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Benchmarks of Duration and Magnitude of Opioid Consumption After Total Hip and Knee Arthroplasty: A Database Analysis of 69,368 Patients.

Cook DJ, Kaskovich SW, Pirkle SC, Mica MAC, Shi LL, Lee MJ.

J Arthroplasty. 2018 Dec 24. pii: S0883-5403(18)31224-5. doi: 10.1016/j.arth.2018.12.023. [Epub ahead of print]


Improving the adoption of optimal venous thromboembolism prophylaxis in critically ill patients: A process evaluation of a complex quality improvement initiative.

Sauro KM, Brundin-Mather R, Parsons Leigh J, Niven DJ, Kushner B, Soo A, Cook DJ, Straus S, Doig CJ, Bagshaw S, Stelfox HT.

J Crit Care. 2018 Nov 29;50:111-117. doi: 10.1016/j.jcrc.2018.11.023. [Epub ahead of print]


Microbial dysbiosis and mortality during mechanical ventilation: a prospective observational study.

Lamarche D, Johnstone J, Zytaruk N, Clarke F, Hand L, Loukov D, Szamosi JC, Rossi L, Schenck LP, Verschoor CP, McDonald E, Meade MO, Marshall JC, Bowdish DME, Karachi T, Heels-Ansdell D, Cook DJ, Surette MG; PROSPECT Investigators; Canadian Critical Care Trials Group; Canadian Critical Care Translational Biology Group.

Respir Res. 2018 Dec 7;19(1):245. doi: 10.1186/s12931-018-0950-5.


CNB-001, a pleiotropic drug is efficacious in embolized agyrencephalic New Zealand white rabbits and ischemic gyrencephalic cynomolgus monkeys.

Lapchak PA, Boitano PD, Bombien R, Cook DJ, Doyan S, Lara JM, Schubert DR.

Exp Neurol. 2018 Dec 4;313:98-108. doi: 10.1016/j.expneurol.2018.11.010. [Epub ahead of print]


Stroke Longitudinal Volumetric Measures Correlate with the Behavioral Score in Non-Human Primates.

Ramirez-Garcia G, Harrison KA, Fernandez-Ruiz J, Nashed JY, Cook DJ.

Neuroscience. 2019 Jan 15;397:41-55. doi: 10.1016/j.neuroscience.2018.11.026. Epub 2018 Nov 24.


Porous titanium-coated polyetheretherketone implants exhibit an improved bone-implant interface: an in vitro and in vivo biochemical, biomechanical, and histological study.

Cheng BC, Koduri S, Wing CA, Woolery N, Cook DJ, Spiro RC.

Med Devices (Auckl). 2018 Oct 29;11:391-402. doi: 10.2147/MDER.S180482. eCollection 2018.


FLUID trial: a protocol for a hospital-wide open-label cluster crossover pragmatic comparative effectiveness randomised pilot trial.

McIntyre L, Taljaard M, McArdle T, Fox-Robichaud A, English SW, Martin C, Marshall J, Menon K, Muscedere J, Cook DJ, Weijer C, Saginur R, Maybee A, Iyengar A, Forster A, Graham ID, Hawken S, McCartney C, Seely AJ, Stiell IG, Thavorn K, Fergusson DA.

BMJ Open. 2018 Aug 23;8(8):e022780. doi: 10.1136/bmjopen-2018-022780.


Iterative Design of Visual Analytics for a Clinician-in-the-loop Smart Home.

Ghods A, Caffrey K, Lin B, Fraga K, Fritz R, Schmitter-Edgecombe M, Hundhausen C, Cook DJ.

IEEE J Biomed Health Inform. 2018 Aug 8. doi: 10.1109/JBHI.2018.2864287. [Epub ahead of print]


Advancing Randomized Controlled Trials in Pediatric Critical Care: The Perspectives of Trialists.

Duffett M, Swinton M, Brouwers M, Meade M, Cook DJ.

Pediatr Crit Care Med. 2018 Nov;19(11):e595-e602. doi: 10.1097/PCC.0000000000001696.


Technology-Enabled Assessment of Functional Health.

Cook DJ, Schmitter-Edgecombe M, Jonsson L.

IEEE Rev Biomed Eng. 2018 Jun 28. doi: 10.1109/RBME.2018.2851500. [Epub ahead of print]


Smart Home-Based Prediction of Multidomain Symptoms Related to Alzheimer's Disease.

