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The Potential Impact of Hydrocarbons on Mussels in Port au Port Bay, Newfoundland.

Cook MC, May A, Kohl L, Van Biesen G, Parrish CC, Morrill PL.

Adv Mar Biol. 2018;81:1-22. doi: 10.1016/bs.amb.2018.09.003. Epub 2018 Oct 15.


Gain-of-function IKBKB mutation causes human combined immune deficiency.

Cardinez C, Miraghazadeh B, Tanita K, da Silva E, Hoshino A, Okada S, Chand R, Asano T, Tsumura M, Yoshida K, Ohnishi H, Kato Z, Yamazaki M, Okuno Y, Miyano S, Kojima S, Ogawa S, Andrews TD, Field MA, Burgio G, Morio T, Vinuesa CG, Kanegane H, Cook MC.

J Exp Med. 2018 Nov 5;215(11):2715-2724. doi: 10.1084/jem.20180639. Epub 2018 Oct 18.


A randomized trial of serological and cellular responses to hepatitis B vaccination in chronic kidney disease.

da Silva EN, Baker A, Alshekaili J, Karpe K, Cook MC.

PLoS One. 2018 Oct 10;13(10):e0204477. doi: 10.1371/journal.pone.0204477. eCollection 2018.


Hypomorphic caspase activation and recruitment domain 11 (CARD11) mutations associated with diverse immunologic phenotypes with or without atopic disease.

Dorjbal B, Stinson JR, Ma CA, Weinreich MA, Miraghazadeh B, Hartberger JM, Frey-Jakobs S, Weidinger S, Moebus L, Franke A, Schäffer AA, Bulashevska A, Fuchs S, Ehl S, Limaye S, Arkwright PD, Briggs TA, Langley C, Bethune C, Whyte AF, Alachkar H, Nejentsev S, DiMaggio T, Nelson CG, Stone KD, Nason M, Brittain EH, Oler AJ, Veltri DP, Leahy TR, Conlon N, Poli MC, Borzutzky A, Cohen JI, Davis J, Lambert MP, Romberg N, Sullivan KE, Paris K, Freeman AF, Lucas L, Chandrakasan S, Savic S, Hambleton S, Patel SY, Jordan MB, Theos A, Lebensburger J, Atkinson TP, Torgerson TR, Chinn IK, Milner JD, Grimbacher B, Cook MC, Snow AL.

J Allergy Clin Immunol. 2018 Aug 28. pii: S0091-6749(18)31201-6. doi: 10.1016/j.jaci.2018.08.013. [Epub ahead of print]


Lung and airway shape in neuroendocrine cell hyperplasia of infancy.

Mastej EJ, DeBoer EM, Humphries SM, Cook MC, Hunter KS, Liptzin DR, Weinman JP, Deterding RR.

Pediatr Radiol. 2018 Nov;48(12):1745-1754. doi: 10.1007/s00247-018-4189-6. Epub 2018 Jun 28.


Nuclear Factor-kappaB in Autoimmunity: Man and Mouse.

Miraghazadeh B, Cook MC.

Front Immunol. 2018 Apr 9;9:613. doi: 10.3389/fimmu.2018.00613. eCollection 2018. Review.


Exploring Mental Health and Substance use Treatment Needs of Commercially Sexually Exploited Youth Participating in a Specialty Juvenile Court.

Cook MC, Barnert E, Ijadi-Maghsoodi R, Ports K, Bath E.

Behav Med. 2018 Jul-Sep;44(3):242-249. doi: 10.1080/08964289.2018.1432552.


STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles.

Alshekaili J, Chand R, Lee CE, Corley S, Kwong K, Papa I, Fulcher DA, Randall KL, Leiding JW, Ma CS, Wilkins MR, Uzel G, Goodnow CC, Vinuesa CG, Tangye SG, Cook MC.

Sci Rep. 2018 Feb 23;8(1):3529. doi: 10.1038/s41598-018-21389-8.


Trichohepatoenteric Syndrome Presenting with Severe Infection and Later Onset Diarrhoea.

Hosking LM, Bannister EG, Cook MC, Choo S, Kumble S, Cole TS.

J Clin Immunol. 2018 Jan;38(1):1-3. doi: 10.1007/s10875-017-0460-0. Epub 2017 Nov 10. No abstract available.


Agammaglobulinaemia despite terminal B-cell differentiation in a patient with a novel LRBA mutation.

