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Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion.

Schulz-Heddergott R, Stark N, Edmunds SJ, Li J, Conradi LC, Bohnenberger H, Ceteci F, Greten FR, Dobbelstein M, Moll UM.

Cancer Cell. 2018 Aug 13;34(2):298-314.e7. doi: 10.1016/j.ccell.2018.07.004.


Outcomes with a latest generation self-expandable, intra-annular, re-sheathable transcatheter heart valve system: analysis of patients with impaired left ventricular function and determinants for pacemaker implantation.

Schaefer A, Neumann N, Linder M, Schofer N, Schneeberger Y, Deuschl F, Schoen G, Blankenberg S, Reichenspurner H, Conradi L, Schäfer U.

Clin Res Cardiol. 2018 Apr 28. doi: 10.1007/s00392-018-1263-x. [Epub ahead of print]


Predictors of paravalvular regurgitation and permanent pacemaker implantation after TAVR with a next-generation self-expanding device.

Mauri V, Deuschl F, Frohn T, Schofer N, Linder M, Kuhn E, Schaefer A, Rudolph V, Madershahian N, Conradi L, Rudolph TK, Schäfer U.

Clin Res Cardiol. 2018 Aug;107(8):688-697. doi: 10.1007/s00392-018-1235-1. Epub 2018 Apr 17.


Off-Pump Coronary Artery Bypass Grafting and Stroke-Exploratory Analysis of the GOPCABE Trial and Methodological Considerations.

Reents W, Zacher M, Boergermann J, Kappert U, Hilker M, Färber G, Albert M, Holzhey D, Conradi L, Riess FC, Veeckman P, Strauch JT, Diegeler A, Böning A.

Thorac Cardiovasc Surg. 2018 Mar 22. doi: 10.1055/s-0038-1636936. [Epub ahead of print]


Prospective multicentre evaluation of a novel, low-profile transapical delivery system for self-expandable transcatheter aortic valve implantation: 6-month outcomes.

Conradi L, Hilker M, Kempfert J, Börgermann J, Treede H, Holzhey DM, Schröfel H, Kim WK, Schaefer U, Walther T.

Eur J Cardiothorac Surg. 2018 Mar 14. doi: 10.1093/ejcts/ezy097. [Epub ahead of print]


Comparative analysis of balloon- versus mechanically-expandable transcatheter heart valves considering landing zone calcification.

Schofer N, Deuschl F, Schön G, Seiffert M, Linder M, Schaefer A, Schirmer J, Lubos E, Reichenspurner H, Blankenberg S, Conradi L, Schäfer U.

J Cardiol. 2018 Jun;71(6):540-546. doi: 10.1016/j.jjcc.2017.09.014. Epub 2018 Mar 13.


RAISEing VEGF-D's importance as predictive biomarker for ramucirumab in metastatic colorectal cancer patients.

Carmeliet P, Li X, Treps L, Conradi LC, Loges S.

Ann Oncol. 2018 Mar 1;29(3):527-529. doi: 10.1093/annonc/mdy028. No abstract available.


First-in-human implantation of a novel self-expanding supra-annular transcatheter heart valve for transcatheter aortic valve implantation inside a small degenerated aortic surgical bioprosthesis.

Schäfer U, Kalbacher D, Voigtländer L, Conradi L.

Catheter Cardiovasc Interv. 2018 Jan 23. doi: 10.1002/ccd.27466. [Epub ahead of print]


In vitro hydrodynamic and acute clinical performance of a novel self-expanding transcatheter heart valve in various surgical bioprostheses.

Sedaghat A, Sinning JM, Werner N, Nickenig G, Conradi L, Toggweiler S, Schäfer U.

EuroIntervention. 2018 Apr 20;13(17):2014-2017. doi: 10.4244/EIJ-D-17-00844. No abstract available.


The JUPITER registry: One-year outcomes of transapical aortic valve implantation using a second generation transcatheter heart valve for aortic regurgitation.

Silaschi M, Conradi L, Wendler O, Schlingloff F, Kappert U, Rastan AJ, Baumbach H, Holzhey D, Eichinger W, Bader R, Treede H.

Catheter Cardiovasc Interv. 2018 Jun;91(7):1345-1351. doi: 10.1002/ccd.27370. Epub 2017 Nov 24.


Minimally Invasive Mitral Valve Annuloplasty With Realignment of Both Papillary Muscles for Correction of Type IIIb Functional Mitral Regurgitation.

Girdauskas E, Conradi L, Harmel EK, Reichenspurner H.

Innovations (Phila). 2017 Sep/Oct;12(5):329-332. doi: 10.1097/IMI.0000000000000402.


