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Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice.

López-Tello J, Pérez-García V, Khaira J, Kusinski LC, Cooper WN, Andreani A, Grant I, Fernández de Liger E, Lam BY, Hemberger M, Sandovici I, Constancia M, Sferruzzi-Perri AN.

Elife. 2019 Jun 26;8. pii: e45282. doi: 10.7554/eLife.45282.


Sex-specific regulation of stress-induced fetal glucocorticoid surge by the mouse placenta.

Wieczorek A, Perani CV, Nixon M, Constancia M, Sandovici I, Zazara DE, Leone G, Zhang MZ, Arck PC, Solano ME.

Am J Physiol Endocrinol Metab. 2019 Jul 1;317(1):E109-E120. doi: 10.1152/ajpendo.00551.2018. Epub 2019 Apr 16.


Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine.

Ziegler AN, Feng Q, Chidambaram S, Testai JM, Kumari E, Rothbard DE, Constancia M, Sandovici I, Cominski T, Pang K, Gao N, Wood TL, Levison SW.

Stem Cell Reports. 2019 Apr 9;12(4):816-830. doi: 10.1016/j.stemcr.2019.02.011. Epub 2019 Mar 21.


Placental polyamine metabolism differs by fetal sex, fetal growth restriction, and preeclampsia.

Gong S, Sovio U, Aye IL, Gaccioli F, Dopierala J, Johnson MD, Wood AM, Cook E, Jenkins BJ, Koulman A, Casero RA Jr, Constância M, Charnock-Jones DS, Smith GC.

JCI Insight. 2018 Jul 12;3(13). pii: 120723. doi: 10.1172/jci.insight.120723.


Genome-wide oxidative bisulfite sequencing identifies sex-specific methylation differences in the human placenta.

Gong S, Johnson MD, Dopierala J, Gaccioli F, Sovio U, Constância M, Smith GC, Charnock-Jones DS.

Epigenetics. 2018;13(3):228-239. doi: 10.1080/15592294.2018.1429857. Epub 2018 Feb 21.


Biomarkers of Aging: From Cellular Senescence to Age-Associated Diseases.

Martins MJ, Constância M, Neves D, Simm A.

Oxid Med Cell Longev. 2017;2017:7280690. doi: 10.1155/2017/7280690. Epub 2017 Aug 2. No abstract available.


Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p'-DDE.

Pestana D, Teixeira D, Meireles M, Marques C, Norberto S, Sá C, Fernandes VC, Correia-Sá L, Faria A, Guardão L, Guimarães JT, Cooper WN, Sandovici I, Domingues VF, Delerue-Matos C, Monteiro R, Constância M, Calhau C.

Sci Rep. 2017 Jun 1;7(1):2738. doi: 10.1038/s41598-017-02885-9.


Placental phenotype and the insulin-like growth factors: resource allocation to fetal growth.

Sferruzzi-Perri AN, Sandovici I, Constancia M, Fowden AL.

J Physiol. 2017 Aug 1;595(15):5057-5093. doi: 10.1113/JP273330. Epub 2017 May 23. Review.


Maternal and fetal genomes interplay through phosphoinositol 3-kinase(PI3K)-p110α signaling to modify placental resource allocation.

Sferruzzi-Perri AN, López-Tello J, Fowden AL, Constancia M.

Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11255-11260. Epub 2016 Sep 12.


Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets.

Sandovici I, Hammerle CM, Cooper WN, Smith NH, Tarry-Adkins JL, Dunmore BJ, Bauer J, Andrews SR, Yeo GS, Ozanne SE, Constância M.

Diabetologia. 2016 Mar;59(3):502-11. doi: 10.1007/s00125-015-3837-8. Epub 2015 Dec 23.


Differential genomic imprinting regulates paracrine and autocrine roles of IGF2 in mouse adult neurogenesis.

Ferrón SR, Radford EJ, Domingo-Muelas A, Kleine I, Ramme A, Gray D, Sandovici I, Constancia M, Ward A, Menheniott TR, Ferguson-Smith AC.

Nat Commun. 2015 Sep 15;6:8265. doi: 10.1038/ncomms9265.


Intergenerational epigenetic inheritance in models of developmental programming of adult disease.

Fernandez-Twinn DS, Constância M, Ozanne SE.

