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Role of the RNA-binding protein Bicaudal-C1 and interacting factors in cystic kidney diseases.

Rothé B, Gagnieux C, Leal-Esteban LC, Constam DB.

Cell Signal. 2019 Dec 12:109499. doi: 10.1016/j.cellsig.2019.109499. [Epub ahead of print]


A novel cell-based sensor detecting the activity of individual basic proprotein convertases.

Löw K, Hardes K, Fedeli C, Seidah NG, Constam DB, Pasquato A, Steinmetzer T, Roulin A, Kunz S.

FEBS J. 2019 Nov;286(22):4597-4620. doi: 10.1111/febs.14979. Epub 2019 Jul 24.


Comment on "Human dignity and gene editing".

Constam DB.

EMBO Rep. 2019 Jan;20(1). pii: e47220. doi: 10.15252/embr.201847220. Epub 2018 Nov 29. No abstract available.


Role of Bicaudal C1 in renal gluconeogenesis and its novel interaction with the CTLH complex.

Leal-Esteban LC, Rothé B, Fortier S, Isenschmid M, Constam DB.

PLoS Genet. 2018 Jul 11;14(7):e1007487. doi: 10.1371/journal.pgen.1007487. eCollection 2018 Jul.


Compartment-Specific Biosensors Reveal a Complementary Subcellular Distribution of Bioactive Furin and PC7.

Ginefra P, Filippi BGH, Donovan P, Bessonnard S, Constam DB.

Cell Rep. 2018 Feb 20;22(8):2176-2189. doi: 10.1016/j.celrep.2018.02.005.


Crystal Structure of Bicc1 SAM Polymer and Mapping of Interactions between the Ciliopathy-Associated Proteins Bicc1, ANKS3, and ANKS6.

Rothé B, Leettola CN, Leal-Esteban L, Cascio D, Fortier S, Isenschmid M, Bowie JU, Constam DB.

Structure. 2018 Feb 6;26(2):209-224.e6. doi: 10.1016/j.str.2017.12.002. Epub 2017 Dec 28.


Paracrine Activin-A Signaling Promotes Melanoma Growth and Metastasis through Immune Evasion.

Donovan P, Dubey OA, Kallioinen S, Rogers KW, Muehlethaler K, Müller P, Rimoldi D, Constam DB.

J Invest Dermatol. 2017 Dec;137(12):2578-2587. doi: 10.1016/j.jid.2017.07.845. Epub 2017 Aug 26.


Epiblast-specific loss of HCF-1 leads to failure in anterior-posterior axis specification.

Minocha S, Bessonnard S, Sung TL, Moret C, Constam DB, Herr W.

Dev Biol. 2016 Oct 1;418(1):75-88. doi: 10.1016/j.ydbio.2016.08.008. Epub 2016 Aug 9.


Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis.

Lemaire LA, Goulley J, Kim YH, Carat S, Jacquemin P, Rougemont J, Constam DB, Grapin-Botton A.

Development. 2016 Jan 1;143(1):181. doi: 10.1242/dev.133934. No abstract available.


ProNodal acts via FGFR3 to govern duration of Shh expression in the prechordal mesoderm.

Ellis PS, Burbridge S, Soubes S, Ohyama K, Ben-Haim N, Chen C, Dale K, Shen MM, Constam D, Placzek M.

Development. 2015 Nov 15;142(22):3821-32. doi: 10.1242/dev.119628. Epub 2015 Sep 28.


PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation.

Bessonnard S, Mesnard D, Constam DB.

J Cell Biol. 2015 Sep 28;210(7):1185-97. doi: 10.1083/jcb.201503042.


Bicc1 Polymerization Regulates the Localization and Silencing of Bound mRNA.

Rothé B, Leal-Esteban L, Bernet F, Urfer S, Doerr N, Weimbs T, Iwaszkiewicz J, Constam DB.

Mol Cell Biol. 2015 Oct;35(19):3339-53. doi: 10.1128/MCB.00341-15. Epub 2015 Jul 27.


Urine Fetuin-A is a biomarker of autosomal dominant polycystic kidney disease progression.

Piazzon N, Bernet F, Guihard L, Leonhard WN, Urfer S, Firsov D, Chehade H, Vogt B, Piergiovanni S, Peters DJ, Bonny O, Constam DB.

J Transl Med. 2015 Mar 30;13:103. doi: 10.1186/s12967-015-0463-7.


Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis.

Lemaire LA, Goulley J, Kim YH, Carat S, Jacquemin P, Rougemont J, Constam DB, Grapin-Botton A.

Development. 2015 Mar 1;142(5):858-70. doi: 10.1242/dev.114611. Erratum in: Development. 2016 Jan 1;143(1):181.


Nodal·Gdf1 heterodimers with bound prodomains enable serum-independent nodal signaling and endoderm differentiation.

