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Carbon monoxide concentration in mainstream E-cigarette emissions measured with diode laser spectroscopy.

Casebolt R, Cook SJ, Islas A, Brown A, Castle K, Dutcher DD.

Tob Control. 2019 Nov 25. pii: tobaccocontrol-2019-055078. doi: 10.1136/tobaccocontrol-2019-055078. [Epub ahead of print]


Dual-mechanism ERK1/2 inhibitors exploit a distinct binding mode to block phosphorylation and nuclear accumulation of ERK1/2.

Kidger AM, Munck JM, Saini HK, Balmanno K, Minihane E, Courtin A, Graham B, O'Reilly M, Odle R, Cook SJ.

Mol Cancer Ther. 2019 Nov 20. pii: molcanther.0505.2019. doi: 10.1158/1535-7163.MCT-19-0505. [Epub ahead of print]


An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis.

Odle RI, Walker SA, Oxley D, Kidger AM, Balmanno K, Gilley R, Okkenhaug H, Florey O, Ktistakis NT, Cook SJ.

Mol Cell. 2019 Nov 6. pii: S1097-2765(19)30794-4. doi: 10.1016/j.molcel.2019.10.016. [Epub ahead of print]


Targeting melanoma's MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors.

Sale MJ, Minihane E, Monks NR, Gilley R, Richards FM, Schifferli KP, Andersen CL, Davies EJ, Vicente MA, Ozono E, Markovets A, Dry JR, Drew L, Flemington V, Proia T, Jodrell DI, Smith PD, Cook SJ.

Nat Commun. 2019 Nov 14;10(1):5167. doi: 10.1038/s41467-019-12409-w.


Evolution of neuronal anatomy and circuitry in two highly divergent nematode species.

Hong RL, Riebesell M, Bumbarger DJ, Cook SJ, Carstensen HR, Sarpolaki T, Cochella L, Castrejon J, Moreno E, Sieriebriennikov B, Hobert O, Sommer RJ.

Elife. 2019 Sep 17;8. pii: e47155. doi: 10.7554/eLife.47155.


Whole-animal connectomes of both Caenorhabditis elegans sexes.

Cook SJ, Jarrell TA, Brittin CA, Wang Y, Bloniarz AE, Yakovlev MA, Nguyen KCQ, Tang LT, Bayer EA, Duerr JS, Bülow HE, Hobert O, Hall DH, Emmons SW.

Nature. 2019 Jul;571(7763):63-71. doi: 10.1038/s41586-019-1352-7. Epub 2019 Jul 3.


Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4.

Myers SM, Miller DC, Molyneux L, Arasta M, Bawn RH, Blackburn TJ, Cook SJ, Edwards N, Endicott JA, Golding BT, Griffin RJ, Hammonds T, Hardcastle IR, Harnor SJ, Heptinstall AB, Lochhead PA, Martin MP, Martin NC, Newell DR, Owen PJ, Pang LC, Reuillon T, Rigoreau LJM, Thomas HD, Tucker JA, Wang LZ, Wong AC, Noble MEM, Wedge SR, Cano C.

Eur J Med Chem. 2019 Sep 15;178:530-543. doi: 10.1016/j.ejmech.2019.05.057. Epub 2019 May 25.


MEK1/2 inhibitor withdrawal reverses acquired resistance driven by BRAFV600E amplification whereas KRASG13D amplification promotes EMT-chemoresistance.

Sale MJ, Balmanno K, Saxena J, Ozono E, Wojdyla K, McIntyre RE, Gilley R, Woroniuk A, Howarth KD, Hughes G, Dry JR, Arends MJ, Caro P, Oxley D, Ashton S, Adams DJ, Saez-Rodriguez J, Smith PD, Cook SJ.

Nat Commun. 2019 May 2;10(1):2030. doi: 10.1038/s41467-019-09438-w.


Validation of an immunoblot assay employing an objective reading system and used as a confirmatory test in equine infectious anaemia surveillance programs.

Scicluna MT, Autorino GL, Cook SJ, Issel CJ, Cook RF, Nardini R.

J Virol Methods. 2019 Apr;266:77-88. doi: 10.1016/j.jviromet.2019.01.012. Epub 2019 Jan 23.


Over-expressed, N-terminally truncated BRAF is detected in the nucleus of cells with nuclear phosphorylated MEK and ERK.

Hey F, Andreadi C, Noble C, Patel B, Jin H, Kamata T, Straatman K, Luo J, Balmanno K, Jones DTW, Collins VP, Cook SJ, Caunt CJ, Pritchard C.

