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Endothelial senescence is induced by phosphorylation and nuclear export of telomeric repeat binding factor 2-interacting protein.

Kotla S, Vu HT, Ko KA, Wang Y, Imanishi M, Heo KS, Fujii Y, Thomas TN, Gi YJ, Mazhar H, Paez-Mayorga J, Shin JH, Tao Y, Giancursio CJ, Medina JL, Taunton J, Lusis AJ, Cooke JP, Fujiwara K, Le NT, Abe JI.

JCI Insight. 2019 May 2;4(9). pii: 124867. doi: 10.1172/jci.insight.124867. eCollection 2019 May 2.


Inflammation and Its Role in Regeneration and Repair.

Cooke JP.

Circ Res. 2019 Apr 12;124(8):1166-1168. doi: 10.1161/CIRCRESAHA.118.314669. No abstract available.


MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis.

Abe JI, Ko KA, Kotla S, Wang Y, Paez-Mayorga J, Shin IJ, Imanishi M, Vu HT, Tao Y, Leiva-Juarez MM, Thomas TN, Medina JL, Won JH, Fujii Y, Giancursio CJ, McBeath E, Shin JH, Guzman L, Abe RJ, Taunton J, Mochizuki N, Faubion W, Cooke JP, Fujiwara K, Evans SE, Le NT.

JCI Insight. 2019 Apr 4;4(7). pii: 125570. doi: 10.1172/jci.insight.125570. eCollection 2019 Apr 4.


Inflammation-targeted vascular nanomedicine.

Cooke JP, Ferrari M.

Nat Biomed Eng. 2018 May;2(5):269-270. doi: 10.1038/s41551-018-0241-y. No abstract available.


Arachidonic acid as a target for treating hypertriglyceridemia reproduced by a causal network analysis and an intervention study.

Yazdani A, Yazdani A, Bowman TA, Marotta F, Cooke JP, Samiei A.

Metabolomics. 2018 May 26;14(6):78. doi: 10.1007/s11306-018-1368-2. No abstract available.


AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate.

Gu Q, Yang X, Lv J, Zhang J, Xia B, Kim JD, Wang R, Xiong F, Meng S, Clements TP, Tandon B, Wagner DS, Diaz MF, Wenzel PL, Miller YI, Traver D, Cooke JP, Li W, Zon LI, Chen K, Bai Y, Fang L.

Science. 2019 Mar 8;363(6431):1085-1088. doi: 10.1126/science.aav1749. Epub 2019 Jan 31.


Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure.

Berry JL, Zhu W, Tang YL, Krishnamurthy P, Ge Y, Cooke JP, Chen Y, Garry DJ, Yang HT, Rajasekaran NS, Koch WJ, Li S, Domae K, Qin G, Cheng K, Kamp TJ, Ye L, Hu S, Ogle BM, Rogers JM, Abel ED, Davis ME, Prabhu SD, Liao R, Pu WT, Wang Y, Ping P, Bursac N, Vunjak-Novakovic G, Wu JC, Bolli R, Menasché P, Zhang J.

Circ Res. 2019 Jan 4;124(1):161-169. doi: 10.1161/CIRCRESAHA.118.314216.


Glycolytic Switch Is Required for Transdifferentiation to Endothelial Lineage.

Lai L, Reineke E, Hamilton DJ, Cooke JP.

Circulation. 2019 Jan 2;139(1):119-133. doi: 10.1161/CIRCULATIONAHA.118.035741.


Novel Markers for Adverse Events in Atrial Fibrillation.

Cooke JP, Sukhovershin RA.

J Am Coll Cardiol. 2018 Aug 14;72(7):734-737. doi: 10.1016/j.jacc.2018.04.091. No abstract available.


Induced pluripotent stem cell-derived endothelial cells promote angiogenesis and accelerate wound closure in a murine excisional wound healing model.

Clayton ZE, Tan RP, Miravet MM, Lennartsson K, Cooke JP, Bursill CA, Wise SG, Patel S.