Short-Term Outcome and Hemodynamic Performance of Next-Generation Self-Expanding Versus Balloon-Expandable Transcatheter Aortic Valves in Patients With Small Aortic Annulus: A Multicenter Propensity-Matched Comparison.

Mauri V, Kim WK, Abumayyaleh M, Walther T, Moellmann H, Schaefer U, Conradi L, Hengstenberg C, Hilker M, Wahlers T, Baldus S, Rudolph V, Madershahian N, Rudolph TK.

Circ Cardiovasc Interv. 2017 Oct;10(10). pii: e005013. doi: 10.1161/CIRCINTERVENTIONS.117.005013.


Transcatheter Tricuspid Valve-In-Ring and Aortic Valve-In-Valve Implantation.

Reichart D, Schofer N, Deuschl F, Schaefer A, Blankenberg S, Reichenspurner H, Schaefer U, Conradi L.

Thorac Cardiovasc Surg Rep. 2017 Jan;6(1):e29-e31. doi: 10.1055/s-0037-1606345. Epub 2017 Sep 18.


Tumor vessel disintegration by maximum tolerable PFKFB3 blockade.

Conradi LC, Brajic A, Cantelmo AR, Bouché A, Kalucka J, Pircher A, Brüning U, Teuwen LA, Vinckier S, Ghesquière B, Dewerchin M, Carmeliet P.

Angiogenesis. 2017 Nov;20(4):599-613. doi: 10.1007/s10456-017-9573-6. Epub 2017 Sep 5.


First-in-human implantation of a novel transfemoral selfexpanding transcatheter heart valve to treat pure aortic regurgitation.

Schäfer U, Schirmer J, Niklas S, Harmel E, Deuschl F, Conradi L.

EuroIntervention. 2017 Dec 20;13(11):1296-1299. doi: 10.4244/EIJ-D-17-00502.


Transcatheter Mitral Valve Replacement for Degenerated Bioprosthetic Valves and Failed Annuloplasty Rings.

Yoon SH, Whisenant BK, Bleiziffer S, Delgado V, Schofer N, Eschenbach L, Fujita B, Sharma R, Ancona M, Yzeiraj E, Cannata S, Barker C, Davies JE, Frangieh AH, Deuschl F, Podlesnikar T, Asami M, Dhoble A, Chyou A, Masson JB, Wijeysundera HC, Blackman DJ, Rampat R, Taramasso M, Gutierrez-Ibanes E, Chakravarty T, Attizzani GF, Kaneko T, Wong SC, Sievert H, Nietlispach F, Hildick-Smith D, Nombela-Franco L, Conradi L, Hengstenberg C, Reardon MJ, Kasel AM, Redwood S, Colombo A, Kar S, Maisano F, Windecker S, Pilgrim T, Ensminger SM, Prendergast BD, Schofer J, Schaefer U, Bax JJ, Latib A, Makkar RR.

J Am Coll Cardiol. 2017 Aug 29;70(9):1121-1131. doi: 10.1016/j.jacc.2017.07.714.


Simultaneous inhibition of IGF1R and EGFR enhances the efficacy of standard treatment for colorectal cancer by the impairment of DNA repair and the induction of cell death.

Oberthür R, Seemann H, Gehrig J, Rave-Fränk M, Bremmer F, Halpape R, Conradi LC, Scharf JG, Burfeind P, Kaulfuß S.

Cancer Lett. 2017 Oct 28;407:93-105. doi: 10.1016/j.canlet.2017.08.009. Epub 2017 Aug 18.


The utilization of multidisciplinary tumor boards (MDT) in clinical routine: results of a health care research study focusing on patients with metastasized colorectal cancer.

Lowes M, Kleiss M, Lueck R, Detken S, Koenig A, Nietert M, Beissbarth T, Stanek K, Langer C, Ghadimi M, Conradi LC, Homayounfar K.

Int J Colorectal Dis. 2017 Oct;32(10):1463-1469. doi: 10.1007/s00384-017-2871-z. Epub 2017 Aug 5.


Comparison of latest generation transfemoral self-expandable and balloon-expandable transcatheter heart valves.

Schaefer A, Linder M, Seiffert M, Schoen G, Deuschl F, Schofer N, Schneeberger Y, Blankenberg S, Reichenspurner H, Schaefer U, Conradi L.

Interact Cardiovasc Thorac Surg. 2017 Dec 1;25(6):905-911. doi: 10.1093/icvts/ivx194.


Structural Valve Deterioration of a Subcoronary Implanted Stentless Bioprosthesis: How to Treat?

