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Epithelial membrane protein 2 governs transepithelial migration of neutrophils into the airspace.

Lin WC, Gowdy KM, Madenspacher JH, Zemans RL, Yamamoto K, Lyons-Cohen MR, Nakano H, Janardhan K, Williams CJ, Cook DN, Mizgerd JP, Fessler MB.

J Clin Invest. 2019 Sep 24. pii: 127144. doi: 10.1172/JCI127144. [Epub ahead of print]


(Inverse) Agonists of Retinoic Acid-Related Orphan Receptor γ: Regulation of Immune Responses, Inflammation, and Autoimmune Disease.

Jetten AM, Cook DN.

Annu Rev Pharmacol Toxicol. 2019 Aug 6. doi: 10.1146/annurev-pharmtox-010919-023711. [Epub ahead of print]


Therapeutic suppression of pulmonary neutrophilia and allergic airway hyperresponsiveness by a RORγt inverse agonist.

Whitehead GS, Kang HS, Thomas SY, Medvedev A, Karcz TP, Izumi G, Nakano K, Makarov SS, Nakano H, Jetten AM, Cook DN.

JCI Insight. 2019 Jun 11;5. pii: 125528. doi: 10.1172/jci.insight.125528.


Endogenous glucocorticoids prevent gastric metaplasia by suppressing spontaneous inflammation.

Busada JT, Ramamoorthy S, Cain DW, Xu X, Cook DN, Cidlowski JA.

J Clin Invest. 2019 Mar 1;129(3):1345-1358. doi: 10.1172/JCI123233. Epub 2019 Feb 18.


Imaging Precision-Cut Lung Slices to Visualize Leukocyte Localization and Trafficking.

Lyons-Cohen MR, Nakano H, Thomas SY, Cook DN.

Methods Mol Biol. 2018;1799:237-246. doi: 10.1007/978-1-4939-7896-0_18.


Isolation and Purification of Epithelial and Endothelial Cells from Mouse Lung.

Nakano H, Nakano K, Cook DN.

Methods Mol Biol. 2018;1799:59-69. doi: 10.1007/978-1-4939-7896-0_6.


Neuropilin-2 regulates airway inflammatory responses to inhaled lipopolysaccharide.

Immormino RM, Lauzier DC, Nakano H, Hernandez ML, Alexis NE, Ghio AJ, Tilley SL, Doerschuk CM, Peden DB, Cook DN, Moran TP.

Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L202-L211. doi: 10.1152/ajplung.00067.2018. Epub 2018 Apr 19.


Pathogenic TH17 inflammation is sustained in the lungs by conventional dendritic cells and Toll-like receptor 4 signaling.

Shalaby KH, Lyons-Cohen MR, Whitehead GS, Thomas SY, Prinz I, Nakano H, Cook DN.

J Allergy Clin Immunol. 2018 Oct;142(4):1229-1242.e6. doi: 10.1016/j.jaci.2017.10.023. Epub 2017 Nov 14.


Reversing SKI-SMAD4-mediated suppression is essential for TH17 cell differentiation.

Zhang S, Takaku M, Zou L, Gu AD, Chou WC, Zhang G, Wu B, Kong Q, Thomas SY, Serody JS, Chen X, Xu X, Wade PA, Cook DN, Ting JPY, Wan YY.

Nature. 2017 Nov 2;551(7678):105-109. doi: 10.1038/nature24283. Epub 2017 Oct 25.


MyD88-dependent dendritic and epithelial cell crosstalk orchestrates immune responses to allergens.

Thomas SY, Whitehead GS, Takaku M, Ward JM, Xu X, Nakano K, Lyons-Cohen MR, Nakano H, Gowdy KM, Wade PA, Cook DN.

Mucosal Immunol. 2018 May;11(3):796-810. doi: 10.1038/mi.2017.84. Epub 2017 Oct 25.


Early Endometriosis in Females Is Directed by Immune-Mediated Estrogen Receptor α and IL-6 Cross-Talk.

Burns KA, Thomas SY, Hamilton KJ, Young SL, Cook DN, Korach KS.

Endocrinology. 2018 Jan 1;159(1):103-118. doi: 10.1210/en.2017-00562.


TNF is required for TLR ligand-mediated but not protease-mediated allergic airway inflammation.

Whitehead GS, Thomas SY, Shalaby KH, Nakano K, Moran TP, Ward JM, Flake GP, Nakano H, Cook DN.

J Clin Invest. 2017 Sep 1;127(9):3313-3326. doi: 10.1172/JCI90890. Epub 2017 Jul 31.


