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C-Terminal HSP90 Inhibitors Block the HIF-1 Hypoxic Response by Degrading HIF-1α through the Oxygen-Dependent Degradation Pathway.

Kataria N, Martinez CA, Kerr B, Zaiter SS, Morgan M, McAlpine SR, Cook KM.

Cell Physiol Biochem. 2019;53(3):480-495. doi: 10.33594/000000152.


Determining the Redox Potential of a Protein Disulphide Bond.

Cook KM.

Methods Mol Biol. 2019;1967:65-86. doi: 10.1007/978-1-4939-9187-7_5.


Obstructive Sleep Apnea Activates HIF-1 in a Hypoxia Dose-Dependent Manner in HCT116 Colorectal Carcinoma Cells.

Martinez CA, Kerr B, Jin C, Cistulli PA, Cook KM.

Int J Mol Sci. 2019 Jan 21;20(2). pii: E445. doi: 10.3390/ijms20020445.


Preclinical Evaluation of Discorhabdins in Antiangiogenic and Antitumor Models.

Harris EM, Strope JD, Beedie SL, Huang PA, Goey AKL, Cook KM, Schofield CJ, Chau CH, Cadelis MM, Copp BR, Gustafson KR, Figg WD.

Mar Drugs. 2018 Jul 19;16(7). pii: E241. doi: 10.3390/md16070241.


Models of intermittent hypoxia and obstructive sleep apnea: molecular pathways and their contribution to cancer.

Hunyor I, Cook KM.

Am J Physiol Regul Integr Comp Physiol. 2018 Oct 1;315(4):R669-R687. doi: 10.1152/ajpregu.00036.2018. Epub 2018 Jul 11. Review.


Incidence of Nephrotoxicity Among Pediatric Patients Receiving Vancomycin With Either Piperacillin-Tazobactam or Cefepime: A Cohort Study.

Cook KM, Gillon J, Grisso AG, Banerjee R, Jimenez-Truque N, Phillips EJ, Van Driest SL.

J Pediatric Infect Dis Soc. 2019 Jul 1;8(3):221-227. doi: 10.1093/jpids/piy030.


Autoregulation of von Willebrand factor function by a disulfide bond switch.

Butera D, Passam F, Ju L, Cook KM, Woon H, Aponte-Santamaría C, Gardiner E, Davis AK, Murphy DA, Bronowska A, Luken BM, Baldauf C, Jackson S, Andrews R, Gräter F, Hogg PJ.

Sci Adv. 2018 Feb 28;4(2):eaaq1477. doi: 10.1126/sciadv.aaq1477. eCollection 2018 Feb.


Analysis of Radionuclide Deposition Ratios from the Fukushima-Daiichi Incident.

Marianno CM, Smith MR, Cook KM.

Health Phys. 2018 Jan;114(1):13-19. doi: 10.1097/HP.0000000000000725.


Zinc is a potent and specific inhibitor of IFN-λ3 signalling.

Read SA, O'Connor KS, Suppiah V, Ahlenstiel CLE, Obeid S, Cook KM, Cunningham A, Douglas MW, Hogg PJ, Booth D, George J, Ahlenstiel G.

Nat Commun. 2017 May 17;8:15245. doi: 10.1038/ncomms15245.


Is There an Accurate Pre-operative Criterion for Dialysis Access Artery or Vein diameter?

Cook KM, Padberg FT Jr.

Eur J Vasc Endovasc Surg. 2017 Jun;53(6):879. doi: 10.1016/j.ejvs.2017.03.005. Epub 2017 Apr 15. No abstract available.


Development of an adaptive, personalized, and scalable dementia care program: Early findings from the Care Ecosystem.

Possin KL, Merrilees J, Bonasera SJ, Bernstein A, Chiong W, Lee K, Wilson L, Hooper SM, Dulaney S, Braley T, Laohavanich S, Feuer JE, Clark AM, Schaffer MW, Schenk AK, Heunis J, Ong P, Cook KM, Bowhay AD, Gearhart R, Chodos A, Naasan G, Bindman AB, Dohan D, Ritchie C, Miller BL.

PLoS Med. 2017 Mar 21;14(3):e1002260. doi: 10.1371/journal.pmed.1002260. eCollection 2017 Mar.


