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Two uptake hydrogenases differentially interact with the aerobic respiratory chain during mycobacterial growth and persistence.

Cordero PRF, Grinter R, Hards K, Cryle MJ, Warr CG, Cook GM, Greening C.

J Biol Chem. 2019 Oct 17. pii: jbc.RA119.011076. doi: 10.1074/jbc.RA119.011076. [Epub ahead of print]


Inhalable Dry Powder of Bedaquiline for Pulmonary Tuberculosis: In Vitro Physicochemical Characterization, Antimicrobial Activity and Safety Studies.

Momin MAM, Rangnekar B, Sinha S, Cheung CY, Cook GM, Das SC.

Pharmaceutics. 2019 Oct 1;11(10). pii: E502. doi: 10.3390/pharmaceutics11100502.


Tackling tuberculosis in the indigenous people of New Zealand.

Aung HL, Devine TJ, Mulholland CV, Arcus VL, Cook GM.

Lancet Public Health. 2019 Oct;4(10):e496. doi: 10.1016/S2468-2667(19)30180-X. No abstract available.


Microtiter Screening Reveals Oxygen-Dependent Antimicrobial Activity of Natural Products Against Mastitis-Causing Bacteria.

Ferguson SA, Menorca A, Van Zuylen EM, Cheung CY, McConnell MA, Rennison D, Brimble MA, Bodle K, McDougall S, Cook GM, Heikal A.

Front Microbiol. 2019 Aug 28;10:1995. doi: 10.3389/fmicb.2019.01995. eCollection 2019.


Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection.

Hasenoehrl EJ, Rae Sajorda D, Berney-Meyer L, Johnson S, Tufariello JM, Fuhrer T, Cook GM, Jacobs WR Jr, Berney M.

Nat Commun. 2019 Sep 16;10(1):4215. doi: 10.1038/s41467-019-12224-3.


The synthesis and evaluation of quinolinequinones as anti-mycobacterial agents.

Santoso KT, Menorca A, Cheung CY, Cook GM, Stocker BL, Timmer MSM.

Bioorg Med Chem. 2019 Aug 15;27(16):3532-3545. doi: 10.1016/j.bmc.2019.06.002. Epub 2019 Jun 1.


Diverse hydrogen production and consumption pathways influence methane production in ruminants.

Greening C, Geier R, Wang C, Woods LC, Morales SE, McDonald MJ, Rushton-Green R, Morgan XC, Koike S, Leahy SC, Kelly WJ, Cann I, Attwood GT, Cook GM, Mackie RI.

ISME J. 2019 Oct;13(10):2617-2632. doi: 10.1038/s41396-019-0464-2. Epub 2019 Jun 26.


Structure of F1-ATPase from the obligate anaerobe Fusobacterium nucleatum.

Petri J, Nakatani Y, Montgomery MG, Ferguson SA, Aragão D, Leslie AGW, Heikal A, Walker JE, Cook GM.

Open Biol. 2019 Jun 28;9(6):190066. doi: 10.1098/rsob.190066. Epub 2019 Jun 26.


Utilization of CRISPR Interference To Validate MmpL3 as a Drug Target in Mycobacterium tuberculosis.

McNeil MB, Cook GM.

Antimicrob Agents Chemother. 2019 Jul 25;63(8). pii: e00629-19. doi: 10.1128/AAC.00629-19. Print 2019 Aug.


Genomewide Profiling of the Enterococcus faecalis Transcriptional Response to Teixobactin Reveals CroRS as an Essential Regulator of Antimicrobial Tolerance.

Darnell RL, Knottenbelt MK, Todd Rose FO, Monk IR, Stinear TP, Cook GM.

mSphere. 2019 May 8;4(3). pii: e00228-19. doi: 10.1128/mSphere.00228-19.


Agricultural Origins of a Highly Persistent Lineage of Vancomycin-Resistant Enterococcus faecalis in New Zealand.

