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Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association.

Tonsing-Carter E, Hernandez KM, Kim CR, Harkless RV, Oh A, Bowie KR, West-Szymanski DC, Betancourt-Ponce MA, Green BD, Lastra RR, Fleming GF, Chandarlapaty S, Conzen SD.

Breast Cancer Res. 2019 Jul 24;21(1):82. doi: 10.1186/s13058-019-1164-6.


Magnetic Resonance Angiography Shows Increased Arterial Blood Supply Associated with Murine Mammary Cancer.

Mustafi D, Leinroth A, Fan X, Markiewicz E, Zamora M, Mueller J, Conzen SD, Karczmar GS.

Int J Biomed Imaging. 2019 Jan 17;2019:5987425. doi: 10.1155/2019/5987425. eCollection 2019.


Glucocorticoid receptor expression is associated with inferior overall survival independent of BRCA mutation status in ovarian cancer.

Veneris JT, Huang L, Churpek JE, Conzen SD, Fleming GF.

Int J Gynecol Cancer. 2019 Jan 25. pii: ijgc-2018-000101. doi: 10.1136/ijgc-2018-000101. [Epub ahead of print]


Psychosocial Stress Exposure Disrupts Mammary Gland Development.

Johnson MB, Hoffmann JN, You HM, Lastra RR, Fernandez S, Strober JW, Allaw AB, Brady MJ, Conzen SD, McClintock MK.

J Mammary Gland Biol Neoplasia. 2018 Jun;23(1-2):59-73. doi: 10.1007/s10911-018-9392-4. Epub 2018 Apr 23.


Discovery of a Glucocorticoid Receptor (GR) Activity Signature Using Selective GR Antagonism in ER-Negative Breast Cancer.

West DC, Kocherginsky M, Tonsing-Carter EY, Dolcen DN, Hosfield DJ, Lastra RR, Sinnwell JP, Thompson KJ, Bowie KR, Harkless RV, Skor MN, Pierce CF, Styke SC, Kim CR, de Wet L, Greene GL, Boughey JC, Goetz MP, Kalari KR, Wang L, Fleming GF, Györffy B, Conzen SD.

Clin Cancer Res. 2018 Jul 15;24(14):3433-3446. doi: 10.1158/1078-0432.CCR-17-2793. Epub 2018 Apr 10.


Magnetic resonance spectroscopy detects differential lipid composition in mammary glands on low fat, high animal fat versus high fructose diets.

He D, Mustafi D, Fan X, Fernandez S, Markiewicz E, Zamora M, Mueller J, Sachleben JR, Brady MJ, Conzen SD, Karczmar GS.

PLoS One. 2018 Jan 11;13(1):e0190929. doi: 10.1371/journal.pone.0190929. eCollection 2018.


Metabolism of megestrol acetate in vitro and the role of oxidative metabolites.

House L, Seminerio MJ, Mirkov S, Ramirez J, Skor M, Sachleben JR, Isikbay M, Singhal H, Greene GL, Vander Griend D, Conzen SD, Ratain MJ.

Xenobiotica. 2018 Oct;48(10):973-983. doi: 10.1080/00498254.2017.1386335. Epub 2017 Nov 10.


Expression of glucocorticoid receptor is associated with aggressive primary endometrial cancer and increases from primary to metastatic lesions.

Tangen IL, Veneris JT, Halle MK, Werner HM, Trovik J, Akslen LA, Salvesen HB, Conzen SD, Fleming GF, Krakstad C.

Gynecol Oncol. 2017 Dec;147(3):672-677. doi: 10.1016/j.ygyno.2017.09.013. Epub 2017 Sep 18.


MRI reveals increased tumorigenesis following high fat feeding in a mouse model of triple-negative breast cancer.

Mustafi D, Fernandez S, Markiewicz E, Fan X, Zamora M, Mueller J, Brady MJ, Conzen SD, Karczmar GS.

NMR Biomed. 2017 Oct;30(10). doi: 10.1002/nbm.3758. Epub 2017 Jun 29.


Recent advances in understanding glucocorticoid receptor function in cancer.

Conzen SD.