Heliyon. 2018 Dec 20;4(12):e01065. doi: 10.1016/j.heliyon.2018.e01065. eCollection 2018 Dec.


Targeting IKKβ in Cancer: Challenges and Opportunities for the Therapeutic Utilisation of IKKβ Inhibitors.

Prescott JA, Cook SJ.

Cells. 2018 Aug 23;7(9). pii: E115. doi: 10.3390/cells7090115. Review.


Differential chemokine receptor expression and usage by pre-cDC1 and pre-cDC2.

Cook SJ, Lee Q, Wong AC, Spann BC, Vincent JN, Wong JJ, Schlitzer A, Gorrell MD, Weninger W, Roediger B.

Immunol Cell Biol. 2018 Nov;96(10):1131-1139. doi: 10.1111/imcb.12186. Epub 2018 Jul 20.


ERK1/2 inhibitors: New weapons to inhibit the RAS-regulated RAF-MEK1/2-ERK1/2 pathway.

Kidger AM, Sipthorp J, Cook SJ.

Pharmacol Ther. 2018 Jul;187:45-60. doi: 10.1016/j.pharmthera.2018.02.007. Epub 2018 Feb 16. Review.


De-RSKing ERK - regulation of ERK1/2-RSK dissociation by phosphorylation within a disordered motif.

Kidger AM, Cook SJ.

FEBS J. 2018 Jan;285(1):42-45. doi: 10.1111/febs.14344.


Calcium phosphate particles stimulate interleukin-1β release from human vascular smooth muscle cells: A role for spleen tyrosine kinase and exosome release.

Dautova Y, Kapustin AN, Pappert K, Epple M, Okkenhaug H, Cook SJ, Shanahan CM, Bootman MD, Proudfoot D.

J Mol Cell Cardiol. 2018 Feb;115:82-93. doi: 10.1016/j.yjmcc.2017.12.007. Epub 2017 Dec 20.


Two Wrongs Make a Right: Addressing Underreporting in Binary Data from Multiple Sources.

Cook SJ, Blas B, Carroll RJ, Sinha S.

Polit Anal. 2017 Apr;25(2):223-240. doi: 10.1017/pan.2016.13. Epub 2017 Apr 11.


Use of multi-criteria decision analysis to identify potentially dangerous glacial lakes.

Kougkoulos I, Cook SJ, Jomelli V, Clarke L, Symeonakis E, Dortch JM, Edwards LA, Merad M.

Sci Total Environ. 2018 Apr 15;621:1453-1466. doi: 10.1016/j.scitotenv.2017.10.083. Epub 2017 Oct 19.


A novel approach to improving efficiency and cost saving in preoperative blood preparation.

Patel SY, Edwards DA, Boulware DC, Serdiuk A, Cook SJ, Benson K, Rice MJ.

Transfusion. 2017 Dec;57(12):3035-3039. doi: 10.1111/trf.14331. Epub 2017 Sep 23.


ERK1/2 signalling protects against apoptosis following endoplasmic reticulum stress but cannot provide long-term protection against BAX/BAK-independent cell death.

Darling NJ, Balmanno K, Cook SJ.

PLoS One. 2017 Sep 20;12(9):e0184907. doi: 10.1371/journal.pone.0184907. eCollection 2017.


Control of cell death and mitochondrial fission by ERK1/2 MAP kinase signalling.

Cook SJ, Stuart K, Gilley R, Sale MJ.

FEBS J. 2017 Dec;284(24):4177-4195. doi: 10.1111/febs.14122. Epub 2017 Jun 18. Review.


Visualization of Endogenous ERK1/2 in Cells with a Bioorthogonal Covalent Probe.

Sipthorp J, Lebraud H, Gilley R, Kidger AM, Okkenhaug H, Saba-El-Leil M, Meloche S, Caunt CJ, Cook SJ, Heightman TD.

Bioconjug Chem. 2017 Jun 21;28(6):1677-1683. doi: 10.1021/acs.bioconjchem.7b00152. Epub 2017 May 12.


Using ILD or ITD Cues for Sound Source Localization and Speech Understanding in a Complex Listening Environment by Listeners With Bilateral and With Hearing-Preservation Cochlear Implants.

Loiselle LH, Dorman MF, Yost WA, Cook SJ, Gifford RH.

J Speech Lang Hear Res. 2016 Aug 1;59(4):810-8. doi: 10.1044/2015_JSLHR-H-14-0355.


