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Zinc for Infection Prevention in Sickle Cell Anemia (ZIPS): study protocol for a randomized placebo-controlled trial in Ugandan children with sickle cell anemia.

Datta D, Namazzi R, Conroy AL, Cusick SE, Hume HA, Tagoola A, Ware RE, Opoka RO, John CC.

Trials. 2019 Jul 26;20(1):460. doi: 10.1186/s13063-019-3569-z.


Biomarkers of Systemic Inflammation in Ugandan Infants and Children Hospitalized With Respiratory Syncytial Virus Infection.

Sawatzky J, Soo J, Conroy AL, Bhargava R, Namasopo S, Opoka RO, Hawkes MT.

Pediatr Infect Dis J. 2019 Aug;38(8):854-859. doi: 10.1097/INF.0000000000002343.


Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria.

Conroy AL, Opoka RO, Bangirana P, Idro R, Ssenkusu JM, Datta D, Hodges JS, Morgan C, John CC.

BMC Med. 2019 May 21;17(1):98. doi: 10.1186/s12916-019-1332-7.


Perspective: L-arginine and L-citrulline Supplementation in Pregnancy: A Potential Strategy to Improve Birth Outcomes in Low-Resource Settings.

Weckman AM, McDonald CR, Baxter JB, Fawzi WW, Conroy AL, Kain KC.

Adv Nutr. 2019 Sep 1;10(5):765-777. doi: 10.1093/advances/nmz015.


Elevated cerebrospinal fluid tau protein concentrations on admission are associated with long-term neurologic and cognitive impairment in Ugandan children with cerebral malaria.

Datta D, Conroy AL, Castelluccio PF, Ssenkusu JM, Park GS, Opoka RO, Bangirana P, Idro R, Saykin AJ, John CC.

Clin Infect Dis. 2019 May 2. pii: ciz325. doi: 10.1093/cid/ciz325. [Epub ahead of print]


Systemic inflammation is associated with malaria and preterm birth in women living with HIV on antiretrovirals and co-trimoxazole.

McDonald CR, Weckman AM, Conroy AL, Olwoch P, Natureeba P, Kamya MR, Havlir DV, Dorsey G, Kain KC.

Sci Rep. 2019 May 1;9(1):6758. doi: 10.1038/s41598-019-43191-w.


An overview of malaria in pregnancy.

Bauserman M, Conroy AL, North K, Patterson J, Bose C, Meshnick S.

Semin Perinatol. 2019 Aug;43(5):282-290. doi: 10.1053/j.semperi.2019.03.018. Epub 2019 Mar 16. Review.


What causes severe malaria and its complications in children? Lessons learned over the past 15 years.

Conroy AL, Datta D, John CC.

BMC Med. 2019 Mar 7;17(1):52. doi: 10.1186/s12916-019-1291-z.


Case Report: Birth Outcome and Neurodevelopment in Placental Malaria Discordant Twins.

Conroy AL, Bangirana P, Muhindo MK, Kakuru A, Jagannathan P, Opoka RO, Liechty EA, Nakalembe M, Kamya MR, Dorsey G, John CC.

Am J Trop Med Hyg. 2019 Mar;100(3):552-555. doi: 10.4269/ajtmh.18-0659.


Handheld Point-of-Care Lactate Measurement at Admission Predicts Mortality in Ugandan Children Hospitalized with Pneumonia: A Prospective Cohort Study.

Ma C, Gunaratnam LC, Ericson A, Conroy AL, Namasopo S, Opoka RO, Hawkes MT.

Am J Trop Med Hyg. 2019 Jan;100(1):37-42. doi: 10.4269/ajtmh.18-0344.


Solar-Powered Oxygen Delivery in Low-Resource Settings: A Randomized Clinical Noninferiority Trial.

Hawkes MT, Conroy AL, Namasopo S, Bhargava R, Kain KC, Mian Q, Opoka RO.

