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Items: 1 to 50 of 174

1.

Comorbidity in multiple sclerosis: its temporal relationships with disease onset and dose effect on mortality.

Chou IJ, Kuo CF, Tanasescu R, Tench CR, Tiley CG, Constantinescu CS, Whitehouse WP.

Eur J Neurol. 2019 Jul 15. doi: 10.1111/ene.14040. [Epub ahead of print]

PMID:
31309645
2.

Congenital monocular elevation deficiency associated with a novel TUBB3 gene variant.

Thomas MG, Maconachie GDE, Constantinescu CS, Chan WM, Barry B, Hisaund M, Sheth V, Kuht HJ, Dineen RA, Harieaswar S, Engle EC, Gottlob I.

Br J Ophthalmol. 2019 Jul 13. pii: bjophthalmol-2019-314293. doi: 10.1136/bjophthalmol-2019-314293. [Epub ahead of print]

3.

Modifiable risk factors for poor health outcomes in multiple sclerosis: The urgent need for research to maximise smoking cessation success.

Marck CH, das Nair R, Grech LB, Borland R, Constantinescu CS.

Mult Scler. 2019 Jun 20:1352458519858730. doi: 10.1177/1352458519858730. [Epub ahead of print]

PMID:
31219393
4.

Granulocyte-Macrophage Colony-Stimulating Factor as a Therapeutic Target in Multiple Sclerosis.

Aram J, Francis A, Tanasescu R, Constantinescu CS.

Neurol Ther. 2019 Jun;8(1):45-57. doi: 10.1007/s40120-018-0120-1. Epub 2018 Dec 1. Review.

5.

Siponimod for the treatment of secondary progressive multiple sclerosis.

Dumitrescu L, Constantinescu CS, Tanasescu R.

Expert Opin Pharmacother. 2019 Feb;20(2):143-150. doi: 10.1080/14656566.2018.1551363. Epub 2018 Dec 5. Review.

PMID:
30517042
6.

Effects of cigarette smoke on immunity, neuroinflammation and multiple sclerosis.

Alrouji M, Manouchehrinia A, Gran B, Constantinescu CS.

J Neuroimmunol. 2019 Apr 15;329:24-34. doi: 10.1016/j.jneuroim.2018.10.004. Epub 2018 Oct 9. Review.

PMID:
30361070
7.

Epilepsy and associated mortality in patients with multiple sclerosis.

Chou IJ, Kuo CF, Tanasescu R, Tench CR, Tiley CG, Constantinescu CS, Whitehouse WP.

Eur J Neurol. 2019 Feb;26(2):342-e23. doi: 10.1111/ene.13821. Epub 2018 Oct 30.

PMID:
30312502
8.

Correction: Genetically enhanced T lymphocytes and the intensive care unit.

Tat T, Li H, Constantinescu CS, Onaciu A, Chira S, Osan C, Pasca S, Petrushev B, Moisoiu V, Micu WT, Berce C, Tranca S, Dima D, Berindan-Neagoe I, Shen J, Tomuleasa C, Qian L.

Oncotarget. 2018 Aug 10;9(62):32097. doi: 10.18632/oncotarget.25983. eCollection 2018 Aug 10.

9.

Genetically enhanced T lymphocytes and the intensive care unit.

Tat T, Li H, Constantinescu CS, Onaciu A, Chira S, Osan C, Pasca S, Petrushev B, Moisoiu V, Micu WT, Berce C, Tranca S, Dima D, Berindan-Neagoe I, Shen J, Tomuleasa C, Qian L.

Oncotarget. 2018 Mar 27;9(23):16557-16572. doi: 10.18632/oncotarget.24637. eCollection 2018 Mar 27. Review. Erratum in: Oncotarget. 2018 Aug 10;9(62):32097.

10.

Therapeutic cannabinoids in multiple sclerosis: immunomodulation revisited.

Constantinescu CS, Gershkovich P.

Eur J Neurol. 2018 Jul;25(7):905-906. doi: 10.1111/ene.13658. Epub 2018 May 3. No abstract available.

PMID:
29633480
11.

Recent developments in interferon-based therapies for multiple sclerosis.

Dumitrescu L, Constantinescu CS, Tanasescu R.

Expert Opin Biol Ther. 2018 Jun;18(6):665-680. doi: 10.1080/14712598.2018.1462793. Epub 2018 Apr 20. Review.

PMID:
29624084
12.

Oral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation.

Zgair A, Lee JB, Wong JCM, Taha DA, Aram J, Di Virgilio D, McArthur JW, Cheng YK, Hennig IM, Barrett DA, Fischer PM, Constantinescu CS, Gershkovich P.

Sci Rep. 2017 Nov 6;7(1):14542. doi: 10.1038/s41598-017-15026-z.

13.

