimoto M, Young M, Batalov S, Liu Y, Warmuth M, Wiltshire T, Cooke MP, Sauer K.

Mol Cell. 2009 Jan 16;33(1):43-52. doi: 10.1016/j.molcel.2008.12.024.


Gene set enrichment in eQTL data identifies novel annotations and pathway regulators.

Wu C, Delano DL, Mitro N, Su SV, Janes J, McClurg P, Batalov S, Welch GL, Zhang J, Orth AP, Walker JR, Glynne RJ, Cooke MP, Takahashi JS, Shimomura K, Kohsaka A, Bass J, Saez E, Wiltshire T, Su AI.

PLoS Genet. 2008 May 9;4(5):e1000070. doi: 10.1371/journal.pgen.1000070.


Beyond IP3: roles for higher order inositol phosphates in immune cell signaling.

Miller AT, Chamberlain PP, Cooke MP.

Cell Cycle. 2008 Feb 15;7(4):463-7. Epub 2008 Jan 3. Review.


Axon growth and guidance genes identify T-dependent germinal centre B cells.

Yu D, Cook MC, Shin DM, Silva DG, Marshall J, Toellner KM, Havran WL, Caroni P, Cooke MP, Morse HC, MacLennan IC, Goodnow CC, Vinuesa CG.

Immunol Cell Biol. 2008 Jan;86(1):3-14. Epub 2007 Oct 16.


Production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation.

Miller AT, Sandberg M, Huang YH, Young M, Sutton S, Sauer K, Cooke MP.

Nat Immunol. 2007 May;8(5):514-21. Epub 2007 Apr 8. Erratum in: Nat Immunol. 2007 Jul;8(7):780.


Positive regulation of Itk PH domain function by soluble IP4.

Huang YH, Grasis JA, Miller AT, Xu R, Soonthornvacharin S, Andreotti AH, Tsoukas CD, Cooke MP, Sauer K.

Science. 2007 May 11;316(5826):886-9. Epub 2007 Apr 5.


Data and animal management software for large-scale phenotype screening.

Ching KA, Cooke MP, Tarantino LM, Lapp H.

Mamm Genome. 2006 Apr;17(4):288-97. Epub 2006 Apr 4. Review.


Interleukin-15 rescues tolerant CD8+ T cells for use in adoptive immunotherapy of established tumors.

Teague RM, Sather BD, Sacks JA, Huang MZ, Dossett ML, Morimoto J, Tan X, Sutton SE, Cooke MP, Ohlén C, Greenberg PD.

Nat Med. 2006 Mar;12(3):335-41. Epub 2006 Feb 12.


Structural insights into enzyme regulation for inositol 1,4,5-trisphosphate 3-kinase B.

Chamberlain PP, Sandberg ML, Sauer K, Cooke MP, Lesley SA, Spraggon G.

Biochemistry. 2005 Nov 8;44(44):14486-93.


Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'.

Bystrykh L, Weersing E, Dontje B, Sutton S, Pletcher MT, Wiltshire T, Su AI, Vellenga E, Wang J, Manly KF, Lu L, Chesler EJ, Alberts R, Jansen RC, Williams RW, Cooke MP, de Haan G.

Nat Genet. 2005 Mar;37(3):225-32. Epub 2005 Feb 13.


Gene expression profile of murine long-term reconstituting vs. short-term reconstituting hematopoietic stem cells.

Zhong JF, Zhao Y, Sutton S, Su A, Zhan Y, Zhu L, Yan C, Gallaher T, Johnston PB, Anderson WF, Cooke MP.

Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2448-53. Epub 2005 Feb 4.


c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation.

Sandberg ML, Sutton SE, Pletcher MT, Wiltshire T, Tarantino LM, Hogenesch JB, Cooke MP.

Dev Cell. 2005 Feb;8(2):153-66.


A gene atlas of the mouse and human protein-encoding transcriptomes.

Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, Block D, Zhang J, Soden R, Hayakawa M, Kreiman G, Cooke MP, Walker JR, Hogenesch JB.

Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6062-7. Epub 2004 Apr 9.


Inositol (1,4,5) trisphosphate 3 kinase B controls positive selection of T cells and modulates Erk activity.

Wen BG, Pletcher MT, Warashina M, Choe SH, Ziaee N, Wiltshire T, Sauer K, Cooke MP.

Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5604-9. Epub 2004 Apr 2.


Exposing oncogenic dependencies for cancer drug target discovery and validation using RNAi.

Deveraux QL, Aza-Blanc P, Wagner KW, Bauerschlag D, Cooke MP, Hampton GM.

Semin Cancer Biol. 2003 Aug;13(4):293-300. Review.


Identification of modulators of TRAIL-induced apoptosis via RNAi-based phenotypic screening.

Aza-Blanc P, Cooper CL, Wagner K, Batalov S, Deveraux QL, Cooke MP.

Mol Cell. 2003 Sep;12(3):627-37.


Optimized protocol for linear RNA amplification and application to gene expression profiling of human renal biopsies.

Scherer A, Krause A, Walker JR, Sutton SE, Serón D, Raulf F, Cooke MP.

Biotechniques. 2003 Mar;34(3):546-50, 552-4, 556.


Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse.

Wiltshire T, Pletcher MT, Batalov S, Barnes SW, Tarantino LM, Cooke MP, Wu H, Smylie K, Santrosyan A, Copeland NG, Jenkins NA, Kalush F, Mural RJ, Glynne RJ, Kay SA, Adams MD, Fletcher CF.

Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3380-5. Epub 2003 Feb 28.


Analysis of B cell memory formation using DNA microarrays.

Vinuesa CG, Cook MC, Cooke MP, Maclennan IC, Goodnow CC.

Ann N Y Acad Sci. 2002 Dec;975:33-45.


Comparative analysis of human genome assemblies reveals genome-level differences.

Li S, Liao J, Cutler G, Hoey T, Hogenesch JB, Cooke MP, Schultz PG, Ling XB.

Genomics. 2002 Aug;80(2):138-9.


Large-scale analysis of the human and mouse transcriptomes.

Su AI, Cooke MP, Ching KA, Hakak Y, Walker JR, Wiltshire T, Orth AP, Vega RG, Sapinoso LM, Moqrich A, Patapoutian A, Hampton GM, Schultz PG, Hogenesch JB.

Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4465-70. Epub 2002 Mar 19.


A self-organized 2-dimensional bifunctional structure formed by supramolecular design.

Hipps KW, Scudiero L, Barlow DE, Cooke MP Jr.

J Am Chem Soc. 2002 Mar 13;124(10):2126-7.


A comparison of the Celera and Ensembl predicted gene sets reveals little overlap in novel genes.

Hogenesch JB, Ching KA, Batalov S, Su AI, Walker JR, Zhou Y, Kay SA, Schultz PG, Cooke MP.

Cell. 2001 Aug 24;106(4):413-5. No abstract available.


Fyn can partially substitute for Lck in T lymphocyte development.

Groves T, Smiley P, Cooke MP, Forbush K, Perlmutter RM, Guidos CJ.

Immunity. 1996 Nov;5(5):417-28.


CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells.

Rathmell JC, Cooke MP, Ho WY, Grein J, Townsend SE, Davis MM, Goodnow CC.

Nature. 1995 Jul 13;376(6536):181-4.


Signaling through murine CD38 is impaired in antigen receptor-unresponsive B cells.

Lund FE, Solvason NW, Cooke MP, Health AW, Grimaldi JC, Parkhouse RM, Goodnow CC, Howard MC.

Eur J Immunol. 1995 May;25(5):1338-45.


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