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Items: 42

1.

MRP1 modulators synergize with buthionine sulfoximine to exploit collateral sensitivity and selectively kill MRP1-expressing cancer cells.

Gana CC, Hanssen KM, Yu DMT, Flemming CL, Wheatley MS, Conseil G, Cole SPC, Norris MD, Haber M, Fletcher JI.

Biochem Pharmacol. 2019 Jul 11. pii: S0006-2952(19)30264-3. doi: 10.1016/j.bcp.2019.07.009. [Epub ahead of print]

PMID:
31302132
2.

Structure-guided probing of the leukotriene C4 binding site in human multidrug resistance protein 1 (MRP1; ABCC1).

Conseil G, Arama-Chayoth M, Tsfadia Y, Cole SPC.

FASEB J. 2019 Jul 16:fj201900140R. doi: 10.1096/fj.201900140R. [Epub ahead of print]

PMID:
31268744
3.

An Outward-Facing Aromatic Amino Acid Is Crucial for Signaling between the Membrane-Spanning and Nucleotide-Binding Domains of Multidrug Resistance Protein 1 (MRP1; ABCC1).

Weigl KE, Conseil G, Rothnie AJ, Arama M, Tsfadia Y, Cole SPC.

Mol Pharmacol. 2018 Sep;94(3):1069-1078. doi: 10.1124/mol.118.112615. Epub 2018 Jul 5.

PMID:
29976562
4.

Polymorphic variants of MRP4/ABCC4 differentially modulate the transport of methylated arsenic metabolites and physiological organic anions.

Banerjee M, Marensi V, Conseil G, Le XC, Cole SP, Leslie EM.

Biochem Pharmacol. 2016 Nov 15;120:72-82. doi: 10.1016/j.bcp.2016.09.016. Epub 2016 Sep 19.

PMID:
27659809
5.

Cysteinyl Leukotriene Receptor 1/2 Antagonists Nonselectively Modulate Organic Anion Transport by Multidrug Resistance Proteins (MRP1-4).

Csandl MA, Conseil G, Cole SP.

Drug Metab Dispos. 2016 Jun;44(6):857-66. doi: 10.1124/dmd.116.069468. Epub 2016 Apr 11.

PMID:
27068271
6.

N-linked glycans do not affect plasma membrane localization of multidrug resistance protein 4 (MRP4) but selectively alter its prostaglandin E2 transport activity.

Miah MF, Conseil G, Cole SP.

Biochem Biophys Res Commun. 2016 Jan 22;469(4):954-9. doi: 10.1016/j.bbrc.2015.12.095. Epub 2015 Dec 23.

PMID:
26721430
7.

Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport.

Jin D, Ni TT, Sun J, Wan H, Amack JD, Yu G, Fleming J, Chiang C, Li W, Papierniak A, Cheepala S, Conseil G, Cole SP, Zhou B, Drummond IA, Schuetz JD, Malicki J, Zhong TP.

Nat Cell Biol. 2014 Sep;16(9):841-51. doi: 10.1038/ncb3029. Epub 2014 Aug 31.

8.

High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4).

Cheung L, Flemming CL, Watt F, Masada N, Yu DM, Huynh T, Conseil G, Tivnan A, Polinsky A, Gudkov AV, Munoz MA, Vishvanath A, Cooper DM, Henderson MJ, Cole SP, Fletcher JI, Haber M, Norris MD.

Biochem Pharmacol. 2014 Sep 1;91(1):97-108. doi: 10.1016/j.bcp.2014.05.023. Epub 2014 Jun 25.

PMID:
24973542
9.
10.

Chalcogenopyrylium dyes as differential modulators of organic anion transport by multidrug resistance protein 1 (MRP1), MRP2, and MRP4.

Myette RL, Conseil G, Ebert SP, Wetzel B, Detty MR, Cole SP.

Drug Metab Dispos. 2013 Jun;41(6):1231-9. doi: 10.1124/dmd.112.050831. Epub 2013 Mar 25.

11.

Chalcogenopyrylium compounds as modulators of the ATP-binding cassette transporters P-glycoprotein (P-gp/ABCB1) and multidrug resistance protein 1 (MRP1/ABCC1).

Ebert SP, Wetzel B, Myette RL, Conseil G, Cole SP, Sawada GA, Loo TW, Bartlett MC, Clarke DM, Detty MR.

J Med Chem. 2012 May 24;55(10):4683-99. doi: 10.1021/jm3004398. Epub 2012 May 10.

PMID:
22533905
12.

Plasmodium falciparum multidrug resistance protein 1 and artemisinin-based combination therapy in Africa.