Biosci Rep. 2018 Jul 31;38(4). pii: BSR20180563. doi: 10.1042/BSR20180563. Print 2018 Aug 31.


Interdisciplinary Models for Research and Clinical Endeavors in Genomic Medicine: A Scientific Statement From the American Heart Association.

Musunuru K, Arora P, Cooke JP, Ferguson JF, Hershberger RE, Hickey KT, Lee JM, Lima JAC, Loscalzo J, Pereira NL, Russell MW, Shah SH, Sheikh F, Wang TJ, MacRae CA; American Heart Association Council on Genomic and Precision Medicine; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; Council on Peripheral Vascular Disease; Council on Quality of Care and Outcomes Research; and Stroke Council.

Circ Genom Precis Med. 2018 Jun;11(6):e000046. doi: 10.1161/HCG.0000000000000046. Review.


Cardiomyocyte Maturation Requires TLR3 Activated Nuclear Factor Kappa B.

Hodgkinson CP, Pratt RE, Kirste I, Dal-Pra S, Cooke JP, Dzau VJ.

Stem Cells. 2018 Aug;36(8):1198-1209. doi: 10.1002/stem.2833. Epub 2018 Apr 22.


Transflammation: How Innate Immune Activation and Free Radicals Drive Nuclear Reprogramming.

Meng S, Chanda P, Thandavarayan RA, Cooke JP.

Antioxid Redox Signal. 2018 Jul 10;29(2):205-218. doi: 10.1089/ars.2017.7364. Epub 2018 Apr 26.


Harnessing and Optimizing the Interplay between Immunotherapy and Radiotherapy to Improve Survival Outcomes.

Mujoo K, Hunt CR, Pandita RK, Ferrari M, Krishnan S, Cooke JP, Hahn S, Pandita TK.

Mol Cancer Res. 2018 Aug;16(8):1209-1214. doi: 10.1158/1541-7786.MCR-17-0743. Epub 2018 Mar 28. Review.


Integration of induced pluripotent stem cell-derived endothelial cells with polycaprolactone/gelatin-based electrospun scaffolds for enhanced therapeutic angiogenesis.

Tan RP, Chan AHP, Lennartsson K, Miravet MM, Lee BSL, Rnjak-Kovacina J, Clayton ZE, Cooke JP, Ng MKC, Patel S, Wise SG.

Stem Cell Res Ther. 2018 Mar 21;9(1):70. doi: 10.1186/s13287-018-0824-2.


TBX20 Regulates Angiogenesis Through the Prokineticin 2-Prokineticin Receptor 1 Pathway.

Meng S, Gu Q, Yang X, Lv J, Owusu I, Matrone G, Chen K, Cooke JP, Fang L.

Circulation. 2018 Aug 28;138(9):913-928. doi: 10.1161/CIRCULATIONAHA.118.033939.


Biomimetic nanoparticles with enhanced affinity towards activated endothelium as versatile tools for theranostic drug delivery.

Martinez JO, Molinaro R, Hartman KA, Boada C, Sukhovershin R, De Rosa E, Kirui D, Zhang S, Evangelopoulos M, Carter AM, Bibb JA, Cooke JP, Tasciotti E.

Theranostics. 2018 Jan 5;8(4):1131-1145. doi: 10.7150/thno.22078. eCollection 2018.


Steroid receptor coactivator-2 (SRC-2) coordinates cardiomyocyte paracrine signaling to promote pressure overload-induced angiogenesis.

Suh JH, Lai L, Nam D, Kim J, Jo J, Taffet GE, Kim E, Kaelber JT, Lee HK, Entman ML, Cooke JP, Reineke EL.

J Biol Chem. 2017 Dec 29;292(52):21643-21652. doi: 10.1074/jbc.M117.804740. Epub 2017 Nov 10.


Transflammation: Innate immune signaling in nuclear reprogramming.