Alberdi A, Weakley A, Schmitter-Edgecombe M, Cook DJ, Aztiria A, Basarab A, Barrenechea M.

IEEE J Biomed Health Inform. 2018 Nov;22(6):1720-1731. doi: 10.1109/JBHI.2018.2798062. Epub 2018 Jan 25.


The Deferred Consent Model in a Prospective Observational Study Evaluating Myocardial Injury in the Intensive Care Unit.

Honarmand K, Belley-Cote EP, Ulic D, Khalifa A, Gibson A, McClure G, Savija N, Alshamsi F, D'Aragon F, Rochwerg B, Duan EH, Karachi T, Lamontagne F, Devereaux PJ, Whitlock RP, Cook DJ.

J Intensive Care Med. 2018 Aug;33(8):475-480. doi: 10.1177/0885066616680772. Epub 2016 Dec 16.


Low-molecular-weight heparin venous thromboprophylaxis in critically ill patients with renal dysfunction: A subgroup analysis of the PROTECT trial.

Pai M, Adhikari NKJ, Ostermann M, Heels-Ansdell D, Douketis JD, Skrobik Y, Qushmaq I, Meade M, Guyatt G, Geerts W, Walsh MW, Crowther MA, Friedrich JO, Burry L, Bellomo R, Brandão da Silva N, Costa Filho R, Cox MJ, Alves Silva S, Cook DJ; PROTECT (Prophylaxis for Thromboembolism in Critical Care Trial) Investigators.

PLoS One. 2018 Jun 1;13(6):e0198285. doi: 10.1371/journal.pone.0198285. eCollection 2018.


Using Smart City Technology to Make Healthcare Smarter.

Cook DJ, Duncan G, Sprint G, Fritz R.

Proc IEEE Inst Electr Electron Eng. 2018 Apr;106(4):708-722. doi: 10.1109/JPROC.2017.2787688. Epub 2018 Jan 23.


Implementing Wearable Sensors for Continuous Assessment of Daytime Heart Rate Response in Inpatient Rehabilitation.

Weeks DL, Sprint GL, Stilwill V, Meisen-Vehrs AL, Cook DJ.

Telemed J E Health. 2018 Apr 2. doi: 10.1089/tmj.2017.0306. [Epub ahead of print]


Assessing frailty in the intensive care unit: A reliability and validity study.

Shears M, Takaoka A, Rochwerg B, Bagshaw SM, Johnstone J, Holding A, Tharmalingam S, Millen T, Clarke F, Rockwood K, Li G, Thabane L, Muscedere J, Stelfox HT, Cook DJ; Canadian Critical Care Trials Group.

J Crit Care. 2018 Jun;45:197-203. doi: 10.1016/j.jcrc.2018.02.004. Epub 2018 Feb 8.


Automatic assessment of functional health decline in older adults based on smart home data.

Alberdi Aramendi A, Weakley A, Aztiria Goenaga A, Schmitter-Edgecombe M, Cook DJ.

J Biomed Inform. 2018 May;81:119-130. doi: 10.1016/j.jbi.2018.03.009. Epub 2018 Mar 15.


International Practice Variation in Weaning Critically Ill Adults from Invasive Mechanical Ventilation.

Burns KEA, Raptis S, Nisenbaum R, Rizvi L, Jones A, Bakshi J, Tan W, Meret A, Cook DJ, Lellouche F, Epstein SK, Gattas D, Kapadia FN, Villar J, Brochard L, Lessard MR, Meade MO.

Ann Am Thorac Soc. 2018 Apr;15(4):494-502. doi: 10.1513/AnnalsATS.201705-410OC.


Learning Activity Predictors from Sensor Data: Algorithms, Evaluation, and Applications.

Minor B, Doppa JR, Cook DJ.

IEEE Trans Knowl Data Eng. 2017 Dec 1;29(12):2744-2757. doi: 10.1109/TKDE.2017.2750669. Epub 2017 Sep 11.


7 versus 14 days of antibiotic treatment for critically ill patients with bloodstream infection: a pilot randomized clinical trial.

Daneman N, Rishu AH, Pinto R, Aslanian P, Bagshaw SM, Carignan A, Charbonney E, Coburn B, Cook DJ, Detsky ME, Dodek P, Hall R, Kumar A, Lamontagne F, Lauzier F, Marshall JC, Martin CM, McIntyre L, Muscedere J, Reynolds S, Sligl W, Stelfox HT, Wilcox ME, Fowler RA; Canadian Critical Care Trials Group.