Decreased function of survival motor neuron protein impairs endocytic pathways.

Dimitriadi M, Derdowski A, Kalloo G, Maginnis MS, O'Hern P, Bliska B, Sorkaç A, Nguyen KC, Cook SJ, Poulogiannis G, Atwood WJ, Hall DH, Hart AC.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4377-86. doi: 10.1073/pnas.1600015113. Epub 2016 Jul 11.


RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence.

Galloway A, Saveliev A, Łukasiak S, Hodson DJ, Bolland D, Balmanno K, Ahlfors H, Monzón-Casanova E, Mannurita SC, Bell LS, Andrews S, Díaz-Muñoz MD, Cook SJ, Corcoran A, Turner M.

Science. 2016 Apr 22;352(6284):453-9. doi: 10.1126/science.aad5978.


Sound Source Localization by Normal-Hearing Listeners, Hearing-Impaired Listeners and Cochlear Implant Listeners.

Dorman MF, Loiselle LH, Cook SJ, Yost WA, Gifford RH.

Audiol Neurootol. 2016;21(3):127-31. doi: 10.1159/000444740. Epub 2016 Apr 15.


Serologically silent, occult equine infectious anemia virus (EIAV) infections in horses.

Ricotti S, Garcia MI, Veaute C, Bailat A, Lucca E, Cook RF, Cook SJ, Soutullo A.

Vet Microbiol. 2016 May 1;187:41-49. doi: 10.1016/j.vetmic.2016.03.007. Epub 2016 Mar 11.


Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation.

Lochhead PA, Clark J, Wang LZ, Gilmour L, Squires M, Gilley R, Foxton C, Newell DR, Wedge SR, Cook SJ.

Cell Cycle. 2016;15(4):506-18. doi: 10.1080/15384101.2015.1120915.


Maternal DNA Methylation Regulates Early Trophoblast Development.

Branco MR, King M, Perez-Garcia V, Bogutz AB, Caley M, Fineberg E, Lefebvre L, Cook SJ, Dean W, Hemberger M, Reik W.

Dev Cell. 2016 Jan 25;36(2):152-63. doi: 10.1016/j.devcel.2015.12.027.


Review of the Persistence of Herpes Zoster Vaccine Efficacy in Clinical Trials.

Cook SJ, Flaherty DK.

Clin Ther. 2015 Nov 1;37(11):2388-97. doi: 10.1016/j.clinthera.2015.09.019. Epub 2015 Oct 23. Review.


Glia-derived neurons are required for sex-specific learning in C. elegans.

Sammut M, Cook SJ, Nguyen KCQ, Felton T, Hall DH, Emmons SW, Poole RJ, Barrios A.

Nature. 2015 Oct 15;526(7573):385-390. doi: 10.1038/nature15700.


MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road.

Caunt CJ, Sale MJ, Smith PD, Cook SJ.

Nat Rev Cancer. 2015 Oct;15(10):577-92. doi: 10.1038/nrc4000. Review.


Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome.

Ashford AL, Dunkley TP, Cockerill M, Rowlinson RA, Baak LM, Gallo R, Balmanno K, Goodwin LM, Ward RA, Lochhead PA, Guichard S, Hudson K, Cook SJ.

Cell Mol Life Sci. 2016 Feb;73(4):883-900. doi: 10.1007/s00018-015-2032-x. Epub 2015 Sep 7.


Stimulating translational research: several European life science institutions put their heads together.

Bentires-Alj M, Rajan A, van Harten W, van Luenen HG, Kubicek S, Andersen JB, Saarela J, Cook SJ, Van Minnebruggen G, Roman-Roman S, Maurer C, Erler JT, Bertero MG.

Trends Mol Med. 2015 Sep;21(9):525-7. doi: 10.1016/j.molmed.2015.07.002. Epub 2015 Aug 5.


DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome.

Najas S, Arranz J, Lochhead PA, Ashford AL, Oxley D, Delabar JM, Cook SJ, Barallobre MJ, Arbonés ML.

EBioMedicine. 2015 Jan 17;2(2):120-34. doi: 10.1016/j.ebiom.2015.01.010. eCollection 2015.


The Cell Death Pathway Regulates Synapse Elimination through Cleavage of Gelsolin in Caenorhabditis elegans Neurons.

Meng L, Mulcahy B, Cook SJ, Neubauer M, Wan A, Jin Y, Yan D.

Cell Rep. 2015 Jun 23;11(11):1737-48. doi: 10.1016/j.celrep.2015.05.031. Epub 2015 Jun 11.