Semin Cell Dev Biol. 2015 Jul;43:85-95. doi: 10.1016/j.semcdb.2015.06.006. Epub 2015 Jun 30. Review.


Extracardiac control of embryonic cardiomyocyte proliferation and ventricular wall expansion.

Shen H, Cavallero S, Estrada KD, Sandovici I, Kumar SR, Makita T, Lien CL, Constancia M, Sucov HM.

Cardiovasc Res. 2015 Mar 1;105(3):271-8. doi: 10.1093/cvr/cvu269. Epub 2015 Jan 5.


Impact on offspring methylation patterns of maternal gestational diabetes mellitus and intrauterine growth restraint suggest common genes and pathways linked to subsequent type 2 diabetes risk.

Quilter CR, Cooper WN, Cliffe KM, Skinner BM, Prentice PM, Nelson L, Bauer J, Ong KK, Constância M, Lowe WL, Affara NA, Dunger DB.

FASEB J. 2014 Nov;28(11):4868-79. doi: 10.1096/fj.14-255240. Epub 2014 Aug 21.


Maternal diet amplifies the hepatic aging trajectory of Cidea in male mice and leads to the development of fatty liver.

Carr SK, Chen JH, Cooper WN, Constância M, Yeo GS, Ozanne SE.

FASEB J. 2014 May;28(5):2191-201. doi: 10.1096/fj.13-242727. Epub 2014 Jan 30.


Placental programming of anxiety in adulthood revealed by Igf2-null models.

Mikaelsson MA, Constância M, Dent CL, Wilkinson LS, Humby T.

Nat Commun. 2013;4:2311. doi: 10.1038/ncomms3311.


An obesogenic diet during mouse pregnancy modifies maternal nutrient partitioning and the fetal growth trajectory.

Sferruzzi-Perri AN, Vaughan OR, Haro M, Cooper WN, Musial B, Charalambous M, Pestana D, Ayyar S, Ferguson-Smith AC, Burton GJ, Constancia M, Fowden AL.

FASEB J. 2013 Oct;27(10):3928-37. doi: 10.1096/fj.13-234823. Epub 2013 Jun 27.


Developmental and environmental epigenetic programming of the endocrine pancreas: consequences for type 2 diabetes.

Sandovici I, Hammerle CM, Ozanne SE, Constância M.

Cell Mol Life Sci. 2013 May;70(9):1575-95. doi: 10.1007/s00018-013-1297-1. Epub 2013 Mar 6. Review.


Maternal-fetal resource allocation.

Fowden AL, Constancia M.

Placenta. 2012 Nov;33 Suppl 2:e1-2. doi: 10.1016/j.placenta.2012.09.005. Epub 2012 Sep 20. No abstract available.


Maternal to offspring resource allocation in plants and mammals.

Gutierrez-Marcos JF, Constância M, Burton GJ.

Placenta. 2012 Nov;33 Suppl 2:e3-10. doi: 10.1016/j.placenta.2012.08.006. Epub 2012 Sep 18. Review.


Igf2 pathway dependency of the Trp53 developmental and tumour phenotypes.

Haley VL, Barnes DJ, Sandovici I, Constancia M, Graham CF, Pezzella F, Bühnemann C, Carter EJ, Hassan AB.

EMBO Mol Med. 2012 Aug;4(8):705-18. doi: 10.1002/emmm.201101105. Epub 2012 Jun 6.


Placental adaptations to the maternal-fetal environment: implications for fetal growth and developmental programming.

Sandovici I, Hoelle K, Angiolini E, Constância M.

Reprod Biomed Online. 2012 Jul;25(1):68-89. doi: 10.1016/j.rbmo.2012.03.017. Epub 2012 Apr 5. Review.


Periconceptional maternal micronutrient supplementation is associated with widespread gender related changes in the epigenome: a study of a unique resource in the Gambia.

Khulan B, Cooper WN, Skinner BM, Bauer J, Owens S, Prentice AM, Belteki G, Constancia M, Dunger D, Affara NA.

Hum Mol Genet. 2012 May 1;21(9):2086-101. doi: 10.1093/hmg/dds026. Epub 2012 Feb 3.


DNA methylation profiling at imprinted loci after periconceptional micronutrient supplementation in humans: results of a pilot randomized controlled trial.

Cooper WN, Khulan B, Owens S, Elks CE, Seidel V, Prentice AM, Belteki G, Ong KK, Affara NA, Constância M, Dunger DB.

