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Divergent LAG-3 versus BTLA, TIGIT, and FCRL3 expression in Sézary syndrome.

Anzengruber F, Ignatova D, Schlaepfer T, Chang YT, French LE, Pascolo S, Contassot E, Bobrowicz M, Hoetzenecker W, Guenova E.

Leuk Lymphoma. 2019 Jan 14:1-9. doi: 10.1080/10428194.2018.1564827. [Epub ahead of print]


Culprit Drugs Induce Specific IL-36 Overexpression in Acute Generalized Exanthematous Pustulosis.

Meier-Schiesser B, Feldmeyer L, Jankovic D, Mellett M, Satoh TK, Yerly D, Navarini A, Abe R, Yawalkar N, Chung WH, French LE, Contassot E.

J Invest Dermatol. 2018 Nov 2. pii: S0022-202X(18)32779-9. doi: 10.1016/j.jid.2018.10.023. [Epub ahead of print]


Vaccinating against Acne: Benefits and Potential Pitfalls.

Contassot E.

J Invest Dermatol. 2018 Nov;138(11):2304-2306. doi: 10.1016/j.jid.2018.06.177. Epub 2018 Aug 28.


Genome Editing of Human Primary Keratinocytes by CRISPR/Cas9 Reveals an Essential Role of the NLRP1 Inflammasome in UVB Sensing.

Fenini G, Grossi S, Contassot E, Biedermann T, Reichmann E, French LE, Beer HD.

J Invest Dermatol. 2018 Dec;138(12):2644-2652. doi: 10.1016/j.jid.2018.07.016. Epub 2018 Aug 7.


CARD14 Gain-of-Function Mutation Alone Is Sufficient to Drive IL-23/IL-17-Mediated Psoriasiform Skin Inflammation In Vivo.

Mellett M, Meier B, Mohanan D, Schairer R, Cheng P, Satoh TK, Kiefer B, Ospelt C, Nobbe S, Thome M, Contassot E, French LE.

J Invest Dermatol. 2018 Sep;138(9):2010-2023. doi: 10.1016/j.jid.2018.03.1525. Epub 2018 Apr 22.


Microcrystalline Tyrosine and Aluminum as Adjuvants in Allergen-Specific Immunotherapy Protect from IgE-Mediated Reactivity in Mouse Models and Act Independently of Inflammasome and TLR Signaling.

Leuthard DS, Duda A, Freiberger SN, Weiss S, Dommann I, Fenini G, Contassot E, Kramer MF, Skinner MA, Kündig TM, Heath MD, Johansen P.

J Immunol. 2018 May 1;200(9):3151-3159. doi: 10.4049/jimmunol.1800035. Epub 2018 Mar 28.


Intraperitoneal administration of aluminium-based adjuvants produces severe transient systemic adverse events in mice.

Freiberger SN, Leuthard DS, Duda A, Contassot E, Thallmair M, Kündig TM, Johansen P.

Eur J Pharm Sci. 2018 Mar 30;115:362-368. doi: 10.1016/j.ejps.2018.01.042. Epub 2018 Feb 2.


Propionibacterium acnes Strains Differentially Regulate the Fate of Th17 Responses in the Skin.

Contassot E, French LE.

J Invest Dermatol. 2018 Feb;138(2):251-253. doi: 10.1016/j.jid.2017.09.041.


Expression of inflammasome proteins and inflammasome activation occurs in human, but not in murine keratinocytes.

Sand J, Haertel E, Biedermann T, Contassot E, Reichmann E, French LE, Werner S, Beer HD.

Cell Death Dis. 2018 Jan 18;9(2):24. doi: 10.1038/s41419-017-0009-4.


The p38 Mitogen-Activated Protein Kinase Critically Regulates Human Keratinocyte Inflammasome Activation.

Fenini G, Grossi S, Gehrke S, Beer HD, Satoh TK, Contassot E, French LE.

J Invest Dermatol. 2018 Jun;138(6):1380-1390. doi: 10.1016/j.jid.2017.10.037. Epub 2017 Dec 26.


Potential of IL-1, IL-18 and Inflammasome Inhibition for the Treatment of Inflammatory Skin Diseases.

Fenini G, Contassot E, French LE.

Front Pharmacol. 2017 May 22;8:278. doi: 10.3389/fphar.2017.00278. eCollection 2017. Review.


Are neutrophilic dermatoses autoinflammatory disorders?

Satoh TK, Mellett M, Contassot E, French LE.

Br J Dermatol. 2018 Mar;178(3):603-613. doi: 10.1111/bjd.15105. Epub 2016 Nov 30. Review.


NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.