Directional Trans-Synaptic Labeling of Specific Neuronal Connections in Live Animals.

Desbois M, Cook SJ, Emmons SW, Bülow HE.

Genetics. 2015 Jul;200(3):697-705. doi: 10.1534/genetics.115.177006. Epub 2015 Apr 27.


Interaural level difference cues determine sound source localization by single-sided deaf patients fit with a cochlear implant.

Dorman MF, Zeitler D, Cook SJ, Loiselle L, Yost WA, Wanna GB, Gifford RH.

Audiol Neurootol. 2015;20(3):183-8. doi: 10.1159/000375394. Epub 2015 Apr 18.


Protective efficacy of centralized and polyvalent envelope immunogens in an attenuated equine lentivirus vaccine.

Craigo JK, Ezzelarab C, Cook SJ, Liu C, Horohov D, Issel CJ, Montelaro RC.

PLoS Pathog. 2015 Jan 8;11(1):e1004610. doi: 10.1371/journal.ppat.1004610. eCollection 2015 Jan.


Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast.

Cambuli F, Murray A, Dean W, Dudzinska D, Krueger F, Andrews S, Senner CE, Cook SJ, Hemberger M.

Nat Commun. 2014 Nov 26;5:5538. doi: 10.1038/ncomms6538.


Epitope shifting of gp90-specific cellular immune responses in EIAV-infected ponies.

Liu C, Cook SJ, Craigo JK, Cook FR, Issel CJ, Montelaro RC, Horohov DW.

Vet Immunol Immunopathol. 2014 Oct 15;161(3-4):161-9. doi: 10.1016/j.vetimm.2014.08.001. Epub 2014 Aug 10.


Intrinsic and acquired resistance to MEK1/2 inhibitors in cancer.

Sale MJ, Cook SJ.

Biochem Soc Trans. 2014 Aug;42(4):776-83. doi: 10.1042/BST20140129. Review.


A novel vacuum assisted closure therapy model for use with percutaneous devices.

Cook SJ, Nichols FR, Brunker LB, Bachus KN.

Med Eng Phys. 2014 Jun;36(6):768-73. doi: 10.1016/j.medengphy.2014.01.008. Epub 2014 Mar 27.


Development and validation of the pediatric AzBio sentence lists.

Spahr AJ, Dorman MF, Litvak LM, Cook SJ, Loiselle LM, DeJong MD, Hedley-Williams A, Sunderhaus LS, Hayes CA, Gifford RH.

Ear Hear. 2014 Jul-Aug;35(4):418-22. doi: 10.1097/AUD.0000000000000031.


Oncogenic K-Ras suppresses IP₃-dependent Ca²⁺ release through remodelling of the isoform composition of IP₃Rs and ER luminal Ca²⁺ levels in colorectal cancer cell lines.

Pierro C, Cook SJ, Foets TC, Bootman MD, Roderick HL.

J Cell Sci. 2014 Apr 1;127(Pt 7):1607-19. doi: 10.1242/jcs.141408. Epub 2014 Feb 12.


The role of MAPK signalling pathways in the response to endoplasmic reticulum stress.

Darling NJ, Cook SJ.

Biochim Biophys Acta. 2014 Oct;1843(10):2150-63. doi: 10.1016/j.bbamcr.2014.01.009. Epub 2014 Jan 15. Review.


The Making of the English: English History, British Identity, Aryan Villages, 1870-1914.

Cook SJ.

J Hist Ideas. 2014 Oct;75(4):629-49. doi: 10.1353/jhi.2014.0030.


Adaptation to mTOR kinase inhibitors by amplification of eIF4E to maintain cap-dependent translation.

Cope CL, Gilley R, Balmanno K, Sale MJ, Howarth KD, Hampson M, Smith PD, Guichard SM, Cook SJ.

J Cell Sci. 2014 Feb 15;127(Pt 4):788-800. doi: 10.1242/jcs.137588. Epub 2013 Dec 20.


A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr(286), not Thr(288).

Ashford AL, Oxley D, Kettle J, Hudson K, Guichard S, Cook SJ, Lochhead PA.

Biochem J. 2014 Jan 1;457(1):43-56. doi: 10.1042/BJ20130461.


MEK inhibitor U0126 reverses protection of axons from Wallerian degeneration independently of MEK-ERK signaling.

Evans C, Cook SJ, Coleman MP, Gilley J.

PLoS One. 2013 Oct 4;8(10):e76505. doi: 10.1371/journal.pone.0076505. eCollection 2013.

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