Fuerer C, Nostro MC, Constam DB.

J Biol Chem. 2014 Jun 20;289(25):17854-71. doi: 10.1074/jbc.M114.550301. Epub 2014 May 5.


Regulation of TGFβ and related signals by precursor processing.

Constam DB.

Semin Cell Dev Biol. 2014 Aug;32:85-97. doi: 10.1016/j.semcdb.2014.01.008. Epub 2014 Feb 5. Review.


Pathogen-free husbandry conditions alleviate behavioral deficits and neurodegeneration in AD10 anti-NGF mice.

Tzanoulinou S, Brandi R, Arisi I, D'Onofrio M, Urfer SM, Sandi C, Constam D, Capsoni S.

J Alzheimers Dis. 2014;38(4):951-64. doi: 10.3233/JAD-131037.


Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice.

Wetsel WC, Rodriguiz RM, Guillemot J, Rousselet E, Essalmani R, Kim IH, Bryant JC, Marcinkiewicz J, Desjardins R, Day R, Constam DB, Prat A, Seidah NG.

Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17362-7. doi: 10.1073/pnas.1314698110. Epub 2013 Oct 7.


Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes.

Essalmani R, Susan-Resiga D, Chamberland A, Asselin MC, Canuel M, Constam D, Creemers JW, Day R, Gauthier D, Prat A, Seidah NG.

J Biol Chem. 2013 Sep 13;288(37):26410-8. doi: 10.1074/jbc.M113.501304. Epub 2013 Aug 5.


Automated design of ligands to polypharmacological profiles.

Besnard J, Ruda GF, Setola V, Abecassis K, Rodriguiz RM, Huang XP, Norval S, Sassano MF, Shin AI, Webster LA, Simeons FR, Stojanovski L, Prat A, Seidah NG, Constam DB, Bickerton GR, Read KD, Wetsel WC, Gilbert IH, Roth BL, Hopkins AL.

Nature. 2012 Dec 13;492(7428):215-20. doi: 10.1038/nature11691.


Cellular heterogeneity during embryonic stem cell differentiation to epiblast stem cells is revealed by the ShcD/RaLP adaptor protein.

Turco MY, Furia L, Dietze A, Fernandez Diaz L, Ronzoni S, Sciullo A, Simeone A, Constam D, Faretta M, Lanfrancone L.

Stem Cells. 2012 Nov;30(11):2423-36. doi: 10.1002/stem.1217.


Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing.

Piazzon N, Maisonneuve C, Guilleret I, Rotman S, Constam DB.

J Mol Cell Biol. 2012 Dec;4(6):398-408. doi: 10.1093/jmcb/mjs027. Epub 2012 May 28.


Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associated with cystic renal dysplasia.

Kraus MR, Clauin S, Pfister Y, Di Maïo M, Ulinski T, Constam D, Bellanné-Chantelot C, Grapin-Botton A.

Hum Mutat. 2012 Jan;33(1):86-90. doi: 10.1002/humu.21610. Epub 2011 Oct 31.


The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities.

Mesnard D, Donnison M, Fuerer C, Pfeffer PL, Constam DB.

Genes Dev. 2011 Sep 1;25(17):1871-80. doi: 10.1101/gad.16738711.


Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10.

Susan-Resiga D, Essalmani R, Hamelin J, Asselin MC, Benjannet S, Chamberland A, Day R, Szumska D, Constam D, Bhattacharya S, Prat A, Seidah NG.

J Biol Chem. 2011 Jul 1;286(26):22785-94. doi: 10.1074/jbc.M111.233577. Epub 2011 May 5.


Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst.

Mesnard D, Constam DB.

J Cell Biol. 2010 Oct 4;191(1):129-39. doi: 10.1083/jcb.201005026. Epub 2010 Sep 27.


KAP1 controls endogenous retroviruses in embryonic stem cells.

Rowe HM, Jakobsson J, Mesnard D, Rougemont J, Reynard S, Aktas T, Maillard PV, Layard-Liesching H, Verp S, Marquis J, Spitz F, Constam DB, Trono D.

Nature. 2010 Jan 14;463(7278):237-40. doi: 10.1038/nature08674.


Bicaudal C, a novel regulator of Dvl signaling abutting RNA-processing bodies, controls cilia orientation and leftward flow.

Maisonneuve C, Guilleret I, Vick P, Weber T, Andre P, Beyer T, Blum M, Constam DB.

Development. 2009 Sep;136(17):3019-30. doi: 10.1242/dev.038174.


Running the gauntlet: an overview of the modalities of travel employed by the putative morphogen Nodal.

Constam DB.

Curr Opin Genet Dev. 2009 Aug;19(4):302-7. doi: 10.1016/j.gde.2009.06.006. Epub 2009 Jul 22. Review.


