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Benchmarks of Duration and Magnitude of Opioid Consumption After Common Spinal Procedures: A Database Analysis of 47,823 Patients.

Cook DJ, Kaskovich S, Pirkle S, Ho A, Conti Mica M, Shi L, Lee M.

Spine (Phila Pa 1976). 2019 Dec 1;44(23):1668-1675. doi: 10.1097/BRS.0000000000003141.


Probiotics in hospitalized adult patients: a systematic review of economic evaluations.

Lau VI, Rochwerg B, Xie F, Johnstone J, Basmaji J, Balakumaran J, Iansavichene A, Cook DJ.

Can J Anaesth. 2019 Nov 12. doi: 10.1007/s12630-019-01525-2. [Epub ahead of print] Review.


Compassionate End-of-Life Care: Mixed-Methods Multisite Evaluation of the 3 Wishes Project.

Vanstone M, Neville TH, Clarke FJ, Swinton M, Sadik M, Takaoka A, Smith O, Baker AJ, LeBlanc A, Foster D, Dhingra V, Phung P, Xu XS, Kao Y, Heels-Ansdell D, Tam B, Toledo F, Boyle A, Cook DJ.

Ann Intern Med. 2019 Nov 12. doi: 10.7326/M19-2438. [Epub ahead of print]


Fostering humanism: a mixed methods evaluation of the Footprints Project in critical care.

Hoad N, Swinton M, Takaoka A, Tam B, Shears M, Waugh L, Toledo F, Clarke FJ, Duan EH, Soth M, Cook DJ.

BMJ Open. 2019 Nov 2;9(11):e029810. doi: 10.1136/bmjopen-2019-029810.


Correction to: Project management lessons learned from the multicentre CYCLE pilot randomized controlled trial.

McCaskell DS, Molloy AJ, Childerhose L, Costigan FA, Reid JC, McCaughan M, Clarke F, Cook DJ, Rudkowski JC, Farley C, Karachi T, Rochwerg B, Newman A, Fox-Robichaud A, Herridge MS, Lo V, Feltracco D, Burns KEA, Porteous R, Seely AJE, Ball IM, Seczek A, Kho ME.

Trials. 2019 Oct 25;20(1):606. doi: 10.1186/s13063-019-3716-6.


Independent representations of ipsilateral and contralateral limbs in primary motor cortex.

Heming EA, Cross KP, Takei T, Cook DJ, Scott SH.

Elife. 2019 Oct 18;8. pii: e48190. doi: 10.7554/eLife.48190.


Frequency of Screening and SBT Technique Trial - North American Weaning Collaboration (FAST-NAWC): a protocol for a multicenter, factorial randomized trial.

Burns KEA, Rizvi L, Cook DJ, Seely AJE, Rochwerg B, Lamontagne F, Devlin JW, Dodek P, Mayette M, Tanios M, Gouskos A, Kay P, Mitchell S, Kiedrowski KC, Hill NS; Canadian Critical Care Trials Group.

Trials. 2019 Oct 11;20(1):587. doi: 10.1186/s13063-019-3641-8.


Frailty and invasive mechanical ventilation: association with outcomes, extubation failure, and tracheostomy.

Fernando SM, McIsaac DI, Rochwerg B, Bagshaw SM, Muscedere J, Munshi L, Ferguson ND, Seely AJE, Cook DJ, Dave C, Tanuseputro P, Kyeremanteng K.

Intensive Care Med. 2019 Dec;45(12):1742-1752. doi: 10.1007/s00134-019-05795-8. Epub 2019 Oct 8.


Research Collaboration in Pediatric Critical Care Randomized Controlled Trials: A Social Network Analysis of Coauthorship.

Duffett M, Brouwers M, Meade MO, Xu GM, Cook DJ.

Pediatr Crit Care Med. 2019 Oct 2. doi: 10.1097/PCC.0000000000002120. [Epub ahead of print]


Robot-Enabled Support of Daily Activities in Smart Home Environments.

Wilson G, Pereyda C, Raghunath N, de la Cruz G, Goel S, Nesaei S, Minor B, Schmitter-Edgecombe M, Taylor ME, Cook DJ.

Cogn Syst Res. 2019 May;54:258-272. doi: 10.1016/j.cogsys.2018.10.032. Epub 2018 Nov 15.


Variation in the practice of discontinuing mechanical ventilation in critically ill adults: study protocol for an international prospective observational study.

