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PAPP-A and the IGF system in atherosclerosis: what's up, what's down?

Steffensen LB, Conover CA, Oxvig C.

Am J Physiol Heart Circ Physiol. 2019 Nov 1;317(5):H1039-H1049. doi: 10.1152/ajpheart.00395.2019. Epub 2019 Sep 13.


Pregnancy-Associated Plasma Protein-A (PAPP-A) in Ewing Sarcoma: Role in Tumor Growth and Immune Evasion.

Heitzeneder S, Sotillo E, Shern JF, Sindiri S, Xu P, Jones R, Pollak M, Noer PR, Lorette J, Fazli L, Alag A, Meltzer P, Lau C, Conover CA, Oxvig C, Sorensen PH, Maris JM, Khan J, Mackall CL.

J Natl Cancer Inst. 2019 Sep 1;111(9):970-982. doi: 10.1093/jnci/djy209.


Characterization of mouse pericardial fat: regulation by PAPP-A.

Bale LK, West SA, Conover CA.

Growth Horm IGF Res. 2018 Oct - Dec;42-43:1-7. doi: 10.1016/j.ghir.2018.07.002. Epub 2018 Jul 11.


PAPP-A and cancer.

Conover CA, Oxvig C.

J Mol Endocrinol. 2018 Jul;61(1):T1-T10. doi: 10.1530/JME-17-0236. Review.


The IGF-p53 connection in cancer.

Conover CA.

Growth Horm IGF Res. 2018 Apr;39:25-28. doi: 10.1016/j.ghir.2017.11.007. Epub 2017 Dec 2. Review.


Inducible knockdown of pregnancy-associated plasma protein-A gene expression in adult female mice extends life span.

Bale LK, West SA, Conover CA.

Aging Cell. 2017 Aug;16(4):895-897. doi: 10.1111/acel.12624. Epub 2017 Jun 9.


PAPP-A: a promising therapeutic target for healthy longevity.

Conover CA, Oxvig C.

Aging Cell. 2017 Apr;16(2):205-209. doi: 10.1111/acel.12564. Epub 2016 Dec 29. Review.


Discrepancies in insulin-like growth factor signaling? No, not really.

Conover CA.

Growth Horm IGF Res. 2016 Oct - Dec;30-31:42-44. doi: 10.1016/j.ghir.2016.10.005. Epub 2016 Oct 22. Review.


Senescent intimal foam cells are deleterious at all stages of atherosclerosis.

Childs BG, Baker DJ, Wijshake T, Conover CA, Campisi J, van Deursen JM.

Science. 2016 Oct 28;354(6311):472-477. Epub 2016 Oct 27.


PAPP-A in normal human mesangial cells: effect of inflammation and factors related to diabetic nephropathy.

Donegan D, Bale LK, Conover CA.

J Endocrinol. 2016 Oct;231(1):71-80. doi: 10.1530/JOE-16-0205. Epub 2016 Aug 12.


The insulin-like growth factor system in multiple myeloma: diagnostic and therapeutic potential.

Bieghs L, Johnsen HE, Maes K, Menu E, Van Valckenborgh E, Overgaard MT, Nyegaard M, Conover CA, Vanderkerken K, De Bruyne E.

Oncotarget. 2016 Jul 26;7(30):48732-48752. doi: 10.18632/oncotarget.8982. Review.


Abnormal IGF-Binding Protein Profile in the Bone Marrow of Multiple Myeloma Patients.

Bieghs L, Brohus M, Kristensen IB, Abildgaard N, Bøgsted M, Johnsen HE, Conover CA, De Bruyne E, Vanderkerken K, Overgaard MT, Nyegaard M.

PLoS One. 2016 Apr 25;11(4):e0154256. doi: 10.1371/journal.pone.0154256. eCollection 2016.


Comparative gene expression and phenotype analyses of skeletal muscle from aged wild-type and PAPP-A-deficient mice.

Conover CA, Bale LK, Nair KS.

Exp Gerontol. 2016 Jul;80:36-42. doi: 10.1016/j.exger.2016.04.005. Epub 2016 Apr 13.