Harmel EK, Conradi L, Schäfer U, Deuschl F, Schofer N, Blankenberg S, Reichenspurner H, Girdauskas E.

Ann Thorac Surg. 2017 Jul;104(1):e53-e55. doi: 10.1016/j.athoracsur.2017.01.109.


The Prognostic Value of Tyrosine Kinase SRC Expression in Locally Advanced Rectal Cancer.

Rühlmann F, Nietert M, Sprenger T, Wolff HA, Homayounfar K, Middel P, Bohnenberger H, Beissbarth T, Ghadimi BM, Liersch T, Conradi LC.

J Cancer. 2017 Apr 10;8(7):1229-1237. doi: 10.7150/jca.16980. eCollection 2017.


Uncommon cause of pulmonary hypertension.

Petersen J, Pecha S, Neumann N, Conradi L, Reichenspurner H, Girdauskas E.

J Card Surg. 2017 Jun;32(6):366-367. doi: 10.1111/jocs.13144. Epub 2017 May 11. No abstract available.


First experience with transfemoral transcatheter aortic valve implantation without prior balloon pre-dilatation using a latest generation repositionable and retrievable transcatheter heart valve†.

Schaefer A, Harmel E, Seiffert M, Reichart D, Deuschl F, Schofer N, Schneeberger Y, Blankenberg S, Reichenspurner H, Schaefer U, Conradi L.

Interact Cardiovasc Thorac Surg. 2017 May 1;24(5):659-662. doi: 10.1093/icvts/ivw446.


Direct percutaneous transaxillary implantation of a novel self-expandable transcatheter heart valve for aortic stenosis.

Deuschl F, Schofer N, Seiffert M, Hakmi S, Mizote I, Schaefer A, Schirmer J, Reichenspurner H, Blankenberg S, Conradi L, Schäfer U.

Catheter Cardiovasc Interv. 2017 Dec 1;90(7):1167-1174. doi: 10.1002/ccd.26986. Epub 2017 Mar 15.


Central Role of Metabolism in Endothelial Cell Function and Vascular Disease.

Bierhansl L, Conradi LC, Treps L, Dewerchin M, Carmeliet P.

Physiology (Bethesda). 2017 Mar;32(2):126-140. doi: 10.1152/physiol.00031.2016. Review.


Safety and efficacy of the percutaneous transaxillary access for transcatheter aortic valve implantation using various transcatheter heart valves in 100 consecutive patients.

Schäfer U, Deuschl F, Schofer N, Frerker C, Schmidt T, Kuck KH, Kreidel F, Schirmer J, Mizote I, Reichenspurner H, Blankenberg S, Treede H, Conradi L.

Int J Cardiol. 2017 Apr 1;232:247-254. doi: 10.1016/j.ijcard.2017.01.010. Epub 2017 Jan 7.


Minimally invasive endoscopic surgery versus catheter-based device occlusion for atrial septal defects in adults: reconsideration of the standard of care.

Schneeberger Y, Schaefer A, Conradi L, Brickwedel J, Reichenspurner H, Kozlik-Feldmann R, Detter C.

Interact Cardiovasc Thorac Surg. 2017 Apr 1;24(4):603-608. doi: 10.1093/icvts/ivw366.


Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy.

Cantelmo AR, Conradi LC, Brajic A, Goveia J, Kalucka J, Pircher A, Chaturvedi P, Hol J, Thienpont B, Teuwen LA, Schoors S, Boeckx B, Vriens J, Kuchnio A, Veys K, Cruys B, Finotto L, Treps L, Stav-Noraas TE, Bifari F, Stapor P, Decimo I, Kampen K, De Bock K, Haraldsen G, Schoonjans L, Rabelink T, Eelen G, Ghesquière B, Rehman J, Lambrechts D, Malik AB, Dewerchin M, Carmeliet P.

Cancer Cell. 2016 Dec 12;30(6):968-985. doi: 10.1016/j.ccell.2016.10.006. Epub 2016 Nov 17.


Repeated adjuvant anti-CEA radioimmunotherapy after resection of colorectal liver metastases: Safety, feasibility, and long-term efficacy results of a prospective phase 2 study.

Sahlmann CO, Homayounfar K, Niessner M, Dyczkowski J, Conradi LC, Braulke F, Meller B, Beißbarth T, Ghadimi BM, Meller J, Goldenberg DM, Liersch T.

Cancer. 2017 Feb 15;123(4):638-649. doi: 10.1002/cncr.30390. Epub 2016 Oct 20.


Neoadjuvant Therapy in Rectal Cancer - Biobanking of Preoperative Tumor Biopsies.