Burns KEA, Rizvi L, Cook DJ, Dodek P, Slutsky AS, Jones A, Villar J, Kapadia FN, Gattas DJ, Epstein SK, Meade MO; Canadian Critical Care Trials Group.

BMJ Open. 2019 Sep 8;9(9):e031775. doi: 10.1136/bmjopen-2019-031775.


Fostering community hospital research.

Gehrke P, Binnie A, Chan SPT, Cook DJ, Burns KEA, Rewa OG, Herridge M, Tsang JLY.

CMAJ. 2019 Sep 3;191(35):E962-E966. doi: 10.1503/cmaj.190055. No abstract available.


Project management lessons learned from the multicentre CYCLE pilot randomized controlled trial.

McCaskell DS, Molloy AJ, Childerhose L, Costigan FA, Reid JC, McCaughan M, Clarke F, Cook DJ, Rudkowski JC, Farley C, Karachi T, Rochwerg B, Newman A, Fox-Robichaud A, Herridge MS, Lo V, Feltracco D, Burns K, Porteous R, Seely AJE, Ball IM, Seczek A, Kho ME.

Trials. 2019 Aug 28;20(1):532. doi: 10.1186/s13063-019-3634-7. Erratum in: Trials. 2019 Oct 25;20(1):606.


Context-Aware Delivery of Ecological Momentary Assessment.

Aminikhanghahi S, Schmitter-Edgecombe M, Cook DJ.

IEEE J Biomed Health Inform. 2019 Aug 22. doi: 10.1109/JBHI.2019.2937116. [Epub ahead of print]


Multi-parametric analysis reveals metabolic and vascular effects driving differences in BOLD-based cerebrovascular reactivity associated with a history of sport concussion.

Champagne AA, Coverdale NS, Germuska M, Cook DJ.

Brain Inj. 2019;33(11):1479-1489. doi: 10.1080/02699052.2019.1644375. Epub 2019 Jul 27.


Changes in volumetric and metabolic parameters relate to differences in exposure to sub-concussive head impacts.

Champagne AA, Coverdale NS, Germuska M, Bhogal AA, Cook DJ.

J Cereb Blood Flow Metab. 2019 Jul 15:271678X19862861. doi: 10.1177/0271678X19862861. [Epub ahead of print]


Improving End-of-Life Care in the Intensive Care Unit: Clinicians' Experiences with the 3 Wishes Project.

Neville TH, Agarwal N, Swinton M, Phung P, Xu X, Kao Y, Seo J, Granone MC, Hjelmhaug K, Hainje J, Pavlish C, Clarke F, Cook DJ.

J Palliat Med. 2019 Jul 25. doi: 10.1089/jpm.2019.0135. [Epub ahead of print]


Data-informed Intervention Improves Football Technique and Reduces Head Impacts.

Champagne AA, Distefano V, Boulanger MM, Magee B, Coverdale NS, Gallucci D, Guskiewicz K, Cook DJ.

Med Sci Sports Exerc. 2019 Nov;51(11):2366-2374. doi: 10.1249/MSS.0000000000002046.


Diarrhoea: interventions, consequences and epidemiology in the intensive care unit (DICE-ICU): a protocol for a prospective multicentre cohort study.

Dionne JC, Sullivan K, Mbuagbaw L, Takaoka A, Duan EH, Alhazzani W, Devlin JW, Duprey M, Moayyedi P, Armstrong D, Thabane L, Tsang JLY, Jaeschke R, Hamielec C, Karachi T, Cartin-Ceba R, Muscedere J, Alshahrani MSS, Cook DJ.

BMJ Open. 2019 Jun 27;9(6):e028237. doi: 10.1136/bmjopen-2018-028237.


Evaluating probiotics for the prevention of ventilator-associated pneumonia: a randomised placebo-controlled multicentre trial protocol and statistical analysis plan for PROSPECT.

Johnstone J, Heels-Ansdell D, Thabane L, Meade M, Marshall J, Lauzier F, Duan EH, Zytaruk N, Lamarche D, Surette M, Cook DJ; PROSPECT Investigators and the Canadian Critical Care Trials Group.

BMJ Open. 2019 Jun 20;9(6):e025228. doi: 10.1136/bmjopen-2018-025228.


Definitions of post-coronary artery bypass grafting myocardial infarction: variations in incidence and prognostic significance.