Stanniocalcin-2 overexpression reduces atherosclerosis in hypercholesterolemic mice.

Steffensen LB, Conover CA, Bjørklund MM, Ledet T, Bentzon JF, Oxvig C.

Atherosclerosis. 2016 May;248:36-43. doi: 10.1016/j.atherosclerosis.2016.02.026. Epub 2016 Mar 3.


Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF-I availability.

Dauber A, Muñoz-Calvo MT, Barrios V, Domené HM, Kloverpris S, Serra-Juhé C, Desikan V, Pozo J, Muzumdar R, Martos-Moreno GÁ, Hawkins F, Jasper HG, Conover CA, Frystyk J, Yakar S, Hwa V, Chowen JA, Oxvig C, Rosenfeld RG, Pérez-Jurado LA, Argente J.

EMBO Mol Med. 2016 Apr 1;8(4):363-74. doi: 10.15252/emmm.201506106.


Targeted Inhibition of Pregnancy-Associated Plasma Protein-A Activity Reduces Atherosclerotic Plaque Burden in Mice.

Conover CA, Bale LK, Oxvig C.

J Cardiovasc Transl Res. 2016 Feb;9(1):77-9. doi: 10.1007/s12265-015-9666-9. Epub 2016 Jan 5.


The Insulin-Like Growth Factor System in the Long-Lived Naked Mole-Rat.

Brohus M, Gorbunova V, Faulkes CG, Overgaard MT, Conover CA.

PLoS One. 2015 Dec 22;10(12):e0145587. doi: 10.1371/journal.pone.0145587. eCollection 2015.


Myocardial and Peripheral Ischemia Causes an Increase in Circulating Pregnancy-Associated Plasma Protein-A in Non-atherosclerotic, Non-heparinized Pigs.

Steffensen LB, Poulsen CB, Shim J, Bek M, Jacobsen K, Conover CA, Bentzon JF, Oxvig C.

J Cardiovasc Transl Res. 2015 Dec;8(9):528-35. doi: 10.1007/s12265-015-9656-y. Epub 2015 Oct 6.


PAPP-A proteolytic activity enhances IGF bioactivity in ascites from women with ovarian carcinoma.

Thomsen J, Hjortebjerg R, Espelund U, Ørtoft G, Vestergaard P, Magnusson NE, Conover CA, Tramm T, Hager H, Høgdall C, Høgdall E, Oxvig C, Frystyk J.

Oncotarget. 2015 Oct 13;6(31):32266-78. doi: 10.18632/oncotarget.5010.


Pregnancy-associated plasma protein-A deficiency improves survival of mice on a high fat diet.

Conover CA, Bale LK, Marler RJ.

Exp Gerontol. 2015 Oct;70:131-4. doi: 10.1016/j.exger.2015.08.007. Epub 2015 Aug 29.


PAPP-A affects tendon structure and mechanical properties.

Yang TH, Thoreson AR, An KN, Zhao C, Conover CA, Amadio PC.

J Struct Biol. 2015 Oct;192(1):59-66. doi: 10.1016/j.jsb.2015.08.012. Epub 2015 Aug 22.


Pregnancy-associated plasma protein-A modulates the anabolic effects of parathyroid hormone in mouse bone.

Clifton KB, Conover CA.

Bone. 2015 Dec;81:413-416. doi: 10.1016/j.bone.2015.08.015. Epub 2015 Aug 20.


A novel neutralizing antibody targeting pregnancy-associated plasma protein-a inhibits ovarian cancer growth and ascites accumulation in patient mouse tumorgrafts.

Becker MA, Haluska P Jr, Bale LK, Oxvig C, Conover CA.

Mol Cancer Ther. 2015 Apr;14(4):973-81. doi: 10.1158/1535-7163.MCT-14-0880. Epub 2015 Feb 18.


Pregnancy-associated plasma protein-A expression in human breast cancer.

Mansfield AS, Visscher DW, Hart SN, Wang C, Goetz MP, Oxvig C, Conover CA.

Growth Horm IGF Res. 2014 Dec;24(6):264-7. doi: 10.1016/j.ghir.2014.10.007.