Spalinger MR, Kasper S, Gottier C, Lang S, Atrott K, Vavricka SR, Scharl S, Raselli T, Frey-Wagner I, Gutte PM, Grütter MG, Beer HD, Contassot E, Chan AC, Dai X, Rawlings DJ, Mair F, Becher B, Falk W, Fried M, Rogler G, Scharl M.

J Clin Invest. 2016 Nov 1;126(11):4388. doi: 10.1172/JCI90897. Epub 2016 Nov 1. No abstract available.


Tumour hypoxia promotes melanoma growth and metastasis via High Mobility Group Box-1 and M2-like macrophages.

Huber R, Meier B, Otsuka A, Fenini G, Satoh T, Gehrke S, Widmer D, Levesque MP, Mangana J, Kerl K, Gebhardt C, Fujii H, Nakashima C, Nonomura Y, Kabashima K, Dummer R, Contassot E, French LE.

Sci Rep. 2016 Jul 18;6:29914. doi: 10.1038/srep29914.


NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.

Spalinger MR, Kasper S, Gottier C, Lang S, Atrott K, Vavricka SR, Scharl S, Raselli T, Frey-Wagner I, Gutte PM, Grütter MG, Beer HD, Contassot E, Chan AC, Dai X, Rawlings DJ, Mair F, Becher B, Falk W, Fried M, Rogler G, Scharl M.

J Clin Invest. 2016 May 2;126(5):1783-800. doi: 10.1172/JCI83669. Epub 2016 Apr 4. Erratum in: J Clin Invest. 2016 Nov 1;126(11):4388.


Cytotoxic Cutaneous Adverse Drug Reactions during Anti-PD-1 Therapy.

Goldinger SM, Stieger P, Meier B, Micaletto S, Contassot E, French LE, Dummer R.

Clin Cancer Res. 2016 Aug 15;22(16):4023-9. doi: 10.1158/1078-0432.CCR-15-2872. Epub 2016 Mar 8.


Expression of CD164 on Malignant T cells in Sézary Syndrome.

Guenova E, Ignatova D, Chang YT, Contassot E, Mehra T, Saulite I, Navarini AA, Mitev V, Dummer R, Kazakov DV, French LE, Hoetzenecker W, Cozzio A.

Acta Derm Venereol. 2016 May;96(4):464-7. doi: 10.2340/00015555-2264.


Canakinumab in adults with steroid-refractory pyoderma gangrenosum.

Kolios AG, Maul JT, Meier B, Kerl K, Traidl-Hoffmann C, Hertl M, Zillikens D, Röcken M, Ring J, Facchiano A, Mondino C, Yawalkar N, Contassot E, Navarini AA, French LE.

Br J Dermatol. 2015 Nov;173(5):1216-23. doi: 10.1111/bjd.14037. Epub 2015 Oct 16.


The inflammasome and IL-1β: implications for the treatment of inflammatory diseases.

Satoh T, Otsuka A, Contassot E, French LE.

Immunotherapy. 2015;7(3):243-54. doi: 10.2217/imt.14.106. Review.


Severe Sweet's Syndrome with Elevated Cutaneous Interleukin-1β after Azathioprine Exposure: Case Report and Review of the Literature.

Imhof L, Meier B, Frei P, Kamarachev J, Rogler G, Kolios A, Navarini AA, Contassot E, French LE.

Dermatology. 2015;230(4):293-8. doi: 10.1159/000371879. Epub 2015 Mar 14. Review.


Photosensitisation facilitates cross-priming of adjuvant-free protein vaccines and stimulation of tumour-suppressing CD8 T cells.

Håkerud M, Selbo PK, Waeckerle-Men Y, Contassot E, Dziunycz P, Kündig TM, Høgset A, Johansen P.

J Control Release. 2015 Jan 28;198:10-7. doi: 10.1016/j.jconrel.2014.11.032. Epub 2014 Dec 4.


Epidermal elafin expression is an indicator of poor prognosis in cutaneous graft-versus-host disease.

Brüggen MC, Petzelbauer P, Greinix H, Contassot E, Jankovic D, French L, Socié G, Rabitsch W, Kuzmina Z, Kalhs P, Knobler R, Stingl G, Stary G.

J Invest Dermatol. 2015 Apr;135(4):999-1006. doi: 10.1038/jid.2014.489. Epub 2014 Nov 18.


Malassezia yeasts activate the NLRP3 inflammasome in antigen-presenting cells via Syk-kinase signalling.

Kistowska M, Fenini G, Jankovic D, Feldmeyer L, Kerl K, Bosshard P, Contassot E, French LE.

