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Items: 1 to 50 of 194

1.

KILchip v1.0: A Novel Plasmodium falciparum Merozoite Protein Microarray to Facilitate Malaria Vaccine Candidate Prioritization.

Kamuyu G, Tuju J, Kimathi R, Mwai K, Mburu J, Kibinge N, Chong Kwan M, Hawkings S, Yaa R, Chepsat E, Njunge JM, Chege T, Guleid F, Rosenkranz M, Kariuki CK, Frank R, Kinyanjui SM, Murungi LM, Bejon P, Färnert A, Tetteh KKA, Beeson JG, Conway DJ, Marsh K, Rayner JC, Osier FHA.

Front Immunol. 2018 Dec 11;9:2866. doi: 10.3389/fimmu.2018.02866. eCollection 2018.

2.

Schizont transcriptome variation among clinical isolates and laboratory-adapted clones of the malaria parasite Plasmodium falciparum.

Tarr SJ, Díaz-Ingelmo O, Stewart LB, Hocking SE, Murray L, Duffy CW, Otto TD, Chappell L, Rayner JC, Awandare GA, Conway DJ.

BMC Genomics. 2018 Dec 10;19(1):894. doi: 10.1186/s12864-018-5257-x.

3.

Multi-population genomic analysis of malaria parasites indicates local selection and differentiation at the gdv1 locus regulating sexual development.

Duffy CW, Amambua-Ngwa A, Ahouidi AD, Diakite M, Awandare GA, Ba H, Tarr SJ, Murray L, Stewart LB, D'Alessandro U, Otto TD, Kwiatkowski DP, Conway DJ.

Sci Rep. 2018 Oct 25;8(1):15763. doi: 10.1038/s41598-018-34078-3.

5.

Complement Factor H Levels Associate With Plasmodium falciparum Malaria Susceptibility and Severity.

van Beek AE, Sarr I, Correa S, Nwakanma D, Brouwer MC, Wouters D, Secka F, Anderson STB, Conway DJ, Walther M, Levin M, Kuijpers TW, Cunnington AJ.

Open Forum Infect Dis. 2018 Jul 20;5(7):ofy166. doi: 10.1093/ofid/ofy166. eCollection 2018 Jul.

6.

Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria.

Lee HJ, Georgiadou A, Walther M, Nwakanma D, Stewart LB, Levin M, Otto TD, Conway DJ, Coin LJ, Cunnington AJ.

Sci Transl Med. 2018 Jun 27;10(447). pii: eaar3619. doi: 10.1126/scitranslmed.aar3619.

7.

Consistent signatures of selection from genomic analysis of pairs of temporal and spatial Plasmodium falciparum populations from The Gambia.

Amambua-Ngwa A, Jeffries D, Amato R, Worwui A, Karim M, Ceesay S, Nyang H, Nwakanma D, Okebe J, Kwiatkowski D, Conway DJ, D'Alessandro U.

Sci Rep. 2018 Jun 26;8(1):9687. doi: 10.1038/s41598-018-28017-5.

8.

Long read assemblies of geographically dispersed Plasmodium falciparum isolates reveal highly structured subtelomeres.

Otto TD, Böhme U, Sanders M, Reid A, Bruske EI, Duffy CW, Bull PC, Pearson RD, Abdi A, Dimonte S, Stewart LB, Campino S, Kekre M, Hamilton WL, Claessens A, Volkman SK, Ndiaye D, Amambua-Ngwa A, Diakite M, Fairhurst RM, Conway DJ, Franck M, Newbold CI, Berriman M.

Wellcome Open Res. 2018 May 3;3:52. doi: 10.12688/wellcomeopenres.14571.1. eCollection 2018.

9.

Transcriptomic Studies of Malaria: a Paradigm for Investigation of Systemic Host-Pathogen Interactions.

Lee HJ, Georgiadou A, Otto TD, Levin M, Coin LJ, Conway DJ, Cunnington AJ.

Microbiol Mol Biol Rev. 2018 Apr 25;82(2). pii: e00071-17. doi: 10.1128/MMBR.00071-17. Print 2018 Jun. Review.

10.

Genome-wide mosaicism in divergence between zoonotic malaria parasite subpopulations with separate sympatric transmission cycles.