JAMA Pediatr. 2018 Jul 1;172(7):694-696. doi: 10.1001/jamapediatrics.2018.0228. No abstract available.


Malaria in pregnancy alters l-arginine bioavailability and placental vascular development.

McDonald CR, Cahill LS, Gamble JL, Elphinstone R, Gazdzinski LM, Zhong KJY, Philson AC, Madanitsa M, Kalilani-Phiri L, Mwapasa V, Ter Kuile FO, Sled JG, Conroy AL, Kain KC.

Sci Transl Med. 2018 Mar 7;10(431). pii: eaan6007. doi: 10.1126/scitranslmed.aan6007.


Chitinase-3-like 1 is a biomarker of acute kidney injury and mortality in paediatric severe malaria.

Conroy AL, Hawkes MT, Elphinstone R, Opoka RO, Namasopo S, Miller C, John CC, Kain KC.

Malar J. 2018 Feb 15;17(1):82. doi: 10.1186/s12936-018-2225-5.


Inhaled nitric oxide and cognition in pediatric severe malaria: A randomized double-blind placebo controlled trial.

Bangirana P, Conroy AL, Opoka RO, Hawkes MT, Hermann L, Miller C, Namasopo S, Liles WC, John CC, Kain KC.

PLoS One. 2018 Jan 25;13(1):e0191550. doi: 10.1371/journal.pone.0191550. eCollection 2018.


Estradiol Levels Are Altered in Human Immunodeficiency Virus-Infected Pregnant Women Randomized to Efavirenz-Versus Lopinavir/Ritonavir-Based Antiretroviral Therapy.

McDonald CR, Conroy AL, Gamble JL, Papp E, Hawkes M, Olwoch P, Natureeba P, Kamya M, Silverman M, Cohan D, Koss CA, Dorsey G, Kain KC, Serghides L.

Clin Infect Dis. 2018 Jan 18;66(3):428-436. doi: 10.1093/cid/cix772.


Altered angiogenesis as a common mechanism underlying preterm birth, small for gestational age, and stillbirth in women living with HIV.

Conroy AL, McDonald CR, Gamble JL, Olwoch P, Natureeba P, Cohan D, Kamya MR, Havlir DV, Dorsey G, Kain KC.

Am J Obstet Gynecol. 2017 Dec;217(6):684.e1-684.e17. doi: 10.1016/j.ajog.2017.10.003. Epub 2017 Oct 12.


Elevated cerebrospinal fluid tumour necrosis factor is associated with acute and long-term neurocognitive impairment in cerebral malaria.

Shabani E, Ouma BJ, Idro R, Bangirana P, Opoka RO, Park GS, Conroy AL, John CC.

Parasite Immunol. 2017 Jul;39(7). doi: 10.1111/pim.12438. Epub 2017 May 28.


Validation of two multiplex platforms to quantify circulating markers of inflammation and endothelial injury in severe infection.

Leligdowicz A, Conroy AL, Hawkes M, Zhong K, Lebovic G, Matthay MA, Kain KC.

PLoS One. 2017 Apr 18;12(4):e0175130. doi: 10.1371/journal.pone.0175130. eCollection 2017.


miR-155 Modifies Inflammation, Endothelial Activation and Blood-Brain Barrier Dysfunction in Cerebral Malaria.

Barker KR, Lu Z, Kim H, Zheng Y, Chen J, Conroy AL, Hawkes M, Cheng HS, Njock MS, Fish JE, Harlan JM, López JA, Liles WC, Kain KC.

Mol Med. 2017 Mar;23:24-33. doi: 10.2119/molmed.2016.00139. Epub 2017 Feb 2.


Methemoglobin and nitric oxide therapy in Ugandan children hospitalized for febrile illness: results from a prospective cohort study and randomized double-blind placebo-controlled trial.

