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Clinical Approach to the Patient in Critical State Following Immunotherapy and/or Stem Cell Transplantation: Guideline for the On-Call Physician.

Constantinescu C, Bodolea C, Pasca S, Teodorescu P, Dima D, Rus I, Tat T, Achimas-Cadariu P, Tanase A, Tomuleasa C, Einsele H.

J Clin Med. 2019 Jun 20;8(6). pii: E884. doi: 10.3390/jcm8060884. Review.


Modifiable risk factors for poor health outcomes in multiple sclerosis: The urgent need for research to maximise smoking cessation success.

Marck CH, das Nair R, Grech LB, Borland R, Constantinescu CS.

Mult Scler. 2019 Jun 20:1352458519858730. doi: 10.1177/1352458519858730. [Epub ahead of print]


Cerebrospinal fluid biomarkers in patients with neurological symptoms but without neurological diseases.

Constantinescu R, Mahamud U, Constantinescu C, Eriksson B, Novakova L, Olsson B, Rosengren L, Blennow K, Axelsson M.

Acta Neurol Scand. 2019 May 14. doi: 10.1111/ane.13118. [Epub ahead of print]


Association between age, uptake of 18F-fluorodeoxyglucose and of 18F-sodium fluoride, as cardiovascular risk factors in the abdominal aorta.

Arani LS, Gharavi MH, Zadeh MZ, Raynor WY, Seraj SM, Constantinescu CM, Gerke O, Werner TJ, Høilund-Carlsen PF, Alavi A.

Hell J Nucl Med. 2019 Jan-Apr;22(1):14-19. doi: 10.1967/s002449910954. Epub 2019 Mar 7.


A brief report on EFSUMB Guidelines and Recommendations for elastography and contrast-enhanced ultrasound.

Constantinescu C, Saftoiu A.

Med Ultrason. 2019 Feb 17;21(1):5-7. doi: 10.11152/mu-1917.


Preclinical evaluation and non-human primate receptor occupancy study of 18F-JNJ-64413739, a novel PET radioligand for P2X7 receptors.

Kolb H, Barret O, Bhattacharya A, Chen G, Constantinescu C, Huang C, Letavic M, Tamagnan G, Xia C, Zhang W, Szardenings AK.

J Nucl Med. 2019 Feb 7. pii: jnumed.118.212696. doi: 10.2967/jnumed.118.212696. [Epub ahead of print]


The impact of photocatalytic Ag/TiO2 and Ag/N-TiO2 nanoparticles on human keratinocytes and epithelial lung cells.

Rebleanu D, Gaidau C, Voicu G, Constantinescu CA, Mansilla Sánchez C, Rojas TC, Carvalho S, Calin M.

Toxicology. 2019 Mar 15;416:30-43. doi: 10.1016/j.tox.2019.01.013. Epub 2019 Jan 31.


Targeted Transfection Using PEGylated Cationic Liposomes Directed Towards P-Selectin Increases siRNA Delivery into Activated Endothelial Cells.

Constantinescu CA, Fuior EV, Rebleanu D, Deleanu M, Simion V, Voicu G, Escriou V, Manduteanu I, Simionescu M, Calin M.

Pharmaceutics. 2019 Jan 21;11(1). pii: E47. doi: 10.3390/pharmaceutics11010047.


Diagnostic manifestations of total hemispheric glucose metabolism ratio in neuronal network diaschisis: diagnostic implications in Alzheimer's disease and mild cognitive impairment.

Segtnan EA, Majdi A, Constantinescu C, Grupe P, Gerke O, Dali HÍ, Strøm OE, Holm J, Alavi A, Sadigh-Eteghad S, Wermuth L, Hildebrandt MG, Gjedde A, Høilund-Carlsen PF.

Eur J Nucl Med Mol Imaging. 2019 May;46(5):1164-1174. doi: 10.1007/s00259-018-4248-0. Epub 2019 Jan 12.