Exp Dermatol. 2014 Dec;23(12):884-9. doi: 10.1111/exd.12552.


Propionibacterium acnes promotes Th17 and Th17/Th1 responses in acne patients.

Kistowska M, Meier B, Proust T, Feldmeyer L, Cozzio A, Kuendig T, Contassot E, French LE.

J Invest Dermatol. 2015 Jan;135(1):110-118. doi: 10.1038/jid.2014.290. Epub 2014 Jul 10.


The inflammasomes in autoinflammatory diseases with skin involvement.

Beer HD, Contassot E, French LE.

J Invest Dermatol. 2014 Jul;134(7):1805-1810. doi: 10.1038/jid.2014.76. Epub 2014 Mar 6.


Metastatic melanoma cell lines do not secrete IL-1β but promote IL-1β production from macrophages.

Gehrke S, Otsuka A, Huber R, Meier B, Kistowska M, Fenini G, Cheng P, Dummer R, Kerl K, Contassot E, French LE.

J Dermatol Sci. 2014 May;74(2):167-9. doi: 10.1016/j.jdermsci.2014.01.006. Epub 2014 Jan 24. No abstract available.


New insights into acne pathogenesis: propionibacterium acnes activates the inflammasome.

Contassot E, French LE.

J Invest Dermatol. 2014 Feb;134(2):310-313. doi: 10.1038/jid.2013.505.


IL-1β drives inflammatory responses to propionibacterium acnes in vitro and in vivo.

Kistowska M, Gehrke S, Jankovic D, Kerl K, Fettelschoss A, Feldmeyer L, Fenini G, Kolios A, Navarini A, Ganceviciene R, Schauber J, Contassot E, French LE.

J Invest Dermatol. 2014 Mar;134(3):677-685. doi: 10.1038/jid.2013.438. Epub 2013 Oct 24.


The Nlrp3 inflammasome regulates acute graft-versus-host disease.

Jankovic D, Ganesan J, Bscheider M, Stickel N, Weber FC, Guarda G, Follo M, Pfeifer D, Tardivel A, Ludigs K, Bouazzaoui A, Kerl K, Fischer JC, Haas T, Schmitt-Gräff A, Manoharan A, Müller L, Finke J, Martin SF, Gorka O, Peschel C, Ruland J, Idzko M, Duyster J, Holler E, French LE, Poeck H, Contassot E, Zeiser R.

J Exp Med. 2013 Sep 23;210(10):1899-910. doi: 10.1084/jem.20130084. Epub 2013 Aug 26.


Rictor in perivascular adipose tissue controls vascular function by regulating inflammatory molecule expression.

Bhattacharya I, Drägert K, Albert V, Contassot E, Damjanovic M, Hagiwara A, Zimmerli L, Humar R, Hall MN, Battegay EJ, Haas E.

Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2105-11. doi: 10.1161/ATVBAHA.112.301001. Epub 2013 Jul 18. Erratum in: Arterioscler Thromb Vasc Biol. 2013 Dec;33(12):e138.


TNF-α and IFN-γ are potential inducers of Fas-mediated keratinocyte apoptosis through activation of inducible nitric oxide synthase in toxic epidermal necrolysis.

Viard-Leveugle I, Gaide O, Jankovic D, Feldmeyer L, Kerl K, Pickard C, Roques S, Friedmann PS, Contassot E, French LE.

J Invest Dermatol. 2013 Feb;133(2):489-98. doi: 10.1038/jid.2012.330. Epub 2012 Sep 20.


Interleukin-1, inflammasomes, autoinflammation and the skin.

Contassot E, Beer HD, French LE.

Swiss Med Wkly. 2012 May 31;142:w13590. doi: 10.4414/smw.2012.13590. eCollection 2012. Review.


Carcinogen treatment in mouse selectively expressing activated N-Ras Q61K in melanocytes recapitulates metastatic cutaneous melanoma development.

Contassot E, Jankovic D, Schuler P, Preynat-Seauve O, Gehrke S, Kerl K, Beermann F, French LE.

Pigment Cell Melanoma Res. 2012 Mar;25(2):275-8. doi: 10.1111/j.1755-148X.2011.00944.x. Epub 2012 Jan 6.


Inflammasome activation and IL-1β target IL-1α for secretion as opposed to surface expression.

Fettelschoss A, Kistowska M, LeibundGut-Landmann S, Beer HD, Johansen P, Senti G, Contassot E, Bachmann MF, French LE, Oxenius A, Kündig TM.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18055-60. doi: 10.1073/pnas.1109176108. Epub 2011 Oct 17.


Epigenetic causes of apoptosis resistance in cutaneous T-cell lymphomas.