Conroy AL, Hawkes M, Hayford K, Hermann L, McDonald CR, Sharma S, Namasopo S, Opoka RO, John CC, Liles WC, Miller C, Kain KC.

BMC Pediatr. 2016 Nov 4;16(1):177.


Brain-derived Neurotrophic Factor Is Associated With Disease Severity and Clinical Outcome in Ugandan Children Admitted to Hospital With Severe Malaria.

McDonald CR, Conroy AL, Hawkes M, Elphinstone RE, Gamble JL, Hayford K, Namasopo S, Opoka RO, Liles WC, Kain KC.

Pediatr Infect Dis J. 2017 Feb;36(2):146-150. doi: 10.1097/INF.0000000000001382.


Host Biomarkers Are Associated With Response to Therapy and Long-Term Mortality in Pediatric Severe Malaria.

Conroy AL, Hawkes M, McDonald CR, Kim H, Higgins SJ, Barker KR, Namasopo S, Opoka RO, John CC, Liles WC, Kain KC.

Open Forum Infect Dis. 2016 Jun 20;3(3):ofw134. eCollection 2016 Sep.


Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria.

Higgins SJ, Purcell LA, Silver KL, Tran V, Crowley V, Hawkes M, Conroy AL, Opoka RO, Hay JG, Quaggin SE, Thurston G, Liles WC, Kain KC.

Sci Transl Med. 2016 Sep 28;8(358):358ra128. doi: 10.1126/scitranslmed.aaf6812.


Notes from the Field: Splenomegaly of Unknown Etiology in Congolese Refugees Applying for Resettlement to the United States - Uganda, 2015.

Goers M, Ope MO, Samuels A, Gitu N, Akandwanaho S, Nabwami G, Nyoka R, Cetron MS, Dalal W, Conroy AL, Cantey P, John C, Naoum M, Weinberg M, Marano N, Stauffer W.

MMWR Morb Mortal Wkly Rep. 2016 Sep 9;65(35):943-4. doi: 10.15585/mmwr.mm6535a5.


Alterations in Systemic Extracellular Heme and Hemopexin Are Associated With Adverse Clinical Outcomes in Ugandan Children With Severe Malaria.

Elphinstone RE, Conroy AL, Hawkes M, Hermann L, Namasopo S, Warren HS, John CC, Liles WC, Kain KC.

J Infect Dis. 2016 Oct 15;214(8):1268-75. doi: 10.1093/infdis/jiw357. Epub 2016 Aug 11.


Acute Kidney Injury Is Common in Pediatric Severe Malaria and Is Associated With Increased Mortality.

Conroy AL, Hawkes M, Elphinstone RE, Morgan C, Hermann L, Barker KR, Namasopo S, Opoka RO, John CC, Liles WC, Kain KC.

Open Forum Infect Dis. 2016 Feb 26;3(2):ofw046. doi: 10.1093/ofid/ofw046. eCollection 2016 Mar.


Biomarkers of hypoxia, endothelial and circulatory dysfunction among climbers in Nepal with AMS and HAPE: a prospective case-control study.

Barker KR, Conroy AL, Hawkes M, Murphy H, Pandey P, Kain KC.

J Travel Med. 2016 Mar 16;23(3). pii: taw005. doi: 10.1093/jtm/taw005. Print 2016 Mar.


Endothelial activation, haemostasis and thrombosis biomarkers in Ugandan children with severe malaria participating in a clinical trial.

Graham SM, Chen J, Chung DW, Barker KR, Conroy AL, Hawkes MT, Namasopo S, Kain KC, López JA, Liles WC.

Malar J. 2016 Feb 2;15:56. doi: 10.1186/s12936-016-1106-z.


Inhaled nitric oxide as adjunctive therapy for severe malaria: a randomized controlled trial.

Hawkes MT, Conroy AL, Opoka RO, Hermann L, Thorpe KE, McDonald C, Kim H, Higgins S, Namasopo S, John C, Miller C, Liles WC, Kain KC.

