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Items: 32

1.

The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist.

Madauss KP, Burkhart WA, Consler TG, Cowan DJ, Gottschalk WK, Miller AB, Short SA, Tran TB, Williams SP.

Acta Crystallogr D Biol Crystallogr. 2009 May;65(Pt 5):449-61. doi: 10.1107/S0907444909008014. Epub 2009 Apr 18.

2.

X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation.

Wang L, Zuercher WJ, Consler TG, Lambert MH, Miller AB, Orband-Miller LA, McKee DD, Willson TM, Nolte RT.

J Biol Chem. 2006 Dec 8;281(49):37773-81. Epub 2006 Sep 21.

3.
4.

Structure-based design of potent retinoid X receptor alpha agonists.

Haffner CD, Lenhard JM, Miller AB, McDougald DL, Dwornik K, Ittoop OR, Gampe RT Jr, Xu HE, Blanchard S, Montana VG, Consler TG, Bledsoe RK, Ayscue A, Croom D.

J Med Chem. 2004 Apr 8;47(8):2010-29.

PMID:
15056000
5.

Correlation between in vitro peptide binding profiles and cellular activities for estrogen receptor-modulating compounds.

Iannone MA, Simmons CA, Kadwell SH, Svoboda DL, Vanderwall DE, Deng SJ, Consler TG, Shearin J, Gray JG, Pearce KH.

Mol Endocrinol. 2004 May;18(5):1064-81. Epub 2004 Feb 19.

PMID:
14976226
6.

Helix 1/8 interactions influence the activity of nuclear receptor ligand-binding domains.

Holt JA, Consler TG, Williams SP, Ayscue AH, Leesnitzer LM, Wisely GB, Billin AN.

Mol Endocrinol. 2003 Sep;17(9):1704-14. Epub 2003 Jun 19.

PMID:
12817079
7.

A new series of estrogen receptor modulators that display selectivity for estrogen receptor beta.

Henke BR, Consler TG, Go N, Hale RL, Hohman DR, Jones SA, Lu AT, Moore LB, Moore JT, Orband-Miller LA, Robinett RG, Shearin J, Spearing PK, Stewart EL, Turnbull PS, Weaver SL, Williams SP, Wisely GB, Lambert MH.

J Med Chem. 2002 Dec 5;45(25):5492-505.

PMID:
12459017
8.

Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition.

Bledsoe RK, Montana VG, Stanley TB, Delves CJ, Apolito CJ, McKee DD, Consler TG, Parks DJ, Stewart EL, Willson TM, Lambert MH, Moore JT, Pearce KH, Xu HE.

Cell. 2002 Jul 12;110(1):93-105.

PMID:
12151000
9.

Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662.

Leesnitzer LM, Parks DJ, Bledsoe RK, Cobb JE, Collins JL, Consler TG, Davis RG, Hull-Ryde EA, Lenhard JM, Patel L, Plunket KD, Shenk JL, Stimmel JB, Therapontos C, Willson TM, Blanchard SG.

Biochemistry. 2002 May 28;41(21):6640-50.

PMID:
12022867
10.

Multiplexed molecular interactions of nuclear receptors using fluorescent microspheres.

Iannone MA, Consler TG, Pearce KH, Stimmel JB, Parks DJ, Gray JG.

Cytometry. 2001 Aug 1;44(4):326-37.

11.

Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha.

Spencer TA, Li D, Russel JS, Collins JL, Bledsoe RK, Consler TG, Moore LB, Galardi CM, McKee DD, Moore JT, Watson MA, Parks DJ, Lambert MH, Willson TM.

J Med Chem. 2001 Mar 15;44(6):886-97.

PMID:
11300870
12.

Solution studies of recombinant human stromal-cell-derived factor-1.

Holmes WD, Consler TG, Dallas WS, Rocque WJ, Willard DH.

Protein Expr Purif. 2001 Apr;21(3):367-77.

PMID:
11281710
13.

Hydration changes implicated in the remarkable temperature-dependent membrane permeation of cyclosporin A.

Augustijns PF, Brown SC, Willard DH, Consler TG, Annaert PP, Hendren RW, Bradshaw TP.

Biochemistry. 2000 Jun 27;39(25):7621-30.

PMID:
10858313
14.

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands.

Moore LB, Parks DJ, Jones SA, Bledsoe RK, Consler TG, Stimmel JB, Goodwin B, Liddle C, Blanchard SG, Willson TM, Collins JL, Kliewer SA.