Rushton-Green R, Darnell RL, Taiaroa G, Carter GP, Cook GM, Morgan XC.

Appl Environ Microbiol. 2019 Jun 17;85(13). pii: e00137-19. doi: 10.1128/AEM.00137-19. Print 2019 Jul 1.


Functional characterization of BcrR: a one-component transmembrane signal transduction system for bacitracin resistance.

Darnell RL, Nakatani Y, Knottenbelt MK, Gebhard S, Cook GM.

Microbiology. 2019 Apr;165(4):475-487. doi: 10.1099/mic.0.000781. Epub 2019 Feb 19.


The structure of the catalytic domain of the ATP synthase from Mycobacterium smegmatis is a target for developing antitubercular drugs.

Zhang AT, Montgomery MG, Leslie AGW, Cook GM, Walker JE.

Proc Natl Acad Sci U S A. 2019 Jan 25. pii: 201817615. doi: 10.1073/pnas.1817615116. [Epub ahead of print]


Synthesis and Investigation of Phthalazinones as Antitubercular Agents.

Santoso KT, Cheung CY, Hards K, Cook GM, Stocker BL, Timmer MSM.

Chem Asian J. 2019 Apr 15;14(8):1278-1285. doi: 10.1002/asia.201801805. Epub 2019 Feb 13.


Alternate quinone coupling in a new class of succinate dehydrogenase may potentiate mycobacterial respiratory control.

Hards K, Rodriguez SM, Cairns C, Cook GM.

FEBS Lett. 2019 Mar;593(5):475-486. doi: 10.1002/1873-3468.13330. Epub 2019 Feb 7.


FAD-sequestering proteins protect mycobacteria against hypoxic and oxidative stress.

Harold LK, Antoney J, Ahmed FH, Hards K, Carr PD, Rapson T, Greening C, Jackson CJ, Cook GM.

J Biol Chem. 2019 Feb 22;294(8):2903-2912. doi: 10.1074/jbc.RA118.006237. Epub 2018 Dec 19.


Chemical Synergy between Ionophore PBT2 and Zinc Reverses Antibiotic Resistance.

Bohlmann L, De Oliveira DMP, El-Deeb IM, Brazel EB, Harbison-Price N, Ong CY, Rivera-Hernandez T, Ferguson SA, Cork AJ, Phan MD, Soderholm AT, Davies MR, Nimmo GR, Dougan G, Schembri MA, Cook GM, McEwan AG, von Itzstein M, McDevitt CA, Walker MJ.

MBio. 2018 Dec 11;9(6). pii: e02391-18. doi: 10.1128/mBio.02391-18.


Pyrazolo[1,5- a]pyridine Inhibitor of the Respiratory Cytochrome bcc Complex for the Treatment of Drug-Resistant Tuberculosis.

Lu X, Williams Z, Hards K, Tang J, Cheung CY, Aung HL, Wang B, Liu Z, Hu X, Lenaerts A, Woolhiser L, Hastings C, Zhang X, Wang Z, Rhee K, Ding K, Zhang T, Cook GM.

ACS Infect Dis. 2019 Feb 8;5(2):239-249. doi: 10.1021/acsinfecdis.8b00225. Epub 2018 Dec 11.


Microbiome dataset from the upper respiratory tract of patients living with HIV, HIV/TB and TB from Myanmar.

Htun KS, Fong Y, Kyaw AA, Aung ST, Oo KZ, Zaw T, Lockhart PJ, Russell B, Cook GM, Aung HL, Hlaing TM.

Data Brief. 2018 Oct 4;21:354-357. doi: 10.1016/j.dib.2018.10.003. eCollection 2018 Dec.


Acquired Resistance to Antituberculosis Drugs.

Aung HL, Nyunt WW, Fong Y, Russell B, Cook GM, Aung ST.

Emerg Infect Dis. 2018 Nov;24(11):2134. doi: 10.3201/eid2411.180465. No abstract available.