Divis PCS, Duffy CW, Kadir KA, Singh B, Conway DJ.

Mol Ecol. 2018 Feb;27(4):860-870. doi: 10.1111/mec.14477. Epub 2018 Feb 13.

11.

Multiplication rate variation in the human malaria parasite Plasmodium falciparum.

Murray L, Stewart LB, Tarr SJ, Ahouidi AD, Diakite M, Amambua-Ngwa A, Conway DJ.

Sci Rep. 2017 Jul 25;7(1):6436. doi: 10.1038/s41598-017-06295-9.

12.

The Institute for Global Orthopedics and Traumatology: A Model for Academic Collaboration in Orthopedic Surgery.

Conway DJ, Coughlin R, Caldwell A, Shearer D.

Front Public Health. 2017 Jun 30;5:146. doi: 10.3389/fpubh.2017.00146. eCollection 2017.

13.

Resistance to malaria through structural variation of red blood cell invasion receptors.

Leffler EM, Band G, Busby GBJ, Kivinen K, Le QS, Clarke GM, Bojang KA, Conway DJ, Jallow M, Sisay-Joof F, Bougouma EC, Mangano VD, Modiano D, Sirima SB, Achidi E, Apinjoh TO, Marsh K, Ndila CM, Peshu N, Williams TN, Drakeley C, Manjurano A, Reyburn H, Riley E, Kachala D, Molyneux M, Nyirongo V, Taylor T, Thornton N, Tilley L, Grimsley S, Drury E, Stalker J, Cornelius V, Hubbart C, Jeffreys AE, Rowlands K, Rockett KA, Spencer CCA, Kwiatkowski DP; Malaria Genomic Epidemiology Network.

Science. 2017 Jun 16;356(6343). pii: eaam6393. doi: 10.1126/science.aam6393. Epub 2017 May 18.

14.

Three Divergent Subpopulations of the Malaria Parasite Plasmodium knowlesi.

Divis PC, Lin LC, Rovie-Ryan JJ, Kadir KA, Anderios F, Hisam S, Sharma RS, Singh B, Conway DJ.

Emerg Infect Dis. 2017 Apr;23(4):616-624. doi: 10.3201/eid2304.161738.

15.

Assessing the impact of differences in malaria transmission intensity on clinical and haematological indices in children with malaria.

Mensah-Brown HE, Abugri J, Asante KP, Dwomoh D, Dosoo D, Atuguba F, Conway DJ, Awandare GA.

Malar J. 2017 Mar 1;16(1):96. doi: 10.1186/s12936-017-1745-8.

16.

Population genetic structure and adaptation of malaria parasites on the edge of endemic distribution.

Duffy CW, Ba H, Assefa S, Ahouidi AD, Deh YB, Tandia A, Kirsebom FCM, Kwiatkowski DP, Conway DJ.

Mol Ecol. 2017 Jun;26(11):2880-2894. doi: 10.1111/mec.14066. Epub 2017 Mar 15.

17.

Culture adaptation of malaria parasites selects for convergent loss-of-function mutants.

Claessens A, Affara M, Assefa SA, Kwiatkowski DP, Conway DJ.

Sci Rep. 2017 Jan 24;7:41303. doi: 10.1038/srep41303.

18.

Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia.

Clarke GM, Rockett K, Kivinen K, Hubbart C, Jeffreys AE, Rowlands K, Jallow M, Conway DJ, Bojang KA, Pinder M, Usen S, Sisay-Joof F, Sirugo G, Toure O, Thera MA, Konate S, Sissoko S, Niangaly A, Poudiougou B, Mangano VD, Bougouma EC, Sirima SB, Modiano D, Amenga-Etego LN, Ghansah A, Koram KA, Wilson MD, Enimil A, Evans J, Amodu OK, Olaniyan S, Apinjoh T, Mugri R, Ndi A, Ndila CM, Uyoga S, Macharia A, Peshu N, Williams TN, Manjurano A, Sepúlveda N, Clark TG, Riley E, Drakeley C, Reyburn H, Nyirongo V, Kachala D, Molyneux M, Dunstan SJ, Phu NH, Quyen NN, Thai CQ, Hien TT, Manning L, Laman M, Siba P, Karunajeewa H, Allen S, Allen A, Davis TM, Michon P, Mueller I, Molloy SF, Campino S, Kerasidou A, Cornelius VJ, Hart L, Shah SS, Band G, Spencer CC, Agbenyega T, Achidi E, Doumbo OK, Farrar J, Marsh K, Taylor T, Kwiatkowski DP; MalariaGEN Consortium.