J Biol Chem. 2000 May 19;275(20):15122-7.

15.

Bile acids: natural ligands for an orphan nuclear receptor.

Parks DJ, Blanchard SG, Bledsoe RK, Chandra G, Consler TG, Kliewer SA, Stimmel JB, Willson TM, Zavacki AM, Moore DD, Lehmann JM.

Science. 1999 May 21;284(5418):1365-8.

16.

The formation of a covalent complex between a dipeptide ligand and the src SH2 domain.

Alligood KJ, Charifson PS, Crosby R, Consler TG, Feldman PL, Gampe RT Jr, Gilmer TM, Jordan SR, Milstead MW, Mohr C, Peel MR, Rocque W, Rodriguez M, Rusnak DW, Shewchuk LM, Sternbach DD.

Bioorg Med Chem Lett. 1998 May 19;8(10):1189-94.

PMID:
9871733
17.

Product release is the major contributor to kcat for the hepatitis C virus helicase-catalyzed strand separation of short duplex DNA.

Porter DJ, Short SA, Hanlon MH, Preugschat F, Wilson JE, Willard DH Jr, Consler TG.

J Biol Chem. 1998 Jul 24;273(30):18906-14.

18.

Development of a scintillation proximity assay for peroxisome proliferator-activated receptor gamma ligand binding domain.

Nichols JS, Parks DJ, Consler TG, Blanchard SG.

Anal Biochem. 1998 Mar 15;257(2):112-9. Erratum in: Anal Biochem 1998 Oct 1;263(1):126.

PMID:
9514791
19.

Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.

Charifson PS, Shewchuk LM, Rocque W, Hummel CW, Jordan SR, Mohr C, Pacofsky GJ, Peel MR, Rodriguez M, Sternbach DD, Consler TG.

Biochemistry. 1997 May 27;36(21):6283-93.

PMID:
9174343
21.

Catalytic activity of the SH2 domain of human pp60c-src; evidence from NMR, mass spectrometry, site-directed mutagenesis and kinetic studies for an inherent phosphatase activity.

Boerner RJ, Consler TG, Gampe RT Jr, Weigl D, Willard DH, Davis DG, Edison AM, Loganzo F Jr, Kassel DB, Xu RX, et al.

Biochemistry. 1995 Nov 21;34(46):15351-8.

PMID:
7578151
23.

Insertion of the polytopic membrane protein lactose permease occurs by multiple mechanisms.

Zen KH, Consler TG, Kaback HR.

Biochemistry. 1995 Mar 14;34(10):3430-7.

PMID:
7880837
24.

Properties and purification of an active biotinylated lactose permease from Escherichia coli.

Consler TG, Persson BL, Jung H, Zen KH, Jung K, Privé GG, Verner GE, Kaback HR.

Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):6934-8.

25.

Energetics of allosteric regulation in muscle pyruvate kinase.

Consler TG, Jennewein MJ, Cai GZ, Lee JC.

Biochemistry. 1992 Sep 1;31(34):7870-8.

PMID:
1510974
26.

Role of proline residues in the structure and function of a membrane transport protein.

Consler TG, Tsolas O, Kaback HR.

Biochemistry. 1991 Feb 5;30(5):1291-8.

PMID:
1991110
27.

Synergistic effects of proton and phenylalanine on the regulation of muscle pyruvate kinase.

Consler TG, Jennewein MJ, Cai GZ, Lee JC.

Biochemistry. 1990 Dec 4;29(48):10765-71.

PMID:
2176882
28.

The lac permease of Escherichia coli: site-directed mutagenesis studies on the mechanism of beta-galactoside/H+ symport.

Roepe PD, Consler TG, Menezes ME, Kaback HR.

Res Microbiol. 1990 Mar-Apr;141(3):290-308.

PMID:
2177909
29.
30.

Domain interaction in rabbit muscle pyruvate kinase. II. Small angle neutron scattering and computer simulation.

Consler TG, Uberbacher EC, Bunick GJ, Liebman MN, Lee JC.

J Biol Chem. 1988 Feb 25;263(6):2794-801.

32.

Measurement of changes of hydrodynamic properties by sedimentation.

Oberfelder RW, Consler TG, Lee JC.

Methods Enzymol. 1985;117:27-40. No abstract available.

PMID:
4079807

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