NIAID, NIEHS, NHLBI, and MCAN Workshop Report: The indoor environment and childhood asthma-implications for home environmental intervention in asthma prevention and management.

Gold DR, Adamkiewicz G, Arshad SH, Celedón JC, Chapman MD, Chew GL, Cook DN, Custovic A, Gehring U, Gern JE, Johnson CC, Kennedy S, Koutrakis P, Leaderer B, Mitchell H, Litonjua AA, Mueller GA, O'Connor GT, Ownby D, Phipatanakul W, Persky V, Perzanowski MS, Ramsey CD, Salo PM, Schwaninger JM, Sordillo JE, Spira A, Suglia SF, Togias A, Zeldin DC, Matsui EC.

J Allergy Clin Immunol. 2017 Oct;140(4):933-949. doi: 10.1016/j.jaci.2017.04.024. Epub 2017 May 10.


Precision-cut Mouse Lung Slices to Visualize Live Pulmonary Dendritic Cells.

Lyons-Cohen MR, Thomas SY, Cook DN, Nakano H.

J Vis Exp. 2017 Apr 5;(122). doi: 10.3791/55465.


Distinct functions of CXCR4, CCR2, and CX3CR1 direct dendritic cell precursors from the bone marrow to the lung.

Nakano H, Lyons-Cohen MR, Whitehead GS, Nakano K, Cook DN.

J Leukoc Biol. 2017 May;101(5):1143-1153. doi: 10.1189/jlb.1A0616-285R. Epub 2017 Feb 1.


Reply to Lagier et al.

Khanna S, Button JE, Lombardo MJ, Vulic M, Henn MR, Cook DN, Pomerantz RJ, Hohmann EL.

J Infect Dis. 2017 Jan 1;215(1):162-164. doi: 10.1093/infdis/jiw490. Epub 2016 Oct 20. No abstract available.


A Novel Microbiome Therapeutic Increases Gut Microbial Diversity and Prevents Recurrent Clostridium difficile Infection.

Khanna S, Pardi DS, Kelly CR, Kraft CS, Dhere T, Henn MR, Lombardo MJ, Vulic M, Ohsumi T, Winkler J, Pindar C, McGovern BH, Pomerantz RJ, Aunins JG, Cook DN, Hohmann EL.

J Infect Dis. 2016 Jul 15;214(2):173-81. doi: 10.1093/infdis/jiv766. Epub 2016 Feb 8.


Inhaled house dust programs pulmonary dendritic cells to promote type 2 T-cell responses by an indirect mechanism.

Moran TP, Nakano K, Whitehead GS, Thomas SY, Cook DN, Nakano H.

Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15;309(10):L1208-18. doi: 10.1152/ajplung.00256.2015. Epub 2015 Sep 18.


Complement receptor C5aR1/CD88 and dipeptidyl peptidase-4/CD26 define distinct hematopoietic lineages of dendritic cells.

Nakano H, Moran TP, Nakano K, Gerrish KE, Bortner CD, Cook DN.

J Immunol. 2015 Apr 15;194(8):3808-19. doi: 10.4049/jimmunol.1402195. Epub 2015 Mar 13.


Distinct Tlr4-expressing cell compartments control neutrophilic and eosinophilic airway inflammation.

McAlees JW, Whitehead GS, Harley IT, Cappelletti M, Rewerts CL, Holdcroft AM, Divanovic S, Wills-Karp M, Finkelman FD, Karp CL, Cook DN.

Mucosal Immunol. 2015 Jul;8(4):863-73. doi: 10.1038/mi.2014.117. Epub 2014 Dec 3.


Epigenetic control of Ccr7 expression in distinct lineages of lung dendritic cells.

Moran TP, Nakano H, Kondilis-Mangum HD, Wade PA, Cook DN.

J Immunol. 2014 Nov 15;193(10):4904-13. doi: 10.4049/jimmunol.1401104. Epub 2014 Oct 8.


Trif-dependent induction of Th17 immunity by lung dendritic cells.

Hsia BJ, Whitehead GS, Thomas SY, Nakano K, Gowdy KM, Aloor JJ, Nakano H, Cook DN.

Mucosal Immunol. 2015 Jan;8(1):186-97. doi: 10.1038/mi.2014.56. Epub 2014 Jul 2.


Modulation of distinct asthmatic phenotypes in mice by dose-dependent inhalation of microbial products.

Whitehead GS, Thomas SY, Cook DN.

Environ Health Perspect. 2014 Jan;122(1):34-42. doi: 10.1289/ehp.1307280. Epub 2013 Oct 29.


Pulmonary antigen presenting cells: isolation, purification, and culture.

Nakano H, Cook DN.