Elife. 2017 Jan 9;6. pii: e15085. doi: 10.7554/eLife.15085.

19.

[Evaluation of malaria rapid diagnostic test Optimal-IT® pLDH along the Plasmodium falciparum distribution limit in Mauritania].

Ba H, Ahouidi AD, Duffy CW, Deh YB, Diedhiou C, Tandia A, Diallo MY, Assefa S, Lô BB, Elkory MB, Conway DJ.

Bull Soc Pathol Exot. 2017 Feb;110(1):31-37. doi: 10.1007/s13149-017-0541-y. Epub 2016 Dec 29. French.

20.

Microsatellite genotyping and genome-wide single nucleotide polymorphism-based indices of Plasmodium falciparum diversity within clinical infections.

Murray L, Mobegi VA, Duffy CW, Assefa SA, Kwiatkowski DP, Laman E, Loua KM, Conway DJ.

Malar J. 2016 May 12;15(1):275. doi: 10.1186/s12936-016-1324-4.

21.

Characterizing the genetic diversity of the monkey malaria parasite Plasmodium cynomolgi.

Sutton PL, Luo Z, Divis PCS, Friedrich VK, Conway DJ, Singh B, Barnwell JW, Carlton JM, Sullivan SA.

Infect Genet Evol. 2016 Jun;40:243-252. doi: 10.1016/j.meegid.2016.03.009. Epub 2016 Mar 14.

22.

Widespread distribution of Plasmodium vivax malaria in Mauritania on the interface of the Maghreb and West Africa.

Ba H, Duffy CW, Ahouidi AD, Deh YB, Diallo MY, Tandia A, Conway DJ.

Malar J. 2016 Feb 9;15:80. doi: 10.1186/s12936-016-1118-8.

23.

Malaria Vaccine Development: Focusing Field Erythrocyte Invasion Studies on Phenotypic Diversity: The West African Merozoite Invasion Network (WAMIN).

WAMIN consortium authors include (in alphabetical order):, Ahouidi AD, Amambua-Ngwa A, Awandare GA, Bei AK, Conway DJ, Diakite M, Duraisingh MT, Rayner JC, Zenonos ZA.

Trends Parasitol. 2016 Apr;32(4):274-283. doi: 10.1016/j.pt.2015.11.009. Epub 2015 Dec 23. Review.

PMID:
26725306
24.

Population Structure Shapes Copy Number Variation in Malaria Parasites.

Cheeseman IH, Miller B, Tan JC, Tan A, Nair S, Nkhoma SC, De Donato M, Rodulfo H, Dondorp A, Branch OH, Mesia LR, Newton P, Mayxay M, Amambua-Ngwa A, Conway DJ, Nosten F, Ferdig MT, Anderson TJ.

Mol Biol Evol. 2016 Mar;33(3):603-20. doi: 10.1093/molbev/msv282. Epub 2015 Nov 26.

25.

Serology describes a profile of declining malaria transmission in Farafenni, The Gambia.

van den Hoogen LL, Griffin JT, Cook J, Sepúlveda N, Corran P, Conway DJ, Milligan P, Affara M, Allen SJ, Proietti C, Ceesay SJ, Targett GA, D'Alessandro U, Greenwood B, Riley EM, Drakeley C.

Malar J. 2015 Oct 22;14:416. doi: 10.1186/s12936-015-0939-1.

26.

Population genomic structure and adaptation in the zoonotic malaria parasite Plasmodium knowlesi.

Assefa S, Lim C, Preston MD, Duffy CW, Nair MB, Adroub SA, Kadir KA, Goldberg JM, Neafsey DE, Divis P, Clark TG, Duraisingh MT, Conway DJ, Pain A, Singh B.

Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):13027-32. doi: 10.1073/pnas.1509534112. Epub 2015 Oct 5.

27.

Plasmodium Infection Is Associated with Impaired Hepatic Dimethylarginine Dimethylaminohydrolase Activity and Disruption of Nitric Oxide Synthase Inhibitor/Substrate Homeostasis.

Chertow JH, Alkaitis MS, Nardone G, Ikeda AK, Cunnington AJ, Okebe J, Ebonyi AO, Njie M, Correa S, Jayasooriya S, Casals-Pascual C, Billker O, Conway DJ, Walther M, Ackerman H.

PLoS Pathog. 2015 Sep 25;11(9):e1005119. doi: 10.1371/journal.ppat.1005119. eCollection 2015 Sep.

28.

Comparison of genomic signatures of selection on Plasmodium falciparum between different regions of a country with high malaria endemicity.

Duffy CW, Assefa SA, Abugri J, Amoako N, Owusu-Agyei S, Anyorigiya T, MacInnis B, Kwiatkowski DP, Conway DJ, Awandare GA.

BMC Genomics. 2015 Jul 16;16:527. doi: 10.1186/s12864-015-1746-3.

29.

Admixture in Humans of Two Divergent Plasmodium knowlesi Populations Associated with Different Macaque Host Species.

Divis PC, Singh B, Anderios F, Hisam S, Matusop A, Kocken CH, Assefa SA, Duffy CW, Conway DJ.

PLoS Pathog. 2015 May 28;11(5):e1004888. doi: 10.1371/journal.ppat.1004888. eCollection 2015 May.

30.

Variation in Plasmodium falciparum erythrocyte invasion phenotypes and merozoite ligand gene expression across different populations in areas of malaria endemicity.

Bowyer PW, Stewart LB, Aspeling-Jones H, Mensah-Brown HE, Ahouidi AD, Amambua-Ngwa A, Awandare GA, Conway DJ.

Infect Immun. 2015 Jun;83(6):2575-82. doi: 10.1128/IAI.03009-14. Epub 2015 Apr 13.

31.

Analysis of Erythrocyte Invasion Mechanisms of Plasmodium falciparum Clinical Isolates Across 3 Malaria-Endemic Areas in Ghana.

Mensah-Brown HE, Amoako N, Abugri J, Stewart LB, Agongo G, Dickson EK, Ofori MF, Stoute JA, Conway DJ, Awandare GA.

J Infect Dis. 2015 Oct 15;212(8):1288-97. doi: 10.1093/infdis/jiv207. Epub 2015 Apr 2.

32.

Human antibodies fix complement to inhibit Plasmodium falciparum invasion of erythrocytes and are associated with protection against malaria.

Boyle MJ, Reiling L, Feng G, Langer C, Osier FH, Aspeling-Jones H, Cheng YS, Stubbs J, Tetteh KK, Conway DJ, McCarthy JS, Muller I, Marsh K, Anders RF, Beeson JG.

Immunity. 2015 Mar 17;42(3):580-90. doi: 10.1016/j.immuni.2015.02.012.

33.

Paths to a malaria vaccine illuminated by parasite genomics.

Conway DJ.

Trends Genet. 2015 Feb;31(2):97-107. doi: 10.1016/j.tig.2014.12.005. Epub 2015 Jan 22. Review.

34.

Remarkable diversity of intron-1 of the para voltage-gated sodium channel gene in an Anopheles gambiae/Anopheles coluzzii hybrid zone.

Santolamazza F, Caputo B, Nwakanma DC, Fanello C, Petrarca V, Conway DJ, Weetman D, Pinto J, Mancini E, della Torre A.

Malar J. 2015 Jan 21;14:9. doi: 10.1186/s12936-014-0522-1.

35.

Efficacy of indoor residual spraying with dichlorodiphenyltrichloroethane against malaria in Gambian communities with high usage of long-lasting insecticidal mosquito nets: a cluster-randomised controlled trial.

Pinder M, Jawara M, Jarju LB, Salami K, Jeffries D, Adiamoh M, Bojang K, Correa S, Kandeh B, Kaur H, Conway DJ, D'Alessandro U, Lindsay SW.