Malar J. 2015 Oct 29;14:421. doi: 10.1186/s12936-015-0946-2.


Host biomarkers are associated with progression to dengue haemorrhagic fever: a nested case-control study.

Conroy AL, Gélvez M, Hawkes M, Rajwans N, Tran V, Liles WC, Villar-Centeno LA, Kain KC.

Int J Infect Dis. 2015 Nov;40:45-53. doi: 10.1016/j.ijid.2015.07.027. Epub 2015 Aug 6.


Inflammatory and Angiogenic Factors at Mid-Pregnancy Are Associated with Spontaneous Preterm Birth in a Cohort of Tanzanian Women.

McDonald CR, Darling AM, Conroy AL, Tran V, Cabrera A, Liles WC, Wang M, Aboud S, Urassa W, Fawzi WW, Kain KC.

PLoS One. 2015 Aug 6;10(8):e0134619. doi: 10.1371/journal.pone.0134619. eCollection 2015.


Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011-2013.

Hawkes M, Conroy AL, Opoka RO, Namasopo S, Zhong K, Liles WC, John CC, Kain KC.

Emerg Infect Dis. 2015 Jul;21(7):1237-9. doi: 10.3201/eid2107.150213.


In rural Alberta. 1935.

Conroy AL.

Can Nurse. 2015 Apr;111(3):11. No abstract available.


Prospective validation of pediatric disease severity scores to predict mortality in Ugandan children presenting with malaria and non-malaria febrile illness.

Conroy AL, Hawkes M, Hayford K, Namasopo S, Opoka RO, John CC, Liles WC, Kain KC.

Crit Care. 2015 Feb 23;19:47. doi: 10.1186/s13054-015-0773-4.


Spread of artemisinin resistance in malaria.

Hawkes M, Conroy AL, Kain KC.

N Engl J Med. 2014 Nov 13;371(20):1944-5. doi: 10.1056/NEJMc1410735. No abstract available.


Angiogenic and inflammatory biomarkers in midpregnancy and small-for-gestational-age outcomes in Tanzania.

Darling AM, McDonald CR, Conroy AL, Hayford KT, Liles WC, Wang M, Aboud S, Urassa WS, Kain KC, Fawzi WW.

Am J Obstet Gynecol. 2014 Nov;211(5):509.e1-8. doi: 10.1016/j.ajog.2014.05.032. Epub 2014 May 29.


Performance of point-of-care diagnostics for glucose, lactate, and hemoglobin in the management of severe malaria in a resource-constrained hospital in Uganda.

Hawkes M, Conroy AL, Opoka RO, Namasopo S, Liles WC, John CC, Kain KC.

Am J Trop Med Hyg. 2014 Apr;90(4):605-8. doi: 10.4269/ajtmh.13-0689. Epub 2014 Mar 3.


Use of a three-band HRP2/pLDH combination rapid diagnostic test increases diagnostic specificity for falciparum malaria in Ugandan children.

Hawkes M, Conroy AL, Opoka RO, Namasopo S, Liles WC, John CC, Kain KC.

Malar J. 2014 Feb 1;13:43. doi: 10.1186/1475-2875-13-43.


Host biomarkers distinguish dengue from leptospirosis in Colombia: a case-control study.

Conroy AL, Gélvez M, Hawkes M, Rajwans N, Liles WC, Villar-Centeno LA, Kain KC.

BMC Infect Dis. 2014 Jan 20;14:35. doi: 10.1186/1471-2334-14-35.


Contrasting pediatric and adult cerebral malaria: the role of the endothelial barrier.

Hawkes M, Elphinstone RE, Conroy AL, Kain KC.

Virulence. 2013 Aug 15;4(6):543-55. doi: 10.4161/viru.25949. Epub 2013 Aug 2. Review.


Complement activation and the resulting placental vascular insufficiency drives fetal growth restriction associated with placental malaria.