Trials. 2018 Feb 17;19(1):111. doi: 10.1186/s13063-018-2474-1.


Functionalized metal-organic framework nanocomposites for dispersive solid phase extraction and enantioselective capture of chiral drug intermediates.

Ma X, Zhou X, Yu A, Zhao W, Zhang W, Zhang S, Wei L, Cook DJ, Roy A.

J Chromatogr A. 2018 Feb 16;1537:1-9. doi: 10.1016/j.chroma.2017.12.067. Epub 2018 Jan 6.


Organ donation in the ICU: A document analysis of institutional policies, protocols, and order sets.

Oczkowski SJW, Centofanti JE, Durepos P, Arseneau E, Kelecevic J, Cook DJ, Meade MO.

Intensive Crit Care Nurs. 2018 Apr;45:58-65. doi: 10.1016/j.iccn.2017.12.005. Epub 2018 Jan 10.


Pooled analysis of higher versus lower blood pressure targets for vasopressor therapy septic and vasodilatory shock.

Lamontagne F, Day AG, Meade MO, Cook DJ, Guyatt GH, Hylands M, Radermacher P, Chrétien JM, Beaudoin N, Hébert P, D'Aragon F, Meziani F, Asfar P.

Intensive Care Med. 2018 Jan;44(1):12-21. doi: 10.1007/s00134-017-5016-5. Epub 2017 Dec 19. Review.


A novel perspective to calibrate temporal delays in cerebrovascular reactivity using hypercapnic and hyperoxic respiratory challenges.

Champagne AA, Bhogal AA, Coverdale NS, Mark CI, Cook DJ.

Neuroimage. 2017 Dec 5. pii: S1053-8119(17)30978-3. doi: 10.1016/j.neuroimage.2017.11.044. [Epub ahead of print]


Recovery after critical illness: putting the puzzle together-a consensus of 29.

Azoulay E, Vincent JL, Angus DC, Arabi YM, Brochard L, Brett SJ, Citerio G, Cook DJ, Curtis JR, Dos Santos CC, Ely EW, Hall J, Halpern SD, Hart N, Hopkins RO, Iwashyna TJ, Jaber S, Latronico N, Mehta S, Needham DM, Nelson J, Puntillo K, Quintel M, Rowan K, Rubenfeld G, Van den Berghe G, Van der Hoeven J, Wunsch H, Herridge M.

Crit Care. 2017 Dec 5;21(1):296. doi: 10.1186/s13054-017-1887-7. Review.


Complete Acid-Based Hydrolysis Assay for Carbohydrate Quantification in Seaweed: A Species-Specific Optimized Approach.

Kostas ET, Wilkinson SJ, White DA, Cook DJ.

Methods Mol Biol. 2017 Nov 14. doi: 10.1007/7651_2017_105. [Epub ahead of print]


Aspirin in Patients With Previous Percutaneous Coronary Intervention Undergoing Noncardiac Surgery.

Graham MM, Sessler DI, Parlow JL, Biccard BM, Guyatt G, Leslie K, Chan MTV, Meyhoff CS, Xavier D, Sigamani A, Kumar PA, Mrkobrada M, Cook DJ, Tandon V, Alvarez-Garcia J, Villar JC, Painter TW, Landoni G, Fleischmann E, Lamy A, Whitlock R, Le Manach Y, Aphang-Lam M, Cata JP, Gao P, Terblanche NCS, Ramana PV, Jamieson KA, Bessissow A, Mendoza GR, Ramirez S, Diemunsch PA, Yusuf S, Devereaux PJ.

Ann Intern Med. 2018 Feb 20;168(4):237-244. doi: 10.7326/M17-2341. Epub 2017 Nov 14.


2009-2010 Influenza A(H1N1)-related critical illness among Aboriginal and non-Aboriginal Canadians.

Jung JJ, Pinto R, Zarychanski R, Cook DJ, Jouvet P, Marshall JC, Kumar A, Long J, Rodin R, Fowler RA; Canadian Critical Care Trials Group H1N1 Collaborative.

PLoS One. 2017 Oct 19;12(10):e0184013. doi: 10.1371/journal.pone.0184013. eCollection 2017.


Collegial Activity Learning between Heterogeneous Sensors.