Lancet. 2015 Apr 11;385(9976):1436-46. doi: 10.1016/S0140-6736(14)61007-2. Epub 2014 Dec 9.

36.

Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts.

Otto TD, Rayner JC, Böhme U, Pain A, Spottiswoode N, Sanders M, Quail M, Ollomo B, Renaud F, Thomas AW, Prugnolle F, Conway DJ, Newbold C, Berriman M.

Nat Commun. 2014 Sep 9;5:4754. doi: 10.1038/ncomms5754.

37.

Prominent intraspecific genetic divergence within Anopheles gambiae sibling species triggered by habitat discontinuities across a riverine landscape.

Caputo B, Nwakanma D, Caputo FP, Jawara M, Oriero EC, Hamid-Adiamoh M, Dia I, Konate L, Petrarca V, Pinto J, Conway DJ, Della Torre A.

Mol Ecol. 2014 Sep;23(18):4574-89. doi: 10.1111/mec.12866. Epub 2014 Aug 18.

PMID:
25040079
38.

Killer-cell immunoglobulin-like receptors and falciparum malaria in southwest Nigeria.

Olaniyan SA, Amodu OK, Yindom LM, Conway DJ, Aka P, Bakare AA, Omotade OO.

Hum Immunol. 2014 Aug;75(8):816-21. doi: 10.1016/j.humimm.2014.06.002. Epub 2014 Jun 11.

PMID:
24929143
39.

A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains.

Preston MD, Campino S, Assefa SA, Echeverry DF, Ocholla H, Amambua-Ngwa A, Stewart LB, Conway DJ, Borrmann S, Michon P, Zongo I, Ouédraogo JB, Djimde AA, Doumbo OK, Nosten F, Pain A, Bousema T, Drakeley CJ, Fairhurst RM, Sutherland CJ, Roper C, Clark TG.

Nat Commun. 2014 Jun 13;5:4052. doi: 10.1038/ncomms5052.

40.

Dynamics of the antibody response to Plasmodium falciparum infection in African children.

White MT, Griffin JT, Akpogheneta O, Conway DJ, Koram KA, Riley EM, Ghani AC.

J Infect Dis. 2014 Oct 1;210(7):1115-22. doi: 10.1093/infdis/jiu219. Epub 2014 Apr 8.

PMID:
24719471
41.

Genome-wide analysis of selection on the malaria parasite Plasmodium falciparum in West African populations of differing infection endemicity.

Mobegi VA, Duffy CW, Amambua-Ngwa A, Loua KM, Laman E, Nwakanma DC, MacInnis B, Aspeling-Jones H, Murray L, Clark TG, Kwiatkowski DP, Conway DJ.

Mol Biol Evol. 2014 Jun;31(6):1490-9. doi: 10.1093/molbev/msu106. Epub 2014 Mar 18.

42.

PlasmoView: a web-based resource to visualise global Plasmodium falciparum genomic variation.

Preston MD, Assefa SA, Ocholla H, Sutherland CJ, Borrmann S, Nzila A, Michon P, Hien TT, Bousema T, Drakeley CJ, Zongo I, Ouédraogo JB, Djimde AA, Doumbo OK, Nosten F, Fairhurst RM, Conway DJ, Roper C, Clark TG.

J Infect Dis. 2014 Jun 1;209(11):1808-15. doi: 10.1093/infdis/jit812. Epub 2013 Dec 12.

43.

Changes in malaria parasite drug resistance in an endemic population over a 25-year period with resulting genomic evidence of selection.

Nwakanma DC, Duffy CW, Amambua-Ngwa A, Oriero EC, Bojang KA, Pinder M, Drakeley CJ, Sutherland CJ, Milligan PJ, Macinnis B, Kwiatkowski DP, Clark TG, Greenwood BM, Conway DJ.

J Infect Dis. 2014 Apr 1;209(7):1126-35. doi: 10.1093/infdis/jit618. Epub 2013 Nov 21.

44.

Analysis of antibodies to newly described Plasmodium falciparum merozoite antigens supports MSPDBL2 as a predicted target of naturally acquired immunity.

Tetteh KK, Osier FH, Salanti A, Kamuyu G, Drought L, Failly M, Martin C, Marsh K, Conway DJ.