Riding shotgun: a dual role for the epidermal growth factor-Cripto/FRL-1/Cryptic protein Cripto in Nodal trafficking.

Constam DB.

Traffic. 2009 Jul;10(7):783-91. doi: 10.1111/j.1600-0854.2009.00874.x. Epub 2009 Feb 19. Review.


Intracellular trafficking and signaling in development.

Constam DB.

F1000 Biol Rep. 2009 Aug 17;1:59. doi: 10.3410/B1-59.


Cripto localizes Nodal at the limiting membrane of early endosomes.

Blanchet MH, Le Good JA, Oorschot V, Baflast S, Minchiotti G, Klumperman J, Constam DB.

Sci Signal. 2008 Nov 11;1(45):ra13. doi: 10.1126/scisignal.1165027.


Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation.

Blanchet MH, Le Good JA, Mesnard D, Oorschot V, Baflast S, Minchiotti G, Klumperman J, Constam DB.

EMBO J. 2008 Oct 8;27(19):2580-91. doi: 10.1038/emboj.2008.174. Epub 2008 Sep 4.


VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5.

Szumska D, Pieles G, Essalmani R, Bilski M, Mesnard D, Kaur K, Franklyn A, El Omari K, Jefferis J, Bentham J, Taylor JM, Schneider JE, Arnold SJ, Johnson P, Tymowska-Lalanne Z, Stammers D, Clarke K, Neubauer S, Morris A, Brown SD, Shaw-Smith C, Cama A, Capra V, Ragoussis J, Constam D, Seidah NG, Prat A, Bhattacharya S.

Genes Dev. 2008 Jun 1;22(11):1465-77. doi: 10.1101/gad.479408.


Cripto promotes A-P axis specification independently of its stimulatory effect on Nodal autoinduction.

D'Andrea D, Liguori GL, Le Good JA, Lonardo E, Andersson O, Constam DB, Persico MG, Minchiotti G.

J Cell Biol. 2008 Feb 11;180(3):597-605. doi: 10.1083/jcb.200709090.


Evolution of the mechanisms and molecular control of endoderm formation.

Grapin-Botton A, Constam D.

Mech Dev. 2007 Apr;124(4):253-78. Epub 2007 Jan 11. Review.


The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4.

Ben-Haim N, Lu C, Guzman-Ayala M, Pescatore L, Mesnard D, Bischofberger M, Naef F, Robertson EJ, Constam DB.

Dev Cell. 2006 Sep;11(3):313-23.


Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning.

Mesnard D, Guzman-Ayala M, Constam DB.

Development. 2006 Jul;133(13):2497-505. Epub 2006 May 25.


Nodal stability determines signaling range.

Le Good JA, Joubin K, Giraldez AJ, Ben-Haim N, Beck S, Chen Y, Schier AF, Constam DB.

Curr Biol. 2005 Jan 11;15(1):31-6.


Nodal protein processing and fibroblast growth factor 4 synergize to maintain a trophoblast stem cell microenvironment.

Guzman-Ayala M, Ben-Haim N, Beck S, Constam DB.

Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15656-60. Epub 2004 Oct 25.


Asymmetric Nodal expression in the mouse is governed by the combinatorial activities of two distinct regulatory elements.

Vincent SD, Norris DP, Le Good JA, Constam DB, Robertson EJ.

Mech Dev. 2004 Nov;121(11):1403-15.


A gene network establishing polarity in the early mouse embryo.

Ang SL, Constam DB.

Semin Cell Dev Biol. 2004 Oct;15(5):555-61. Review.


Extraembryonic proteases regulate Nodal signalling during gastrulation.

Beck S, Le Good JA, Guzman M, Ben Haim N, Roy K, Beermann F, Constam DB.

Nat Cell Biol. 2002 Dec;4(12):981-5.


SPC4/PACE4 regulates a TGFbeta signaling network during axis formation.

Constam DB, Robertson EJ.

Genes Dev. 2000 May 1;14(9):1146-55.


Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin.

Roebroek AJ, Umans L, Pauli IG, Robertson EJ, van Leuven F, Van de Ven WJ, Constam DB.

Development. 1998 Dec;125(24):4863-76.


Cloning of the human puromycin-sensitive aminopeptidase and evidence for expression in neurons.

Tobler AR, Constam DB, Schmitt-Gräff A, Malipiero U, Schlapbach R, Fontana A.

J Neurochem. 1997 Mar;68(3):889-97.


Neurons induced to express major histocompatibility complex class I antigen are killed via the perforin and not the Fas (APO-1/CD95) pathway.

Rensing-Ehl A, Malipiero U, Irmler M, Tschopp J, Constam D, Fontana A.

Eur J Immunol. 1996 Sep;26(9):2271-4.


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