Methods Mol Biol. 2013;1032:19-29. doi: 10.1007/978-1-62703-496-8_2.


CC chemokine receptor 8 potentiates donor Treg survival and is critical for the prevention of murine graft-versus-host disease.

Coghill JM, Fowler KA, West ML, Fulton LM, van Deventer H, McKinnon KP, Vincent BG, Lin K, Panoskaltsis-Mortari A, Cook DN, Blazar BR, Serody JS.

Blood. 2013 Aug 1;122(5):825-36. doi: 10.1182/blood-2012-06-435735. Epub 2013 Jun 24.


Migratory properties of pulmonary dendritic cells are determined by their developmental lineage.

Nakano H, Burgents JE, Nakano K, Whitehead GS, Cheong C, Bortner CD, Cook DN.

Mucosal Immunol. 2013 Jul;6(4):678-91. doi: 10.1038/mi.2012.106. Epub 2012 Nov 21.


The Toll-like receptor 5 ligand flagellin promotes asthma by priming allergic responses to indoor allergens.

Wilson RH, Maruoka S, Whitehead GS, Foley JF, Flake GP, Sever ML, Zeldin DC, Kraft M, Garantziotis S, Nakano H, Cook DN.

Nat Med. 2012 Nov;18(11):1705-10. doi: 10.1038/nm.2920. Epub 2012 Oct 14.


ATP binding cassette transporter G1 deletion induces IL-17-dependent dysregulation of pulmonary adaptive immunity.

Draper DW, Gowdy KM, Madenspacher JH, Wilson RH, Whitehead GS, Nakano H, Pandiri AR, Foley JF, Remaley AT, Cook DN, Fessler MB.

J Immunol. 2012 Jun 1;188(11):5327-36. doi: 10.4049/jimmunol.1101605. Epub 2012 Apr 25.


Pulmonary CD103(+) dendritic cells prime Th2 responses to inhaled allergens.

Nakano H, Free ME, Whitehead GS, Maruoka S, Wilson RH, Nakano K, Cook DN.

Mucosal Immunol. 2012 Jan;5(1):53-65. doi: 10.1038/mi.2011.47. Epub 2011 Oct 19.


IL-35 production by inducible costimulator (ICOS)-positive regulatory T cells reverses established IL-17-dependent allergic airways disease.

Whitehead GS, Wilson RH, Nakano K, Burch LH, Nakano H, Cook DN.

J Allergy Clin Immunol. 2012 Jan;129(1):207-15.e1-5. doi: 10.1016/j.jaci.2011.08.009. Epub 2011 Sep 8.


Cyclooxygenase-2 regulates Th17 cell differentiation during allergic lung inflammation.

Li H, Bradbury JA, Dackor RT, Edin ML, Graves JP, DeGraff LM, Wang PM, Bortner CD, Maruoka S, Lih FB, Cook DN, Tomer KB, Jetten AM, Zeldin DC.

Am J Respir Crit Care Med. 2011 Jul 1;184(1):37-49. doi: 10.1164/rccm.201010-1637OC. Epub 2011 Apr 7.


Strain-dependent genomic factors affect allergen-induced airway hyperresponsiveness in mice.

Kelada SN, Wilson MS, Tavarez U, Kubalanza K, Borate B, Whitehead GS, Maruoka S, Roy MG, Olive M, Carpenter DE, Brass DM, Wynn TA, Cook DN, Evans CM, Schwartz DA, Collins FS.

Am J Respir Cell Mol Biol. 2011 Oct;45(4):817-24. doi: 10.1165/rcmb.2010-0315OC. Epub 2011 Mar 4.


The chemokine, CCL3, and its receptor, CCR1, mediate thoracic radiation-induced pulmonary fibrosis.

Yang X, Walton W, Cook DN, Hua X, Tilley S, Haskell CA, Horuk R, Blackstock AW, Kirby SL.

Am J Respir Cell Mol Biol. 2011 Jul;45(1):127-35. doi: 10.1165/rcmb.2010-0265OC. Epub 2010 Sep 24.


Ozone activates pulmonary dendritic cells and promotes allergic sensitization through a Toll-like receptor 4-dependent mechanism.

Hollingsworth JW, Free ME, Li Z, Andrews LN, Nakano H, Cook DN.

J Allergy Clin Immunol. 2010 May;125(5):1167-70. doi: 10.1016/j.jaci.2010.03.001. Epub 2010 Apr 15. No abstract available.


Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness.

Wilson RH, Whitehead GS, Nakano H, Free ME, Kolls JK, Cook DN.

Am J Respir Crit Care Med. 2009 Oct 15;180(8):720-30. doi: 10.1164/rccm.200904-0573OC. Epub 2009 Aug 6.


Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses.

Nakano H, Lin KL, Yanagita M, Charbonneau C, Cook DN, Kakiuchi T, Gunn MD.

Nat Immunol. 2009 Apr;10(4):394-402. doi: 10.1038/ni.1707. Epub 2009 Mar 1.


Alloimmune lung injury induced by local innate immune activation through inhaled lipopolysaccharide.

Garantziotis S, Palmer SM, Snyder LD, Ganous T, Chen BJ, Wang T, Cook DN, Schwartz DA.

Transplantation. 2007 Oct 27;84(8):1012-9.


The chemokine receptor CCR6 is an important component of the innate immune response.

Wen H, Hogaboam CM, Lukacs NW, Cook DN, Lira SA, Kunkel SL.

Eur J Immunol. 2007 Sep;37(9):2487-98.


Innate immune control of pulmonary dendritic cell trafficking.

Cook DN, Bottomly K.

Proc Am Thorac Soc. 2007 Jul;4(3):234-9. Review.


Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6.

Martinez de la Torre Y, Buracchi C, Borroni EM, Dupor J, Bonecchi R, Nebuloni M, Pasqualini F, Doni A, Lauri E, Agostinis C, Bulla R, Cook DN, Haribabu B, Meroni P, Rukavina D, Vago L, Tedesco F, Vecchi A, Lira SA, Locati M, Mantovani A.

Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2319-24. Epub 2007 Feb 5.


The chemokine receptor D6 has opposing effects on allergic inflammation and airway reactivity.

Whitehead GS, Wang T, DeGraff LM, Card JW, Lira SA, Graham GJ, Cook DN.

Am J Respir Crit Care Med. 2007 Feb 1;175(3):243-9. Epub 2006 Nov 9.


Cutting edge: the silent chemokine receptor D6 is required for generating T cell responses that mediate experimental autoimmune encephalomyelitis.

Liu L, Graham GJ, Damodaran A, Hu T, Lira SA, Sasse M, Canasto-Chibuque C, Cook DN, Ransohoff RM.

J Immunol. 2006 Jul 1;177(1):17-21.


Control of microglial neurotoxicity by the fractalkine receptor.

Cardona AE, Pioro EP, Sasse ME, Kostenko V, Cardona SM, Dijkstra IM, Huang D, Kidd G, Dombrowski S, Dutta R, Lee JC, Cook DN, Jung S, Lira SA, Littman DR, Ransohoff RM.

Nat Neurosci. 2006 Jul;9(7):917-24. Epub 2006 Jun 18.


TLR4 signaling attenuates ongoing allergic inflammation.

Hollingsworth JW, Whitehead GS, Lin KL, Nakano H, Gunn MD, Schwartz DA, Cook DN.

J Immunol. 2006 May 15;176(10):5856-62.


Selective targeting of antitumor immune responses with engineered live-attenuated Listeria monocytogenes.

Yoshimura K, Jain A, Allen HE, Laird LS, Chia CY, Ravi S, Brockstedt DG, Giedlin MA, Bahjat KS, Leong ML, Slansky JE, Cook DN, Dubensky TW, Pardoll DM, Schulick RD.

Cancer Res. 2006 Jan 15;66(2):1096-104.


Spontaneous mutations in recombinant inbred mice: mutant toll-like receptor 4 (Tlr4) in BXD29 mice.

Cook DN, Whitehead GS, Burch LH, Berman KG, Kapadia Z, Wohlford-Lenane C, Schwartz DA.

Genetics. 2006 Mar;172(3):1751-5. Epub 2005 Dec 1.


Polymorphisms of the Toll-like receptors and human disease.

Schwartz DA, Cook DN.

Clin Infect Dis. 2005 Nov 15;41 Suppl 7:S403-7.


CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection.

Tyner JW, Uchida O, Kajiwara N, Kim EY, Patel AC, O'Sullivan MP, Walter MJ, Schwendener RA, Cook DN, Danoff TM, Holtzman MJ.

Nat Med. 2005 Nov;11(11):1180-7. Epub 2005 Oct 2.


Killed but metabolically active microbes: a new vaccine paradigm for eliciting effector T-cell responses and protective immunity.

Brockstedt DG, Bahjat KS, Giedlin MA, Liu W, Leong M, Luckett W, Gao Y, Schnupf P, Kapadia D, Castro G, Lim JY, Sampson-Johannes A, Herskovits AA, Stassinopoulos A, Bouwer HG, Hearst JE, Portnoy DA, Cook DN, Dubensky TW Jr.

Nat Med. 2005 Aug;11(8):853-60. Epub 2005 Jul 24.


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