Infect Immun. 2013 Oct;81(10):3835-42. doi: 10.1128/IAI.00301-13. Epub 2013 Jul 29.

45.

Seroepidemiological and parasitological evaluation of the heterogeneity of malaria infection in the Gambia.

Oduro AR, Conway DJ, Schellenberg D, Satoguina J, Greenwood BM, Bojang KA.

Malar J. 2013 Jul 1;12:222. doi: 10.1186/1475-2875-12-222.

46.

Imputation-based meta-analysis of severe malaria in three African populations.

Band G, Le QS, Jostins L, Pirinen M, Kivinen K, Jallow M, Sisay-Joof F, Bojang K, Pinder M, Sirugo G, Conway DJ, Nyirongo V, Kachala D, Molyneux M, Taylor T, Ndila C, Peshu N, Marsh K, Williams TN, Alcock D, Andrews R, Edkins S, Gray E, Hubbart C, Jeffreys A, Rowlands K, Schuldt K, Clark TG, Small KS, Teo YY, Kwiatkowski DP, Rockett KA, Barrett JC, Spencer CC; Malaria Genomic Epidemiology Network.

PLoS Genet. 2013 May;9(5):e1003509. doi: 10.1371/journal.pgen.1003509. Epub 2013 May 23. Erratum in: PLoS Genet. 2013 Jun;9(6). doi:10.1371/annotation/adc2beaf-4bee-4e22-925b-6788d62fe029. Malaria Genomic Epidemiological Network [corrected to Malaria Genomic Epidemiology Network].

47.

Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia.

Miotto O, Almagro-Garcia J, Manske M, Macinnis B, Campino S, Rockett KA, Amaratunga C, Lim P, Suon S, Sreng S, Anderson JM, Duong S, Nguon C, Chuor CM, Saunders D, Se Y, Lon C, Fukuda MM, Amenga-Etego L, Hodgson AV, Asoala V, Imwong M, Takala-Harrison S, Nosten F, Su XZ, Ringwald P, Ariey F, Dolecek C, Hien TT, Boni MF, Thai CQ, Amambua-Ngwa A, Conway DJ, Djimdé AA, Doumbo OK, Zongo I, Ouedraogo JB, Alcock D, Drury E, Auburn S, Koch O, Sanders M, Hubbart C, Maslen G, Ruano-Rubio V, Jyothi D, Miles A, O'Brien J, Gamble C, Oyola SO, Rayner JC, Newbold CI, Berriman M, Spencer CC, McVean G, Day NP, White NJ, Bethell D, Dondorp AM, Plowe CV, Fairhurst RM, Kwiatkowski DP.

Nat Genet. 2013 Jun;45(6):648-55. doi: 10.1038/ng.2624. Epub 2013 Apr 28.

48.

PfHPRT: a new biomarker candidate of acute Plasmodium falciparum infection.

Thézénas ML, Huang H, Njie M, Ramaprasad A, Nwakanma DC, Fischer R, Digleria K, Walther M, Conway DJ, Kessler BM, Casals-Pascual C.

J Proteome Res. 2013 Mar 1;12(3):1211-22. doi: 10.1021/pr300858g. Epub 2013 Feb 12.

PMID:
23339668
49.

Breakdown in the process of incipient speciation in Anopheles gambiae.

Nwakanma DC, Neafsey DE, Jawara M, Adiamoh M, Lund E, Rodrigues A, Loua KM, Konate L, Sy N, Dia I, Awolola TS, Muskavitch MA, Conway DJ.

Genetics. 2013 Apr;193(4):1221-31. doi: 10.1534/genetics.112.148718. Epub 2013 Jan 18.

50.

Population genomic scan for candidate signatures of balancing selection to guide antigen characterization in malaria parasites.

Amambua-Ngwa A, Tetteh KK, Manske M, Gomez-Escobar N, Stewart LB, Deerhake ME, Cheeseman IH, Newbold CI, Holder AA, Knuepfer E, Janha O, Jallow M, Campino S, Macinnis B, Kwiatkowski DP, Conway DJ.

PLoS Genet. 2012;8(11):e1002992. doi: 10.1371/journal.pgen.1002992. Epub 2012 Nov 1.

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