Clin Adv Hematol Oncol. 2017 May;15(5):338-340. No abstract available.


High glucocorticoid receptor expression predicts short progression-free survival in ovarian cancer.

Veneris JT, Darcy KM, Mhawech-Fauceglia P, Tian C, Lengyel E, Lastra RR, Pejovic T, Conzen SD, Fleming GF.

Gynecol Oncol. 2017 Jul;146(1):153-160. doi: 10.1016/j.ygyno.2017.04.012. Epub 2017 Apr 26.


Selective Glucocorticoid Receptor Modulators (SGRMs) Delay Castrate-Resistant Prostate Cancer Growth.

Kach J, Long TM, Selman P, Tonsing-Carter EY, Bacalao MA, Lastra RR, de Wet L, Comiskey S, Gillard M, VanOpstall C, West DC, Chan WC, Griend DV, Conzen SD, Szmulewitz RZ.

Mol Cancer Ther. 2017 Aug;16(8):1680-1692. doi: 10.1158/1535-7163.MCT-16-0923. Epub 2017 Apr 20.


MRI ductography of contrast agent distribution and leakage in normal mouse mammary ducts and ducts with in situ cancer.

Markiewicz E, Fan X, Mustafi D, Zamora M, Conzen SD, Karczmar GS.

Magn Reson Imaging. 2017 Jul;40:48-52. doi: 10.1016/j.mri.2017.03.009. Epub 2017 Mar 30.


Quantitative MRI radiomics in the prediction of molecular classifications of breast cancer subtypes in the TCGA/TCIA data set.

Li H, Zhu Y, Burnside ES, Huang E, Drukker K, Hoadley KA, Fan C, Conzen SD, Zuley M, Net JM, Sutton E, Whitman GJ, Morris E, Perou CM, Ji Y, Giger ML.

NPJ Breast Cancer. 2016;2. pii: 16012. Epub 2016 May 11.


MR Imaging Radiomics Signatures for Predicting the Risk of Breast Cancer Recurrence as Given by Research Versions of MammaPrint, Oncotype DX, and PAM50 Gene Assays.

Li H, Zhu Y, Burnside ES, Drukker K, Hoadley KA, Fan C, Conzen SD, Whitman GJ, Sutton EJ, Net JM, Ganott M, Huang E, Morris EA, Perou CM, Ji Y, Giger ML.

Radiology. 2016 Nov;281(2):382-391. Epub 2016 May 5.


A randomized phase I trial of nanoparticle albumin-bound paclitaxel with or without mifepristone for advanced breast cancer.

Nanda R, Stringer-Reasor EM, Saha P, Kocherginsky M, Gibson J, Libao B, Hoffman PC, Obeid E, Merkel DE, Khramtsova G, Skor M, Krausz T, Cohen RN, Ratain MJ, Fleming GF, Conzen SD.

Springerplus. 2016 Jun 30;5(1):947. doi: 10.1186/s40064-016-2457-1. eCollection 2016.


GR and ER Coactivation Alters the Expression of Differentiation Genes and Associates with Improved ER+ Breast Cancer Outcome.

West DC, Pan D, Tonsing-Carter EY, Hernandez KM, Pierce CF, Styke SC, Bowie KR, Garcia TI, Kocherginsky M, Conzen SD.

Mol Cancer Res. 2016 Aug;14(8):707-19. doi: 10.1158/1541-7786.MCR-15-0433. Epub 2016 May 2.


Mammary Adipose Tissue-Derived Lysophospholipids Promote Estrogen Receptor-Negative Mammary Epithelial Cell Proliferation.

Volden PA, Skor MN, Johnson MB, Singh P, Patel FN, McClintock MK, Brady MJ, Conzen SD.

Cancer Prev Res (Phila). 2016 May;9(5):367-78. doi: 10.1158/1940-6207.CAPR-15-0107. Epub 2016 Feb 9.


Hsp90 Inhibition Results in Glucocorticoid Receptor Degradation in Association with Increased Sensitivity to Paclitaxel in Triple-Negative Breast Cancer.