Seven-Tesla Magnetization Transfer Imaging to Detect Multiple Sclerosis White Matter Lesions.

Chou IJ, Lim SY, Tanasescu R, Al-Radaideh A, Mougin OE, Tench CR, Whitehouse WP, Gowland PA, Constantinescu CS.

J Neuroimaging. 2018 Mar;28(2):183-190. doi: 10.1111/jon.12474. Epub 2017 Sep 25.

PMID:
28944575
14.

DAB389IL-2 recombinant fusion toxin effect on lymphocyte- and macrophage-producing cytokine subpopulation cells in experimentally induced demyelinating disease in mice.

Bhopale MK, Hilliard B, Constantinescu CS, Phillips SM, Rostami A.

Immunopharmacol Immunotoxicol. 2017 Dec;39(6):318-329. doi: 10.1080/08923973.2017.1369099. Epub 2017 Sep 20.

15.

Prevalence of a history of prior varicella/herpes zoster infection in multiple sclerosis.

Manouchehrinia A, Tanasescu R, Kareem H, Jerca OP, Jabeen F, Shafei R, Breuer J, Neal K, Irving W, Constantinescu CS.

J Neurovirol. 2017 Dec;23(6):839-844. doi: 10.1007/s13365-017-0569-1. Epub 2017 Sep 11.

16.

Prognostic factors for long-term outcomes in relapsing-remitting multiple sclerosis.

Traboulsee AL, Cornelisseª P, Sandberg-Wollheim M, Uitdehaag BM, Kappos L, Jongen PJ, Constantinescu CS, di Cantogno EV, Li DK.

Mult Scler J Exp Transl Clin. 2016 Sep 6;2:2055217316666406. doi: 10.1177/2055217316666406. eCollection 2016 Jan-Dec.

17.

Smoking Cessation and the Reduction of Disability Progression in Multiple Sclerosis: A Cohort Study.

Tanasescu R, Constantinescu CS, Tench CR, Manouchehrinia A.

Nicotine Tob Res. 2018 Apr 2;20(5):589-595. doi: 10.1093/ntr/ntx084.

PMID:
28402456
18.

Coordinate based random effect size meta-analysis of neuroimaging studies.

Tench CR, Tanasescu R, Constantinescu CS, Auer DP, Cottam WJ.

Neuroimage. 2017 Jun;153:293-306. doi: 10.1016/j.neuroimage.2017.04.002. Epub 2017 Apr 5.

PMID:
28389386
19.

The association between human endogenous retroviruses and multiple sclerosis: A systematic review and meta-analysis.

Morandi E, Tanasescu R, Tarlinton RE, Constantinescu CS, Zhang W, Tench C, Gran B.

PLoS One. 2017 Feb 16;12(2):e0172415. doi: 10.1371/journal.pone.0172415. eCollection 2017. Review.

20.

Decreased interferon-β induced STAT-4 activation in immune cells and clinical outcome in multiple sclerosis.

Tanasescu R, Midgley A, Robins RA, Constantinescu CS.

Acta Neurol Scand. 2017 Sep;136(3):233-238. doi: 10.1111/ane.12715. Epub 2016 Dec 5.

PMID:
27918083
21.

Coordinate based meta-analysis does not show grey matter atrophy in narcolepsy.

Tench CR, Tanasescu R, Cottam WJ, Constantinescu CS, Auer DP.

Neurosci Biobehav Rev. 2019 Jul;102:427-429. doi: 10.1016/j.neubiorev.2016.10.019. Epub 2016 Nov 5. No abstract available.

PMID:
27826067
22.

The future of multiple sclerosis treatments.

Coclitu C, Constantinescu CS, Tanasescu R.

Expert Rev Neurother. 2016 Dec;16(12):1341-1356. Epub 2016 Oct 21. Review.

PMID:
27682738
23.

Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis-based medicines.

Zgair A, Wong JC, Lee JB, Mistry J, Sivak O, Wasan KM, Hennig IM, Barrett DA, Constantinescu CS, Fischer PM, Gershkovich P.

Am J Transl Res. 2016 Aug 15;8(8):3448-59. eCollection 2016.

24.

Time- and Region-Specific Season of Birth Effects in Multiple Sclerosis in the United Kingdom.

Rodríguez Cruz PM, Matthews L, Boggild M, Cavey A, Constantinescu CS, Evangelou N, Giovannoni G, Gray O, Hawkins S, Nicholas R, Oppenheimer M, Robertson N, Zajicek J, Rothwell PM, Palace J.

JAMA Neurol. 2016 Aug 1;73(8):954-60. doi: 10.1001/jamaneurol.2016.1463.

PMID:
27366989
25.

Paediatric Multiple Sclerosis: Update on Diagnostic Criteria, Imaging, Histopathology and Treatment Choices.

Chou IJ, Wang HS, Whitehouse WP, Constantinescu CS.