Meng S, Chanda P, Thandavarayan RA, Cooke JP.

Adv Drug Deliv Rev. 2017 Oct 1;120:133-141. doi: 10.1016/j.addr.2017.09.010. Epub 2017 Sep 13. Review.


Lmo2 (LIM-Domain-Only 2) Modulates Sphk1 (Sphingosine Kinase) and Promotes Endothelial Cell Migration.

Matrone G, Meng S, Gu Q, Lv J, Fang L, Chen K, Cooke JP.

Arterioscler Thromb Vasc Biol. 2017 Oct;37(10):1860-1868. doi: 10.1161/ATVBAHA.117.309609. Epub 2017 Aug 3.


A Missing LNC in Vascular Diseases.

Cooke JP, Leeper NJ.

Circ Res. 2017 Aug 4;121(4):320-322. doi: 10.1161/CIRCRESAHA.117.311493. No abstract available.


Telomerase mRNA Reverses Senescence in Progeria Cells.

Li Y, Zhou G, Bruno IG, Cooke JP.

J Am Coll Cardiol. 2017 Aug 8;70(6):804-805. doi: 10.1016/j.jacc.2017.06.017. No abstract available.


Peripheral Blood Cytokine Levels After Acute Myocardial Infarction: IL-1β- and IL-6-Related Impairment of Bone Marrow Function.

Shahrivari M, Wise E, Resende M, Shuster JJ, Zhang J, Bolli R, Cooke JP, Hare JM, Henry TD, Khan A, Taylor DA, Traverse JH, Yang PC, Pepine CJ, Cogle CR; Cardiovascular Cell Therapy Research Network (CCTRN).

Circ Res. 2017 Jun 9;120(12):1947-1957. doi: 10.1161/CIRCRESAHA.116.309947. Epub 2017 May 10.


AIBP Limits Angiogenesis Through γ-Secretase-Mediated Upregulation of Notch Signaling.

Mao R, Meng S, Gu Q, Araujo-Gutierrez R, Kumar S, Yan Q, Almazan F, Youker KA, Fu Y, Pownall HJ, Cooke JP, Miller YI, Fang L.

Circ Res. 2017 May 26;120(11):1727-1739. doi: 10.1161/CIRCRESAHA.116.309754. Epub 2017 Mar 21.


Discovery of novel determinants of endothelial lineage using chimeric heterokaryons.

Wong WT, Matrone G, Tian X, Tomoiaga SA, Au KF, Meng S, Yamazoe S, Sieveking D, Chen K, Burns DM, Chen JK, Blau HM, Cooke JP.

Elife. 2017 Mar 21;6. pii: e23588. doi: 10.7554/eLife.23588.


Retinoic Acid Inducible Gene 1 Protein (RIG1)-Like Receptor Pathway Is Required for Efficient Nuclear Reprogramming.

Sayed N, Ospino F, Himmati F, Lee J, Chanda P, Mocarski ES, Cooke JP.

Stem Cells. 2017 May;35(5):1197-1207. doi: 10.1002/stem.2607. Epub 2017 Mar 27.


The Nicotinic Cholinergic Pathway Contributes to Retinal Neovascularization in a Mouse Model of Retinopathy of Prematurity.

Hackett SF, Seidel C, Abraham S, Chadha R, Fortmann SD, Campochiaro PA, Cooke JP.

Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):1296-1303. doi: 10.1167/iovs.16-20670.


A comparison of the pro-angiogenic potential of human induced pluripotent stem cell derived endothelial cells and induced endothelial cells in a murine model of peripheral arterial disease.

Clayton ZE, Yuen GS, Sadeghipour S, Hywood JD, Wong JW, Huang NF, Ng MK, Cooke JP, Patel S.

Int J Cardiol. 2017 May 1;234:81-89. doi: 10.1016/j.ijcard.2017.01.125. Epub 2017 Jan 31.