Agyeman AS, Jun WJ, Proia DA, Kim CR, Skor MN, Kocherginsky M, Conzen SD.

Horm Cancer. 2016 Apr;7(2):114-26. doi: 10.1007/s12672-016-0251-8. Epub 2016 Feb 8.


Using computer-extracted image phenotypes from tumors on breast magnetic resonance imaging to predict breast cancer pathologic stage.

Burnside ES, Drukker K, Li H, Bonaccio E, Zuley M, Ganott M, Net JM, Sutton EJ, Brandt KR, Whitman GJ, Conzen SD, Lan L, Ji Y, Zhu Y, Jaffe CC, Huang EP, Freymann JB, Kirby JS, Morris EA, Giger ML.

Cancer. 2016 Mar 1;122(5):748-57. doi: 10.1002/cncr.29791. Epub 2015 Nov 30.


Glucocorticoid receptor ChIP-sequencing of subcutaneous fat reveals modulation of inflammatory pathways.

Singh P, Brock CO, Volden PA, Hernandez K, Skor M, Kocherginsky M, Park JE, Brady MJ, Conzen SD.

Obesity (Silver Spring). 2015 Nov;23(11):2286-93. doi: 10.1002/oby.21251. Epub 2015 Sep 26.


Targeting the glucocorticoid receptor in breast and prostate cancers.

Kach J, Conzen SD, Szmulewitz RZ.

Sci Transl Med. 2015 Sep 16;7(305):305ps19. doi: 10.1126/scitranslmed.aac7531.


Correlation of In Vivo and Ex Vivo ADC and T2 of In Situ and Invasive Murine Mammary Cancers.

Fan X, Macleod K, Mustafi D, Conzen SD, Markiewicz E, Zamora M, Vosicky J, Mueller J, Karczmar GS.

PLoS One. 2015 Jul 24;10(7):e0129212. doi: 10.1371/journal.pone.0129212. eCollection 2015.


MRI accurately identifies early murine mammary cancers and reliably differentiates between in situ and invasive cancer: correlation of MRI with histology.

Mustafi D, Zamora M, Fan X, Markiewicz E, Mueller J, Conzen SD, Karczmar GS.

NMR Biomed. 2015 Sep;28(9):1078-86. doi: 10.1002/nbm.3348. Epub 2015 Jul 7.


Glucocorticoid receptor activation inhibits chemotherapy-induced cell death in high-grade serous ovarian carcinoma.

Stringer-Reasor EM, Baker GM, Skor MN, Kocherginsky M, Lengyel E, Fleming GF, Conzen SD.

Gynecol Oncol. 2015 Sep;138(3):656-62. doi: 10.1016/j.ygyno.2015.06.033. Epub 2015 Jun 24.


Mammary cancer initiation and progression studied with magnetic resonance imaging.

Fan X, Mustafi D, Markiewicz E, Zamora M, Vosicky J, Leinroth A, Mueller J, Macleod K, Conzen SD, Karczmar GS.

Breast Cancer Res. 2014 Dec 16;16(6):495. doi: 10.1186/s13058-014-0495-6.


High resolution 3D MRI of mouse mammary glands with intra-ductal injection of contrast media.

Markiewicz E, Fan X, Mustafi D, Zamora M, Roman BB, Jansen SA, Macleod K, Conzen SD, Karczmar GS.

Magn Reson Imaging. 2015 Jan;33(1):161-5. doi: 10.1016/j.mri.2014.08.035. Epub 2014 Aug 29.


Gene expression of peripheral blood cells reveals pathways downstream of glucocorticoid receptor antagonism and nab-paclitaxel treatment.

Maranville JC, Nanda R, Fleming GF, Skor MN, Di Rienzo A, Conzen SD.

Pharmacogenet Genomics. 2014 Sep;24(9):451-8. doi: 10.1097/FPC.0000000000000077.


Aliphatic chain length by isotropic mixing (ALCHIM): determining composition of complex lipid samples by ¹H NMR spectroscopy.

Sachleben JR, Yi R, Volden PA, Conzen SD.