6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.

Buckley BJ, Aboelela A, Minaei E, Jiang LX, Xu Z, Ali U, Fildes K, Cheung CY, Cook SM, Johnson DC, Bachovchin DA, Cook GM, Apte M, Huang M, Ranson M, Kelso MJ.

J Med Chem. 2018 Sep 27;61(18):8299-8320. doi: 10.1021/acs.jmedchem.8b00838. Epub 2018 Sep 7.


Evaluation of the rapid molecular diagnostic test for the New Zealand Mycobacterium tuberculosis Rangipo strain in a clinical setting.

Mulholland CV, Thorpe D, Cursons RT, Karalus N, Fong Y, Arcus VL, Cook GM, Aung HL.

N Z Med J. 2018 Jul 13;131(1478):70-72. No abstract available.


Sequences of Circadian Clock Proteins in the Nudibranch Molluscs Hermissenda crassicornis, Melibe leonina, and Tritonia diomedea.

Cook GM, Gruen AE, Morris J, Pankey MS, Senatore A, Katz PS, Watson WH 3rd, Newcomb JM.

Biol Bull. 2018 Jun;234(3):207-218. doi: 10.1086/698467. Epub 2018 Jun 5.


Ionophoric effects of the antitubercular drug bedaquiline.

Hards K, McMillan DGG, Schurig-Briccio LA, Gennis RB, Lill H, Bald D, Cook GM.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7326-7331. doi: 10.1073/pnas.1803723115. Epub 2018 Jun 25.


'Tethering' fragment-based drug discovery to identify inhibitors of the essential respiratory membrane protein type II NADH dehydrogenase.

Heikal A, Nakatani Y, Jiao W, Wilson C, Rennison D, Weimar MR, Parker EJ, Brimble MA, Cook GM.

Bioorg Med Chem Lett. 2018 Jul 15;28(13):2239-2243. doi: 10.1016/j.bmcl.2018.05.048. Epub 2018 May 26.


Localization and expression of putative circadian clock transcripts in the brain of the nudibranch Melibe leonina.

Duback VE, Sabrina Pankey M, Thomas RI, Huyck TL, Mbarani IM, Bernier KR, Cook GM, O'Dowd CA, Newcomb JM, Watson WH 3rd.

Comp Biochem Physiol A Mol Integr Physiol. 2018 Sep;223:52-59. doi: 10.1016/j.cbpa.2018.05.002. Epub 2018 May 9.


Structure of the NDH-2 - HQNO inhibited complex provides molecular insight into quinone-binding site inhibitors.

Petri J, Shimaki Y, Jiao W, Bridges HR, Russell ER, Parker EJ, Aragão D, Cook GM, Nakatani Y.

Biochim Biophys Acta Bioenerg. 2018 Jul;1859(7):482-490. doi: 10.1016/j.bbabio.2018.03.014. Epub 2018 Apr 3.


Targeting bacterial energetics to produce new antimicrobials.

Hards K, Cook GM.

Drug Resist Updat. 2018 Jan;36:1-12. doi: 10.1016/j.drup.2017.11.001. Epub 2017 Nov 11. Review.


Complete Genome Sequence of a New Zealand Isolate of the Bovine Pathogen Streptococcus uberis.

Taiaroa G, Harbison-Price N, Ferguson SA, Carter GP, Williamson DA, Macknight RC, Cook GM, Heikal A.

Genome Announc. 2018 Mar 1;6(9). pii: e00119-18. doi: 10.1128/genomeA.00119-18.


Total Synthesis and Conformational Study of Callyaerin A: Anti-Tubercular Cyclic Peptide Bearing a Rare Rigidifying (Z)-2,3- Diaminoacrylamide Moiety.

Zhang S, De Leon Rodriguez LM, Leung IKH, Cook GM, Harris PWR, Brimble MA.