Al Sukaiti N, AbdelRahman K, AlShekaili J, Al Oraimi S, Al Sinani A, Al Rahbi N, Cho V, Field M, Cook MC.

Clin Transl Immunology. 2017 May 26;6(5):e144. doi: 10.1038/cti.2017.20. eCollection 2017 May.


Comparison of enzyme-linked immunosorbent assay and rapid chemiluminescent analyser in the detection of myeloperoxidase and proteinase 3 autoantibodies.

Pucar PA, Hawkins CA, Randall KL, Li C, McNaughton E, Cook MC.

Pathology. 2017 Jun;49(4):413-418. doi: 10.1016/j.pathol.2017.02.006. Epub 2017 May 23.


Technical Note: Unified imaging and robotic couch quality assurance.

Cook MC, Roper J, Elder ES, Schreibmann E.

Med Phys. 2016 Sep;43(9):5080. doi: 10.1118/1.4960369.


Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets.

Ma CS, Wong N, Rao G, Nguyen A, Avery DT, Payne K, Torpy J, O'Young P, Deenick E, Bustamante J, Puel A, Okada S, Kobayashi M, Martinez-Barricarte R, Elliott M, Sebnem Kilic S, El Baghdadi J, Minegishi Y, Bousfiha A, Robertson N, Hambleton S, Arkwright PD, French M, Blincoe AK, Hsu P, Campbell DE, Stormon MO, Wong M, Adelstein S, Fulcher DA, Cook MC, Stepensky P, Boztug K, Beier R, Ikincioğullari A, Ziegler JB, Gray P, Picard C, Boisson-Dupuis S, Phan TG, Grimbacher B, Warnatz K, Holland SM, Uzel G, Casanova JL, Tangye SG.

J Exp Med. 2016 Jul 25;213(8):1589-608. doi: 10.1084/jem.20151467. Epub 2016 Jul 11.


Heterogeneity of Human Neutrophil CD177 Expression Results from CD177P1 Pseudogene Conversion.

Wu Z, Liang R, Ohnesorg T, Cho V, Lam W, Abhayaratna WP, Gatenby PA, Perera C, Zhang Y, Whittle B, Sinclair A, Goodnow CC, Field M, Andrews TD, Cook MC.

PLoS Genet. 2016 May 26;12(5):e1006067. doi: 10.1371/journal.pgen.1006067. eCollection 2016 May.


Sexual Risk Behaviors and Substance Use Among Men Sexually Victimized by Women.

Cook MC, Morisky DE, Williams JK, Ford CL, Gee GC.

Am J Public Health. 2016 Jul;106(7):1263-9. doi: 10.2105/AJPH.2016.303136. Epub 2016 Apr 14.


The determination of Fukushima-derived cesium-134 and cesium-137 in Japanese green tea samples and their distribution subsequent to simulated beverage preparation.

Cook MC, Stukel MJ, Zhang W, Mercier JF, Cooke MW.

J Environ Radioact. 2016 Mar;153:23-30. doi: 10.1016/j.jenvrad.2015.12.010. Epub 2015 Dec 20.


Medical case reports in the age of genomic medicine.

Cook MC.

Clin Transl Immunology. 2015 Oct 16;4(10):e45. doi: 10.1038/cti.2015.15. eCollection 2015 Oct. Review.


Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies.

Ma CS, Wong N, Rao G, Avery DT, Torpy J, Hambridge T, Bustamante J, Okada S, Stoddard JL, Deenick EK, Pelham SJ, Payne K, Boisson-Dupuis S, Puel A, Kobayashi M, Arkwright PD, Kilic SS, El Baghdadi J, Nonoyama S, Minegishi Y, Mahdaviani SA, Mansouri D, Bousfiha A, Blincoe AK, French MA, Hsu P, Campbell DE, Stormon MO, Wong M, Adelstein S, Smart JM, Fulcher DA, Cook MC, Phan TG, Stepensky P, Boztug K, Kansu A, İkincioğullari A, Baumann U, Beier R, Roscioli T, Ziegler JB, Gray P, Picard C, Grimbacher B, Warnatz K, Holland SM, Casanova JL, Uzel G, Tangye SG.

J Allergy Clin Immunol. 2015 Oct;136(4):993-1006.e1. doi: 10.1016/j.jaci.2015.05.036. Epub 2015 Jul 7.


Comparison of orthogonal chromatographic and lectin-affinity microarray methods for glycan profiling of a therapeutic monoclonal antibody.