J Biomol NMR. 2014 Jul;59(3):161-73. doi: 10.1007/s10858-014-9836-0. Epub 2014 May 15.


Glucocorticoid receptor activity contributes to resistance to androgen-targeted therapy in prostate cancer.

Isikbay M, Otto K, Kregel S, Kach J, Cai Y, Vander Griend DJ, Conzen SD, Szmulewitz RZ.

Horm Cancer. 2014 Apr;5(2):72-89. doi: 10.1007/s12672-014-0173-2. Epub 2014 Mar 11.


Serum- and glucocorticoid-induced protein kinase 1 (SGK1) is regulated by store-operated Ca2+ entry and mediates cytoprotection against necrotic cell death.

Brickley DR, Agyeman AS, Kopp RF, Hall BA, Harbeck MC, Belova L, Volden PA, Wu W, Roe MW, Conzen SD.

J Biol Chem. 2013 Nov 8;288(45):32708-19. doi: 10.1074/jbc.M113.507210. Epub 2013 Sep 16.


Glucocorticoid receptor antagonism as a novel therapy for triple-negative breast cancer.

Skor MN, Wonder EL, Kocherginsky M, Goyal A, Hall BA, Cai Y, Conzen SD.

Clin Cancer Res. 2013 Nov 15;19(22):6163-72. doi: 10.1158/1078-0432.CCR-12-3826. Epub 2013 Sep 9.


The role of adrenergic signaling in breast cancer biology.

Obeid EI, Conzen SD.

Cancer Biomark. 2013;13(3):161-9. doi: 10.3233/CBM-130347. Review.


Chronic social isolation is associated with metabolic gene expression changes specific to mammary adipose tissue.

Volden PA, Wonder EL, Skor MN, Carmean CM, Patel FN, Ye H, Kocherginsky M, McClintock MK, Brady MJ, Conzen SD.

Cancer Prev Res (Phila). 2013 Jul;6(7):634-45. doi: 10.1158/1940-6207.CAPR-12-0458. Epub 2013 Jun 18.


The vanadyl chelate bis(acetylacetonato)oxovanadium(IV) increases the fractional uptake of 2-(fluorine-18)-2-deoxy-D-glucose by cultured human breast carcinoma cells.

Makinen MW, Bamba R, Ikejimba L, Wietholt C, Chen CT, Conzen SD.

Dalton Trans. 2013 Sep 7;42(33):11862-7. doi: 10.1039/c3dt50549a.


The influence of glucocorticoid signaling on tumor progression.

Volden PA, Conzen SD.

Brain Behav Immun. 2013 Mar;30 Suppl:S26-31. doi: 10.1016/j.bbi.2012.10.022. Epub 2012 Nov 16. Review.


Serum and glucocorticoid-regulated kinase 1 (SGK1) activation in breast cancer: requirement for mTORC1 activity associates with ER-alpha expression.

Hall BA, Kim TY, Skor MN, Conzen SD.

Breast Cancer Res Treat. 2012 Sep;135(2):469-79. doi: 10.1007/s10549-012-2161-y. Epub 2012 Jul 29.


T(2)∗ relaxation times of intraductal murine mammary cancer, invasive mammary cancer, and normal mammary gland.

Hipp E, Fan X, Jansen SA, Markiewicz EJ, Vosicky J, Newstead GM, Conzen SD, Krausz T, Karczmar GS.

Med Phys. 2012 Mar;39(3):1309-13. doi: 10.1118/1.3684950.


Phase II trial of temsirolimus in patients with metastatic breast cancer.

Fleming GF, Ma CX, Huo D, Sattar H, Tretiakova M, Lin L, Hahn OM, Olopade FO, Nanda R, Hoffman PC, Naughton MJ, Pluard T, Conzen SD, Ellis MJ.

Breast Cancer Res Treat. 2012 Nov;136(2):355-63. doi: 10.1007/s10549-011-1910-7. Epub 2012 Jan 13.


Activation of the glucocorticoid receptor is associated with poor prognosis in estrogen receptor-negative breast cancer.

Pan D, Kocherginsky M, Conzen SD.