FASEB J. 2012 May;26(5):1782-90. doi: 10.1096/fj.11-192708. Epub 2012 Jan 20.


Placental-specific Igf2 deficiency alters developmental adaptations to undernutrition in mice.

Sferruzzi-Perri AN, Vaughan OR, Coan PM, Suciu MC, Darbyshire R, Constancia M, Burton GJ, Fowden AL.

Endocrinology. 2011 Aug;152(8):3202-12. doi: 10.1210/en.2011-0240. Epub 2011 Jun 14.


Dietary composition programmes placental phenotype in mice.

Coan PM, Vaughan OR, McCarthy J, Mactier C, Burton GJ, Constância M, Fowden AL.

J Physiol. 2011 Jul 15;589(Pt 14):3659-70. doi: 10.1113/jphysiol.2011.208629. Epub 2011 May 30.


Maternal diet, aging and diabetes meet at a chromatin loop.

Ozanne SE, Sandovici I, Constância M.

Aging (Albany NY). 2011 May;3(5):548-54.


Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets.

Sandovici I, Smith NH, Nitert MD, Ackers-Johnson M, Uribe-Lewis S, Ito Y, Jones RH, Marquez VE, Cairns W, Tadayyon M, O'Neill LP, Murrell A, Ling C, Constância M, Ozanne SE.

Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5449-54. doi: 10.1073/pnas.1019007108. Epub 2011 Mar 8.


Increased placental glucose transport rates in pregnant mice carrying fetuses with targeted disruption of their placental-specific Igf2 transcripts are not associated with raised circulating glucose concentrations.

Petry CJ, Evans ML, Wingate DL, Ong KK, Reik W, Constância M, Dunger DB.

Exp Diabetes Res. 2011;2011:171376. doi: 10.1155/2011/171376. Epub 2011 Feb 8.


Developmental adaptations to increased fetal nutrient demand in mouse genetic models of Igf2-mediated overgrowth.

Angiolini E, Coan PM, Sandovici I, Iwajomo OH, Peck G, Burton GJ, Sibley CP, Reik W, Fowden AL, Constância M.

FASEB J. 2011 May;25(5):1737-45. doi: 10.1096/fj.10-175273. Epub 2011 Jan 31.


Imprinted genes and the epigenetic regulation of placental phenotype.

Fowden AL, Coan PM, Angiolini E, Burton GJ, Constancia M.

Prog Biophys Mol Biol. 2011 Jul;106(1):281-8. doi: 10.1016/j.pbiomolbio.2010.11.005. Epub 2010 Nov 23. Review.


Child health, developmental plasticity, and epigenetic programming.

Hochberg Z, Feil R, Constancia M, Fraga M, Junien C, Carel JC, Boileau P, Le Bouc Y, Deal CL, Lillycrop K, Scharfmann R, Sheppard A, Skinner M, Szyf M, Waterland RA, Waxman DJ, Whitelaw E, Ong K, Albertsson-Wikland K.

Endocr Rev. 2011 Apr;32(2):159-224. doi: 10.1210/er.2009-0039. Epub 2010 Oct 22. Review.


How genome-wide approaches can be used to unravel the remaining secrets of the imprintome.

Cooper WN, Constância M.

Brief Funct Genomics. 2010 Jul;9(4):315-28. doi: 10.1093/bfgp/elq018. Review.


Placental-specific Igf2 knockout mice exhibit hypocalcemia and adaptive changes in placental calcium transport.

Dilworth MR, Kusinski LC, Cowley E, Ward BS, Husain SM, Constância M, Sibley CP, Glazier JD.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3894-9. doi: 10.1073/pnas.0911710107. Epub 2010 Feb 4.


IFPA Meeting 2009 workshops report.

Lash GE, Burton GJ, Chamley LW, Clifton VL, Constancia M, Crocker IP, Dantzer V, Desoye G, Drewlo S, Hemmings DG, Hiendleder S, Kalionis B, Keelan JA, Kudo Y, Lewis RM, Manuelpillai U, Murthi P, Natale D, Pfarrer C, Robertson S, Saffery R, Saito S, Sferruzzi-Perri A, Sobrevia L, Waddell BJ, Roberts CT.

Placenta. 2010 Mar;31 Suppl:S4-20. doi: 10.1016/j.placenta.2009.12.008. Epub 2010 Jan 12.