Cook MC, Kaldas SJ, Muradia G, Rosu-Myles M, Kunkel JP.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Aug 1;997:162-78. doi: 10.1016/j.jchromb.2015.05.035. Epub 2015 Jun 9.


Determination of meningococcal serogroups in formulated monovalent and multivalent polysaccharide and polysaccharide-conjugate vaccines.

Cook MC, Kunkel JP.

Anal Chem. 2015 May 5;87(9):5009-11. doi: 10.1021/acs.analchem.5b00276. Epub 2015 Apr 14. No abstract available.


Reducing the search space for causal genetic variants with VASP.

Field MA, Cho V, Cook MC, Enders A, Vinuesa CG, Whittle B, Andrews TD, Goodnow CC.

Bioinformatics. 2015 Jul 15;31(14):2377-9. doi: 10.1093/bioinformatics/btv135. Epub 2015 Mar 8.


A deleterious RNF43 germline mutation in a severely affected serrated polyposis kindred.

Taupin D, Lam W, Rangiah D, McCallum L, Whittle B, Zhang Y, Andrews D, Field M, Goodnow CC, Cook MC.

Hum Genome Var. 2015 Apr 16;2:15013. doi: 10.1038/hgv.2015.13. eCollection 2015.


Autosomal-dominant B-cell deficiency with alopecia due to a mutation in NFKB2 that results in nonprocessable p100.

Lee CE, Fulcher DA, Whittle B, Chand R, Fewings N, Field M, Andrews D, Goodnow CC, Cook MC.

Blood. 2014 Nov 6;124(19):2964-72. doi: 10.1182/blood-2014-06-578542. Epub 2014 Sep 18.


Identification of a pathogenic variant in TREX1 in early-onset cerebral systemic lupus erythematosus by Whole-exome sequencing.

Ellyard JI, Jerjen R, Martin JL, Lee AY, Field MA, Jiang SH, Cappello J, Naumann SK, Andrews TD, Scott HS, Casarotto MG, Goodnow CC, Chaitow J, Pascual V, Hertzog P, Alexander SI, Cook MC, Vinuesa CG.

Arthritis Rheumatol. 2014 Dec;66(12):3382-6.


STAT3 is a central regulator of lymphocyte differentiation and function.

Kane A, Deenick EK, Ma CS, Cook MC, Uzel G, Tangye SG.

Curr Opin Immunol. 2014 Jun;28:49-57. doi: 10.1016/j.coi.2014.01.015. Epub 2014 Mar 6. Review.


Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+ T cells.

Altin JA, Daley SR, Howitt J, Rickards HJ, Batkin AK, Horikawa K, Prasad SJ, Nelms KA, Kumar S, Wu LC, Tan SS, Cook MC, Goodnow CC.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2067-74. doi: 10.1073/pnas.1322739111. Epub 2014 Jan 13.


Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells.

Deenick EK, Avery DT, Chan A, Berglund LJ, Ives ML, Moens L, Stoddard JL, Bustamante J, Boisson-Dupuis S, Tsumura M, Kobayashi M, Arkwright PD, Averbuch D, Engelhard D, Roesler J, Peake J, Wong M, Adelstein S, Choo S, Smart JM, French MA, Fulcher DA, Cook MC, Picard C, Durandy A, Klein C, Holland SM, Uzel G, Casanova JL, Ma CS, Tangye SG.

J Exp Med. 2013 Nov 18;210(12):2739-53. doi: 10.1084/jem.20130323. Epub 2013 Nov 11.


IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts.

Berglund LJ, Avery DT, Ma CS, Moens L, Deenick EK, Bustamante J, Boisson-Dupuis S, Wong M, Adelstein S, Arkwright PD, Bacchetta R, Bezrodnik L, Dadi H, Roifman CM, Fulcher DA, Ziegler JB, Smart JM, Kobayashi M, Picard C, Durandy A, Cook MC, Casanova JL, Uzel G, Tangye SG.

Blood. 2013 Dec 5;122(24):3940-50. doi: 10.1182/blood-2013-06-506865. Epub 2013 Oct 24.


Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure.

He J, Tsai LM, Leong YA, Hu X, Ma CS, Chevalier N, Sun X, Vandenberg K, Rockman S, Ding Y, Zhu L, Wei W, Wang C, Karnowski A, Belz GT, Ghali JR, Cook MC, Riminton DS, Veillette A, Schwartzberg PL, Mackay F, Brink R, Tangye SG, Vinuesa CG, Mackay CR, Li Z, Yu D.