Angew Chem Int Ed Engl. 2018 Mar 26;57(14):3631-3635. doi: 10.1002/anie.201712792. Epub 2018 Feb 14.


The mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure.

Hill CH, Cook GM, Spratley SJ, Fawke S, Graham SC, Deane JE.

Nat Commun. 2018 Jan 11;9(1):151. doi: 10.1038/s41467-017-02361-y.


Association between anti-tuberculosis drug resistance-conferring mutations and treatment outcomes in Myanmar.

Aung HL, Tun T, Nyunt WW, Fong Y, Crump JA, Thinn KK, Aung ST, Cook GM.

Infect Dis (Lond). 2018 May;50(5):388-390. doi: 10.1080/23744235.2017.1404632. Epub 2017 Dec 1. No abstract available.


Overexpression of a newly identified d-amino acid transaminase in Mycobacterium smegmatis complements glutamate racemase deletion.

Mortuza R, Aung HL, Taiaroa G, Opel-Reading HK, Kleffmann T, Cook GM, Krause KL.

Mol Microbiol. 2018 Jan;107(2):198-213. doi: 10.1111/mmi.13877. Epub 2017 Dec 7.


Crystal structure of type II NADH:quinone oxidoreductase from Caldalkalibacillus thermarum with an improved resolution of 2.15 Å.

Nakatani Y, Jiao W, Aragão D, Shimaki Y, Petri J, Parker EJ, Cook GM.

Acta Crystallogr F Struct Biol Commun. 2017 Oct 1;73(Pt 10):541-549. doi: 10.1107/S2053230X17013073. Epub 2017 Sep 23.


Synthesis and biological evaluation of novel teixobactin analogues.

Schumacher CE, Harris PWR, Ding XB, Krause B, Wright TH, Cook GM, Furkert DP, Brimble MA.

Org Biomol Chem. 2017 Oct 25;15(41):8755-8760. doi: 10.1039/c7ob02169k.


Role of Alanine Racemase Mutations in Mycobacterium tuberculosis d-Cycloserine Resistance.

Nakatani Y, Opel-Reading HK, Merker M, Machado D, Andres S, Kumar SS, Moradigaravand D, Coll F, Perdigão J, Portugal I, Schön T, Nair D, Devi KRU, Kohl TA, Beckert P, Clark TG, Maphalala G, Khumalo D, Diel R, Klaos K, Aung HL, Cook GM, Parkhill J, Peacock SJ, Swaminathan S, Viveiros M, Niemann S, Krause KL, Köser CU.

Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01575-17. doi: 10.1128/AAC.01575-17. Print 2017 Dec.


Mixotrophy drives niche expansion of verrucomicrobial methanotrophs.

Carere CR, Hards K, Houghton KM, Power JF, McDonald B, Collet C, Gapes DJ, Sparling R, Boyd ES, Cook GM, Greening C, Stott MB.

ISME J. 2017 Nov;11(11):2599-2610. doi: 10.1038/ismej.2017.112. Epub 2017 Aug 4.


Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection.

Kalia NP, Hasenoehrl EJ, Ab Rahman NB, Koh VH, Ang MLT, Sajorda DR, Hards K, Grüber G, Alonso S, Cook GM, Berney M, Pethe K.

Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):7426-7431. doi: 10.1073/pnas.1706139114. Epub 2017 Jun 26.


Evaluation of the genotype MTBDRsl test for detection of second-line drug resistance in drug-resistant Mycobacterium tuberculosis strains in Myanmar.

Nyunt WW, Aung ST, Cook GM, Aung HL.

Infect Dis (Lond). 2017 Nov - Dec;49(11-12):865-866. doi: 10.1080/23744235.2017.1341056. Epub 2017 Jun 20. No abstract available.


Oxidative Phosphorylation as a Target Space for Tuberculosis: Success, Caution, and Future Directions.

Cook GM, Hards K, Dunn E, Heikal A, Nakatani Y, Greening C, Crick DC, Fontes FL, Pethe K, Hasenoehrl E, Berney M.

