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Thrombin: Coagulation's master regulator of innate immunity.

Conway EM.

J Thromb Haemost. 2019 Aug 20. doi: 10.1111/jth.14586. [Epub ahead of print] No abstract available.


Specific loss of adipocyte CD248 improves metabolic health via reduced white adipose tissue hypoxia, fibrosis and inflammation.

Petrus P, Fernandez TL, Kwon MM, Huang JL, Lei V, Safikhan NS, Karunakaran S, O'Shannessy DJ, Zheng X, Catrina SB, Albone E, Laine J, Virtanen K, Clee SM, Kieffer TJ, Noll C, Carpentier AC, Johnson JD, Rydén M, Conway EM.

EBioMedicine. 2019 Jun;44:489-501. doi: 10.1016/j.ebiom.2019.05.057. Epub 2019 Jun 17.


Polyphosphates and Complement Activation.

Conway EM.

Front Med (Lausanne). 2019 Apr 4;6:67. doi: 10.3389/fmed.2019.00067. eCollection 2019. Review.


Low-calorie sweetener use, weight, and metabolic health among children: A mini-review.

Young J, Conway EM, Rother KI, Sylvetsky AC.

Pediatr Obes. 2019 Aug;14(8):e12521. doi: 10.1111/ijpo.12521. Epub 2019 Apr 14. Review.


Advances in Clinical and Basic Science of Coagulation: Illustrated abstracts of the 9th Chapel Hill Symposium on Hemostasis.

Bergmeier W, Antoniak S, Conway EM, Denis CV, George LA, Isermann B, Key NS, Krishnaswamy S, Lam WA, Lillicrap D, Liu J, Looney MR, López JA, Maas C, Peyvandi F, Ruf W, Sood AK, Versteeg HH, Wolberg AS, Wong PC, Wood JP, Weiler H.

Res Pract Thromb Haemost. 2018 Apr 12;2(3):407-428. doi: 10.1002/rth2.12095. eCollection 2018 Jul. Review.


Exploring traditional and nontraditional roles for thrombomodulin.

Loghmani H, Conway EM.

Blood. 2018 Jul 12;132(2):148-158. doi: 10.1182/blood-2017-12-768994. Epub 2018 Jun 4. Review.


How Non-nutritive Sweeteners Influence Hormones and Health.

Rother KI, Conway EM, Sylvetsky AC.

Trends Endocrinol Metab. 2018 Jul;29(7):455-467. doi: 10.1016/j.tem.2018.04.010. Epub 2018 May 30. Review.


Canagliflozin triggers the FGF23/1,25-dihydroxyvitamin D/PTH axis in healthy volunteers in a randomized crossover study.

Blau JE, Bauman V, Conway EM, Piaggi P, Walter MF, Wright EC, Bernstein S, Courville AB, Collins MT, Rother KI, Taylor SI.

JCI Insight. 2018 Apr 19;3(8). pii: 99123. doi: 10.1172/jci.insight.99123. eCollection 2018 Apr 19.


Basic weapons to degrade C3a and C5a.

Foley JH, Conway EM.

J Thromb Haemost. 2018 May;16(5):987-990. doi: 10.1111/jth.13999. Epub 2018 Apr 6. No abstract available.


Complement-coagulation connections.

Conway EM.

Blood Coagul Fibrinolysis. 2018 Apr;29(3):243-251. doi: 10.1097/MBC.0000000000000720. Review.


The Structural Basis for Complement Inhibition by Gigastasin, a Protease Inhibitor from the Giant Amazon Leech.

Pang SS, Wijeyewickrema LC, Hor L, Tan S, Lameignere E, Conway EM, Blom AM, Mohlin FC, Liu X, Payne RJ, Whisstock JC, Pike RN.

J Immunol. 2017 Dec 1;199(11):3883-3891. doi: 10.4049/jimmunol.1700158. Epub 2017 Oct 23.


Connect the Dots-November 2017.

Underwood J, Fields A, Conway EM, Chescheir NC.

Obstet Gynecol. 2017 Nov;130(5):1155-1156. doi: 10.1097/AOG.0000000000002337. No abstract available.


Development of Sweet Taste Perception: Implications for Artificial Sweetener Use.

Sylvetsky AC, Conway EM, Malhotra S, Rother KI.

Endocr Dev. 2017;32:87-99. doi: 10.1159/000475733. Epub 2017 Aug 15. Review.


