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Items: 15


Crystallographic structure of a small molecule SIRT1 activator-enzyme complex.

Dai H, Case AW, Riera TV, Considine T, Lee JE, Hamuro Y, Zhao H, Jiang Y, Sweitzer SM, Pietrak B, Schwartz B, Blum CA, Disch JS, Caldwell R, Szczepankiewicz B, Oalmann C, Yee Ng P, White BH, Casaubon R, Narayan R, Koppetsch K, Bourbonais F, Wu B, Wang J, Qian D, Jiang F, Mao C, Wang M, Hu E, Wu JC, Perni RB, Vlasuk GP, Ellis JL.

Nat Commun. 2015 Jul 2;6:7645. doi: 10.1038/ncomms8645.


Evidence for a common mechanism of SIRT1 regulation by allosteric activators.

Hubbard BP, Gomes AP, Dai H, Li J, Case AW, Considine T, Riera TV, Lee JE, E SY, Lamming DW, Pentelute BL, Schuman ER, Stevens LA, Ling AJ, Armour SM, Michan S, Zhao H, Jiang Y, Sweitzer SM, Blum CA, Disch JS, Ng PY, Howitz KT, Rolo AP, Hamuro Y, Moss J, Perni RB, Ellis JL, Vlasuk GP, Sinclair DA.

Science. 2013 Mar 8;339(6124):1216-9. doi: 10.1126/science.1231097.


SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity.

Yang H, Zhang W, Pan H, Feldser HG, Lainez E, Miller C, Leung S, Zhong Z, Zhao H, Sweitzer S, Considine T, Riera T, Suri V, White B, Ellis JL, Vlasuk GP, Loh C.

PLoS One. 2012;7(9):e46364. doi: 10.1371/journal.pone.0046364. Epub 2012 Sep 28.


Update from the New Jersey Department of Banking and Insurance.

Considine T.

MD Advis. 2011 Spring;4(2):4-5. No abstract available.


SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator.

Dai H, Kustigian L, Carney D, Case A, Considine T, Hubbard BP, Perni RB, Riera TV, Szczepankiewicz B, Vlasuk GP, Stein RL.

J Biol Chem. 2010 Oct 22;285(43):32695-703. doi: 10.1074/jbc.M110.133892. Epub 2010 Aug 11.


Subsurface detection of fossil fuel pollutants by photoionization and gas chromatography/mass spectrometry.

Robbat A Jr, Considine T, Antle PM.

Chemosphere. 2010 Sep;80(11):1370-6. doi: 10.1016/j.chemosphere.2010.06.005. Epub 2010 Jul 1.


N-terminal domains of DELLA proteins are intrinsically unstructured in the absence of interaction with GID1/gibberellic acid receptors.

Sun X, Jones WT, Harvey D, Edwards PJ, Pascal SM, Kirk C, Considine T, Sheerin DJ, Rakonjac J, Oldfield CJ, Xue B, Dunker AK, Uversky VN.

J Biol Chem. 2010 Apr 9;285(15):11557-71. doi: 10.1074/jbc.M109.027011. Epub 2010 Jan 26.


Binding of flavor compounds and whey protein isolate as affected by heat and high pressure treatments.

Kühn J, Considine T, Singh H.

J Agric Food Chem. 2008 Nov 12;56(21):10218-24. doi: 10.1021/jf801810b. Epub 2008 Oct 21.


Binding of 2-nonanone and milk proteins in aqueous model systems.

Kühn J, Zhu XQ, Considine T, Singh H.

J Agric Food Chem. 2007 May 2;55(9):3599-604. Epub 2007 Apr 6.


Pressure-induced unfolding and aggregation of the proteins in whey protein concentrate solutions.

Patel HA, Singh H, Havea P, Considine T, Creamer LK.

J Agric Food Chem. 2005 Nov 30;53(24):9590-601.


Effects of standardization of whole milk with dry milk protein concentrate on the yield and ripening of reduced-fat cheddar cheese.

Shakeel-Ur-Rehman, Farkye NY, Considine T, Schaffner A, Drake MA.

J Dairy Sci. 2003 May;86(5):1608-15.


Giant neurilemoma: unusual scrotal mass.

Fernandez MJ, Martino A, Khan H, Considine TJ, Burden J.

Urology. 1987 Jul;30(1):74-6.


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