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Items: 1 to 50 of 222

1.

Early onset of action with a 17β-estradiol, softgel, vaginal insert for treating vulvar and vaginal atrophy and moderate to severe dyspareunia.

Constantine G, Millheiser LS, Kaunitz AM, Parish SJ, Graham S, Bernick B, Mirkin S.

Menopause. 2019 Aug 19. doi: 10.1097/GME.0000000000001394. [Epub ahead of print]

PMID:
31433355
2.

Pharmacokinetics and tolerability of a novel progesterone intravaginal ring in sheep.

Weiss H, Martell B, Constantine GD, Davis SM, Vidal JD, Mayer PR, Doorbar M, Friend DR.

Drug Deliv Transl Res. 2019 Oct;9(5):1008-1016. doi: 10.1007/s13346-019-00646-x.

PMID:
31066007
3.

Pharmacokinetics and Tolerability of a Novel 17β-Estradiol and Progesterone Intravaginal Ring in Sheep.

Weiss H, Martell B, Constantine GD, Davis SM, Vidal JD, Mayer PR, Doorbar M, Friend DR.

J Pharm Sci. 2019 Aug;108(8):2677-2684. doi: 10.1016/j.xphs.2019.03.032. Epub 2019 Apr 5.

PMID:
30959058
4.

Endometrial safety of low-dose vaginal estrogens in menopausal women: a systematic evidence review.

Constantine GD, Graham S, Lapane K, Ohleth K, Bernick B, Liu J, Mirkin S.

Menopause. 2019 Jul;26(7):800-807. doi: 10.1097/GME.0000000000001315.

5.

TX-004HR clinically improves symptoms of vulvar and vaginal atrophy in postmenopausal women.

Simon JA, Kagan R, Archer DF, Constantine GD, Bernick B, Graham S, Mirkin S.

Climacteric. 2019 Aug;22(4):412-418. doi: 10.1080/13697137.2019.1577379. Epub 2019 Mar 12.

PMID:
30862193
6.

Estradiol and progesterone bioavailability for moderate to severe vasomotor symptom treatment and endometrial protection with the continuous-combined regimen of TX-001HR (oral estradiol and progesterone capsules).

Lobo RA, Liu J, Stanczyk FZ, Constantine GD, Pickar JH, Shadiack AM, Bernick B, Mirkin S.

Menopause. 2019 Jul;26(7):720-727. doi: 10.1097/GME.0000000000001306.

7.

A conceptual time window-based model for the early stratification of trauma patients.

Lamparello AJ, Namas RA, Constantine G, McKinley TO, Elster E, Vodovotz Y, Billiar TR.

J Intern Med. 2019 Jul;286(1):2-15. doi: 10.1111/joim.12874. Epub 2019 Jan 9. Review.

PMID:
30623510
8.

Relationship between vasomotor symptom improvements and quality of life and sleep outcomes in menopausal women treated with oral, combined 17β-estradiol/progesterone.

Mirkin S, Graham S, Revicki DA, Bender RH, Bernick B, Constantine GD.

Menopause. 2019 Jan 9;26(6):637-642. doi: 10.1097/GME.0000000000001294.

9.

Improvement in sleep outcomes with a 17β-estradiol-progesterone oral capsule (TX-001HR) for postmenopausal women.

Kagan R, Constantine G, Kaunitz AM, Bernick B, Mirkin S.

Menopause. 2018 Dec 21;26(6):622-628. doi: 10.1097/GME.0000000000001278.

10.

Lessons from primary immunodeficiencies: Autoimmune regulator and autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.

Constantine GM, Lionakis MS.

Immunol Rev. 2019 Jan;287(1):103-120. doi: 10.1111/imr.12714. Review.

PMID:
30565240
11.

Evaluation of clinical meaningfulness of estrogen plus progesterone oral capsule (TX-001HR) on moderate to severe vasomotor symptoms.

Constantine GD, Revicki DA, Kagan R, Simon JA, Graham S, Bernick B, Mirkin S.

Menopause. 2019 May;26(5):513-519. doi: 10.1097/GME.0000000000001261.

12.

Increased Incidence of Endometrial Cancer Following the Women's Health Initiative: An Assessment of Risk Factors.

Constantine GD, Kessler G, Graham S, Goldstein SR.

J Womens Health (Larchmt). 2019 Feb;28(2):237-243. doi: 10.1089/jwh.2018.6956. Epub 2018 Nov 28.

13.

Ascorbic acid-induced oxalate nephropathy: a case report and discussion of pathologic mechanisms.

Lin WV, Turin CG, McCormick DW, Haas C, Constantine G.

CEN Case Rep. 2019 Feb;8(1):67-70. doi: 10.1007/s13730-018-0366-6. Epub 2018 Oct 1.