Belley-Cote EP, Lamy A, Devereaux PJ, Kavsak P, Lamontagne F, Cook DJ, Kennedy K, Vincent J, Ou Y, Tagarakis G, Whitlock RP.

Eur J Cardiothorac Surg. 2019 Jun 10. pii: ezz161. doi: 10.1093/ejcts/ezz161. [Epub ahead of print]


The PROTROPIC feasibility study: prognostic value of elevated troponins in critical illness.

Belley-Cote EP, Whitlock RP, Ulic DV, Honarmand K, Khalifa A, McClure GR, Gibson A, Alshamsi F, D'Aragon F, Rochwerg B, Duan E, Savija N, Karachi T, Lamontagne F, Kavsak P, Cook DJ.

Can J Anaesth. 2019 Jun;66(6):648-657. doi: 10.1007/s12630-019-01375-y. Epub 2019 Apr 29.


Multicentre pilot randomised clinical trial of early in-bed cycle ergometry with ventilated patients.

Kho ME, Molloy AJ, Clarke FJ, Reid JC, Herridge MS, Karachi T, Rochwerg B, Fox-Robichaud AE, Seely AJ, Mathur S, Lo V, Burns KE, Ball IM, Pellizzari JR, Tarride JE, Rudkowski JC, Koo K, Heels-Ansdell D, Cook DJ.

BMJ Open Respir Res. 2019 Feb 18;6(1):e000383. doi: 10.1136/bmjresp-2018-000383. eCollection 2019.


A Device on Trial - Intermittent Pneumatic Compression in Critical Care.

Lauzier F, Douketis JD, Cook DJ.

N Engl J Med. 2019 Apr 4;380(14):1367-1368. doi: 10.1056/NEJMe1902334. No abstract available.


Frequency of Screening for Weaning From Mechanical Ventilation: Two Contemporaneous Proof-of-Principle Randomized Controlled Trials.

Burns KEA, Wong JTY, Dodek P, Cook DJ, Lamontagne F, Cohen A, Mehta S, Kho ME, Hebert PC, Aslanian P, Friedrich JO, Brochard L, Rizvi L, Hand L, Meade MO, Amaral AC, Seely AJ; Canadian Critical Care Trials Group.

Crit Care Med. 2019 Jun;47(6):817-825. doi: 10.1097/CCM.0000000000003722.


A Multidisciplinary Survey to Assess Facilitators and Barriers to Successful Organ Donation in the Intensive Care Unit.

Oczkowski SJW, Durepos P, Centofanti J, Arsenau E, Dhanani S, Cook DJ, Meade MO.

Prog Transplant. 2019 Jun;29(2):179-184. doi: 10.1177/1526924819835826. Epub 2019 Mar 21.


Resting CMRO2 fluctuations show persistent network hyper-connectivity following exposure to sub-concussive collisions.

Champagne AA, Coverdale NS, Nashed JY, Fernandez-Ruiz J, Cook DJ.

Neuroimage Clin. 2019;22:101753. doi: 10.1016/j.nicl.2019.101753. Epub 2019 Mar 12.


Barriers and facilitators to adopting high value practices and de-adopting low value practices in Canadian intensive care units: a multimethod study.

Sauro K, Bagshaw SM, Niven D, Soo A, Brundin-Mather R, Parsons Leigh J, Cook DJ, Stelfox HT.

BMJ Open. 2019 Mar 15;9(3):e024159. doi: 10.1136/bmjopen-2018-024159.


A mixed-methods study of organ donation in the intensive care unit: 22 actionable practices to improve organ donation.

Oczkowski SJW, Arnold E, Centofanti J, Durepos P, Sarti A, Arseneau E, Dhanani S, Cook DJ, Meade MO.

Can J Anaesth. 2019 Jun;66(6):686-695. doi: 10.1007/s12630-019-01332-9. Epub 2019 Feb 26.


A multicentre controlled pre-post trial of an implementation science intervention to improve venous thromboembolism prophylaxis in critically ill patients.

Stelfox HT, Brundin-Mather R, Soo A, Parsons Leigh J, Niven DJ, Fiest KM, Doig CJ, Zuege DJ, Kushner B, Clement F, Straus SE, Cook DJ, Bagshaw SM, Sauro KM.

Intensive Care Med. 2019 Feb;45(2):211-222. doi: 10.1007/s00134-019-05532-1. Epub 2019 Feb 1.


Feasibility, Reliability, Responsiveness, and Validity of the Patient-Reported Functional Scale for the Intensive Care Unit: A Pilot Study.