Identification of cardiovascular risk factors associated with bone marrow cell subsets in patients with STEMI: a biorepository evaluation from the CCTRN TIME and LateTIME clinical trials.

Contreras A, Orozco AF, Resende M, Schutt RC, Traverse JH, Henry TD, Lai D, Cooke JP, Bolli R, Cohen ML, Moyé L, Pepine CJ, Yang PC, Perin EC, Willerson JT, Taylor DA; Cardiovascular Cell Therapy Research Network (CCTRN).

Basic Res Cardiol. 2017 Jan;112(1):3. Epub 2016 Nov 23.


Vascular Inflammation: A Novel Access Route for Nanomedicine.

Molinaro R, Boada C, Del Rosal GM, Hartman KA, Corbo C, Andrews ED, Toledano-Furman NE, Cooke JP, Tasciotti E.

Methodist Debakey Cardiovasc J. 2016 Sep;12(3):169-174. Review.


Enhancing Stent Effectiveness with Nanofeatures.

Bassous N, Cooke JP, Webster TJ.

Methodist Debakey Cardiovasc J. 2016 Sep;12(3):163-168. Review.


Nanotherapeutic Solutions for Cardiovascular Disease.

Cooke JP, Atkins J.

Methodist Debakey Cardiovasc J. 2016 Sep;12(3):132-133. No abstract available.


The senescence accelerated mouse prone 8 (SAMP8): A novel murine model for cardiac aging.

Karuppagounder V, Arumugam S, Babu SS, Palaniyandi SS, Watanabe K, Cooke JP, Thandavarayan RA.

Ageing Res Rev. 2017 May;35:291-296. doi: 10.1016/j.arr.2016.10.006. Epub 2016 Nov 5. Review.


LIM Domain Only 2 Regulates Endothelial Proliferation, Angiogenesis, and Tissue Regeneration.

Meng S, Matrone G, Lv J, Chen K, Wong WT, Cooke JP.

J Am Heart Assoc. 2016 Oct 6;5(10). pii: e004117.


The use of machine learning for the identification of peripheral artery disease and future mortality risk.

Ross EG, Shah NH, Dalman RL, Nead KT, Cooke JP, Leeper NJ.

J Vasc Surg. 2016 Nov;64(5):1515-1522.e3. doi: 10.1016/j.jvs.2016.04.026. Epub 2016 Jun 3.


Dynamic measures of skeletal muscle dialysate and plasma amino acid concentration in response to exercise and nutrient ingestion in healthy adult males.

McCormack WG, Cooke JP, O'Connor WT, Jakeman PM.

Amino Acids. 2017 Jan;49(1):151-159. doi: 10.1007/s00726-016-2343-8. Epub 2016 Oct 4.


Erratum: Enhancement of the in vivo persistence and antitumor efficacy of CD19 chimeric antigen receptor T cells through the delivery of modified TERT mRNA.

Bai Y, Kan S, Zhou S, Wang Y, Xu J, Cooke JP, Wen J, Deng H.

Cell Discov. 2016 Aug 30;2:16032. doi: 10.1038/celldisc.2016.32. eCollection 2016.


Transdifferentiation Requires iNOS Activation: Role of RING1A S-Nitrosylation.

Meng S, Zhou G, Gu Q, Chanda PK, Ospino F, Cooke JP.

Circ Res. 2016 Oct 14;119(9):e129-e138. Epub 2016 Sep 13.


Bone marrow cell characteristics associated with patient profile and cardiac performance outcomes in the LateTIME-Cardiovascular Cell Therapy Research Network (CCTRN) trial.

Bhatnagar A, Bolli R, Johnstone BH, Traverse JH, Henry TD, Pepine CJ, Willerson JT, Perin EC, Ellis SG, Zhao DX, Yang PC, Cooke JP, Schutt RC, Trachtenberg BH, Orozco A, Resende M, Ebert RF, Sayre SL, Simari RD, Moyé L, Cogle CR, Taylor DA; Cardiovascular Cell Therapy Research Network (CCTRN).