Immunity. 2013 Oct 17;39(4):770-81. doi: 10.1016/j.immuni.2013.09.007.


Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function.

Ives ML, Ma CS, Palendira U, Chan A, Bustamante J, Boisson-Dupuis S, Arkwright PD, Engelhard D, Averbuch D, Magdorf K, Roesler J, Peake J, Wong M, Adelstein S, Choo S, Smart JM, French MA, Fulcher DA, Cook MC, Picard C, Durandy A, Tsumura M, Kobayashi M, Uzel G, Casanova JL, Tangye SG, Deenick EK.

J Allergy Clin Immunol. 2013 Aug;132(2):400-11.e9. doi: 10.1016/j.jaci.2013.05.029. Epub 2013 Jul 4.


Quantitation of serogroups in multivalent polysaccharide-based meningococcal vaccines: optimisation of hydrolysis conditions and chromatographic methods.

Cook MC, Bliu A, Kunkel JP.

Vaccine. 2013 Aug 12;31(36):3702-11. doi: 10.1016/j.vaccine.2013.05.098. Epub 2013 Jun 10.


Serogroup quantitation of multivalent polysaccharide and polysaccharide-conjugate meningococcal vaccines from China.

Cook MC, Gibeault S, Filippenko V, Ye Q, Wang J, Kunkel JP.

Biologicals. 2013 Jul;41(4):261-8. doi: 10.1016/j.biologicals.2013.03.003. Epub 2013 May 9.


Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation.

Pratama A, Ramiscal RR, Silva DG, Das SK, Athanasopoulos V, Fitch J, Botelho NK, Chang PP, Hu X, Hogan JJ, Maña P, Bernal D, Korner H, Yu D, Goodnow CC, Cook MC, Vinuesa CG.

Immunity. 2013 Apr 18;38(4):669-80. doi: 10.1016/j.immuni.2013.01.011. Epub 2013 Apr 11.


The unfolded protein response is activated in Helicobacter-induced gastric carcinogenesis in a non-cell autonomous manner.

Baird M, Woon Ang P, Clark I, Bishop D, Oshima M, Cook MC, Hemmings C, Takeishi S, Worthley D, Boussioutas A, Wang TC, Taupin D.

Lab Invest. 2013 Jan;93(1):112-22. doi: 10.1038/labinvest.2012.131. Epub 2012 Oct 29.


Autoimmunity in primary antibody deficiency is associated with protein tyrosine phosphatase nonreceptor type 22 (PTPN22).

Chew GY, Sinha U, Gatenby PA, DeMalmanche T, Adelstein S, Garsia R, Hissaria P, French MA, Wilson A, Whittle B, Kirkpatrick P, Riminton DS, Fulcher DA, Cook MC.

J Allergy Clin Immunol. 2013 Apr;131(4):1130-5, 1135.e1. doi: 10.1016/j.jaci.2012.06.023. Epub 2012 Jul 31.


Prior abdominal open surgery does not impair outcomes of laparoscopic colorectal surgery: a case-control study in 367 patients.

Maggiori L, Cook MC, Bretagnol F, Ferron M, Alves A, Panis Y.

Colorectal Dis. 2013 Feb;15(2):236-43. doi: 10.1111/j.1463-1318.2012.03150.x.


Heterozygosity for Roquinsan leads to angioimmunoblastic T-cell lymphoma-like tumors in mice.

Ellyard JI, Chia T, Rodriguez-Pinilla SM, Martin JL, Hu X, Navarro-Gonzalez M, Garcia JF, Delfau-Larue MH, Montes-Moreno S, Gaulard P, Cook MC, Walters G, Piris MA, Vinuesa CG.

Blood. 2012 Jul 26;120(4):812-21. doi: 10.1182/blood-2011-07-365130. Epub 2012 Jun 13.


IL-10+ CTLA-4+ Th2 inhibitory cells form in a Foxp3-independent, IL-2-dependent manner from Th2 effectors during chronic inflammation.

Altin JA, Goodnow CC, Cook MC.

J Immunol. 2012 Jun 1;188(11):5478-88. doi: 10.4049/jimmunol.1102994. Epub 2012 Apr 30.


Functional STAT3 deficiency compromises the generation of human T follicular helper cells.