Curr Neurol Neurosci Rep. 2016 Jul;16(7):68. doi: 10.1007/s11910-016-0663-4. Review.

26.

Cognitive Rehabilitation for Attention and Memory in people with Multiple Sclerosis: study protocol for a randomised controlled trial (CRAMMS).

Lincoln NB, das Nair R, Bradshaw L, Constantinescu CS, Drummond AE, Erven A, Evans AL, Fitzsimmons D, Montgomery AA, Morgan M.

Trials. 2015 Dec 8;16:556. doi: 10.1186/s13063-015-1016-3.

27.

Laquinimod (ABR-215062) for the treatment of relapsing multiple sclerosis.

Constantinescu SE, Constantinescu CS.

Expert Rev Clin Pharmacol. 2016;9(1):49-57. doi: 10.1586/17512433.2016.1108189. Epub 2015 Nov 4. Review.

PMID:
26536299
28.

Coordinate based meta-analysis does not show grey matter atrophy in narcolepsy.

Tanasescu R, Tench CR, Cottam WJ, Constantinescu CS, Auer DP.

Neurosci Biobehav Rev. 2015 Oct;57:297-8. doi: 10.1016/j.neubiorev.2015.07.016. Epub 2015 Sep 25. No abstract available.

PMID:
26408072
29.

Histogram analysis of quantitative T1 and MT maps from ultrahigh field MRI in clinically isolated syndrome and relapsing-remitting multiple sclerosis.

Al-Radaideh A, Mougin OE, Lim SY, Chou IJ, Constantinescu CS, Gowland P.

NMR Biomed. 2015 Nov;28(11):1374-82. doi: 10.1002/nbm.3385. Epub 2015 Sep 7.

PMID:
26346925
30.

Randomized phase 1b trial of MOR103, a human antibody to GM-CSF, in multiple sclerosis.

Constantinescu CS, Asher A, Fryze W, Kozubski W, Wagner F, Aram J, Tanasescu R, Korolkiewicz RP, Dirnberger-Hertweck M, Steidl S, Libretto SE, Sprenger T, Radue EW.

Neurol Neuroimmunol Neuroinflamm. 2015 May 21;2(4):e117. doi: 10.1212/NXI.0000000000000117. eCollection 2015 Aug.

31.

Development of a simple and sensitive HPLC-UV method for the simultaneous determination of cannabidiol and Δ(9)-tetrahydrocannabinol in rat plasma.

Zgair A, Wong JC, Sabri A, Fischer PM, Barrett DA, Constantinescu CS, Gershkovich P.

J Pharm Biomed Anal. 2015 Oct 10;114:145-51. doi: 10.1016/j.jpba.2015.05.019. Epub 2015 May 22.

PMID:
26048666
32.

PEGylated IFNβ-1a in the treatment of multiple sclerosis.

Khan UT, Tanasescu R, Constantinescu CS.

Expert Opin Biol Ther. 2015 Jul;15(7):1077-84. doi: 10.1517/14712598.2015.1053206. Epub 2015 Jun 3. Review.

PMID:
26036950
33.

Multiple sclerosis course and clinical outcomes in patients with comorbid asthma: a survey study.

Manouchehrinia A, Edwards LJ, Roshanisefat H, Tench CR, Constantinescu CS.

BMJ Open. 2015 May 20;5(5):e007806. doi: 10.1136/bmjopen-2015-007806.

34.

TLR2 stimulation regulates the balance between regulatory T cell and Th17 function: a novel mechanism of reduced regulatory T cell function in multiple sclerosis.

Nyirenda MH, Morandi E, Vinkemeier U, Constantin-Teodosiu D, Drinkwater S, Mee M, King L, Podda G, Zhang GX, Ghaemmaghami A, Constantinescu CS, Bar-Or A, Gran B.

J Immunol. 2015 Jun 15;194(12):5761-74. doi: 10.4049/jimmunol.1400472. Epub 2015 May 15.

35.

Mortality in multiple sclerosis: meta-analysis of standardised mortality ratios.

Manouchehrinia A, Tanasescu R, Tench CR, Constantinescu CS.

J Neurol Neurosurg Psychiatry. 2016 Mar;87(3):324-31. doi: 10.1136/jnnp-2015-310361. Epub 2015 May 2.

PMID:
25935887
36.

MRI-Based Measurement of Brain Stem Cross-Sectional Area in Relapsing-Remitting Multiple Sclerosis.

Chivers TR, Constantinescu CS, Tench CR.

J Neuroimaging. 2015 Nov-Dec;25(6):1002-6. doi: 10.1111/jon.12244. Epub 2015 Apr 19.

PMID:
25892669
37.

Helicobacter pylori infection reduces disease severity in an experimental model of multiple sclerosis.