Dahlström S, Ferreira PE, Veiga MI, Sedighi N, Wiklund L, Mårtensson A, Färnert A, Sisowath C, Osório L, Darban H, Andersson B, Kaneko A, Conseil G, Björkman A, Gil JP.

J Infect Dis. 2009 Nov 1;200(9):1456-64. doi: 10.1086/606009.

PMID:
19807279
13.

Molecular basis for reduced estrone sulfate transport and altered modulator sensitivity of transmembrane helix (TM) 6 and TM17 mutants of multidrug resistance protein 1 (ABCC1).

Maeno K, Nakajima A, Conseil G, Rothnie A, Deeley RG, Cole SP.

Drug Metab Dispos. 2009 Jul;37(7):1411-20. doi: 10.1124/dmd.109.026633. Epub 2009 Apr 27.

PMID:
19398503
14.

Involvement of NHERF1 in apical membrane localization of MRP4 in polarized kidney cells.

Hoque MT, Conseil G, Cole SP.

Biochem Biophys Res Commun. 2009 Jan 30;379(1):60-4. doi: 10.1016/j.bbrc.2008.12.014. Epub 2008 Dec 13.

PMID:
19073137
15.

Multiple roles of charged amino acids in cytoplasmic loop 7 for expression and function of the multidrug and organic anion transporter MRP1 (ABCC1).

Conseil G, Rothnie AJ, Deeley RG, Cole SP.

Mol Pharmacol. 2009 Feb;75(2):397-406. doi: 10.1124/mol.108.052860. Epub 2008 Nov 17.

PMID:
19015228
16.

Mechanistic differences between GSH transport by multidrug resistance protein 1 (MRP1/ABCC1) and GSH modulation of MRP1-mediated transport.

Rothnie A, Conseil G, Lau AY, Deeley RG, Cole SP.

Mol Pharmacol. 2008 Dec;74(6):1630-40. doi: 10.1124/mol.108.049080. Epub 2008 Sep 2.

PMID:
18768387
17.

Molecular modeling of the human multidrug resistance protein 1 (MRP1/ABCC1).

DeGorter MK, Conseil G, Deeley RG, Campbell RL, Cole SP.

Biochem Biophys Res Commun. 2008 Jan 4;365(1):29-34. Epub 2007 Oct 31.

PMID:
17980150
19.

Polymorphisms of MRP1 (ABCC1) and related ATP-dependent drug transporters.

Conseil G, Deeley RG, Cole SP.

Pharmacogenet Genomics. 2005 Aug;15(8):523-33. Review.

PMID:
16006996
20.

Role of two adjacent cytoplasmic tyrosine residues in MRP1 (ABCC1) transport activity and sensitivity to sulfonylureas.

Conseil G, Deeley RG, Cole SP.

Biochem Pharmacol. 2005 Feb 1;69(3):451-61. Epub 2004 Dec 16.

PMID:
15652236
21.

Functional expression of the human breast cancer resistance protein in Pichia pastoris.

Mao Q, Conseil G, Gupta A, Cole SP, Unadkat JD.

Biochem Biophys Res Commun. 2004 Jul 30;320(3):730-7.

PMID:
15240109
24.

The MRP-related and BCRP/ABCG2 multidrug resistance proteins: biology, substrate specificity and regulation.

Haimeur A, Conseil G, Deeley RG, Cole SP.

Curr Drug Metab. 2004 Feb;5(1):21-53. Review.

PMID:
14965249
26.

Potent competitive inhibition of drug binding to the Saccharomyces cerevisiae ABC exporter Pdr5p by the hydrophobic estradiol-derivative RU49953.

Conseil G, Perez-Victoria JM, Renoir JM, Goffeau A, Di Pietro A.

Biochim Biophys Acta. 2003 Aug 7;1614(2):131-4.

27.

RU49953: a non-hormonal steroid derivative that potently inhibits P-glycoprotein and reverts cellular multidrug resistance.

Perez-Victorias FJ, Conseil G, Munoz-Martinez F, Perez-Victoria JM, Dayan G, Marsaud V, Castanys S, Gamarro F, Renoir JM, Di Pietro A.

Cell Mol Life Sci. 2003 Mar;60(3):526-35.

PMID:
12737312
28.

A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris).

Appendino G, Della Porta C, Conseil G, Sterner O, Mercalli E, Dumontet C, Di Pietro A.

J Nat Prod. 2003 Jan;66(1):140-2.

PMID:
12542364
29.

Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters.

Di Pietro A, Conseil G, Pérez-Victoria JM, Dayan G, Baubichon-Cortay H, Trompier D, Steinfels E, Jault JM, de Wet H, Maitrejean M, Comte G, Boumendjel A, Mariotte AM, Dumontet C, McIntosh DB, Goffeau A, Castanys S, Gamarro F, Barron D.