14.

Estradiol vaginal inserts (4 µg and 10 µg) for treating moderate to severe vulvar and vaginal atrophy: a review of phase 3 safety, efficacy and pharmacokinetic data.

Constantine GD, Simon JA, Pickar JH, Archer DF, Bernick B, Graham S, Mirkin S.

Curr Med Res Opin. 2018 Dec;34(12):2131-2136. doi: 10.1080/03007995.2018.1527578. Epub 2018 Sep 28.

PMID:
30238814
15.

Twelve-year follow-up of omalizumab therapy for anaphylaxis in 2 patients with systemic mastocytosis.

Constantine GM, Bressler PB, Petroni D, Metcalfe DD, Carter MC.

J Allergy Clin Immunol Pract. 2019 Apr;7(4):1314-1316. doi: 10.1016/j.jaip.2018.07.041. Epub 2018 Aug 24. No abstract available.

PMID:
30149096
16.

Translation and Validation of the Sinhalese Version of the Brief Medication Questionnaire in Patients with Diabetes Mellitus.

Ranasinghe P, Jayawardena R, Katulanda P, Constantine GR, Ramanayake V, Galappatthy P.

J Diabetes Res. 2018 May 23;2018:7519462. doi: 10.1155/2018/7519462. eCollection 2018.

17.

To the Editor.

Archer DF, Pickar JH, Constantine GD, Shadiack AM, Bernick B, Mirkin S.

Menopause. 2018 Aug;25(8):952-953. doi: 10.1097/GME.0000000000001146. No abstract available.

PMID:
29944639
18.

A 17β-Estradiol-Progesterone Oral Capsule for Vasomotor Symptoms in Postmenopausal Women: A Randomized Controlled Trial.

Lobo RA, Archer DF, Kagan R, Kaunitz AM, Constantine GD, Pickar JH, Graham S, Bernick B, Mirkin S.

Obstet Gynecol. 2018 Jul;132(1):161-170. doi: 10.1097/AOG.0000000000002645. Erratum in: Obstet Gynecol. 2018 Sep;132(3):786.

PMID:
29889748
19.

Sublingual nitroglycerin for early blood pressure control in hypertensive emergencies: observations from an emergency department clinical audit in Sri Lanka.

Prasanna N, Dissanayake HA, Constantine GR.

BMC Res Notes. 2018 Jun 5;11(1):355. doi: 10.1186/s13104-018-3460-0.

20.

Spectrum of low-density lipoprotein receptor (LDLR) mutations in a cohort of Sri Lankan patients with familial hypercholesterolemia - a preliminary report.

Paththinige CS, Rajapakse JRDK, Constantine GR, Sem KP, Singaraja RR, Jayasekara RW, Dissanayake VHW.

Lipids Health Dis. 2018 May 2;17(1):100. doi: 10.1186/s12944-018-0763-z.

21.

Prevalence, patterns, and associations of dyslipidemia among Sri Lankan adults-Sri Lanka Diabetes and Cardiovascular Study in 2005-2006.

Katulanda P, Dissanayake HA, De Silva SDN, Katulanda GW, Liyanage IK, Constantine GR, Sheriff R, Matthews DR.

J Clin Lipidol. 2018 Mar - Apr;12(2):447-454. doi: 10.1016/j.jacl.2018.01.006. Epub 2018 Jan 31.

PMID:
29429894
22.

Study protocol: a randomised controlled trial of supervised resistance training versus aerobic training in Sri Lankan adults with type 2 diabetes mellitus: SL-DART study.

Ranasinghe C, Hills AP, Constantine GR, Finlayson G, Katulanda P, King NA.

BMC Public Health. 2018 Jan 24;18(1):176. doi: 10.1186/s12889-018-5069-6.

23.

Evaluation of pharmacodynamic properties and safety of Cinnamomum zeylanicum (Ceylon cinnamon) in healthy adults: a phase I clinical trial.

Ranasinghe P, Jayawardena R, Pigera S, Wathurapatha WS, Weeratunga HD, Premakumara GAS, Katulanda P, Constantine GR, Galappaththy P.

BMC Complement Altern Med. 2017 Dec 28;17(1):550. doi: 10.1186/s12906-017-2067-7.

24.

Peer assisted learning among Sri Lankan medical undergraduates: a cross sectional study.

de Silva NL, Parththipan B, Rodrigo C, Constantine G, Fernando SD, Rajapakse S.

BMC Res Notes. 2017 Nov 14;10(1):595. doi: 10.1186/s13104-017-2920-2.

25.

Zinc supplementation in prediabetes: A randomized double-blind placebo-controlled clinical trial.