IL-33 acts as a foe to MIA PaCa-2 pancreatic cancer.

Fang Y, Zhao L, Xiao H, Cook KM, Bai Q, Herrick EJ, Chen X, Qin C, Zhu Z, Wakefield MR, Nicholl MB.

Med Oncol. 2017 Feb;34(2):23. doi: 10.1007/s12032-016-0880-3. Epub 2017 Jan 5.


A substrate-driven allosteric switch that enhances PDI catalytic activity.

Bekendam RH, Bendapudi PK, Lin L, Nag PP, Pu J, Kennedy DR, Feldenzer A, Chiu J, Cook KM, Furie B, Huang M, Hogg PJ, Flaumenhaft R.

Nat Commun. 2016 Aug 30;7:12579. doi: 10.1038/ncomms12579.


Screening and Biological Effects of Marine Pyrroloiminoquinone Alkaloids: Potential Inhibitors of the HIF-1α/p300 Interaction.

Goey AK, Chau CH, Sissung TM, Cook KM, Venzon DJ, Castro A, Ransom TR, Henrich CJ, McKee TC, McMahon JB, Grkovic T, Cadelis MM, Copp BR, Gustafson KR, Figg WD.

J Nat Prod. 2016 May 27;79(5):1267-75. doi: 10.1021/acs.jnatprod.5b00846. Epub 2016 May 3.


Exposure to Suboptimal Temperatures during Metamorphosis Reveals a Critical Developmental Window in the Solitary Bee, Megachile rotundata.

Bennett MM, Cook KM, Rinehart JP, Yocum GD, Kemp WP, Greenlee KJ.

Physiol Biochem Zool. 2015 Sep-Oct;88(5):508-20. doi: 10.1086/682024. Epub 2015 May 29.


Structural Elucidation and Synthesis of Eudistidine A: An Unusual Polycyclic Marine Alkaloid that Blocks Interaction of the Protein Binding Domains of p300 and HIF-1α.

Chan ST, Patel PR, Ransom TR, Henrich CJ, McKee TC, Goey AK, Cook KM, Figg WD, McMahon JB, Schnermann MJ, Gustafson KR.

J Am Chem Soc. 2015 Apr 29;137(16):5569-75. doi: 10.1021/jacs.5b02156. Epub 2015 Apr 20.


Effect of oxidation of carbon material on suspension electrodes for flow electrode capacitive deionization.

Hatzell KB, Hatzell MC, Cook KM, Boota M, Housel GM, McBride A, Kumbur EC, Gogotsi Y.

Environ Sci Technol. 2015 Mar 3;49(5):3040-7. doi: 10.1021/es5055989. Epub 2015 Feb 11.


Crystal structure of tetra-kis-(μ-N-phenyl-acetamidato)-κ(4) N:O;κ(4) O:N-bis-[(2-methyl-benzo-nitrile-κN)rhodium(II)](Rh-Rh).

Eagle CT, Atem-Tambe N, Kpogo KK, Tan J, Cook KM.

Acta Crystallogr Sect E Struct Rep Online. 2014 Aug 20;70(Pt 9):m333-4. doi: 10.1107/S1600536814017930. eCollection 2014 Sep 1.


(3-Methyl-benzo-nitrile-1κN)-cis-tetra-kis(μ-N-phenyl-acetamidato)-1:2κ(4) N:O;1:2κ(4) O:N-dirhodium(II)(Rh-Rh).

Eagle CT, Quarshie F, Cook KM.

Acta Crystallogr Sect E Struct Rep Online. 2014 Jul 23;70(Pt 8):m304. doi: 10.1107/S1600536814016031. eCollection 2014 Aug 1.


IL-35 promotes pancreas cancer growth through enhancement of proliferation and inhibition of apoptosis: evidence for a role as an autocrine growth factor.

Nicholl MB, Ledgewood CL, Chen X, Bai Q, Qin C, Cook KM, Herrick EJ, Diaz-Arias A, Moore BJ, Fang Y.

Cytokine. 2014 Dec;70(2):126-33. doi: 10.1016/j.cyto.2014.06.020. Epub 2014 Jul 26.


Inhibition of the HIF1α-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II).