Motor and memory testing of long-lived pregnancy-associated plasma protein--a knock-out mice.

Mason EJ, Grell JA, West SA, Conover CA.

Growth Horm IGF Res. 2014 Dec;24(6):251-5. doi: 10.1016/j.ghir.2014.08.006. Epub 2014 Aug 20.


Tissue-specific changes in pregnancy associated plasma protein-A expression with age in mice.

Harstad SL, Conover CA.

Exp Gerontol. 2014 Sep;57:13-7. doi: 10.1016/j.exger.2014.04.011. Epub 2014 May 9.


Preferential expression of PAPPA in human preadipocytes from omental fat.

Davidge-Pitts C, Escande CJ, Conover CA.

J Endocrinol. 2014 Jul;222(1):87-97. doi: 10.1530/JOE-13-0610. Epub 2014 Apr 29.


Heparin-binding mechanism of the IGF2/IGF-binding protein 2 complex.

Lund J, Søndergaard MT, Conover CA, Overgaard MT.

J Mol Endocrinol. 2014 Jun;52(3):345-55. doi: 10.1530/JME-13-0184. Epub 2014 Mar 6.


Indirect targeting of IGF receptor signaling in vivo by substrate-selective inhibition of PAPP-A proteolytic activity.

Mikkelsen JH, Resch ZT, Kalra B, Savjani G, Kumar A, Conover CA, Oxvig C.

Oncotarget. 2014 Feb 28;5(4):1014-25.


Inducible reduction in pregnancy-associated plasma protein-A gene expression inhibits established atherosclerotic plaque progression in mice.

Bale LK, Chakraborty S, Conover CA.

Endocrinology. 2014 Apr;155(4):1184-7. doi: 10.1210/en.2013-2110. Epub 2014 Feb 7.


Preferential impact of pregnancy-associated plasma protein-A deficiency on visceral fat in mice on high-fat diet.

Conover CA, Harstad SL, Tchkonia T, Kirkland JL.

Am J Physiol Endocrinol Metab. 2013 Nov 1;305(9):E1145-53. doi: 10.1152/ajpendo.00405.2013. Epub 2013 Sep 17.


Mice deficient in PAPP-A show resistance to the development of diabetic nephropathy.

Mader JR, Resch ZT, McLean GR, Mikkelsen JH, Oxvig C, Marler RJ, Conover CA.

J Endocrinol. 2013 Sep 6;219(1):51-8. doi: 10.1530/JOE-13-0167. Print 2013 Oct.


Inducible knock out of pregnancy-associated plasma protein-a gene expression in the adult mouse: effect on vascular injury response.

Conover CA, Bale LK, Powell DR.

Endocrinology. 2013 Aug;154(8):2734-8. doi: 10.1210/en.2013-1320. Epub 2013 Jun 7.


Pregnancy-associated plasma protein A (PAPP-A) modulates the early developmental rate in zebrafish independently of its proteolytic activity.

Kjaer-Sorensen K, Engholm DH, Kamei H, Morch MG, Kristensen AO, Zhou J, Conover CA, Duan C, Oxvig C.

J Biol Chem. 2013 Apr 5;288(14):9982-92. doi: 10.1074/jbc.M112.426304. Epub 2013 Feb 19.


Constitutive expression of pregnancy-associated plasma protein-A in arterial smooth muscle reduces the vascular response to injury in vivo.

Bale LK, Resch ZT, Harstad SL, Overgaard MT, Conover CA.

Am J Physiol Endocrinol Metab. 2013 Jan 15;304(2):E139-44. doi: 10.1152/ajpendo.00376.2012. Epub 2012 Nov 20.


Effects of mutated pregnancy-associated plasma protein-a on atherosclerotic lesion development in mice.

Boldt HB, Bale LK, Resch ZT, Oxvig C, Overgaard MT, Conover CA.

Endocrinology. 2013 Jan;154(1):246-52. doi: 10.1210/en.2012-1552. Epub 2012 Nov 16.


Role of PAPP-A in aging and age-related disease.