A novel 2-stage approach that detects complement activation in patients with antiphospholipid antibody syndrome.

Rand JH, Wu XX, Wolgast LR, Lei V, Conway EM.

Thromb Res. 2017 Aug;156:119-125. doi: 10.1016/j.thromres.2017.06.014. Epub 2017 Jun 9.


Diagnosis of Western Red Cedar Asthma Using a Blood-based Gene Expression Biomarker Panel.

Yang CX, Singh A, Kim YW, Conway EM, Carlsten C, Tebbutt SJ.

Am J Respir Crit Care Med. 2017 Dec 15;196(12):1615-1617. doi: 10.1164/rccm.201608-1740LE. No abstract available.


Alteration of blood clotting and lung damage by protamine are avoided using the heparin and polyphosphate inhibitor UHRA.

Kalathottukaren MT, Abraham L, Kapopara PR, Lai BF, Shenoi RA, Rosell FI, Conway EM, Pryzdial EL, Morrissey JH, Haynes CA, Kizhakkedathu JN.

Blood. 2017 Mar 9;129(10):1368-1379. doi: 10.1182/blood-2016-10-747915. Epub 2016 Dec 29.


Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia.

Cines DB, Yarovoi SV, Zaitsev SV, Lebedeva T, Rauova L, Poncz M, Arepally GM, Khandelwal S, Stepanova V, Rux AH, Cuker A, Guo C, Ocariza LM, Travers RJ, Smith SA, Kim H, Morrissey JH, Conway EM.

Blood Adv. 2016 Nov 22;1(1):62-74. doi: 10.1182/bloodadvances.2016000877. eCollection 2016 Nov 29.


Emerging roles of T helper 17 and regulatory T cells in lung cancer progression and metastasis.

Marshall EA, Ng KW, Kung SH, Conway EM, Martinez VD, Halvorsen EC, Rowbotham DA, Vucic EA, Plumb AW, Becker-Santos DD, Enfield KS, Kennett JY, Bennewith KL, Lockwood WW, Lam S, English JC, Abraham N, Lam WL.

Mol Cancer. 2016 Oct 27;15(1):67. Review.


Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor.

Wijeyewickrema LC, Lameignere E, Hor L, Duncan RC, Shiba T, Travers RJ, Kapopara PR, Lei V, Smith SA, Kim H, Morrissey JH, Pike RN, Conway EM.

Blood. 2016 Sep 29;128(13):1766-76. doi: 10.1182/blood-2016-02-699561. Epub 2016 Jun 23.


Sweeteners for factor H.

Conway EM.

Blood. 2016 Jun 2;127(22):2656-8. doi: 10.1182/blood-2016-04-708172. No abstract available.


Hepatocellular carcinoma repression by TNFα-mediated synergistic lethal effect of mitosis defect-induced senescence and cell death sensitization.

Li D, Fu J, Du M, Zhang H, Li L, Cen J, Li W, Chen X, Lin Y, Conway EM, Pikarsky E, Wang H, Pan G, Ji Y, Wang HY, Hui L.

Hepatology. 2016 Oct;64(4):1105-20. doi: 10.1002/hep.28637. Epub 2016 Jun 11.


Cross Talk Pathways Between Coagulation and Inflammation.

Foley JH, Conway EM.

Circ Res. 2016 Apr 29;118(9):1392-408. doi: 10.1161/CIRCRESAHA.116.306853. Review.


Complement Activation in Arterial and Venous Thrombosis is Mediated by Plasmin.

Foley JH, Walton BL, Aleman MM, O'Byrne AM, Lei V, Harrasser M, Foley KA, Wolberg AS, Conway EM.

EBioMedicine. 2016 Feb 6;5:175-82. doi: 10.1016/j.ebiom.2016.02.011. eCollection 2016 Mar.


A Nuclear Attack on Thrombosis and Inflammation.

Conway EM.

Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):221-3. doi: 10.1161/ATVBAHA.115.306979. No abstract available.


Essential Role for Survivin in the Proliferative Expansion of Progenitor and Mature B Cells.

Miletic AV, Jellusova J, Cato MH, Lee CR, Baracho GV, Conway EM, Rickert RC.

J Immunol. 2016 Mar 1;196(5):2195-204. doi: 10.4049/jimmunol.1501690. Epub 2016 Jan 25.