Conroy AL, Silver KL, Zhong K, Rennie M, Ward P, Sarma JV, Molyneux ME, Sled J, Fletcher JF, Rogerson S, Kain KC.

Cell Host Microbe. 2013 Feb 13;13(2):215-26. doi: 10.1016/j.chom.2013.01.010.


Malaria in pregnancy: diagnosing infection and identifying fetal risk.

Conroy AL, McDonald CR, Kain KC.

Expert Rev Anti Infect Ther. 2012 Nov;10(11):1331-42. doi: 10.1586/eri.12.123. Review.


Angiopoietin-2 levels are associated with retinopathy and predict mortality in Malawian children with cerebral malaria: a retrospective case-control study*.

Conroy AL, Glover SJ, Hawkes M, Erdman LK, Seydel KB, Taylor TE, Molyneux ME, Kain KC.

Crit Care Med. 2012 Mar;40(3):952-9. doi: 10.1097/CCM.0b013e3182373157.


Performance characteristics of combinations of host biomarkers to identify women with occult placental malaria: a case-control study from Malawi.

Conroy AL, Liles WC, Molyneux ME, Rogerson SJ, Kain KC.

PLoS One. 2011;6(12):e28540. doi: 10.1371/journal.pone.0028540. Epub 2011 Dec 12.


Circulating soluble endoglin levels in pregnant women in Cameroon and Malawi--associations with placental malaria and fetal growth restriction.

Silver KL, Conroy AL, Leke RG, Leke RJ, Gwanmesia P, Molyneux ME, Taylor DW, Rogerson SJ, Kain KC.

PLoS One. 2011;6(9):e24985. doi: 10.1371/journal.pone.0024985. Epub 2011 Sep 22. Erratum in: PLoS One. 2011;6(10). doi:10.1371/annotation/e9946f72-821d-45ea-bcd4-3fa3ff89a5fe. Wallace, Diane Taylor [corrected to Taylor, Diane Wallace].


Inhaled nitric oxide for the adjunctive therapy of severe malaria: protocol for a randomized controlled trial.

Hawkes M, Opoka RO, Namasopo S, Miller C, Thorpe KE, Lavery JV, Conroy AL, Liles WC, John CC, Kain KC.

Trials. 2011 Jul 13;12:176. doi: 10.1186/1745-6215-12-176.


Nitric oxide for the adjunctive treatment of severe malaria: hypothesis and rationale.

Hawkes M, Opoka RO, Namasopo S, Miller C, Conroy AL, Serghides L, Kim H, Thampi N, Liles WC, John CC, Kain KC.

Med Hypotheses. 2011 Sep;77(3):437-44. doi: 10.1016/j.mehy.2011.06.003. Epub 2011 Jul 13.


Complement activation: a critical mediator of adverse fetal outcomes in placental malaria?

Conroy AL, McDonald CR, Silver KL, Liles WC, Kain KC.

Trends Parasitol. 2011 Jul;27(7):294-9. doi: 10.1016/ Epub 2011 Apr 12.


Combinations of host biomarkers predict mortality among Ugandan children with severe malaria: a retrospective case-control study.

Erdman LK, Dhabangi A, Musoke C, Conroy AL, Hawkes M, Higgins S, Rajwans N, Wolofsky KT, Streiner DL, Liles WC, Cserti-Gazdewich CM, Kain KC.

PLoS One. 2011 Feb 25;6(2):e17440. doi: 10.1371/journal.pone.0017440.


Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis.

Ricciuto DR, dos Santos CC, Hawkes M, Toltl LJ, Conroy AL, Rajwans N, Lafferty EI, Cook DJ, Fox-Robichaud A, Kahnamoui K, Kain KC, Liaw PC, Liles WC.

Crit Care Med. 2011 Apr;39(4):702-10. doi: 10.1097/CCM.0b013e318206d285.


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