Jo P, Nietert M, Gusky L, Kitz J, Conradi LC, Müller-Dornieden A, Schüler P, Wolff HA, Rüschoff J, Ströbel P, Grade M, Liersch T, Beißbarth T, Ghadimi MB, Sax U, Gaedcke J.

Sci Rep. 2016 Oct 18;6:35589. doi: 10.1038/srep35589.


Transcatheter valve-in-valve implantation versus redo surgical aortic valve replacement in patients with failed aortic bioprostheses.

Silaschi M, Wendler O, Seiffert M, Castro L, Lubos E, Schirmer J, Blankenberg S, Reichenspurner H, Schäfer U, Treede H, MacCarthy P, Conradi L.

Interact Cardiovasc Thorac Surg. 2017 Jan;24(1):63-70. doi: 10.1093/icvts/ivw300. Epub 2016 Sep 13.


Meta-analysis of clinical metabolic profiling studies in cancer: challenges and opportunities.

Goveia J, Pircher A, Conradi LC, Kalucka J, Lagani V, Dewerchin M, Eelen G, DeBerardinis RJ, Wilson ID, Carmeliet P.

EMBO Mol Med. 2016 Oct 4;8(10):1134-1142. doi: 10.15252/emmm.201606798. Print 2016 Oct.


Glycolytic regulation of cell rearrangement in angiogenesis.

Cruys B, Wong BW, Kuchnio A, Verdegem D, Cantelmo AR, Conradi LC, Vandekeere S, Bouché A, Cornelissen I, Vinckier S, Merks RM, Dejana E, Gerhardt H, Dewerchin M, Bentley K, Carmeliet P.

Nat Commun. 2016 Jul 20;7:12240. doi: 10.1038/ncomms12240.


Subannular perforation of left ventricular outflow tract associated with transcatheter valve implantation: pathophysiological background and clinical implications.

Girdauskas E, Owais T, Fey B, Kuntze F, Lauer B, Borger MA, Conradi L, Reichenspurner H, Kuntze T.

Eur J Cardiothorac Surg. 2017 Jan;51(1):91-96. doi: 10.1093/ejcts/ezw252. Epub 2016 Jul 13.


Manipulating Angiogenesis by Targeting Endothelial Metabolism: Hitting the Engine Rather than the Drivers-A New Perspective?

Treps L, Conradi LC, Harjes U, Carmeliet P.

Pharmacol Rev. 2016 Jul;68(3):872-87. doi: 10.1124/pr.116.012492. Review.


A matched pairs analysis of non-rib-spreading, fully endoscopic, mini-incision technique versus conventional mini-thoracotomy for mitral valve repair.

Westhofen S, Conradi L, Deuse T, Detter C, Vettorazzi E, Treede H, Reichenspurner H.

Eur J Cardiothorac Surg. 2016 Dec;50(6):1181-1187. doi: 10.1093/ejcts/ezw184. Epub 2016 Jun 3.


The Value of Circulating Biomarkers in Bicuspid Aortic Valve-Associated Aortopathy.

Naito S, Hillebrand M, Bernhardt AMJ, Jagodzinski A, Conradi L, Detter C, Sydow K, Reichenspurner H, Kodolitsch YV, Girdauskas E.

Thorac Cardiovasc Surg. 2018 Jun;66(4):278-286. doi: 10.1055/s-0036-1583525. Epub 2016 May 5.


A case of anomalous left coronary artery obstruction caused by lotus valve implantation.

Mizote I, Conradi L, Schäfer U.

Catheter Cardiovasc Interv. 2017 Dec 1;90(7):1227-1231. doi: 10.1002/ccd.26541. Epub 2016 May 3.


Baseline anemia and its impact on midterm outcome after transcatheter aortic valve implantation.

Seiffert M, Conradi L, Gutwein A, Schön G, Deuschl F, Schofer N, Becker N, Schirmer J, Reichenspurner H, Blankenberg S, Treede H, Schäfer U.

Catheter Cardiovasc Interv. 2017 Jan;89(1):E44-E52. doi: 10.1002/ccd.26563. Epub 2016 May 3.


[Lymph node metastases in ypT1/2 rectal cancer after neoadjuvant chemoradiotherapy : The Achilles heel of organ-preserving operative procedures?].

Sprenger T, Rothe H, Beissbarth T, Conradi LC, Kauffels A, Homayounfar K, Behnes CL, Rödel C, Liersch T, Ghadimi M.

Chirurg. 2016 Jul;87(7):593-601. doi: 10.1007/s00104-016-0170-9. German.