Contassot E, French LE.

J Invest Dermatol. 2010 Apr;130(4):922-4. doi: 10.1038/jid.2009.427.


Lymph node tumor metastases: more susceptible than primary tumors to CD8(+) T-cell immune destruction.

Contassot E, Preynat-Seauve O, French L, Huard B.

Trends Immunol. 2009 Dec;30(12):569-73. doi: 10.1016/


Targeting apoptosis defects in cutaneous T-cell lymphoma.

Contassot E, French LE.

J Invest Dermatol. 2009 May;129(5):1059-61. doi: 10.1038/jid.2009.14.


Direct presentation of a melanocyte-associated antigen in peripheral lymph nodes induces cytotoxic CD8+ T cells.

Schuler P, Contassot E, Irla M, Hugues S, Preynat-Seauve O, Beermann F, Donda A, French LE, Huard B.

Cancer Res. 2008 Oct 15;68(20):8410-8. doi: 10.1158/0008-5472.CAN-08-0809.


Danger signaling through the inflammasome acts as a master switch between tolerance and sensitization.

Watanabe H, Gehrke S, Contassot E, Roques S, Tschopp J, Friedmann PS, French LE, Gaide O.

J Immunol. 2008 May 1;180(9):5826-32.


Resistance to FasL and tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in Sezary syndrome T-cells associated with impaired death receptor and FLICE-inhibitory protein expression.

Contassot E, Kerl K, Roques S, Shane R, Gaide O, Dupuis M, Rook AH, French LE.

Blood. 2008 May 1;111(9):4780-7. doi: 10.1182/blood-2007-08-109074. Epub 2008 Feb 26.


Death receptors and apoptosis.

Contassot E, Gaide O, French LE.

Dermatol Clin. 2007 Oct;25(4):487-501, vii. Review.


T cell tolerance to the skin: a central role for central tolerance.

Schuler P, Contassot E, Huard B.

Semin Immunopathol. 2007 Apr;29(1):59-64. Review.


Extralymphatic tumors prepare draining lymph nodes to invasion via a T-cell cross-tolerance process.

Preynat-Seauve O, Contassot E, Schuler P, Piguet V, French LE, Huard B.

Cancer Res. 2007 May 15;67(10):5009-16.


Melanoma-infiltrating dendritic cells induce protective antitumor responses mediated by T cells.

Preynat-Seauve O, Contassot E, Schuler P, French LE, Huard B.

Melanoma Res. 2007 Jun;17(3):169-76.


Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity.

Watanabe H, Gaide O, Pétrilli V, Martinon F, Contassot E, Roques S, Kummer JA, Tschopp J, French LE.

J Invest Dermatol. 2007 Aug;127(8):1956-63. Epub 2007 Apr 12.


Indirect effects of leptin receptor deficiency on lymphocyte populations and immune response in db/db mice.

Palmer G, Aurrand-Lions M, Contassot E, Talabot-Ayer D, Ducrest-Gay D, Vesin C, Chobaz-Péclat V, Busso N, Gabay C.

J Immunol. 2006 Sep 1;177(5):2899-907.


Tumor-infiltrating dendritic cells are potent antigen-presenting cells able to activate T cells and mediate tumor rejection.

Preynat-Seauve O, Schuler P, Contassot E, Beermann F, Huard B, French LE.

J Immunol. 2006 Jan 1;176(1):61-7.


Homing phenotypes of tumor-specific CD8 T cells are predetermined at the tumor site by crosspresenting APCs.

Calzascia T, Masson F, Di Berardino-Besson W, Contassot E, Wilmotte R, Aurrand-Lions M, Rüegg C, Dietrich PY, Walker PR.

Immunity. 2005 Feb;22(2):175-84.


Arachidonylethanolamide induces apoptosis of human glioma cells through vanilloid receptor-1.

Contassot E, Wilmotte R, Tenan M, Belkouch MC, Schnüriger V, de Tribolet N, Burkhardt K, Dietrich PY.

J Neuropathol Exp Neurol. 2004 Sep;63(9):956-63. Erratum in: J Neuropathol Exp Neurol. 2004 Nov;63(11):1114. Bourkhardt, Karim [corrected to Burkhardt, Karim].


Impaired CD40L signaling is a cause of defective IL-12 and TNF-alpha production in Sézary syndrome: circumvention by hexameric soluble CD40L.

French LE, Huard B, Wysocka M, Shane R, Contassot E, Arrighi JF, Piguet V, Calderara S, Rook AH.

Blood. 2005 Jan 1;105(1):219-25. Epub 2004 Aug 17.

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