Cancer Res. 2011 Oct 15;71(20):6360-70. doi: 10.1158/0008-5472.CAN-11-0362. Epub 2011 Aug 25.


Beta-blocker use is associated with improved relapse-free survival in patients with triple-negative breast cancer.

Melhem-Bertrandt A, Chavez-Macgregor M, Lei X, Brown EN, Lee RT, Meric-Bernstam F, Sood AK, Conzen SD, Hortobagyi GN, Gonzalez-Angulo AM.

J Clin Oncol. 2011 Jul 1;29(19):2645-52. doi: 10.1200/JCO.2010.33.4441. Epub 2011 May 31.


Serum/glucocorticoid-regulated kinase 1 expression in primary human prostate cancers.

Szmulewitz RZ, Chung E, Al-Ahmadie H, Daniel S, Kocherginsky M, Razmaria A, Zagaja GP, Brendler CB, Stadler WM, Conzen SD.

Prostate. 2012 Feb 1;72(2):157-64. doi: 10.1002/pros.21416. Epub 2011 May 11.


In vivo MRI of early stage mammary cancers and the normal mouse mammary gland.

Jansen SA, Conzen SD, Fan X, Markiewicz E, Krausz T, Newstead GM, Karczmar GS.

NMR Biomed. 2011 Aug;24(7):880-7. doi: 10.1002/nbm.1643. Epub 2011 Jan 25.


Social isolation dysregulates endocrine and behavioral stress while increasing malignant burden of spontaneous mammary tumors.

Hermes GL, Delgado B, Tretiakova M, Cavigelli SA, Krausz T, Conzen SD, McClintock MK.

Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22393-8. doi: 10.1073/pnas.0910753106. Epub 2009 Dec 11.


Ductal carcinoma in situ: X-ray fluorescence microscopy and dynamic contrast-enhanced MR imaging reveals gadolinium uptake within neoplastic mammary ducts in a murine model.

Jansen SA, Paunesku T, Fan X, Woloschak GE, Vogt S, Conzen SD, Krausz T, Newstead GM, Karczmar GS.

Radiology. 2009 Nov;253(2):399-406. doi: 10.1148/radiol.2533082026.


A model of gene-environment interaction reveals altered mammary gland gene expression and increased tumor growth following social isolation.

Williams JB, Pang D, Delgado B, Kocherginsky M, Tretiakova M, Krausz T, Pan D, He J, McClintock MK, Conzen SD.

Cancer Prev Res (Phila). 2009 Oct;2(10):850-861. doi: 10.1158/1940-6207.CAPR-08-0238. Epub 2009 Sep 29.


Magnetic resonance imaging of the natural history of in situ mammary neoplasia in transgenic mice: a pilot study.

Jansen SA, Conzen SD, Fan X, Markiewicz EJ, Newstead GM, Karczmar GS.

Breast Cancer Res. 2009;11(5):R65. doi: 10.1186/bcr2357.


Adaptive variation regulates the expression of the human SGK1 gene in response to stress.

Luca F, Kashyap S, Southard C, Zou M, Witonsky D, Di Rienzo A, Conzen SD.

PLoS Genet. 2009 May;5(5):e1000489. doi: 10.1371/journal.pgen.1000489. Epub 2009 May 22.


Administration of glucocorticoids to ovarian cancer patients is associated with expression of the anti-apoptotic genes SGK1 and MKP1/DUSP1 in ovarian tissues.

Melhem A, Yamada SD, Fleming GF, Delgado B, Brickley DR, Wu W, Kocherginsky M, Conzen SD.

Clin Cancer Res. 2009 May 1;15(9):3196-204. doi: 10.1158/1078-0432.CCR-08-2131. Epub 2009 Apr 21.


Detection of in situ mammary cancer in a transgenic mouse model: in vitro and in vivo MRI studies demonstrate histopathologic correlation.

Jansen SA, Conzen SD, Fan X, Krausz T, Zamora M, Foxley S, River J, Newstead GM, Karczmar GS.

Phys Med Biol. 2008 Oct 7;53(19):5481-93. doi: 10.1088/0031-9155/53/19/014. Epub 2008 Sep 9.

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