Reid JC, Clarke F, Cook DJ, Molloy A, Rudkowski JC, Stratford P, Kho ME.

J Intensive Care Med. 2019 Jan 22:885066618824534. doi: 10.1177/0885066618824534. [Epub ahead of print]


Benchmarks of Duration and Magnitude of Opioid Consumption After Total Hip and Knee Arthroplasty: A Database Analysis of 69,368 Patients.

Cook DJ, Kaskovich SW, Pirkle SC, Mica MAC, Shi LL, Lee MJ.

J Arthroplasty. 2019 Apr;34(4):638-644.e1. doi: 10.1016/j.arth.2018.12.023. Epub 2018 Dec 24.


Improving the adoption of optimal venous thromboembolism prophylaxis in critically ill patients: A process evaluation of a complex quality improvement initiative.

Sauro KM, Brundin-Mather R, Parsons Leigh J, Niven DJ, Kushner B, Soo A, Cook DJ, Straus S, Doig CJ, Bagshaw S, Stelfox HT.

J Crit Care. 2019 Apr;50:111-117. doi: 10.1016/j.jcrc.2018.11.023. Epub 2018 Nov 29.


Microbial dysbiosis and mortality during mechanical ventilation: a prospective observational study.

Lamarche D, Johnstone J, Zytaruk N, Clarke F, Hand L, Loukov D, Szamosi JC, Rossi L, Schenck LP, Verschoor CP, McDonald E, Meade MO, Marshall JC, Bowdish DME, Karachi T, Heels-Ansdell D, Cook DJ, Surette MG; PROSPECT Investigators; Canadian Critical Care Trials Group; Canadian Critical Care Translational Biology Group.

Respir Res. 2018 Dec 7;19(1):245. doi: 10.1186/s12931-018-0950-5.


CNB-001, a pleiotropic drug is efficacious in embolized agyrencephalic New Zealand white rabbits and ischemic gyrencephalic cynomolgus monkeys.

Lapchak PA, Boitano PD, Bombien R, Cook DJ, Doyan S, Lara JM, Schubert DR.

Exp Neurol. 2019 Mar;313:98-108. doi: 10.1016/j.expneurol.2018.11.010. Epub 2018 Dec 4.


Stroke Longitudinal Volumetric Measures Correlate with the Behavioral Score in Non-Human Primates.

Ramirez-Garcia G, Harrison KA, Fernandez-Ruiz J, Nashed JY, Cook DJ.

Neuroscience. 2019 Jan 15;397:41-55. doi: 10.1016/j.neuroscience.2018.11.026. Epub 2018 Nov 24.


Porous titanium-coated polyetheretherketone implants exhibit an improved bone-implant interface: an in vitro and in vivo biochemical, biomechanical, and histological study.

Cheng BC, Koduri S, Wing CA, Woolery N, Cook DJ, Spiro RC.

Med Devices (Auckl). 2018 Oct 29;11:391-402. doi: 10.2147/MDER.S180482. eCollection 2018.


Cages in ACDF are Associated With a Higher Nonunion Rate Than Allograft: A Stratified Comparative Analysis of 6130 Patients.

Pirkle S, Kaskovich S, Cook DJ, Ho A, Shi LL, Lee MJ.

Spine (Phila Pa 1976). 2019 Mar 15;44(6):384-388. doi: 10.1097/BRS.0000000000002854.


FLUID trial: a protocol for a hospital-wide open-label cluster crossover pragmatic comparative effectiveness randomised pilot trial.

McIntyre L, Taljaard M, McArdle T, Fox-Robichaud A, English SW, Martin C, Marshall J, Menon K, Muscedere J, Cook DJ, Weijer C, Saginur R, Maybee A, Iyengar A, Forster A, Graham ID, Hawken S, McCartney C, Seely AJ, Stiell IG, Thavorn K, Fergusson DA.

BMJ Open. 2018 Aug 23;8(8):e022780. doi: 10.1136/bmjopen-2018-022780.


Iterative Design of Visual Analytics for a Clinician-in-the-Loop Smart Home.

Ghods A, Caffrey K, Lin B, Fraga K, Fritz R, Schmitter-Edgecombe M, Hundhausen C, Cook DJ.

IEEE J Biomed Health Inform. 2019 Jul;23(4):1742-1748. doi: 10.1109/JBHI.2018.2864287. Epub 2018 Aug 8.