Ranasinghe P, Wathurapatha WS, Galappatthy P, Katulanda P, Jayawardena R, Constantine GR.

J Diabetes. 2018 May;10(5):386-397. doi: 10.1111/1753-0407.12621. Epub 2018 Jan 3.

PMID:
29072815
26.

Cinnamomum zeylanicum (Ceylon cinnamon) as a potential pharmaceutical agent for type-2 diabetes mellitus: study protocol for a randomized controlled trial.

Ranasinghe P, Galappaththy P, Constantine GR, Jayawardena R, Weeratunga HD, Premakumara S, Katulanda P.

Trials. 2017 Sep 29;18(1):446. doi: 10.1186/s13063-017-2192-0.

27.

In Reply.

Archer DF, Constantine GD, Simon J, Kushner H, Mayer P, Bernick B, Graham S, Mirkin S.

Menopause. 2017 Aug;24(8):988-989. doi: 10.1097/GME.0000000000000940. No abstract available.

PMID:
28719419
28.

Combination Steroid and Test-based Food Elimination for Eosinophilic Esophagitis: A Retrospective Analysis.

Constantine G, Seth N, Chokshi N, Minard CG, Guffey D, Olive AP, Davis CM.

J Pediatr Gastroenterol Nutr. 2017 Jun;64(6):933-938. doi: 10.1097/MPG.0000000000001584.

29.

Visual improvements in vaginal mucosa correlate with symptoms of VVA: data from a double-blind, placebo-controlled trial.

Simon JA, Archer DF, Kagan R, Bernick B, Graham S, Constantine GD, Mirkin S.

Menopause. 2017 Sep;24(9):1003-1010. doi: 10.1097/GME.0000000000000880.

30.

A vaginal estradiol softgel capsule, TX-004HR, has negligible to very low systemic absorption of estradiol: Efficacy and pharmacokinetic data review.

Simon JA, Archer DF, Constantine GD, Pickar JH, Amadio JM, Bernick B, Graham S, Mirkin S.

Maturitas. 2017 May;99:51-58. doi: 10.1016/j.maturitas.2017.02.008. Epub 2017 Feb 16. Review.

31.

Consistency of Effect with a Low-Dose, Estradiol Vaginal Capsule (TX-004HR): Evaluating Improvement in Vaginal Physiology and Moderate-to-Severe Dyspareunia in Subgroups of Postmenopausal Women.

Constantine GD, Bouchard C, Pickar JH, Archer DF, Graham S, Bernick B, Mirkin S.

J Womens Health (Larchmt). 2017 Jun;26(6):616-623. doi: 10.1089/jwh.2016.6187. Epub 2017 Mar 29.

32.

Addition of Propranolol in Resistant Arterial hypertension Treatment (APROPRIATE study): study protocol for a randomized double-blind placebo-controlled trial.

Constantine GR, Ranasinghe P, Weeratunga P, Weeraratne C, Galappatthy P, Rajapakse S, Senarath U, Katulanda P.

Trials. 2017 Mar 14;18(1):124. doi: 10.1186/s13063-017-1863-1.

33.

Patient acceptability and satisfaction with a low-dose solubilized vaginal estradiol softgel capsule, TX-004HR.

Kingsberg SA, Kroll R, Goldstein I, Kushner H, Bernick B, Graham S, Mirkin S, Constantine GD.

Menopause. 2017 Aug;24(8):894-899. doi: 10.1097/GME.0000000000000848.

34.

Inflammatory Mediators Associated With Pressure Ulcer Development in Individuals With Pneumonia After Traumatic Spinal Cord Injury: A Pilot Study.

Krishnan S, Vodovotz Y, Karg PE, Constantine G, Sowa GA, Constantine FJ, Brienza DM.

Arch Phys Med Rehabil. 2017 Sep;98(9):1792-1799. doi: 10.1016/j.apmr.2016.12.018. Epub 2017 Jan 25.

PMID:
28130082
35.

TX-004HR vaginal estradiol has negligible to very low systemic absorption of estradiol.

Archer DF, Constantine GD, Simon JA, Kushner H, Mayer P, Bernick B, Graham S, Mirkin S; REJOICE Study Group.

Menopause. 2017 May;24(5):510-516. doi: 10.1097/GME.0000000000000790.

36.

The REJOICE trial: a phase 3 randomized, controlled trial evaluating the safety and efficacy of a novel vaginal estradiol soft-gel capsule for symptomatic vulvar and vaginal atrophy.

Constantine GD, Simon JA, Pickar JH, Archer DF, Kushner H, Bernick B, Gasper G, Graham S, Mirkin S; REJOICE Study Group.

Menopause. 2017 Apr;24(4):409-416. doi: 10.1097/GME.0000000000000786.