Cell Mol Life Sci. 2002 Feb;59(2):307-22. Review.

PMID:
11915946
30.

Sequence requirements of the ATP-binding site within the C-terminal nucleotide-binding domain of mouse P-glycoprotein: structure-activity relationships for flavonoid binding.

de Wet H, McIntosh DB, Conseil G, Baubichon-Cortay H, Krell T, Jault JM, Daskiewicz JB, Barron D, Di Pietro A.

Biochemistry. 2001 Aug 28;40(34):10382-91.

PMID:
11513617
31.

Protein kinase C effectors bind to multidrug ABC transporters and inhibit their activity.

Conseil G, Perez-Victoria JM, Jault JM, Gamarro F, Goffeau A, Hofmann J, Di Pietro A.

Biochemistry. 2001 Feb 27;40(8):2564-71.

PMID:
11327879
32.

C-Isoprenylation of flavonoids enhances binding affinity toward P-glycoprotein and modulation of cancer cell chemoresistance.

Comte G, Daskiewicz JB, Bayet C, Conseil G, Viornery-Vanier A, Dumontet C, Di Pietro A, Barron D.

J Med Chem. 2001 Mar 1;44(5):763-8.

PMID:
11262086
33.

High-affinity binding of silybin derivatives to the nucleotide-binding domain of a Leishmania tropica P-glycoprotein-like transporter and chemosensitization of a multidrug-resistant parasite to daunomycin.

Pérez-Victoria JM, Pérez-Victoria FJ, Conseil G, Maitrejean M, Comte G, Barron D, Di Pietro A, Castanys S, Gamarro F.

Antimicrob Agents Chemother. 2001 Feb;45(2):439-46.

34.

B-ring substituted 5,7-dihydroxyflavonols with high-affinity binding to P-glycoprotein responsible for cell multidrug resistance.

Boumendjel A, Bois F, Beney C, Mariotte AM, Conseil G, Di Pietro A.

Bioorg Med Chem Lett. 2001 Jan 8;11(1):75-7.

PMID:
11140738
35.

Prenylated xanthones as potential P-glycoprotein modulators.

Tchamo DN, Dijoux-Franca MG, Mariotte AM, Tsamo E, Daskiewicz JB, Bayet C, Barron D, Conseil G, Di Pietro A.

Bioorg Med Chem Lett. 2000 Jun 19;10(12):1343-5.

PMID:
10890160
36.

Prenyl-flavonoids as potent inhibitors of the Pdr5p multidrug ABC transporter from Saccharomyces cerevisiae.

Conseil G, Decottignies A, Jault JM, Comte G, Barron D, Goffeau A, Di Pietro A.

Biochemistry. 2000 Jun 13;39(23):6910-7.

PMID:
10841772
37.

The flavanolignan silybin and its hemisynthetic derivatives, a novel series of potential modulators of P-glycoprotein.

Maitrejean M, Comte G, Barron D, El Kirat K, Conseil G, Di Pietro A.

Bioorg Med Chem Lett. 2000 Jan 17;10(2):157-60.

PMID:
10673101
38.

Synthesis and biological activity of 4-alkoxy chalcones: potential hydrophobic modulators of P-glycoprotein-mediated multidrug resistance.

Bois F, Boumendjel A, Mariotte AM, Conseil G, Di Petro A.

Bioorg Med Chem. 1999 Dec;7(12):2691-5.

PMID:
10658573
39.

P-glycoprotein-mediated resistance to chemotherapy in cancer cells: using recombinant cytosolic domains to establish structure-function relationships.

Di Pietro A, Dayan G, Conseil G, Steinfels E, Krell T, Trompier D, Baubichon-Cortay H, Jault J.

Braz J Med Biol Res. 1999 Aug;32(8):925-39. Review.

40.

Correlation between the affinity of flavonoids binding to the cytosolic site of Leishmania tropica multidrug transporter and their efficiency to revert parasite resistance to daunomycin.

Pérez-Victoria JM, Chiquero MJ, Conseil G, Dayan G, Di Pietro A, Barron D, Castanys S, Gamarro F.

Biochemistry. 1999 Feb 9;38(6):1736-43.

PMID:
10026252
41.

Halogenated chalcones with high-affinity binding to P-glycoprotein: potential modulators of multidrug resistance.

Bois F, Beney C, Boumendjel A, Mariotte AM, Conseil G, Di Pietro A.

J Med Chem. 1998 Oct 8;41(21):4161-4.

PMID:
9767651
42.

Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein.

Conseil G, Baubichon-Cortay H, Dayan G, Jault JM, Barron D, Di Pietro A.

Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9831-6.

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