Granulocyte-Macrophage Colony-Stimulating Factor as a Therapeutic Target in Multiple Sclerosis.

Aram J, Francis A, Tanasescu R, Constantinescu CS.

Neurol Ther. 2019 Jun;8(1):45-57. doi: 10.1007/s40120-018-0120-1. Epub 2018 Dec 1. Review.


Siponimod for the treatment of secondary progressive multiple sclerosis.

Dumitrescu L, Constantinescu CS, Tanasescu R.

Expert Opin Pharmacother. 2019 Feb;20(2):143-150. doi: 10.1080/14656566.2018.1551363. Epub 2018 Dec 5. Review.


Evaluation of [18 F]2FP3 in pigs and non-human primates.

Hansen HD, Constantinescu CC, Barret O, Herth MM, Magnussen JH, Lehel S, Dyssegaard A, Colomb J, Billard T, Zimmer L, Tamagnan G, Knudsen GM.

J Labelled Comp Radiopharm. 2019 Jan;62(1):34-42. doi: 10.1002/jlcr.3692. Epub 2018 Dec 6.


Effects of cigarette smoke on immunity, neuroinflammation and multiple sclerosis.

Alrouji M, Manouchehrinia A, Gran B, Constantinescu CS.

J Neuroimmunol. 2019 Apr 15;329:24-34. doi: 10.1016/j.jneuroim.2018.10.004. Epub 2018 Oct 9. Review.


The Role of PET in Evaluating Atherosclerosis: A Critical Review.

Moghbel M, Al-Zaghal A, Werner TJ, Constantinescu CM, Høilund-Carlsen PF, Alavi A.

Semin Nucl Med. 2018 Nov;48(6):488-497. doi: 10.1053/j.semnuclmed.2018.07.001. Epub 2018 Aug 30. Review.


Epilepsy and associated mortality in patients with multiple sclerosis.

Chou IJ, Kuo CF, Tanasescu R, Tench CR, Tiley CG, Constantinescu CS, Whitehouse WP.

Eur J Neurol. 2019 Feb;26(2):342-e23. doi: 10.1111/ene.13821. Epub 2018 Oct 30.


Chimerism Monitoring by Short Tandem Repeat (STR) Markers in Allogeneic Stem Cell Transplantation.

Dumache R, Enache A, Barbarii L, Constantinescu C, Pascalau A, Jinca C, Arghirescu S.

Clin Lab. 2018 Sep 1;64(9):1535-1543. doi: 10.7754/Clin.Lab.2018.180409.


Correction: Genetically enhanced T lymphocytes and the intensive care unit.

Tat T, Li H, Constantinescu CS, Onaciu A, Chira S, Osan C, Pasca S, Petrushev B, Moisoiu V, Micu WT, Berce C, Tranca S, Dima D, Berindan-Neagoe I, Shen J, Tomuleasa C, Qian L.

Oncotarget. 2018 Aug 10;9(62):32097. doi: 10.18632/oncotarget.25983. eCollection 2018 Aug 10.


Development and In Vivo Preclinical Imaging of Fluorine-18-Labeled Synaptic Vesicle Protein 2A (SV2A) PET Tracers.

Constantinescu CC, Tresse C, Zheng M, Gouasmat A, Carroll VM, Mistico L, Alagille D, Sandiego CM, Papin C, Marek K, Seibyl JP, Tamagnan GD, Barret O.

Mol Imaging Biol. 2019 Jun;21(3):509-518. doi: 10.1007/s11307-018-1260-5.


Advanced Atherosclerosis with Leriche Syndrome, in a Patient with Carney Complex.

Visoiu IS, Constantinescu C, Patrascu N, Stoicescu CI, Dorobat B, Brezeanu R, Anton C, Vinereanu D, Cinteza M.

Maedica (Buchar). 2018 Jun;13(2):147-151. doi: 10.26574/maedica.2018.13.2.147.