Am Heart J. 2016 Sep;179:142-50. doi: 10.1016/j.ahj.2016.06.018. Epub 2016 Jul 6.


Erratum: Enhancement of the in vivo persistence and antitumor efficacy of CD19 chimeric antigen receptor T cells through the delivery of modified TERT mRNA.

Bai Y, Kan S, Zhou S, Wang Y, Xu J, Cooke JP, Wen J, Deng H.

Cell Discov. 2016 Jan 26;2:15052. doi: 10.1038/celldisc.2015.52. eCollection 2016.


Aligned nanofibrillar collagen scaffolds - Guiding lymphangiogenesis for treatment of acquired lymphedema.

Hadamitzky C, Zaitseva TS, Bazalova-Carter M, Paukshto MV, Hou L, Strassberg Z, Ferguson J, Matsuura Y, Dash R, Yang PC, Kretchetov S, Vogt PM, Rockson SG, Cooke JP, Huang NF.

Biomaterials. 2016 Sep;102:259-267. doi: 10.1016/j.biomaterials.2016.05.040. Epub 2016 Jun 7.


Proton Pump Inhibitors Accelerate Endothelial Senescence.

Yepuri G, Sukhovershin R, Nazari-Shafti TZ, Petrascheck M, Ghebre YT, Cooke JP.

Circ Res. 2016 Jun 10;118(12):e36-42. doi: 10.1161/CIRCRESAHA.116.308807. Epub 2016 May 10.


Optimal ROS Signaling Is Critical for Nuclear Reprogramming.

Zhou G, Meng S, Li Y, Ghebre YT, Cooke JP.

Cell Rep. 2016 May 3;15(5):919-925. doi: 10.1016/j.celrep.2016.03.084. Epub 2016 Apr 21.


Therapeutic transdifferentiation of human fibroblasts into endothelial cells using forced expression of lineage-specific transcription factors.

Wong WT, Cooke JP.

J Tissue Eng. 2016 Feb 1;7:2041731416628329. doi: 10.1177/2041731416628329. eCollection 2016 Jan-Dec.


How May Proton Pump Inhibitors Impair Cardiovascular Health?

Sukhovershin RA, Cooke JP.

Am J Cardiovasc Drugs. 2016 Jun;16(3):153-61. doi: 10.1007/s40256-016-0160-9. Review.


Targeted delivery of human iPS-ECs overexpressing IL-8 receptors inhibits neointimal and inflammatory responses to vascular injury in the rat.

Giordano S, Zhao X, Xing D, Hage F, Oparil S, Cooke JP, Lee J, Nakayama KH, Huang NF, Chen YF.

Am J Physiol Heart Circ Physiol. 2016 Mar 15;310(6):H705-15. doi: 10.1152/ajpheart.00587.2015. Epub 2016 Jan 22.



Shah NH, Cooke JP, Leeper NJ.

Gastroenterology. 2016 Feb;150(2):528. doi: 10.1053/j.gastro.2015.12.017. Epub 2015 Dec 22. No abstract available.


Therapeutic Transdifferentiation: A Novel Approach for Ischemic Syndromes.

Connell JP, Kodali S, Cooke JP.

Methodist Debakey Cardiovasc J. 2015 Jul-Sep;11(3):176-80. doi: 10.14797/mdcj-11-3-176. Review.


Telomerase Therapy to Reverse Cardiovascular Senescence.

Nazari-Shafti TZ, Cooke JP.

Methodist Debakey Cardiovasc J. 2015 Jul-Sep;11(3):172-5. doi: 10.14797/mdcj-11-3-172. Review.


New Insights Into Tobacco-Induced Vascular Disease: Clinical Ramifications.

Cooke JP.

Methodist Debakey Cardiovasc J. 2015 Jul-Sep;11(3):156-9. doi: 10.14797/mdcj-11-3-156. Review.

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