Conover CA.

Exp Gerontol. 2013 Jul;48(7):612-3. doi: 10.1016/j.exger.2012.06.017. Epub 2012 Jul 10. Review.


Key questions and answers about pregnancy-associated plasma protein-A.

Conover CA.

Trends Endocrinol Metab. 2012 May;23(5):242-9. doi: 10.1016/j.tem.2012.02.008. Epub 2012 Mar 28. Review.


Insulin-like growth factor (IGF)-I and IGF-II contribute differentially to the phenotype of pregnancy associated plasma protein-A knock-out mice.

Mason EJ, Grell JA, Wan J, Cohen P, Conover CA.

Growth Horm IGF Res. 2011 Oct;21(5):243-7. doi: 10.1016/j.ghir.2011.06.002. Epub 2011 Jul 28.


Pregnancy-associated plasma protein-A2 (PAPP-A2): tissue expression and biological consequences of gene knockout in mice.

Conover CA, Boldt HB, Bale LK, Clifton KB, Grell JA, Mader JR, Mason EJ, Powell DR.

Endocrinology. 2011 Jul;152(7):2837-44. doi: 10.1210/en.2011-0036. Epub 2011 May 17.


Overexpression of pregnancy-associated plasma protein-A in ovarian cancer cells promotes tumor growth in vivo.

Boldt HB, Conover CA.

Endocrinology. 2011 Apr;152(4):1470-8. doi: 10.1210/en.2010-1095. Epub 2011 Feb 8.


PAPP-A: a new anti-aging target?

Conover CA.

Aging Cell. 2010 Dec;9(6):942-6. doi: 10.1111/j.1474-9726.2010.00630.x. Epub 2010 Oct 21. Review.


Longevity is not influenced by prenatal programming of body size.

Conover CA, Bale LK, Grell JA, Mader JR, Mason MA.

Aging Cell. 2010 Aug;9(4):647-9. doi: 10.1111/j.1474-9726.2010.00589.x. Epub 2010 Jun 9.


Transgenic overexpression of pregnancy-associated plasma protein-A in murine arterial smooth muscle accelerates atherosclerotic lesion development.

Conover CA, Mason MA, Bale LK, Harrington SC, Nyegaard M, Oxvig C, Overgaard MT.

Am J Physiol Heart Circ Physiol. 2010 Aug;299(2):H284-91. doi: 10.1152/ajpheart.00904.2009. Epub 2010 May 14.


Longevity and age-related pathology of mice deficient in pregnancy-associated plasma protein-A.

Conover CA, Bale LK, Mader JR, Mason MA, Keenan KP, Marler RJ.

J Gerontol A Biol Sci Med Sci. 2010 Jun;65(6):590-9. doi: 10.1093/gerona/glq032. Epub 2010 Mar 29.


Lack of functional pregnancy-associated plasma protein-A (PAPPA) compromises mouse ovarian steroidogenesis and female fertility.

Nyegaard M, Overgaard MT, Su YQ, Hamilton AE, Kwintkiewicz J, Hsieh M, Nayak NR, Conti M, Conover CA, Giudice LC.

Biol Reprod. 2010 Jun;82(6):1129-38. doi: 10.1095/biolreprod.109.079517. Epub 2010 Feb 3.


Transforming growth factor-beta1 modulates insulin-like growth factor binding protein-4 expression and proteolysis in cultured periosteal explants.

Gonzalez C, Auw Yang KG, Schwab JH, Fitzsimmons JS, Reinholz MM, Resch ZT, Bale LK, Clemens VR, Conover CA, O'Driscoll SW, Reinholz GG.

Growth Horm IGF Res. 2010 Apr;20(2):81-6. doi: 10.1016/j.ghir.2009.06.002. Epub 2009 Aug 4.


Resistance to age-dependent thymic atrophy in long-lived mice that are deficient in pregnancy-associated plasma protein A.

Vallejo AN, Michel JJ, Bale LK, Lemster BH, Borghesi L, Conover CA.

Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11252-7. doi: 10.1073/pnas.0807025106. Epub 2009 Jun 22.

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