Jayatunga MK, Thompson S, McKee TC, Chan MC, Reece KM, Hardy AP, Sekirnik R, Seden PT, Cook KM, McMahon JB, Figg WD, Schofield CJ, Hamilton AD.

Eur J Med Chem. 2015 Apr 13;94:509-16. doi: 10.1016/j.ejmech.2014.06.006. Epub 2014 Jun 27.


Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1α/p300 complex in a preclinical model of prostate cancer.

Reece KM, Richardson ED, Cook KM, Campbell TJ, Pisle ST, Holly AJ, Venzon DJ, Liewehr DJ, Chau CH, Price DK, Figg WD.

Mol Cancer. 2014 Apr 28;13:91. doi: 10.1186/1476-4598-13-91.


Transparent Conductive Two-Dimensional Titanium Carbide Epitaxial Thin Films.

Halim J, Lukatskaya MR, Cook KM, Lu J, Smith CR, Näslund LA, May SJ, Hultman L, Gogotsi Y, Eklund P, Barsoum MW.

Chem Mater. 2014 Apr 8;26(7):2374-2381. Epub 2014 Feb 28.


Do all β-blockers attenuate the excess hematopoietic progenitor cell mobilization from the bone marrow following trauma/hemorrhagic shock?

Pasupuleti LV, Cook KM, Sifri ZC, Alzate WD, Livingston DH, Mohr AM.

J Trauma Acute Care Surg. 2014 Apr;76(4):970-5. doi: 10.1097/TA.0000000000000181.


Control of blood proteins by functional disulfide bonds.

Butera D, Cook KM, Chiu J, Wong JW, Hogg PJ.

Blood. 2014 Mar 27;123(13):2000-7. doi: 10.1182/blood-2014-01-549816. Epub 2014 Feb 12. Review.


New two-dimensional niobium and vanadium carbides as promising materials for Li-ion batteries.

Naguib M, Halim J, Lu J, Cook KM, Hultman L, Gogotsi Y, Barsoum MW.

J Am Chem Soc. 2013 Oct 30;135(43):15966-9. doi: 10.1021/ja405735d. Epub 2013 Oct 21.


Allosteric control of βII-tryptase by a redox active disulfide bond.

Cook KM, McNeil HP, Hogg PJ.

J Biol Chem. 2013 Nov 29;288(48):34920-9. doi: 10.1074/jbc.M113.523506. Epub 2013 Oct 18.


Spatially selective formation of hydrocarbon, fluorocarbon, and hydroxyl-terminated monolayers on a microelectrode array.

Cook KM, Nissley DA, Ferguson GS.

Langmuir. 2013 Jun 11;29(23):6779-83. doi: 10.1021/la401250d. Epub 2013 May 24.


Hydrogen peroxide enhances radiation-induced apoptosis and inhibition of melanoma cell proliferation.

Fang Y, Moore BJ, Bai Q, Cook KM, Herrick EJ, Nicholl MB.

Anticancer Res. 2013 May;33(5):1799-807.


A potential role for resveratrol as a radiation sensitizer for melanoma treatment.

Fang Y, Bradley MJ, Cook KM, Herrick EJ, Nicholl MB.

J Surg Res. 2013 Aug;183(2):645-53. doi: 10.1016/j.jss.2013.02.037. Epub 2013 Mar 14.


Beta Blockade Protection of Bone Marrow Following Injury: A Critical Link between Heart Rate and Immunomodulation.

Baranski GM, Pasupuleti LV, Sifri ZC, Cook KM, Alzate WD, Rameshwar P, Livingston DH, Mohr AM.

J Bone Marrow Res. 2013;1. pii: 1000124.


Post-translational control of protein function by disulfide bond cleavage.

Cook KM, Hogg PJ.

Antioxid Redox Signal. 2013 May 20;18(15):1987-2015. doi: 10.1089/ars.2012.4807. Epub 2013 Feb 15. Review.


The role of plasma granulocyte colony stimulating factor and bone marrow dysfunction after severe trauma.

Cook KM, Sifri ZC, Baranski GM, Mohr AM, Livingston DH.

J Am Coll Surg. 2013 Jan;216(1):57-64. doi: 10.1016/j.jamcollsurg.2012.08.028. Epub 2012 Oct 10.


Does selective beta-1 blockade provide bone marrow protection after trauma/hemorrhagic shock?