The performance of ultrasound-based quantification of the hyomental distance ratio in predicting difficult airway in anaesthesia: A STARD-compliant prospective diagnostic study.

Petrişor C, Szabo R, Constantinescu C, Prie A, Trancă S, Hagău N.

Eur J Anaesthesiol. 2018 Aug;35(8):627-628. doi: 10.1097/EJA.0000000000000849. No abstract available.


Hypothermia in Multiple Sclerosis: Beyond the Hypothalamus? A Case Report and Review of the Literature.

Berti F, Arif Z, Constantinescu C, Gran B.

Case Rep Neurol Med. 2018 Mar 21;2018:2768493. doi: 10.1155/2018/2768493. eCollection 2018.


18F-F13640 preclinical evaluation in rodent, cat and primate as a 5-HT1A receptor agonist for PET neuroimaging.

Vidal B, Fieux S, Colom M, Billard T, Bouillot C, Barret O, Constantinescu C, Tamagnan G, Newman-Tancredi A, Zimmer L.

Brain Struct Funct. 2018 Jul;223(6):2973-2988. doi: 10.1007/s00429-018-1672-7. Epub 2018 May 5.


Genetically enhanced T lymphocytes and the intensive care unit.

Tat T, Li H, Constantinescu CS, Onaciu A, Chira S, Osan C, Pasca S, Petrushev B, Moisoiu V, Micu WT, Berce C, Tranca S, Dima D, Berindan-Neagoe I, Shen J, Tomuleasa C, Qian L.

Oncotarget. 2018 Mar 27;9(23):16557-16572. doi: 10.18632/oncotarget.24637. eCollection 2018 Mar 27. Review. Erratum in: Oncotarget. 2018 Aug 10;9(62):32097.


Therapeutic cannabinoids in multiple sclerosis: immunomodulation revisited.

Constantinescu CS, Gershkovich P.

Eur J Neurol. 2018 Jul;25(7):905-906. doi: 10.1111/ene.13658. Epub 2018 May 3. No abstract available.


Correction to: Secondary antibody deficiency: a complication of anti-CD20 therapy for neuroinflammation.

Tallantyre EC, Whittam DH, Jolles S, Paling D, Constantinescu C, Robertson NP, Jacob A.

J Neurol. 2018 May;265(5):1123. doi: 10.1007/s00415-018-8833-8.


Recent developments in interferon-based therapies for multiple sclerosis.

Dumitrescu L, Constantinescu CS, Tanasescu R.

Expert Opin Biol Ther. 2018 Jun;18(6):665-680. doi: 10.1080/14712598.2018.1462793. Epub 2018 Apr 20. Review.


Chimeric Antigen Receptor T-Cells for the Treatment of B-Cell Acute Lymphoblastic Leukemia.

Tomuleasa C, Fuji S, Berce C, Onaciu A, Chira S, Petrushev B, Micu WT, Moisoiu V, Osan C, Constantinescu C, Pasca S, Jurj A, Pop L, Berindan-Neagoe I, Dima D, Kitano S.

Front Immunol. 2018 Feb 19;9:239. doi: 10.3389/fimmu.2018.00239. eCollection 2018. Review.


Endoscopic ultrasound guided needle-based confocal laser endomicroscopy in solid pancreatic masses - a prospective validation study.

Karstensen JG, Cârţână T, Constantinescu C, Dumitrașcu S, Kovacevic B, Klausen P, Hassan H, Klausen TW, Bertani H, Bhutani MS, Săftoiu A, Vilmann P.

Endosc Int Open. 2018 Jan;6(1):E78-E85. doi: 10.1055/s-0043-121987. Epub 2018 Jan 16.


Lipopolysaccharide-induced inflammation in monocytes/macrophages is blocked by liposomal delivery of Gi-protein inhibitor.

Tucureanu MM, Rebleanu D, Constantinescu CA, Deleanu M, Voicu G, Butoi E, Calin M, Manduteanu I.