Feuz KD, Cook DJ.

Knowl Inf Syst. 2017 Nov;53(2):337-364. doi: 10.1007/s10115-017-1043-3. Epub 2017 Mar 27.


Smart Secure Homes: A Survey of Smart Home Technologies that Sense, Assess, and Respond to Security Threats.

Dahmen J, Cook DJ, Wang X, Honglei W.

J Reliab Intell Environ. 2017 Aug;3(2):83-98. doi: 10.1007/s40860-017-0035-0. Epub 2017 Feb 15.


Canada-DONATE study protocol: a prospective national observational study of the medical management of deceased organ donors.

D'Aragon F, Dhanani S, Lamontagne F, Cook DJ, Burns K, Akhtar A, Chassé M, Frenette AJ, Keenan S, Lize JF, Kutsogiannis DJ, Kramer A, Hand LE, Arseneau E, Masse MH, Ribic C, Ball I, Baker A, Boyd G, Rochwerg B, Healey A, Hanna S, Guyatt GH, Meade MO; Canadian Critical Care Trials Group and the Canadian National Transplant Research Program.

BMJ Open. 2017 Sep 28;7(9):e018858. doi: 10.1136/bmjopen-2017-018858.


Management of Acute Respiratory Distress Syndrome and Refractory Hypoxemia. A Multicenter Observational Study.

Duan EH, Adhikari NKJ, D'Aragon F, Cook DJ, Mehta S, Alhazzani W, Goligher E, Charbonney E, Arabi YM, Karachi T, Turgeon AF, Hand L, Zhou Q, Austin P, Friedrich J, Lamontagne F, Lauzier F, Patel R, Muscedere J, Hall R, Aslanian P, Piraino T, Albert M, Bagshaw SM, Jacka M, Wood G, Henderson W, Dorscheid D, Ferguson ND, Meade MO; Canadian Critical Care Trials Group.

Ann Am Thorac Soc. 2017 Dec;14(12):1818-1826. doi: 10.1513/AnnalsATS.201612-1042OC.


Need for a Randomized Controlled Trial of Stress Ulcer Prophylaxis in Critically Ill Children: A Canadian Survey.

Duffett M, Choong K, Foster J, Gilfoyle E, Lacroix J, Cook DJ.

Can J Hosp Pharm. 2017 Jul-Aug;70(4):288-293. Epub 2017 Aug 31.


Erratum to: Pediatric intensive care stress ulcer prevention (PIC-UP): a protocol for a pilot randomized trial.

Duffett M, Choong K, Foster J, Gilfoyle E, Lacroix J, Pai N, Thabane L, Cook DJ; Canadian Critical Care Trials Group.

Pilot Feasibility Stud. 2017 Aug 18;3:33. doi: 10.1186/s40814-017-0173-4. eCollection 2017.


The authors reply.

Oczkowski SJW, Duan EH, Groen A, Warren D, Cook DJ.

Crit Care Med. 2017 Sep;45(9):e990-e991. doi: 10.1097/CCM.0000000000002545. No abstract available.


Increased functional connectivity after stroke correlates with behavioral scores in non-human primate model.

Hernandez-Castillo CR, Nashed JY, Fernandez-Ruiz J, Wang J, Gallivan J, Cook DJ.

Sci Rep. 2017 Jul 27;7(1):6701. doi: 10.1038/s41598-017-07175-y.


Fluids in Sepsis and Septic Shock (FISSH): protocol for a pilot randomised controlled trial.

Rochwerg B, Millen T, Austin P, Zeller M, D'Aragon F, Jaeschke R, Masse MH, Mehta S, Lamontagne F, Meade M, Guyatt G, Cook DJ; Canadian Critical Care Trials Group.

BMJ Open. 2017 Jul 20;7(7):e017602. doi: 10.1136/bmjopen-2017-017602.


Protocol adherence for continuously titrated interventions in randomized trials: an overview of the current methodology and case study.

Lauzier F, Adhikari NK, Seely A, Koo KKY, Belley-Côté EP, Burns KEA, Cook DJ, D'Aragon F, Rochwerg B, Kho ME, Oczkowksi SJW, Duan EH, Meade MO, Day AG, Lamontagne F; for ACCADEMY (Academy of Critical Care – Development, Evaluation, and Methodology).

BMC Med Res Methodol. 2017 Jul 17;17(1):106. doi: 10.1186/s12874-017-0388-3.