Ma CS, Avery DT, Chan A, Batten M, Bustamante J, Boisson-Dupuis S, Arkwright PD, Kreins AY, Averbuch D, Engelhard D, Magdorf K, Kilic SS, Minegishi Y, Nonoyama S, French MA, Choo S, Smart JM, Peake J, Wong M, Gray P, Cook MC, Fulcher DA, Casanova JL, Deenick EK, Tangye SG.

Blood. 2012 Apr 26;119(17):3997-4008. doi: 10.1182/blood-2011-11-392985. Epub 2012 Mar 8.


Updated assessment of the prevalence, spectrum and case definition of autoimmune disease.

Hayter SM, Cook MC.

Autoimmun Rev. 2012 Aug;11(10):754-65. doi: 10.1016/j.autrev.2012.02.001. Epub 2012 Feb 23. Review.


Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP.

Palendira U, Low C, Chan A, Hislop AD, Ho E, Phan TG, Deenick E, Cook MC, Riminton DS, Choo S, Loh R, Alvaro F, Booth C, Gaspar HB, Moretta A, Khanna R, Rickinson AB, Tangye SG.

PLoS Biol. 2011 Nov;9(11):e1001187. doi: 10.1371/journal.pbio.1001187. Epub 2011 Nov 1.


Foxp3⁺ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis.

Tian L, Altin JA, Makaroff LE, Franckaert D, Cook MC, Goodnow CC, Dooley J, Liston A.

Blood. 2011 Aug 18;118(7):1845-53. doi: 10.1182/blood-2011-04-346056. Epub 2011 Jun 28.


Decreased T-cell receptor signaling through CARD11 differentially compromises forkhead box protein 3-positive regulatory versus T(H)2 effector cells to cause allergy.

Altin JA, Tian L, Liston A, Bertram EM, Goodnow CC, Cook MC.

J Allergy Clin Immunol. 2011 May;127(5):1277-85.e5. doi: 10.1016/j.jaci.2010.12.1081. Epub 2011 Feb 12.


Blood relatives of follicular helper T cells.

Vinuesa CG, Cook MC.

Immunity. 2011 Jan 28;34(1):10-2. doi: 10.1016/j.immuni.2011.01.006.


An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity.

Eri RD, Adams RJ, Tran TV, Tong H, Das I, Roche DK, Oancea I, Png CW, Jeffery PL, Radford-Smith GL, Cook MC, Florin TH, McGuckin MA.

Mucosal Immunol. 2011 May;4(3):354-64. doi: 10.1038/mi.2010.74. Epub 2010 Nov 24.


IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells.

Batten M, Ramamoorthi N, Kljavin NM, Ma CS, Cox JH, Dengler HS, Danilenko DM, Caplazi P, Wong M, Fulcher DA, Cook MC, King C, Tangye SG, de Sauvage FJ, Ghilardi N.

J Exp Med. 2010 Dec 20;207(13):2895-906. doi: 10.1084/jem.20100064. Epub 2010 Nov 22.


De novo infantile primary antiphospholipid antibody syndrome.

Alshekaili J, Reynolds G, Cook MC.

Lupus. 2010 Nov;19(13):1565-8. doi: 10.1177/0961203310375263. Epub 2010 Jul 27.


Heterophile interference accounts for method-specific dsDNA antibodies in patients receiving anti-TNF treatment.

Alshekaili J, Li C, Cook MC.

Rheumatology (Oxford). 2010 May;49(5):891-7. doi: 10.1093/rheumatology/keq018. Epub 2010 Feb 23.


B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans.

Avery DT, Deenick EK, Ma CS, Suryani S, Simpson N, Chew GY, Chan TD, Palendira U, Bustamante J, Boisson-Dupuis S, Choo S, Bleasel KE, Peake J, King C, French MA, Engelhard D, Al-Hajjar S, Al-Muhsen S, Magdorf K, Roesler J, Arkwright PD, Hissaria P, Riminton DS, Wong M, Brink R, Fulcher DA, Casanova JL, Cook MC, Tangye SG.

J Exp Med. 2010 Jan 18;207(1):155-71. doi: 10.1084/jem.20091706. Epub 2010 Jan 4.


Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus.

Simpson N, Gatenby PA, Wilson A, Malik S, Fulcher DA, Tangye SG, Manku H, Vyse TJ, Roncador G, Huttley GA, Goodnow CC, Vinuesa CG, Cook MC.

Arthritis Rheum. 2010 Jan;62(1):234-44. doi: 10.1002/art.25032.

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