Int J Nanomedicine. 2017 Dec 20;13:63-76. doi: 10.2147/IJN.S150918. eCollection 2018.


Oral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation.

Zgair A, Lee JB, Wong JCM, Taha DA, Aram J, Di Virgilio D, McArthur JW, Cheng YK, Hennig IM, Barrett DA, Fischer PM, Constantinescu CS, Gershkovich P.

Sci Rep. 2017 Nov 6;7(1):14542. doi: 10.1038/s41598-017-15026-z.


Seven-Tesla Magnetization Transfer Imaging to Detect Multiple Sclerosis White Matter Lesions.

Chou IJ, Lim SY, Tanasescu R, Al-Radaideh A, Mougin OE, Tench CR, Whitehouse WP, Gowland PA, Constantinescu CS.

J Neuroimaging. 2018 Mar;28(2):183-190. doi: 10.1111/jon.12474. Epub 2017 Sep 25.


DAB389IL-2 recombinant fusion toxin effect on lymphocyte- and macrophage-producing cytokine subpopulation cells in experimentally induced demyelinating disease in mice.

Bhopale MK, Hilliard B, Constantinescu CS, Phillips SM, Rostami A.

Immunopharmacol Immunotoxicol. 2017 Dec;39(6):318-329. doi: 10.1080/08923973.2017.1369099. Epub 2017 Sep 20.


Prevalence of a history of prior varicella/herpes zoster infection in multiple sclerosis.

Manouchehrinia A, Tanasescu R, Kareem H, Jerca OP, Jabeen F, Shafei R, Breuer J, Neal K, Irving W, Constantinescu CS.

J Neurovirol. 2017 Dec;23(6):839-844. doi: 10.1007/s13365-017-0569-1. Epub 2017 Sep 11.


Biopolymers/poly(ε-caprolactone)/polyethylenimine functionalized nano-hydroxyapatite hybrid cryogel: Synthesis, characterization and application in gene delivery.

Simionescu BC, Drobota M, Timpu D, Vasiliu T, Constantinescu CA, Rebleanu D, Calin M, David G.

Mater Sci Eng C Mater Biol Appl. 2017 Dec 1;81:167-176. doi: 10.1016/j.msec.2017.07.031. Epub 2017 Jul 19.


Assessment of performance indicators of a radiotherapy department using an electronic medical record system.

Bahadur YA, Constantinescu C, Bahadur AY, Bahadur RY.

Rep Pract Oncol Radiother. 2017 Sep-Oct;22(5):360-367. doi: 10.1016/j.rpor.2017.06.002. Epub 2017 Jul 21.


Prognostic factors for long-term outcomes in relapsing-remitting multiple sclerosis.

Traboulsee AL, Cornelisseª P, Sandberg-Wollheim M, Uitdehaag BM, Kappos L, Jongen PJ, Constantinescu CS, di Cantogno EV, Li DK.

Mult Scler J Exp Transl Clin. 2016 Sep 6;2:2055217316666406. doi: 10.1177/2055217316666406. eCollection 2016 Jan-Dec.


The relationship between disease activity, quality of life, and personality types in rheumatoid arthritis and ankylosing spondylitis patients.

Donisan T, Bojincă VC, Dobrin MA, Bălănescu DV, Predețeanu D, Bojincă M, Berghea F, Opriș D, Groșeanu L, Borangiu A, Constantinescu CL, Ionescu R, Bălănescu AR.

Clin Rheumatol. 2017 Jul;36(7):1511-1519. doi: 10.1007/s10067-017-3654-1. Epub 2017 Apr 27.


Smoking Cessation and the Reduction of Disability Progression in Multiple Sclerosis: A Cohort Study.

Tanasescu R, Constantinescu CS, Tench CR, Manouchehrinia A.

Nicotine Tob Res. 2018 Apr 2;20(5):589-595. doi: 10.1093/ntr/ntx084.