Forecasting Occurrences of Activities.

Minor B, Cook DJ.

Pervasive Mob Comput. 2017 Jul;38(Pt 1):77-91. doi: 10.1016/j.pmcj.2016.09.010. Epub 2016 Sep 27.


Measuring Changes in Gait and Vehicle Transfer Ability During Inpatient Rehabilitation with Wearable Inertial Sensors.

Borisov V, Sprint G, Cook DJ, Weeks DL.

Proc IEEE Int Conf Pervasive Comput Commun Workshops. 2017 Mar;2017. doi: 10.1109/PERCOMW.2017.7917600. Epub 2017 May 4.


Genome-scale metabolic models applied to human health and disease.

Cook DJ, Nielsen J.

Wiley Interdiscip Rev Syst Biol Med. 2017 Nov;9(6). doi: 10.1002/wsbm.1393. Epub 2017 Jun 23. Review.


An environmental scan of quality indicators in critical care.

Valiani S, Rigal R, Stelfox HT, Muscedere J, Martin CM, Dodek P, Lamontagne F, Fowler R, Gheshmy A, Cook DJ, Forster AJ, Hébert PC.

CMAJ Open. 2017 Jun 21;5(2):E488-E495. doi: 10.9778/cmajo.20150139.


A Survey of Methods for Time Series Change Point Detection.

Aminikhanghahi S, Cook DJ.

Knowl Inf Syst. 2017 May;51(2):339-367. doi: 10.1007/s10115-016-0987-z. Epub 2016 Sep 8.


Pediatric intensive care stress ulcer prevention (PIC-UP): a protocol for a pilot randomized trial.

Duffett M, Choong K, Foster J, Gilfoyle E, Lacroix J, Pai N, Thabane L, Cook DJ; Canadian Critical Care Trials Group.

Pilot Feasibility Stud. 2017 May 19;3:26. doi: 10.1186/s40814-017-0142-y. eCollection 2017. Erratum in: Pilot Feasibility Stud. 2017 Aug 18;3:33.


Erratum to: Cardiac ischemia in patients with septic shock randomized to vasopressin or norepinephrine.

Mehta S, Granton J, Gordon AC, Cook DJ, Lapinsky S, Newton G, Bandayrel K, Little A, Siau C, Ayers D, Singer J, Lee TCK, Walley KR, Storms M, Cooper DJ, Holmes CL, Hebert P, Presneill J, Russell JA; Vasopressin and Septic Shock Trial (VASST) Investigators.

Crit Care. 2017 May 4;21(1):98. doi: 10.1186/s13054-017-1680-7. No abstract available.


Activity Learning as a Foundation for Security Monitoring in Smart Homes.

Dahmen J, Thomas BL, Cook DJ, Wang X.

Sensors (Basel). 2017 Mar 31;17(4). pii: E737. doi: 10.3390/s17040737.


The Use of Bowel Protocols in Critically Ill Adult Patients: A Systematic Review and Meta-Analysis.

Oczkowski SJW, Duan EH, Groen A, Warren D, Cook DJ.

Crit Care Med. 2017 Jul;45(7):e718-e726. doi: 10.1097/CCM.0000000000002315.


High-Quality Randomized Controlled Trials in Pediatric Critical Care: A Survey of Barriers and Facilitators.

Duffett M, Choong K, Foster J, Meade M, Menon K, Parker M, Cook DJ; Canadian Critical Care Trials Group.

Pediatr Crit Care Med. 2017 May;18(5):405-413. doi: 10.1097/PCC.0000000000001144.


Toward personalized and context-aware prompting for smartphone-based intervention.

Fallahzadeh R, Aminikhanghahi S, Gibson AN, Cook DJ.

Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:6010-6013. doi: 10.1109/EMBC.2016.7592098.


Severity of Hypoxemia and Effect of High-Frequency Oscillatory Ventilation in Acute Respiratory Distress Syndrome.

Meade MO, Young D, Hanna S, Zhou Q, Bachman TE, Bollen C, Slutsky AS, Lamb SE, Adhikari NKJ, Mentzelopoulos SD, Cook DJ, Sud S, Brower RG, Thompson BT, Shah S, Stenzler A, Guyatt G, Ferguson ND.

Am J Respir Crit Care Med. 2017 Sep 15;196(6):727-733. doi: 10.1164/rccm.201609-1938OC.


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