Advancing Randomized Controlled Trials in Pediatric Critical Care: The Perspectives of Trialists.

Duffett M, Swinton M, Brouwers M, Meade M, Cook DJ.

Pediatr Crit Care Med. 2018 Nov;19(11):e595-e602. doi: 10.1097/PCC.0000000000001696.


Technology-Enabled Assessment of Functional Health.

Cook DJ, Schmitter-Edgecombe M, Jonsson L, Morant AV.

IEEE Rev Biomed Eng. 2019;12:319-332. doi: 10.1109/RBME.2018.2851500. Epub 2018 Jun 28. Review.


Smart Home-Based Prediction of Multidomain Symptoms Related to Alzheimer's Disease.

Alberdi A, Weakley A, Schmitter-Edgecombe M, Cook DJ, Aztiria A, Basarab A, Barrenechea M.

IEEE J Biomed Health Inform. 2018 Nov;22(6):1720-1731. doi: 10.1109/JBHI.2018.2798062. Epub 2018 Jan 25.


The Deferred Consent Model in a Prospective Observational Study Evaluating Myocardial Injury in the Intensive Care Unit.

Honarmand K, Belley-Cote EP, Ulic D, Khalifa A, Gibson A, McClure G, Savija N, Alshamsi F, D'Aragon F, Rochwerg B, Duan EH, Karachi T, Lamontagne F, Devereaux PJ, Whitlock RP, Cook DJ.

J Intensive Care Med. 2018 Aug;33(8):475-480. doi: 10.1177/0885066616680772. Epub 2016 Dec 16.


Low-molecular-weight heparin venous thromboprophylaxis in critically ill patients with renal dysfunction: A subgroup analysis of the PROTECT trial.

Pai M, Adhikari NKJ, Ostermann M, Heels-Ansdell D, Douketis JD, Skrobik Y, Qushmaq I, Meade M, Guyatt G, Geerts W, Walsh MW, Crowther MA, Friedrich JO, Burry L, Bellomo R, Brandão da Silva N, Costa Filho R, Cox MJ, Alves Silva S, Cook DJ; PROTECT (Prophylaxis for Thromboembolism in Critical Care Trial) Investigators.

PLoS One. 2018 Jun 1;13(6):e0198285. doi: 10.1371/journal.pone.0198285. eCollection 2018.


Using Smart City Technology to Make Healthcare Smarter.

Cook DJ, Duncan G, Sprint G, Fritz R.

Proc IEEE Inst Electr Electron Eng. 2018 Apr;106(4):708-722. doi: 10.1109/JPROC.2017.2787688. Epub 2018 Jan 23.


Implementing Wearable Sensors for Continuous Assessment of Daytime Heart Rate Response in Inpatient Rehabilitation.

Weeks DL, Sprint GL, Stilwill V, Meisen-Vehrs AL, Cook DJ.

Telemed J E Health. 2018 Apr 2. doi: 10.1089/tmj.2017.0306. [Epub ahead of print]


Assessing frailty in the intensive care unit: A reliability and validity study.

Shears M, Takaoka A, Rochwerg B, Bagshaw SM, Johnstone J, Holding A, Tharmalingam S, Millen T, Clarke F, Rockwood K, Li G, Thabane L, Muscedere J, Stelfox HT, Cook DJ; Canadian Critical Care Trials Group.

J Crit Care. 2018 Jun;45:197-203. doi: 10.1016/j.jcrc.2018.02.004. Epub 2018 Feb 8.


Automatic assessment of functional health decline in older adults based on smart home data.

Alberdi Aramendi A, Weakley A, Aztiria Goenaga A, Schmitter-Edgecombe M, Cook DJ.

J Biomed Inform. 2018 May;81:119-130. doi: 10.1016/j.jbi.2018.03.009. Epub 2018 Mar 15.


International Practice Variation in Weaning Critically Ill Adults from Invasive Mechanical Ventilation.

Burns KEA, Raptis S, Nisenbaum R, Rizvi L, Jones A, Bakshi J, Tan W, Meret A, Cook DJ, Lellouche F, Epstein SK, Gattas D, Kapadia FN, Villar J, Brochard L, Lessard MR, Meade MO.

Ann Am Thorac Soc. 2018 Apr;15(4):494-502. doi: 10.1513/AnnalsATS.201705-410OC. Erratum in: Ann Am Thorac Soc. 2018 Jul;15(7):894.


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