Coordinate based random effect size meta-analysis of neuroimaging studies.

Tench CR, Tanasescu R, Constantinescu CS, Auer DP, Cottam WJ.

Neuroimage. 2017 Jun;153:293-306. doi: 10.1016/j.neuroimage.2017.04.002. Epub 2017 Apr 5.


The association between human endogenous retroviruses and multiple sclerosis: A systematic review and meta-analysis.

Morandi E, Tanasescu R, Tarlinton RE, Constantinescu CS, Zhang W, Tench C, Gran B.

PLoS One. 2017 Feb 16;12(2):e0172415. doi: 10.1371/journal.pone.0172415. eCollection 2017. Review.


Delayed interval delivery in twin pregnancy - case reports.

Văduva CC, Constantinescu C, Ţenovici M, Văduva AR, Niculescu M, DiŢescu D, Albu CC, Albu DF.

Rom J Morphol Embryol. 2016;57(3):1089-1098.


Decreased interferon-β induced STAT-4 activation in immune cells and clinical outcome in multiple sclerosis.

Tanasescu R, Midgley A, Robins RA, Constantinescu CS.

Acta Neurol Scand. 2017 Sep;136(3):233-238. doi: 10.1111/ane.12715. Epub 2016 Dec 5.


PET radiotracer development for imaging high-affinity state of dopamine D2 and D3 receptors: Binding studies of fluorine-18 labeled aminotetralins in rodents.

Mukherjee J, Majji D, Kaur J, Constantinescu CC, Narayanan TK, Shi B, Nour MT, Pan ML.

Synapse. 2017 Mar;71(3). doi: 10.1002/syn.21950. Epub 2016 Nov 30.


Pregnancy resulting from IMSI after testicular biopsy in a patient with obstructive azoospermia.

Văduva CC, Constantinescu C, Radu MM, Văduva AR, Pănuş A, Ţenovici M, DiŢescu D, Albu DF.

Rom J Morphol Embryol. 2016;57(2 Suppl):879-883.


Coordinate based meta-analysis does not show grey matter atrophy in narcolepsy.

Tench CR, Tanasescu R, Cottam WJ, Constantinescu CS, Auer DP.

Neurosci Biobehav Rev. 2019 Jul;102:427-429. doi: 10.1016/j.neubiorev.2016.10.019. Epub 2016 Nov 5. No abstract available.


Prognostic Implications of Total Hemispheric Glucose Metabolism Ratio in Cerebrocerebellar Diaschisis.

Segtnan EA, Grupe P, Jarden JO, Gerke O, Ivanidze J, Christlieb SB, Constantinescu C, Pedersen JE, Houshmand S, Hess S, Zarei M, Gjedde A, Alavi A, Høilund-Carlsen PF.

J Nucl Med. 2017 May;58(5):768-773. doi: 10.2967/jnumed.116.180398. Epub 2016 Oct 27.


The future of multiple sclerosis treatments.

Coclitu C, Constantinescu CS, Tanasescu R.

Expert Rev Neurother. 2016 Dec;16(12):1341-1356. Epub 2016 Oct 21. Review.


Low vitamin D status in systemic sclerosis and the impact on disease phenotype.

Groseanu L, Bojinca V, Gudu T, Saulescu I, Predeteanu D, Balanescu A, Berghea F, Opris D, Borangiu A, Constantinescu C, Negru M, Ionescu R.

Eur J Rheumatol. 2016 Jun;3(2):50-55. Epub 2016 Feb 1.


P-Selectin Targeted Dexamethasone-Loaded Lipid Nanoemulsions: A Novel Therapy to Reduce Vascular Inflammation.

Simion V, Constantinescu CA, Stan D, Deleanu M, Tucureanu MM, Butoi E, Manduteanu I, Simionescu M, Calin M.

Mediators Inflamm. 2016;2016:1625149. Epub 2016 Sep 14.

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