Cook KW, Crooks J, Hussain K, O'Brien K, Braitch M, Kareem H, Constantinescu CS, Robinson K, Gran B.

Front Microbiol. 2015 Feb 13;6:52. doi: 10.3389/fmicb.2015.00052. eCollection 2015.

38.

What role does tobacco smoking play in multiple sclerosis disability and mortality? A review of the evidence.

Weston M, Constantinescu CS.

Neurodegener Dis Manag. 2015;5(1):19-25. doi: 10.2217/nmt.14.45. Review.

PMID:
25711451
39.

Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells.

Jean-Gilles L, Braitch M, Latif ML, Aram J, Fahey AJ, Edwards LJ, Robins RA, Tanasescu R, Tighe PJ, Gran B, Showe LC, Alexander SP, Chapman V, Kendall DA, Constantinescu CS.

Acta Physiol (Oxf). 2015 May;214(1):63-74. doi: 10.1111/apha.12474. Epub 2015 Mar 10.

40.

Reciprocal Regulation of Substance P and IL-12/IL-23 and the Associated Cytokines, IFNγ/IL-17: A Perspective on the Relevance of This Interaction to Multiple Sclerosis.

Vilisaar J, Kawabe K, Braitch M, Aram J, Furtun Y, Fahey AJ, Chopra M, Tanasescu R, Tighe PJ, Gran B, Pothoulakis C, Constantinescu CS.

J Neuroimmune Pharmacol. 2015 Sep;10(3):457-67. doi: 10.1007/s11481-015-9589-x. Epub 2015 Feb 18.

41.

Helminth Therapy for MS.

Tanasescu R, Constantinescu CS.

Curr Top Behav Neurosci. 2015;26:195-220. doi: 10.1007/7854_2014_361. Review.

PMID:
25472634
42.

Functionally relevant white matter degradation in multiple sclerosis: a tract-based spatial meta-analysis.

Welton T, Kent D, Constantinescu CS, Auer DP, Dineen RA.

Radiology. 2015 Apr;275(1):89-96. doi: 10.1148/radiol.14140925. Epub 2014 Nov 24.

PMID:
25426773
43.

Subjective discomfort in children receiving 3 T MRI and experienced adults' perspective on children's tolerability of 7 T: a cross-sectional questionnaire survey.

Chou IJ, Tench CR, Gowland P, Jaspan T, Dineen RA, Evangelou N, Abdel-Fahim R, Whitehouse WP, Constantinescu CS.

BMJ Open. 2014 Oct 15;4(10):e006094. doi: 10.1136/bmjopen-2014-006094.

44.

Coordinate based meta-analysis of functional neuroimaging data using activation likelihood estimation; full width half max and group comparisons.

Tench CR, Tanasescu R, Auer DP, Cottam WJ, Constantinescu CS.

PLoS One. 2014 Sep 16;9(9):e106735. doi: 10.1371/journal.pone.0106735. eCollection 2014.

45.

Increase in the iron content of the substantia nigra and red nucleus in multiple sclerosis and clinically isolated syndrome: a 7 Tesla MRI study.

Blazejewska AI, Al-Radaideh AM, Wharton S, Lim SY, Bowtell RW, Constantinescu CS, Gowland PA.

J Magn Reson Imaging. 2015 Apr;41(4):1065-70. doi: 10.1002/jmri.24644. Epub 2014 May 20.

PMID:
24841344
46.

Diagnostic modalities in multiple sclerosis: perspectives in children.

Chou IJ, Whitehouse WP, Wang HS, Tanasescu R, Constantinescu CS.

Biomed J. 2014 Mar-Apr;37(2):50-9. doi: 10.4103/2319-4170.129269. Review.

47.

Advances in the treatment of relapsing-remitting multiple sclerosis.

Tanasescu R, Ionete C, Chou IJ, Constantinescu CS.

Biomed J. 2014 Mar-Apr;37(2):41-9. doi: 10.4103/2319-4170.130440. Review.

48.

The essential role of T cells in multiple sclerosis: a reappraisal.

Constantinescu CS, Gran B.

Biomed J. 2014 Mar-Apr;37(2):34-40. doi: 10.4103/2319-4170.128746. Review.

49.

Pharmacokinetic evaluation of fingolimod for the treatment of multiple sclerosis.

Tanasescu R, Constantinescu CS.

Expert Opin Drug Metab Toxicol. 2014 Apr;10(4):621-30. doi: 10.1517/17425255.2014.894019. Epub 2014 Mar 1. Review.

PMID:
24579791
50.

Tobacco smoking and excess mortality in multiple sclerosis: a cohort study.

Manouchehrinia A, Weston M, Tench CR, Britton J, Constantinescu CS.

J Neurol Neurosurg Psychiatry. 2014 Oct;85(10):1091-5. doi: 10.1136/jnnp-2013-307187. Epub 2014 Feb 25.

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