Pasupuleti LV, Cook KM, Sifri ZC, Kotamarti S, Calderon GM, Alzate WD, Livingston DH, Mohr AM.

Surgery. 2012 Sep;152(3):322-30. doi: 10.1016/j.surg.2012.06.016.


Monomorphic ventricular tachycardia after intentional citalopram overdose.

Maddry JK, Breyer K, Cook KM, Heard K.

Am J Emerg Med. 2013 Feb;31(2):447.e5-8. doi: 10.1016/j.ajem.2012.05.039. Epub 2012 Aug 3. No abstract available.


Is the sympathetic system involved in shock-induced gut and lung injury?

Baranski GM, Sifri ZC, Cook KM, Alzate WD, Livingston DH, Mohr AM.

J Trauma Acute Care Surg. 2012 Aug;73(2):343-50; discussion 350. doi: 10.1097/TA.0b013e31825a785a.


Promoting and measuring family caregiver self-efficacy in caregiver-physician interactions.

Moore CD, Cook KM.

Soc Work Health Care. 2011;50(10):801-14. doi: 10.1080/00981389.2011.580835.


Gold oxide as a protecting group for regioselective surface chemistry.

Cook KM, Ferguson GS.

Chem Commun (Camb). 2011 Dec 14;47(46):12550-2. doi: 10.1039/c1cc15742f. Epub 2011 Oct 25.


The National Vaccine Injury Compensation Program.

Cook KM, Evans G.

Pediatrics. 2011 May;127 Suppl 1:S74-7. doi: 10.1542/peds.2010-1722K. Epub 2011 Apr 18.


Angiogenesis inhibitors: current strategies and future prospects.

Cook KM, Figg WD.

CA Cancer J Clin. 2010 Jul-Aug;60(4):222-43. doi: 10.3322/caac.20075. Epub 2010 Jun 16. Review.


Student-run low-income family medicine clinic: controlling costs while providing comprehensive medication management.

Dvoracek JJ, Cook KM, Klepser DG.

J Am Pharm Assoc (2003). 2010 May-Jun;50(3):384-7. doi: 10.1331/JAPhA.2010.09058.


Conservative management of a young adult with hip arthrosis.

Cook KM, Heiderscheit B.

J Orthop Sports Phys Ther. 2009 Dec;39(12):858-66. doi: 10.2519/jospt.2009.3207.


Slowing of dexterous manipulation in old age: force and kinematic findings from the 'nut-and-rod' task.

Cole KJ, Cook KM, Hynes SM, Darling WG.

Exp Brain Res. 2010 Mar;201(2):239-47. doi: 10.1007/s00221-009-2030-z. Epub 2009 Oct 1.


Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism.

Cook KM, Hilton ST, Mecinovic J, Motherwell WB, Figg WD, Schofield CJ.

J Biol Chem. 2009 Sep 25;284(39):26831-8. doi: 10.1074/jbc.M109.009498. Epub 2009 Jul 9.


Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.

Coleman ML, McDonough MA, Hewitson KS, Coles C, Mecinovic J, Edelmann M, Cook KM, Cockman ME, Lancaster DE, Kessler BM, Oldham NJ, Ratcliffe PJ, Schofield CJ.

J Biol Chem. 2007 Aug 17;282(33):24027-38. Epub 2007 Jun 15.


Synthesis and cytotoxicity of novel sansalvamide A derivatives.

Carroll CL, Johnston JV, Kekec A, Brown JD, Parry E, Cajica J, Medina I, Cook KM, Corral R, Pan PS, McAlpine SR.

Org Lett. 2005 Aug 4;7(16):3481-4. Erratum in: Org Lett. 2005 Oct 13;7(21):4785.


Physicians fill void in health care system.

Cook KM.

Va Med Q. 1994 Winter;121(1):26-7. No abstract available.


Overseas elective in Swaziland.

Cook KM, Cook TR.

Kans Med. 1989 Mar;90(3):77, 84. No abstract available.


Femur-bending properties as influenced by gravity: V. Strength vs. calcium and gravity in rats exposed for 2 weeks.

Wunder CC, Cook KM, Watkins SR, Moressi WJ.

Aviat Space Environ Med. 1987 Oct;58(10):977-82.


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