Combined rendezvous approach with the Direct Flow Medical® aortic valve prosthesis to treat aortic and mitral stenosis.

Sinning C, Conradi L, Deuschl FG, Schofer N, Hakmi S, Schäfer U.

Int J Cardiol. 2016 Jul 1;214:284-5. doi: 10.1016/j.ijcard.2016.03.094. Epub 2016 Apr 4. No abstract available.


Heterogeneity of KRAS Mutation Status in Rectal Cancer.

Jo P, König A, Schirmer M, Kitz J, Conradi LC, Azizian A, Bernhardt M, Wolff HA, Grade M, Ghadimi M, Ströbel P, Schildhaus HU, Gaedcke J.

PLoS One. 2016 Apr 11;11(4):e0153278. doi: 10.1371/journal.pone.0153278. eCollection 2016.


Stage-Dependent Frequency of Lymph Node Metastases in Patients With Rectal Carcinoma After Preoperative Chemoradiation: Results from the CAO/ARO/AIO-94 Trial and From a Comparative Prospective Evaluation With Extensive Pathological Workup.

Sprenger T, Rothe H, Conradi LC, Beissbarth T, Kauffels A, Kitz J, Homayounfar K, Wolff H, Ströbel P, Ghadimi M, Wittekind C, Sauer R, Rödel C, Liersch T.

Dis Colon Rectum. 2016 May;59(5):377-85. doi: 10.1097/DCR.0000000000000570.


Transcatheter Mitral Valve Repair in Surgical High-Risk Patients: Gender-Specific Acute and Long-Term Outcomes.

Tigges E, Kalbacher D, Thomas C, Appelbaum S, Deuschl F, Schofer N, Schlüter M, Conradi L, Schirmer J, Treede H, Reichenspurner H, Blankenberg S, Schäfer U, Lubos E.

Biomed Res Int. 2016;2016:3934842. doi: 10.1155/2016/3934842. Epub 2016 Mar 2.


Haemodynamic benefits of rapid deployment aortic valve replacement via a minimally invasive approach: 1-year results of a prospective multicentre randomized controlled trial.

Borger MA, Dohmen PM, Knosalla C, Hammerschmidt R, Merk DR, Richter M, Doenst T, Conradi L, Treede H, Moustafine V, Holzhey DM, Duhay F, Strauch J.

Eur J Cardiothorac Surg. 2016 Oct;50(4):713-720. Epub 2016 Mar 2.


Improving outcomes: case-matched comparison of novel second-generation versus first-generation self-expandable transcatheter heart valves.

Schaefer A, Treede H, Schoen G, Deuschl F, Schofer N, Schneeberger Y, Blankenberg S, Reichenspurner H, Schaefer U, Conradi L.

Eur J Cardiothorac Surg. 2016 Aug;50(2):368-73. doi: 10.1093/ejcts/ezw021. Epub 2016 Feb 16.


β-catenin-independent WNT signaling and Ki67 in contrast to the estrogen receptor status are prognostic and associated with poor prognosis in breast cancer liver metastases.

Bleckmann A, Conradi LC, Menck K, Schmick NA, Schubert A, Rietkötter E, Arackal J, Middel P, Schambony A, Liersch T, Homayounfar K, Beißbarth T, Klemm F, Binder C, Pukrop T.

Clin Exp Metastasis. 2016 Apr;33(4):309-23. doi: 10.1007/s10585-016-9780-3. Epub 2016 Feb 9.


Large Biatrial Thrombembolus Caught in Transit across a Patent Foramen Ovale.

Schaefer A, Treede H, Reichenspurner H, Conradi L.

Thorac Cardiovasc Surg Rep. 2015 Dec;4(1):44-5. doi: 10.1055/s-0035-1559828. Epub 2015 Aug 20.


Repeat transcatheter aortic valve implantation using a latest generation balloon-expandable device for treatment of failing transcatheter heart valves.

Schaefer A, Treede H, Seiffert M, Deuschl F, Schofer N, Schneeberger Y, Blankenberg S, Reichenspurner H, Schaefer U, Conradi L.

J Cardiothorac Surg. 2016 Jan 15;11:2. doi: 10.1186/s13019-016-0398-y.


Spontaneous Formation of Extensive Vessel-Like Structures in Murine Engineered Heart Tissue.

Stoehr A, Hirt MN, Hansen A, Seiffert M, Conradi L, Uebeler J, Limbourg FP, Eschenhagen T.

Tissue Eng Part A. 2016 Feb;22(3-4):326-35. doi: 10.1089/ten.TEA.2015.0242.

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