37.

Response and Rebuttal to Editorial Comment on TX-004HR Improves Sexual Function as Measured by the Female Sexual Function Index in Postmenopausal Women with Vulvar and Vaginal Atrophy: The REJOICE Trial.

Kingsberg SA, Derogatis L, Simon JA, Constantine GD, Graham S, Bernick B, Gasper G, Mirkin S.

J Sex Med. 2016 Dec;13(12):1940-1941. doi: 10.1016/j.jsxm.2016.10.011. No abstract available.

PMID:
27914565
38.

Dynamic Profiling: Modeling the Dynamics of Inflammation and Predicting Outcomes in Traumatic Brain Injury Patients.

Constantine G, Buliga M, Mi Q, Constantine F, Abboud A, Zamora R, Puccio A, Okonkwo D, Vodovotz Y.

Front Pharmacol. 2016 Nov 1;7:383. eCollection 2016.

39.

Inflammation Following Traumatic Brain Injury in Humans: Insights from Data-Driven and Mechanistic Models into Survival and Death.

Abboud A, Mi Q, Puccio A, Okonkwo D, Buliga M, Constantine G, Vodovotz Y.

Front Pharmacol. 2016 Sep 27;7:342. eCollection 2016.

40.

TX-004HR Improves Sexual Function as Measured by the Female Sexual Function Index in Postmenopausal Women With Vulvar and Vaginal Atrophy: The REJOICE Trial.

Kingsberg SA, Derogatis L, Simon JA, Constantine GD, Graham S, Bernick B, Gasper G, Mirkin S.

J Sex Med. 2016 Dec;13(12):1930-1937. doi: 10.1016/j.jsxm.2016.09.002. Epub 2016 Sep 28.

41.

Prescribing of FDA-approved and compounded hormone therapy differs by specialty.

Constantine GD, Archer DF, Graham S, Bernick BA, Mirkin S.

Menopause. 2016 Oct;23(10):1075-82. doi: 10.1097/GME.0000000000000683.

42.
43.

Ospemifene's effect on vasomotor symptoms: a post hoc analysis of phase 2 and 3 clinical data.

Constantine GD, Archer DF, Pollycove R, Jiang W, Altomare C, Pinkerton JV.

Menopause. 2016 Sep;23(9):957-64. doi: 10.1097/GME.0000000000000656.

PMID:
27404027
44.

Biological screening of selected Pacific Northwest forest plants using the brine shrimp (Artemia salina) toxicity bioassay.

Karchesy YM, Kelsey RG, Constantine G, Karchesy JJ.

Springerplus. 2016 Apr 23;5:510. doi: 10.1186/s40064-016-2145-1. eCollection 2016.

45.

Effects of ospemifene on bone parameters including clinical biomarkers in postmenopausal women.

Constantine GD, Kagan R, Miller PD.

Menopause. 2016 Jun;23(6):638-44. doi: 10.1097/GME.0000000000000619. Review.

PMID:
27045700
46.

Behaviours and attitudes influencing treatment decisions for menopausal symptoms in five European countries.

Constantine GD, Graham S, Clerinx C, Bernick BA, Krassan M, Mirkin S, Currie H.

Post Reprod Health. 2016 Sep;22(3):112-22. doi: 10.1177/2053369116632439. Epub 2016 Feb 18.

47.

Early Detection of Pressure Ulcer Development Following Traumatic Spinal Cord Injury Using Inflammatory Mediators.

Krishnan S, Karg PE, Boninger ML, Vodovotz Y, Constantine G, Sowa GA, Brienza DM.

Arch Phys Med Rehabil. 2016 Oct;97(10):1656-62. doi: 10.1016/j.apmr.2016.01.003. Epub 2016 Jan 25.

PMID:
26820323
48.

Compounded non-FDA-approved menopausal hormone therapy prescriptions have increased: results of a pharmacy survey.

Pinkerton JV, Constantine GD.

Menopause. 2016 Apr;23(4):359-67. doi: 10.1097/GME.0000000000000567.

49.

Eosinophilic Esophagitis in Children and Its Relationship with Parental Allergies: Texas Children's Hospital Experience.

Hiremath G, Byramji D, Pacheco A, Constantine G, Davis C, Shulman R, Olive A.

Dig Dis Sci. 2016 Feb;61(2):501-6. doi: 10.1007/s10620-015-3903-6. Epub 2015 Oct 6.

50.

Zinc and diabetes mellitus: understanding molecular mechanisms and clinical implications.

Ranasinghe P, Pigera S, Galappatthy P, Katulanda P, Constantine GR.

Daru. 2015 Sep 17;23:44. doi: 10.1186/s40199-015-0127-4. Review.

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