Microbiol Spectr. 2017 Jun;5(3). doi: 10.1128/microbiolspec.TBTB2-0014-2016. Review.


Development of Multiwell-Plate Methods Using Pure Cultures of Methanogens To Identify New Inhibitors for Suppressing Ruminant Methane Emissions.

Weimar MR, Cheung J, Dey D, McSweeney C, Morrison M, Kobayashi Y, Whitman WB, Carbone V, Schofield LR, Ronimus RS, Cook GM.

Appl Environ Microbiol. 2017 Jul 17;83(15). pii: e00396-17. doi: 10.1128/AEM.00396-17. Print 2017 Aug 1.


First 2 Extensively Drug-Resistant Tuberculosis Cases From Myanmar Treated With Bedaquiline.

Aung HL, Nyunt WW, Fong Y, Cook GM, Aung ST.

Clin Infect Dis. 2017 Aug 1;65(3):531-532. doi: 10.1093/cid/cix365. No abstract available.


Rapid molecular diagnosis of the Mycobacterium tuberculosis Rangipo strain responsible for the largest recurring TB cluster in New Zealand.

Mulholland CV, Ruthe A, Cursons RT, Durrant R, Karalus N, Coley K, Bower J, Permina E, Coleman MJ, Roberts SA, Arcus VL, Cook GM, Aung HL.

Diagn Microbiol Infect Dis. 2017 Jun;88(2):138-140. doi: 10.1016/j.diagmicrobio.2017.03.012. Epub 2017 Mar 23.


First- and second-line antituberculosis drug resistance patterns among previous treatment failure patients in Myanmar.

Nyunt WW, Aung ST, Lwin T, Cook GM, Aung HL.

J Glob Antimicrob Resist. 2017 Jun;9:34-35. doi: 10.1016/j.jgar.2017.02.007. Epub 2017 Mar 18. No abstract available.


The mechanism of catalysis by type-II NADH:quinone oxidoreductases.

Blaza JN, Bridges HR, Aragão D, Dunn EA, Heikal A, Cook GM, Nakatani Y, Hirst J.

Sci Rep. 2017 Jan 9;7:40165. doi: 10.1038/srep40165.


Drug-resistant tuberculosis among previously treated patients in Yangon, Myanmar.

Tun T, Nyunt WW, Latt KZ, Samaranayaka A, Crump JA, Thinn KK, Cook GM, Aung HL.

Int J Mycobacteriol. 2016 Sep;5(3):366-367. doi: 10.1016/j.ijmyco.2016.06.004. Epub 2016 Jun 23. No abstract available.


Draft Genome Sequences of Two Drug-Resistant Mycobacterium tuberculosis Isolates from Myanmar.

Aung HL, Tun T, Permina E, Nyunt WW, Aung ST, Thinn KK, Crump JA, Cook GM.

Genome Announc. 2016 Oct 27;4(5). pii: e00850-16. doi: 10.1128/genomeA.00850-16.


Genotypic diversity of Mycobacterium tuberculosis strains in Myanmar.

Tun T, Aye KS, Nyunt WW, Crump JA, Nakajima C, Suzuki Y, Thinn KK, Cook GM, Aung HL.

Infect Dis (Lond). 2017 Mar;49(3):237-239. doi: 10.1080/23744235.2016.1231419. Epub 2016 Sep 19. No abstract available.


Structure and Function of AmtR in Mycobacterium smegmatis: Implications for Post-Transcriptional Regulation of Urea Metabolism through a Small Antisense RNA.

Petridis M, Vickers C, Robson J, McKenzie JL, Bereza M, Sharrock A, Aung HL, Arcus VL, Cook GM.

J Mol Biol. 2016 Oct 23;428(21):4315-4329. doi: 10.1016/j.jmb.2016.09.009. Epub 2016 Sep 15.


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