Simulation and Spacecraft Design: Engineering Mars Landings.

Conway EM.

Technol Cult. 2015 Oct;56(4):812-38. doi: 10.1353/tech.2015.0113.


Macrophages, Inflammation, and Lung Cancer.

Conway EM, Pikor LA, Kung SH, Hamilton MJ, Lam S, Lam WL, Bennewith KL.

Am J Respir Crit Care Med. 2016 Jan 15;193(2):116-30. doi: 10.1164/rccm.201508-1545CI.


The lectin like domain of thrombomodulin is involved in the defence against pyelonephritis.

Lattenist L, Teske G, Claessen N, Florquin S, Conway EM, Roelofs JJ.

Thromb Res. 2015 Dec;136(6):1325-31. doi: 10.1016/j.thromres.2015.11.004. Epub 2015 Nov 10.


HUS and the case for complement.

Conway EM.

Blood. 2015 Oct 29;126(18):2085-90. doi: 10.1182/blood-2015-03-569277. Epub 2015 Sep 22.


Reincarnation of ancient links between coagulation and complement.

Conway EM.

J Thromb Haemost. 2015 Jun;13 Suppl 1:S121-32. doi: 10.1111/jth.12950. Review.


Hi-Fi SELEX: A High-Fidelity Digital-PCR Based Therapeutic Aptamer Discovery Platform.

Ouellet E, Foley JH, Conway EM, Haynes C.

Biotechnol Bioeng. 2015 Aug;112(8):1506-22.


Interplay between fibrinolysis and complement: plasmin cleavage of iC3b modulates immune responses.

Foley JH, Peterson EA, Lei V, Wan LW, Krisinger MJ, Conway EM.

J Thromb Haemost. 2015 Apr;13(4):610-8. doi: 10.1111/jth.12837. Epub 2015 Feb 4.


Macrophage matrix metalloproteinase-12 dampens inflammation and neutrophil influx in arthritis.

Bellac CL, Dufour A, Krisinger MJ, Loonchanta A, Starr AE, Auf dem Keller U, Lange PF, Goebeler V, Kappelhoff R, Butler GS, Burtnick LD, Conway EM, Roberts CR, Overall CM.

Cell Rep. 2014 Oct 23;9(2):618-32. doi: 10.1016/j.celrep.2014.09.006. Epub 2014 Oct 9.


Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma.

Brun SN, Markant SL, Esparza LA, Garcia G, Terry D, Huang JM, Pavlyukov MS, Li XN, Grant GA, Crawford JR, Levy ML, Conway EM, Smith LH, Nakano I, Berezov A, Greene MI, Wang Q, Wechsler-Reya RJ.

Oncogene. 2015 Jul;34(29):3770-9. doi: 10.1038/onc.2014.304. Epub 2014 Sep 22.


Modulation of complement activation and amplification on nanoparticle surfaces by glycopolymer conformation and chemistry.

Yu K, Lai BF, Foley JH, Krisinger MJ, Conway EM, Kizhakkedathu JN.

ACS Nano. 2014 Aug 26;8(8):7687-703. doi: 10.1021/nn504186b. Epub 2014 Aug 15.


Survivin modulates genes with divergent molecular functions and regulates proliferation of hematopoietic stem cells through Evi-1.

Fukuda S, Hoggatt J, Singh P, Abe M, Speth JM, Hu P, Conway EM, Nucifora G, Yamaguchi S, Pelus LM.

Leukemia. 2015 Feb;29(2):433-40. doi: 10.1038/leu.2014.183. Epub 2014 Jun 6.


An unanticipated role for survivin in organ transplant damage.

Cassis P, Solini S, Azzollini N, Aiello S, Rocchetta F, Conti S, Novelli R, Gagliardini E, Mister M, Rapezzi F, Rapezzi S, Benigni A, Remuzzi G, Conway EM, Noris M.

Am J Transplant. 2014 May;14(5):1046-60. doi: 10.1111/ajt.12677. Epub 2014 Apr 14.


TGFβ-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells.

Suresh Babu S, Valdez Y, Xu A, O'Byrne AM, Calvo F, Lei V, Conway EM.

BMC Cancer. 2014 Feb 20;14:113. doi: 10.1186/1471-2407-14-113.


Mice lacking the lectin-like domain of thrombomodulin are protected against melioidosis.