Adaptations in placental phenotype support fetal growth during undernutrition of pregnant mice.

Coan PM, Vaughan OR, Sekita Y, Finn SL, Burton GJ, Constancia M, Fowden AL.

J Physiol. 2010 Feb 1;588(Pt 3):527-38. doi: 10.1113/jphysiol.2009.181214. Epub 2009 Nov 30.


Raised late pregnancy glucose concentrations in mice carrying pups with targeted disruption of H19delta13.

Petry CJ, Evans ML, Wingate DL, Ong KK, Reik W, Constância M, Dunger DB.

Diabetes. 2010 Jan;59(1):282-6. doi: 10.2337/db09-0757. Epub 2009 Sep 30.


Placental efficiency and adaptation: endocrine regulation.

Fowden AL, Sferruzzi-Perri AN, Coan PM, Constancia M, Burton GJ.

J Physiol. 2009 Jul 15;587(Pt 14):3459-72. doi: 10.1113/jphysiol.2009.173013. Epub 2009 May 18. Review.


Disproportional effects of Igf2 knockout on placental morphology and diffusional exchange characteristics in the mouse.

Coan PM, Fowden AL, Constancia M, Ferguson-Smith AC, Burton GJ, Sibley CP.

J Physiol. 2008 Oct 15;586(20):5023-32. doi: 10.1113/jphysiol.2008.157313. Epub 2008 Aug 28.


Adaptations in placental nutrient transfer capacity to meet fetal growth demands depend on placental size in mice.

Coan PM, Angiolini E, Sandovici I, Burton GJ, Constância M, Fowden AL.

J Physiol. 2008 Sep 15;586(18):4567-76. doi: 10.1113/jphysiol.2008.156133. Epub 2008 Jul 24.


Mechanisms of disease: the developmental origins of disease and the role of the epigenotype.

Ozanne SE, Constância M.

Nat Clin Pract Endocrinol Metab. 2007 Jul;3(7):539-46. Review.


Imprinted genes, placental development and fetal growth.

Fowden AL, Sibley C, Reik W, Constancia M.

Horm Res. 2006;65 Suppl 3:50-8. Epub 2006 Apr 10. Review.


Epigenetics and imprinting of the trophoblast -- a workshop report.

Ferguson-Smith AC, Moore T, Detmar J, Lewis A, Hemberger M, Jammes H, Kelsey G, Roberts CT, Jones H, Constancia M.

Placenta. 2006 Apr;27 Suppl A:S122-6. Epub 2006 Apr 3. Erratum in: Placenta. 2006 Sep-Oct;27(9-10):1036.


Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human.

Monk D, Sanches R, Arnaud P, Apostolidou S, Hills FA, Abu-Amero S, Murrell A, Friess H, Reik W, Stanier P, Constância M, Moore GE.

Hum Mol Genet. 2006 Apr 15;15(8):1259-69. Epub 2006 Mar 10.


Regulation of placental efficiency for nutrient transport by imprinted genes.

Angiolini E, Fowden A, Coan P, Sandovici I, Smith P, Dean W, Burton G, Tycko B, Reik W, Sibley C, Constância M.

Placenta. 2006 Apr;27 Suppl A:S98-102. Epub 2006 Feb 28. Review.


Programming placental nutrient transport capacity.

Fowden AL, Ward JW, Wooding FP, Forhead AJ, Constancia M.

J Physiol. 2006 Apr 1;572(Pt 1):5-15. Epub 2006 Jan 26. Review.


Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems.

Constância M, Angiolini E, Sandovici I, Smith P, Smith R, Kelsey G, Dean W, Ferguson-Smith A, Sibley CP, Reik W, Fowden A.

Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19219-24. Epub 2005 Dec 19.


Resourceful imprinting.

Constância M, Kelsey G, Reik W.

Nature. 2004 Nov 4;432(7013):53-7. No abstract available.


Placental-specific insulin-like growth factor 2 (Igf2) regulates the diffusional exchange characteristics of the mouse placenta.

Sibley CP, Coan PM, Ferguson-Smith AC, Dean W, Hughes J, Smith P, Reik W, Burton GJ, Fowden AL, Constância M.

Proc Natl Acad Sci U S A. 2004 May 25;101(21):8204-8. Epub 2004 May 18.

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