Kager LM, Wiersinga WJ, Roelofs JJ, Stroo I, Achouiti A, van 't Veer C, Conway EM, van der Poll T.

Crit Care Med. 2014 Mar;42(3):e221-30. doi: 10.1097/CCM.0000000000000134.


Polyphosphate suppresses complement via the terminal pathway.

Wat JM, Foley JH, Krisinger MJ, Ocariza LM, Lei V, Wasney GA, Lameignere E, Strynadka NC, Smith SA, Morrissey JH, Conway EM.

Blood. 2014 Jan 30;123(5):768-76. doi: 10.1182/blood-2013-07-515726. Epub 2013 Dec 13.


Thrombomodulin's lectin-like domain reduces myocardial damage by interfering with HMGB1-mediated TLR2 signalling.

Herzog C, Lorenz A, Gillmann HJ, Chowdhury A, Larmann J, Harendza T, Echtermeyer F, Müller M, Schmitz M, Stypmann J, Seidler DG, Damm M, Stehr SN, Koch T, Wollert KC, Conway EM, Theilmeier G.

Cardiovasc Res. 2014 Mar 1;101(3):400-10. doi: 10.1093/cvr/cvt275. Epub 2013 Dec 9.


New specs for arteriovenous identity.

Conway EM.

Blood. 2013 Dec 5;122(24):3857-8. doi: 10.1182/blood-2013-10-533141.


The thrombomodulin lectin-like domain does not change host responses to tuberculosis.

Kager LM, de Vos AF, Roelofs JJ, van der Loos CM, de Boer OJ, van't Veer C, Conway EM, van der Poll T.

Thromb Haemost. 2014 Feb;111(2):345-53. doi: 10.1160/TH13-08-0719. Epub 2013 Oct 17.


Survivin mediates renal proximal tubule recovery from AKI.

Chen J, Chen JK, Conway EM, Harris RC.

J Am Soc Nephrol. 2013 Dec;24(12):2023-33. doi: 10.1681/ASN.2013010076. Epub 2013 Aug 15.


Loss of survivin in the prostate epithelium impedes carcinogenesis in a mouse model of prostate adenocarcinoma.

Adisetiyo H, Liang M, Liao CP, Aycock-Williams A, Cohen MB, Xu S, Neamati N, Conway EM, Cheng CY, Nikitin AY, Roy-Burman P.

PLoS One. 2013 Jul 31;8(7):e69484. doi: 10.1371/journal.pone.0069484. Print 2013.


Hepatic loss of survivin impairs postnatal liver development and promotes expansion of hepatic progenitor cells in mice.

Li D, Cen J, Chen X, Conway EM, Ji Y, Hui L.

Hepatology. 2013 Dec;58(6):2109-21. doi: 10.1002/hep.26601. Epub 2013 Oct 21.


Small-molecule inhibition of CBP/catenin interactions eliminates drug-resistant clones in acute lymphoblastic leukemia.

Gang EJ, Hsieh YT, Pham J, Zhao Y, Nguyen C, Huantes S, Park E, Naing K, Klemm L, Swaminathan S, Conway EM, Pelus LM, Crispino J, Mullighan CG, McMillan M, Müschen M, Kahn M, Kim YM.

Oncogene. 2014 Apr 24;33(17):2169-78. doi: 10.1038/onc.2013.169. Epub 2013 Jun 3.


Loss of Survivin influences liver regeneration and is associated with impaired Aurora B function.

Hagemann S, Wohlschlaeger J, Bertram S, Levkau B, Musacchio A, Conway EM, Moellmann D, Kneiseler G, Pless-Petig G, Lorenz K, Sitek B, Baba HA.

Cell Death Differ. 2013 Jun;20(6):834-44. doi: 10.1038/cdd.2013.20. Epub 2013 Mar 22.


Gas6 gains entry into the coagulation cascade.

Foley JH, Conway EM.

Blood. 2013 Jan 24;121(4):570-1. doi: 10.1182/blood-2012-11-468678. No abstract available.


Loss of survivin in neural precursor cells results in impaired long-term potentiation in the dentate gyrus and CA1-region.

Iscru E, Ahmed T, Coremans V, Bozzi Y, Caleo M, Conway EM, D'Hooge R, Balschun D.

Neuroscience. 2013 Feb 12;231:413-9. doi: 10.1016/j.neuroscience.2012.10.049. Epub 2012 Nov 2.


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